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Frontiers in Biophotonics for Translational Medicine
by Malini Olivo U. S. DinishThe present book provides recent developments in various in vivo imaging and sensing techniques such as photo acoustics (PA) imaging and microscopy, ultrasound-PA combined modalities, optical coherence tomography (OCT) and micro OCT, Raman and surface enhanced Raman scattering (SERS), Fluorescence lifetime imaging (FLI) techniques and nanoparticle enabled endoscopy etc. There is also a contributing chapter from leading medical instrumentation company on their view of optical imaging techniques in clinical laparoscopic surgery. The UN proclaimed 2015 as the International Year of Light and Light-based Technologies, emphasizing achievements in the optical sciences and their importance to human beings. In this context, this book focusses on the recent advances in biophotonics techniques primarily focused towards translational medicine contributed by thought leaders who have made cutting edge developments in various photonics techniques.
Frontiers in Cancer Research
by Carlo C. Maley Mel GreavesThis is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention.
Frontiers in Gynecological Endocrinology
by Andrea R. Genazzani Mark BrincatThis volume represents an up-to-date overview on the major areas of gynecological endocrinology, providing the reader with a complete explanation of female endocrine regulation and metabolism and relevant disorders and treatment. It is published within the International Society of Gynecological Endocrinology (ISGE) Series and is based on the 2013 International School of Gynecological and Reproductive Endocrinology Summer Course. The book covers a very wide range of topics - from primary amenorrhea to menopause, from the impact of ovarian surgery on fertility to fertility cryopreservation, from metabolic syndrome and polycystic ovary to premature ovarian failure and from the clinical impact of selective progesterone receptor modulators to the use of progesterone in prevention of premature labor. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women's health as well as interested GPs.
Frontiers in Gynecological Endocrinology
by Andrea R. Genazzani Bart C. J. M. FauserThis volume offers an up-to-date overview on the major areas of gynecological endocrinology, presenting the latest advances in adolescent gynecological endocrinology, assisted reproduction, menstrual-related disorders, sexuality and transsexualism, polycystic ovary syndrome, myometrial pathology and adenomyosis, obesity and metabolic syndrome, hormonal contraception, premature ovarian failure and menopause. In each chapter the recent advances deriving from basic science and clinical investigations are related to the practical management of the condition under consideration, taking into account the need for individualized therapies. The book is published within the ISGE Book Series, a joint venture between the International Society of Gynecological Endocrinology and Springer and is based on the 2014 International School of Gynecological and Reproductive Endocrinology Winter Course. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women's health as well as interested GPs.
Frontiers in Gynecological Endocrinology
by Andrea R. Genazzani Charles SultanThis volume provides a comprehensive, up-to-date overview on pediatric and adolescent gynecological endocrinology. It covers a very wide range of topics with a particular focus on disorders of sex differentiation, pubertal maturation, growth disorders, primary and secondary amenorrhea, menstrual disorders in adolescents and young adults, sexuality, contraception, and pregnancy. The authors are international well-known experts who document the latest clinical experience in this continuously evolving field and provide practical guidance on the evaluation and treatment of female pubertal problems. The book is published within the International Society of Gynecological Endocrinology (ISGE) Series and is based on the 2015 International School of Gynecological and Reproductive Endocrinology (ISGRE) Summer Course. It will be an invaluable reference for gynecologists, endocrinologists, pediatricians, and experts in women's health.
Frontiers in Gynecological Endocrinology
by Andrea R. Genazzani Basil C. TarlatzisThis volume represents an up-to-date overview on ovarian functions and reproduction, providing the reader with the latest advances in gynecological endocrinology. It is published within the International Society of Gynecological Endocrinology (ISGE) Series, and is based on the 2015 International School of Gynecological and Reproductive Endocrinology Winter Course. The book covers a very wide range of topics with particular focus on ovulation and assisted reproduction, ovarian aging and fertility, and premature ovarian failure. The volume will be an invaluable tool for gynecologists, endocrinologists, obstetrician, and experts in women's health.
Frontiers in Nano-therapeutics
by Nishat Tasnim Baiju G. Nair Katla Sai Krishna Sudhakar Kalagara Mahesh Narayan Juan C. Noveron Binata JoddarThis brief highlights recent research advances in the area of nano-therapeutics. Nanotechnology holds immense potential for application in a wide range of biological and engineering applications such as molecular sensors for disease diagnosis, therapeutic agents for the treatment of diseases, a vehicle for delivering therapeutics and imaging agents for theranostic applications, both in-vitro and in-vivo. The brief is grouped into the following sections namely, A) Discrete Nanosystems ; B) Anisotropic Nanoparticles; C) Nano-films/coated/layered and D) Nano-composites.
