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GI Emergencies: A Quick Reference Guide
by Robert Lowe Francis A. FarrayeGI Emergencies: A Quick Reference Guide contains practical information regarding the diagnosis and management of common gastrointestinal emergencies. Each chapter is written by a fellow or resident with an experienced clinician. This offers the perspective of a trainee, who has many basic questions about how to handle a given situation, combined with the experience of a seasoned practitioner who can guide the work-up and treatment of each clinical case. The result is a reference that provides the clinical acumen of a trained gastroenterologist in an easy-to-use format for physicians to approach GI emergencies efficiently and thoroughly. The dual-perspectives blend perfectly together to create a practical, evidence-based read for the learning physician.In GI Emergencies: A Quick Reference Guide, Dr. Robert C. Lowe and Dr. Francis A. Farraye, along with 20 contributors, help physicians deal with problems as they occur in a “real-time” format. Some Topics Include: • Evaluation and management of acute liver failure• Caustic ingestions, foreign bodies, and food impaction• Nonvariceal upper GI hemorrhage• Acute pancreatitis• Complications of endoscopyThe case-based format is less formal than that of a typical textbook, making it enjoyable without losing the educational value and evidence-based recommendations needed to provide excellent patient care. With succinct key teaching points, GI Emergencies: A Quick Reference Guide assists physicians who are training interns, residents, and medical students in training, making it an all-around reference for those in the gastroenterology field.
GI Endoscopic Emergencies
by Louis M. Wong Kee Song Emmanuel C. Gorospe Todd H. BaronThis volume provides a concise, yet comprehensive, state-of-the art overview of GI endoscopic emergencies. Although the emphasis is on endoscopic management, peri-procedural considerations, adjunctive medical therapy, and clinical approaches to commonly encountered GI emergencies are discussed in detail. This sets the stage for the in-depth review of current as well as innovative devices and techniques for endotherapy in GI emergencies. Technical aspects of endoscopic procedures are emphasized and supplemented by online video clips to enhance the educational experience. Written by experts in the field, GI Endoscopic Emergencies serves as a valuable resource for practitioners who deal with GI emergencies.
GI Epidemiology
by G. Richard Locke Yuri A. Saito Nicholas J. Talley Joseph J. West Paul Moayyedi Alexander C. FordThe only book to combine epidemiological analysis of gastrointestinal diseases with an examination of the methodologies of clinical research, GI Epidemiology, 2nd Edition, unites global experts to identify why and how GI diseases occur, to whom, and what can be done to prevent them. With new editors, new contributors, and a new, more user-friendly approach to epidemiology, this edition presents vital information in an accessible framework.
GI Surgery Annual
by Peush Sahni Sujoy PalThe twenty-second volume of GI Surgery Annual covers a gamut of topics from oesophageal adenocarcinoma, to motility disorders of the colon and rectum, mesenteric tumours as well as the contemporary technique of ALPPS, acute portal vein thrombosis and small for size syndrome in live donor liver transplant. The chapter on advances in gastrointestinal surgery as every year reviews the important new information in the field in an easy to understand manner.
GI Surgery Annual
by Peush Sahni Sujoy PalThe 23rd volume of this highly successful series includes new contemporary topics such as PET in HPB diseases, short gut syndrome, current status of extended lymphadenectomy in esophageal cancer, splenectomy for haematological disorders, postoperative liver failure, HIPEC, and current issues in surgery of pancreatic cancer. Finally, the chapter on advances in GI surgery, like in each volume in the past, reviews the important new developments in the field. The GI Surgery Annual 23rd Volume provides an overall round up of selected topics that are considered relevant and contemporary by the editors of the series.
GI Surgery Annual: Volume 23 (GI Surgery Annual #23)
by Peush Sahni Sujoy PalThe 24th volume of this highly successful series includes new contemporary topics such as corrosive injuries of the oesophagus, post-gastrectomy complications, advances in imaging of inflammatory bowel disease, unusual presentations of gallstones, gall bladder cancer with jaundice, minimally invasive pancreatic surgery, and enhanced recovery after surgery. Finally, the chapter on advances in GI surgery, like in each past volume, reviews important new developments in the field. The GI Surgery Annual 24th Volume provides an overall roundup of selected topics that were deemed particularly relevant and topical by the series editors.
GI Surgery Annual: Volume 25 (GI Surgery Annual #25)
by Peush Sahni Sujoy Pal T. K. ChattopadhyayThe 25th volume of this highly successful series covers a range of interesting topics, including biological therapy in inflammatory bowel disease, recent surgical approaches in rectal cancer, tumor markers in HPB and GI malignancies, bridging therapy for hepatocellular carcinoma, adjuncts to liver resection, IgG-related HPB diseases, ERCP-induced perforations and superior mesenteric artery syndrome. As in the previous volumes, the chapter on advances in GI surgery reviews the important new developments in the field. The GI Surgery Annual 25th Volume provides up-to-date information on current hot topics.
GI Surgery Annual: Volume 26 (GI Surgery Annual #26)
by T. K. ChattopadhyayThe twenty-sixth volume of GI Surgery Annual includes chapters on current and upcoming topics in gastrointestinal surgery pertaining to cholangiopancreatoscopy, robotic liver resections and transplants, primary familial intrahepatic cholestasis, managing a patient after total pancreatectomy, transplant immunology and immunosuppression as well as the chapter on advances in gastrointestinal surgery. The authors have expertise and excellent academic track record in the relevant subspecialties. Marrying academic excellence with publishing expertise is going to be the new mantra for the present as well as the upcoming issues of GI Surgery Annual.
GI and Liver Disease During Pregnancy: A Practical Approach
by Kim Isaacs Millie LongGI and Liver Disease During Pregnancy: A Practical Approach by Drs. Kim Isaacs and Millie D. Long is a unique handbook focusing on common gastrointestinal symptoms and diseases seen in pregnant patients. Each chapter addresses the diseases or symptoms and focuses on key questions to ask the patient and key points regarding diagnosis and management. This handbook is organized to have each chapter focus on a common complaint or discrete disease, making it easy to find exact information in a ready reference. Also provided are tables of drug safety during pregnancy and breast feeding. Unique features also include a section on alternative therapies and a chapter on care in post bariatric surgery patients.Each Chapter Covers:· Epidemiology· Pathology· Presentation and Evaluation· Management · Summary· Key PointsPocket-sized and easy to read, GI and Liver Disease During Pregnancy: A Practical Approach is a convenient and accessible reference for gastroenterology fellows, OB/GYN fellows and residents, and practicing gastroenterologists.
GIS And Public Health
by Sara McLafferty Ellen CromleyAuthoritative and comprehensive, this is the leading text and professional resource on using geographic information systems (GIS) to analyze and address public health problems. Basic GIS concepts and tools are explained, including ways to access and manage spatial databases. The book presents state-of-the-art methods for mapping and analyzing data on population, health events, risk factors, and health services, and for incorporating geographical knowledge into planning and policy. Numerous maps, diagrams, and real-world applications are featured. The companion Web page provides lab exercises with data that can be downloaded for individual or course use.
GIS in Public Health Practice
by Massimo Craglia Ravi MaheswaranSignificant advances in the evaluation and use of geographic information have had a major effect on key elements of public health. Strides in mapping technology as well as the availability and accuracy of health information enable public health practitioners to link and analyze data in new ways at international, regional, and even street levels. Th
GISTs - Gastrointestinal Stromal Tumors
by Antonella Messina Elisabetta de Lutio di CastelguidoneThis book aims to provide a complete overview of the diagnosis and treatment of gastrointestinal stromal tumors (GISTs). It has been conceived to be both a detailed guide for clinical practice and an updated reference for all those involved in the evaluation of GISTs imaging. The publication provides comprehensive descriptions of the full range of common imaging and nonimaging techniques used in the diagnosis and followup of GISTs. Techniques reviewed include: Conventional radiography· Endoscopy and endoscopic ultrasound· Conventional, color-Doppler and contrast-enhanced ultrasound· Computed tomography· Magnetic resonance imaging, and· Contrast-enhanced PET/CT imaging. Both medical and surgical treatment strategies are also fully reviewed. Finally, the book concludes with a chapter that aims to stimulate widespread interest in the formation of new GISTs Units. Written by experts in the field, the book is enriched throughout by numerous black-and-white and color images, making it an invaluable source of information as well as an indispensable guide to interpreting images for radiologists, gastroenterologists, pathologists, oncologists and surgeons.