Frontiers in Orthopaedic Biomechanics
by Cheng-Kung Cheng Savio L-Y. WooThis book provides state-of-the-art and up-to-date discussions on the pathology-related considerations and implications in the field of orthopaedic biomechanics. It presents fundamental engineering and mechanical theories concerning the biomechanics of orthopaedic and anatomical structures, and explores the biological and mechanical features that influence or modify the biomechanics of these structures. It also addresses clinically relevant biomechanical issues with a focus on diagnosis, injury, prevention and treatment. The first 12 chapters of the book provide a detailed review of the principles of orthopaedic biomechanics in the musculoskeletal system, including cartilage, bone, muscles and tendon, ligament, and multiple joints. Each chapter also covers important biomechanical concepts relevant to surgical and clinical practice. The remaining chapters examines clinically relevant trauma and injury challenges in the field, including diagnostic techniques such as movement analysis and rehabilitation intervention. Lastly it describes advanced considerations and approaches for fracture fixation, implant design, and biomaterials.
Frontiers in Ovarian Cancer Science
by Hidetaka KatabuchiThis volume presents the latest advances and the current status of our understanding regarding ovarian cancer, addressing both the basic and clinical aspects of the disease. In terms of basic medicine, the WHO Classification of Tumors of Female Reproductive Organs was revised in 2014, and that version addresses several new concepts and histopathological classifications not previously included. One of the most revolutionary breakthroughs concerns the genesis of epithelial ovarian tumors, shifting the focus from the ovarian surface epithelium to serous tubal intraepithelial carcinomas. Clinically, the mortality rate of epithelial ovarian cancer has gradually increased over the past few decades, making it essential to pursue multidisciplinary treatment and apply novel techniques such as neoadjuvant chemotherapy in daily clinical practice. The primary clinical task is the effective treatment of recurrent ovarian cancer with early palliative medicine. Fertility-sparing surgery may also be pursued depending on histologic subtypes, stage, extent of disease, and preexisting ovarian reserve with the concept of oncofertility. On the basis of the considerations described above, each expert author elucidates the science of ovarian cancer in detail, thus providing a collection that will benefit young medical oncologists and seasoned gynecologists and obstetricians alike.
Frontiers in Pharmacology of Neurotransmitters
by Puneet Kumar Pran Kishore DebNumerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.
Frontiers in Protein Structure, Function, and Dynamics
by Dev Bukhsh Singh Timir TripathiThis book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics. Starting with a basic introduction to protein purification, estimation, storage, and its effect on the protein structure, function, and dynamics, it also discusses various experimental and computational structure determination approaches; the importance of molecular interactions and water in protein stability, folding and dynamics; kinetic and thermodynamic parameters associated with protein-ligand binding; single molecule techniques and their applications in studying protein folding and aggregation; protein quality control; the role of amino acid sequence in protein aggregation; muscarinic acetylcholine receptors, antimuscarinic drugs, and their clinical significances. Further, the book explains the current understanding on the therapeutic importance of the enzyme dopamine beta hydroxylase; structural dynamics and motions in molecular motors; role of cathepsins in controlling degradation of extracellular matrix during disease states; and the important structure-function relationship of iron-binding proteins, ferritins. Overall, the book is an important guide and a comprehensive resource for understanding protein structure, function, dynamics, and interaction.
Frontiers in Psychiatry: Artificial Intelligence, Precision Medicine, and Other Paradigm Shifts (Advances in Experimental Medicine and Biology #1192)
by Yong-Ku KimThis book reviews key recent advances and new frontiers within psychiatric research and clinical practice. These advances either represent or are enabling paradigm shifts in the discipline and are influencing how we observe, derive and test hypotheses, and intervene. Progress in information technology is allowing the collection of scattered, fragmented data and the discovery of hidden meanings from stored data, and the impacts on psychiatry are fully explored. Detailed attention is also paid to the applications of artificial intelligence, machine learning, and data science technology in psychiatry and to their role in the development of new hypotheses, which in turn promise to lead to new discoveries and treatments. Emerging research methods for precision medicine are discussed, as are a variety of novel theoretical frameworks for research, such as theoretical psychiatry, the developmental approach to the definition of psychopathology, and the theory of constructed emotion. The concluding section considers novel interventions and treatment avenues, including psychobiotics, the use of neuromodulation to augment cognitive control of emotion, and the role of the telomere-telomerase system in psychopharmacological interventions.