GLP Quality Audit Manual
by Milton A. AndersonDesigned to enable readers to plan and execute their own audits, this comprehensive guide presents discussions of and practical applications related to establishing a GLP QA unit and performing effective GLP audits. The first section provides the foundation of information needed for designing and initiating a Good Laboratory Practice quality assurance program. Section II contains ready-to-use audit checklists and regulatory references that are in accordance with the most recent regulations. Section Ill comprises the full texts of the relevant standards and regulations along with the Priniciples of Good Laboratory Practice.
GM3 Signaling
by Cheorl-Ho KimThis book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.
GMO Myths and Truths: A Citizen’s Guide to the Evidence on the Safety and Efficacy of Genetically Modified Crops and Foods, 3rd Edition
by Claire Robinson John Fagan Michael AntoniouIt is often claimed that the case against genetically modified (GM) crops and foods is based on emotion, not science, and that to oppose GM crop and food technology is to be anti-science. It is also claimed that GM crops offer higher yields and better nutrition, that they are safe for health and the environment, that they reduce agrochemical use, and that they are needed to feed the world's growing population. This book, co-authored by two genetic engineers and a writer/researcher, exposes these claims as false, using scientific and other documented evidence. GMO Myths and Truths summarizes the facts on the safety and efficacy of genetically modified (GM) crops and foods in terms that are accessible to the non-scientist but still relevant to scientists, policymakers and educators. The evidence presented points to many hazards, risks, and limitations of genetic engineering technology. These include harms found in animal feeding and ecological studies, which in turn indicate risks to health and the environment posed by GM crops and foods. The layout of the book enables those readers with limited time to read the chapter summaries, while providing more detail and full references for those who require them. At 164 pages of paperback size, this new condensed version is shorter and more accessible than the authors' 330-page report by the same name, which has been downloaded over half a million times. The book shows that conventional breeding continues to outstrip GM in developing crops that deliver high yields, better nutrition, and tolerance to extreme weather conditions and poor soils. In agreement with over 400 international experts who co-authored a UN and World Bank-sponsored report on the future of farming, the authors conclude that modern agroecology, rather than GM, is the best path for feeding the world's current and future populations in a safe and sustainable way.
GMP Audits in Pharmaceutical and Biotechnology Industries (ISSN)
by Mustafa EdikThe fact that good manufacturing practice (GMP) audits in the pharmaceutical and biotechnology industries have to be evaluated, and with very limited resources, has created a gap in this field. The lack of trained and qualified GMP auditors is on the rise in all organizations that are required to implement FDA, EMA, MHRA, WHO, TGA, and PIC/S regulations. This volume is an essential reference source for those organizations operating in the field of health and presents the basic knowledge needed to perform audits. The author also provides useful tips and a selection of samples about GMP audits that are indispensable for professionals and health inspectors working in industry and health authorities.Features An essential reference source for those organizations operating in the field of health and presents the basic knowledge needed to perform audits Anyone working in the manufacturing sector needs to be aware of GMP, be able to identify operational flaws as well as legal violations, and have a clear understanding of how to meet GMP standards Assists readers in understanding the importance of GMP and how they can apply each aspect in their working environment Covers a global regulatory landscape Suitable for relevant degree courses including industrial pharmaceutics and pharmaceutical biotechnology
GMP Compliance, Productivity, and Quality: Achieving Synergy in Healthcare Manufacturing
by Vinay BhattWritten by twenty-eight experts, filled with recommendations that can immediately be put into action, this book provides the strategies and tactics required to link and harmonize manufacturing processes with GMP to achieve optimum operability and cost-effective regulatory compliance. Drawn from name brand and generic companies and regulatory and co
GMP-Risikoanalysen (essentials)
by Patric U. VogelRisikoanalysen sind Methoden des Qualitätsrisikomanagements und nehmen eine wichtige Stellung ein. Der pharmazeutische Prozess umfasst verschiedene Bereiche, u.a. die Produktentwicklung, das regelkonforme Betreiben von Produktionsanlagen, die Beschaffung von Ausgangsmaterialien, die Fertigung von Produktchargen, die Prüfung in der Qualitätskontrolle, die Überwachung der Einhaltung aller Regularien durch die Qualitätssicherung, die Dokumentation und die Bewertung von Auffälligkeiten oder Abweichungen bis hin zur Lagerung und dem Vertrieb der Produkte. Risikoanalysen sind ein essenzielles Werkzeug, das auf alle diese Stufen und Bereiche angewendet wird. Das Ziel ist es Risiken zu identifizieren und zu bewerten, um durch geeignete Maßnahmen das Risiko ausreichend unter Kontrolle zu halten und damit die Produktqualität sicherzustellen.