Frontiers in Spray Drying (Advances in Drying Science and Technology)
by Jie Xiao Meng Wai Woo Nan Fu Xiao Dong ChenThis book covers the latest developments and advances in spray drying and describes how they impact the basic aspect of designing and operating spray dryers. This generic approach allows users to understand how different basic aspects of spray drying have advanced. Users will learn how to apply these advances in their own specific spray drying applications. This book also discusses the handling and control of spray dried products. Includes the latest techniques for use in the design and operation of spray drying operations Covers the basic operations of spray drying that can be applied to different applications of spray drying Discusses the handling and control of spray dried product qualities from a general approach, allowing readers to tailor these approaches to their own specific products This book is aimed at professionals, researchers, and academics working in the fields of food, chemical, pharmaceutical, and industrial engineering.
Frontiers in Statistical Quality Control 12 (Frontiers in Statistical Quality Control)
by Sven Knoth Wolfgang SchmidThis book provides insights into important new developments in the area of statistical quality control and critically discusses methods used in on-line and off-line statistical quality control.The book is divided into three parts: Part I covers statistical process control, Part II deals with design of experiments, while Part III focuses on fields such as reliability theory and data quality. The 12th International Workshop on Intelligent Statistical Quality Control (Hamburg, Germany, August 16 – 19, 2016) was jointly organized by Professors Sven Knoth and Wolfgang Schmid. The contributions presented in this volume were carefully selected and reviewed by the conference’s scientific program committee. Taken together, they bridge the gap between theory and practice, making the book of interest to both practitioners and researchers in the field of quality control.
Frontiers in Statistical Quality Control 13 (Frontiers in Statistical Quality Control)
by Sven Knoth Wolfgang SchmidThis contributed book focuses on major aspects of statistical quality control, shares insights into important new developments in the field, and adapts established statistical quality control methods for use in e.g. big data, network analysis and medical applications. The content is divided into two parts, the first of which mainly addresses statistical process control, also known as statistical process monitoring. In turn, the second part explores selected topics in statistical quality control, including measurement uncertainty analysis and data quality.The peer-reviewed contributions gathered here were originally presented at the 13th International Workshop on Intelligent Statistical Quality Control, ISQC 2019, held in Hong Kong on August 12-14, 2019. Taken together, they bridge the gap between theory and practice, making the book of interest to both practitioners and researchers in the field of statistical quality control.
Frontiers of COVID-19: Scientific and Clinical Aspects of the Novel Coronavirus 2019
by Paul Griffin Sasan Adibi Melvin Sanicas Maryam Rashidi Francesco LanfranchiThis book aims to serve the critical interests of the global community by supplying the most current knowledge and understanding of Covid-19 epidemiology, treatment, and prognoses. There was much uncertain and contradictory information published in the first year of the novel coronavirus. The dynamics of COVID-19 have now been realized, including the type of antibodies produced in infected patients and their limited lasting endurance. This book will set the record straight on the concept of “herd immunity” and explore the current vaccine trials taking place in different countries. This comprehensive book will illuminate recent advances regarding COVID-19 and offer a possible roadmap on how to move forward. Frontiers of COVID-19: A Pathophysiology and Epidemiology Roadmap of Novel Coronavirus Disease will be a vital and forward-looking guide for infectious disease clinicians, scientists and researchers, and students at the graduate level.
Frontiers of Cord Blood Science
by Phillip Stubblefield Niranjan BhattacharyaCord blood is a significant source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Cord blood is also an alternative to embryos as a source of tissue for regenerative medicine. Cells from cord blood have been shown to transdifferentiate into nonhematopoietic cells, including those of the brain, heart, liver, pancreas, bone, and cartilage, in tissue culture and in animal systems. Recently it has been demonstrated that both cardiac and glial cell differentiation of cord blood donor cells occurred in recipients of unrelated donor cord blood transplantation as part of a treatment regime for Krabbe disease and Sanfilippo syndrome. These observations raise the possibility that cord blood may serve as a source of cells to facilitate tissue repair and regeneration in the future. CD34 stem cell-rich umbilical cord whole blood transfusion has the potential to have an immediate benefit of better tissue oxygenation with an additional delayed benefit of possible engraftment of umbilical cord stem cells.
Frontiers of ICT in Healthcare: Proceedings of EAIT 2022 (Lecture Notes in Networks and Systems #519)
by Debashis De Jyotsna Kumar MandalThe book includes original unpublished contributions presented at the Seventh International Conference on Emerging Applications of Information Technology (EAIT 2022), organized by Computer Society of India, Kolkata, Chapter during March 30–31, 2022. The book covers the topics such as image processing for smart healthcare applications, computer vision and pattern recognition for health care, Internet of Health Things, 5G and beyond in smart health care for sustainable cities.
Frontiers of Statistics and Data Science (IISA Series on Statistics and Data Science)
by Subhashis Ghosal Anindya RoyThis book addresses a diverse set of topics of contemporary interest in statistics and data science such as biostatistics and machine learning. Each chapter provides an overview of the topic under discussion, so that any reader with an understanding of graduate-level statistics, but not necessarily with a prior background on the topic should be able to get a summary of developments in the field. These chapters serve as basic introductory references for new researchers in these fields, as well as the basis of teaching a course on the topic, or with a part of the course on topics of precision medicine, deep learning, high-dimensional central limit theorems, multivariate rank testing, R programming for statistics, Bayesian nonparametrics, large deviation asymptotics, spatio-temporal modeling of Covid-19, statistical network models, hidden Markov models, statistical record linkage analysis. The edited volume will be most useful for graduate students looking for an overview of any of the covered topics for their research and for instructors for developing certain courses by including any of the topics as part of the course. Students enrolled in a course covering any of the included topics can also benefit from these chapters.
Frontline Surgeon: New Zealand Medical Pioneer Douglas Jolly
by Mark DerbyAlthough a young doctor when he volunteered for the Spanish Civil War in late 1936, New Zealander Douglas Jolly swiftly acquired a reputation as one of the most gifted and energetic surgeons of the Republican Army&’s medical services. Over the next two years he performed countless life-saving operations on wounded combatants from both sides of the conflict, as well as on civilians. Tireless, dedicated, and courageous, he developed significant and innovative treatment systems based on the principle of working as near as possible to the front line. Jolly used this unprecedented battlefield experience to write a manual that was widely used in World War II and the Korean and Vietnam Wars.Frontline Surgeon traces Jolly&’s remarkable career from medical training in 1920s New Zealand, postgraduate study during the rise of fascism in Europe, almost a decade of frontline surgery, and into civilian life as medical director of Britain&’s largest hospital for amputees. One of the greatest war surgeons of the twentieth century, Jolly has been mysteriously omitted from the ranks of pioneers of modern medicine. This engaging biography, intensively researched in many countries, both explains and redresses that omission.
Frontofacial Monobloc Advancement with Internal Distraction: Tactics And Strategy In Faciocraniosynostosis
by Eric Arnaud Giovanna Paternoster Roman Hossein Khonsari Samer E. Haber<p>Based on the experience at one of the largest centers for craniosynostosis and craniofacial malformations, this book reports on the clinical use of a rare technique known as Frontofacial Monobloc Advancement (FFMBA), one of the most rewarding procedures for upper- and mid-face reconstruction in patients with faciocraniosynostosis, a rare craniofacial anomaly associated with premature fusion of multiple cranial sutures presenting with brachycephaly, orbital proptosis, maxillary hypoplasia and anterior crossbite. Technical refinements and strategic planning have made it almost a routine procedure at the French Reference Center for Craniosynostosis and Craniofacial Malformations.<p> <p>This easy-to-consult, well illustrated book includes technical tips and indications for its use in Crouzon, Pfeiffer and Apert syndromes. It also provides a prool, including a proposed management algorithm for faciocraniosynostosis. As such, it will appeal to craniofacial surgeons, especially those at large craniofacial centers.<p>
Frontofacial Monobloc Advancement with Internal Distraction: Tactics and Strategy in Faciocraniosynostosis
by Eric Arnaud Giovanna Paternoster Roman Hossein Khonsari Samer E. HaberBased on the experience at one of the largest centers for craniosynostosis and craniofacial malformations, this book reports on the clinical use of a rare technique known as Frontofacial Monobloc Advancement (FFMBA), one of the most rewarding procedures for upper- and mid-face reconstruction in patients with faciocraniosynostosis, a rare craniofacial anomaly associated with premature fusion of multiple cranial sutures presenting with brachycephaly, orbital proptosis, maxillary hypoplasia and anterior crossbite.Technical refinements and strategic planning have made it almost a routine procedure at the French Reference Center for Craniosynostosis and Craniofacial Malformations. This easy-to-consult, well illustrated book includes technical tips and indications for its use in Crouzon, Pfeiffer and Apert syndromes. It also provides a protocol, including a proposed management algorithm for faciocraniosynostosis. As such, it will appeal to craniofacial surgeons, especially those at large craniofacial centers.