GMP/ISO Quality Audit Manual for Healthcare Manufacturers and Their Suppliers, (Volume 1 - With Checklists and Software Package): Regulations, Standards, And Guidelines
by Leonard SteinbornVolume 1 of this two-part package provides a complete set of checklists for internal and contract device and drug manufacturers and developers, contract software developers, and suppliers of chemical, printed material, electronic component, and general supplies. It also includes a simulated QSIT audit, and a new-product market launch. All of these
GMP/ISO Quality Audit Manual for Healthcare Manufacturers and Their Suppliers, (Volume 2 - Regulations, Standards, and Guidelines): Regulations, Standards, and Guidelines
by Leonard SteinbornThis well-known QA manual has been updated to provide the guidance readers need to assess their compliance with standard regulations. This Volume 2 of a three-part package contains the full text on: * FDA regulations* EC and IPEC guidelines* ISO/BSI standards referenced in the checklists furnished in volume 1Easy-to-read and organized to provide fa
GP Wellbeing: Combatting Burnout in General Practice
by Adam Staten Euan LawsonThis is the first book to explore the impact of 'burnout' on the current NHS GP workforce and how this can be addressed, from an insider GP perspective. Adam Staten, recently qualified GP, and Euan Lawson, Fellow of the RCGP with over 20 years experience, discuss in engaging, accessible chapters how burnout manifests psychologically, the complex reasons why GPs burn out and the individual and broader impact this can have. Most importantly, the book offers practical advice on how to avoid burning out and combat the negative effects of an increasingly high-pressure role, exploring how GPs can develop resilience and work in a way that builds a healthier work-life balance. A section is dedicated to the array of GP job options, with testimonies from practitioners working in diverse areas from education and academia to military and humanitarian settings. This book explores the challenges of working in general practice today, but it also demonstrates the potential for every GP to experience a personally and professionally satisfying career. Providing practical, workable advice and links to resources for help and support, the book enables readers to find opportunity within the perceived 'crisis'. By reading this book, you will find the means to improve not just your own working life but also to enhance the way you deliver care to your patients.
GPCR Molecular Pharmacology and Drug Targeting
by Annette GilchristG protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference.
GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity
by Terence E. Hébert Ralf Jockers Denis J. DupréMain Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.
GPCRs as Therapeutic Targets
by Annette GilchristA thorough discussion of the structure, pharmacology, function, and role of G protein-coupled receptors In GPCRs as Therapeutic Agents, distinguished researcher Dr. Annette Gilchrist delivers an authoritative and in-depth compendium of a vibrant and active area of academic and industrial drug discovery. The book serves as an important reference for new and experienced researchers studying G protein-coupled receptors and discusses the molecular pharmacology of this important target class. It also includes up-to-date material on GPCR structures and structure-based drug design. The book explores the role of GPCRs in the treatment of disease and novel approaches to their study. In addition to providing information on the structure, pharmacology, and function of GPCRs, it discusses their role in disease states, and advances new methods for measuring GPCR activity in an accessible and engaging way. The book includes: A thorough introduction to the molecular pharmacology of G protein-coupled receptors, including up-to-date material on GPCR structures and structure-based drug design In-depth discussions of the evolving pharmacology for GPCRs, intracellular trafficking, and subcellular GPCR signaling Comprehensive explorations of allosteric modulation, receptor dimerization, deorphanization, and ubiquitination Fulsome treatments of the role played by GPCRs in the treatments of cancer, substance use disorders, cerebrovascular diseases, and metabolic diseasesPerfect for researchers in biochemistry, cell biology, and pharmacology, GPCRs as Therapeutic Agents will also earn a place in the libraries of professionals working in medicinal chemistry, structural biology, and clinical pharmacology.
GPCRs: From Deorphanization to Lead Structure Identification
by H. Bourne J. Kuhnke H. Michel Richard HorukThis book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also reflects the actual trends in the fast-emerging field of GPCR research in academia and industry. It is based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006.