Frontoffice en administratie voor tandartsassistenten (Basiswerk AG)
by Maria de Vries Elly HogeveenDit studieboek is bedoeld voor studenten van de mbo-opleiding tandartsassistent. De theorie en verwerkingsopdrachten helpen je bij de communicatie met patiënten en een goede tandheelkundige administratie te voeren, zowel in de frontoffice, backoffice als aan de behandelstoel. Het leert je hoe je een patiëntenadministratie voert en hoe je declaraties correct afhandelt. Daarbij is inzicht en kennis van wet- en regelgeving noodzakelijk. Het studieboek is bedoeld voor assistenten in opleiding, maar is ook geschikt als naslagwerk voor medewerkers in de mondzorgpraktijk.Deze vierde druk is geactualiseerd na de invoering van het nieuwe kwalificatiedossier. Het boek is uitgebreid met nog meer kennis en vaardigheden. De theorie is waar mogelijk zo veel mogelijk versimpeld en er zijn nieuwe afbeeldingen toegevoegd. Er staan veel verwerkingsopdrachten in om zelf te kunnen oefenen met de lesstof. Ten slotte is het laatste hoofdstuk over beheertaken uit dit boek verwijderd. Het boek Management, beheer en organisatie voor tandartsassistenten voorziet in de behoefte aan meer uitleg en informatie over dit thema en veel meer. Elly Hogeveen is van oorsprong tandarts- en preventieassistent en is docent aan de opleiding tot tandartsassistent aan ROC Friese Poort in Leeuwarden. Ook is zij praktijkmanager in een tandartsenpraktijk te Grou. Maria de Vries is begonnen als tandartsassistent en is docent aan de opleiding tot tandartsassistent aan de Noorderpoort in Groningen. Tevens is zij praktijkmanager in een tandartsenpraktijk te Burgum. Beiden verzorgen een breed scala aan lessen over administratie, management, beheer & organisatie, praktijkvoering en omgangskunde.
Frontoffice en administratie voor tandartsassistenten (Basiswerk AG)
by Maria de Vries Elly HogeveenDit studieboek helpt je een goede tandheelkundige administratie te voeren zowel in de frontoffice als aan de behandelstoel. Het leert je de patiëntenadministratie en de bijbehorende declaraties correct af te handelen, rekening houdende met de wet- en regelgeving. Het boek Frontoffice en administratie voor tandartsassistenten is bedoeld voor tandartsassistenten in opleiding, maar is ook een prima naslagwerk voor medewerkers in de mondzorgpraktijk. Deze vijfde druk is geactualiseerd. De theorie is daar waar mogelijk versimpeld en aangevuld met nog betere afbeeldingen. Er staan nog steeds veel opdrachten in om zelf te kunnen oefenen met de lesstof. Elk hoofdstuk kan worden afgesloten met een theorietoets. Elly Hogeveen is van oorsprong tandarts- en preventieassistent, heeft jarenlange ervaring als docent aan de opleiding tot tandartsassistent in Leeuwarden. Daarnaast heeft ze gewerkt als praktijkmanager in een tandartsenpraktijk te Grou. Op dit moment is zij werkzaam als teamleider bij Firda, mbo-college Sneek. Tevens schrijft zij de opdrachten voor het Nederlands Kampioenschap tandartsassistent van WorldSkills Netherlands, en is ze verantwoordelijk voor de organisatie van The Finals van WorldSkills. Maria de Vries is ook begonnen als tandartsassistent en is op dit moment docent aan de opleiding tot tandartsassistent in Groningen. Tevens is zij praktijkmanager bij Tandartsenpraktijk Burgum. Daarnaast is zij vaststeller van de Proeves van Bekwaamheid en keuzedelen van Dentallect en is lid van de adviesraad van E-Wise.
Frontotemporal Dementias: Emerging Milestones of the 21st Century (Advances in Experimental Medicine and Biology #1281)
by Bernardino Ghetti Emanuele Buratti Bradley Boeve Rosa RademakersUnder the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind. In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders. This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements that are relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD. The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD. This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD. Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD.