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Fundamentals of Drug Delivery
by Heather A E BensonA comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.
Fundamentals of Drug Development
by Jeffrey S. BarrettFundamentals of DRUG DEVELOPMENT Enables readers to understand the process of pharmaceutical research, its regulatory basis, and how it fits into the global healthcare environment This book discusses how to conduct pharmaceutical research and the context for how the industry fits into global healthcare. Holistically, the well-qualified author helps readers and students of drug development appreciate the time and expense of the process. Specifically, the work identifies the emerging trends shaping the future of drug development, along with important related topics like generic drugs, data sharing, and collaboration. To aid in seamless reader comprehension, the book includes a glossary of terms and a self-assessment quiz for each chapter at the end. PowerPoint slides are also available as an online ancillary for adopting professors. Sample topics covered in the book include: Drug development and its phases Decision-making processes, drug development milestones, and compound progression metrics The various disciplines involved along with an assessment of the complexity and risks associated across the stages of development Differences in the nature and scope of development programs due to the therapeutic area of interest Associated costs and resources required Graduate students and professors teaching courses in drug development, drug discovery, pharmaceuticals, medicinal chemistry, and drug synthesis will be able to use this book as a complete resource for understanding all the complexities and nuances involved in the drug development process.
Fundamentals of Drug and Non-Drug Interactions: Physiopathological Perspectives and Clinical Approaches
by James O. FajemiroyeThis book covers nutrients, active principles from phytotherapy/herbal products, and drug classes while identifying potential interactions. Didactic approaches to drug and non-drug interactions and cutting-edge reports are included in each chapter that promotes safer drug prescription and use. The physiopathological overview in this book provides background for chemistry, pharmacology, and mechanistic bases of drug and non-drug interaction as well as clinical cases and predictive screenings. This book is intended for undergraduate students studying medicine, nursing, nutrition, biomedicine, and pharmacy.
Fundamentals of Environmental Assessment
by Glenn W. Suter IIBased on the "go to" book in the field of ecological risk assessment, this shorter, principles-based, updated textbook is essential for students and new practitioners who want to understand the purposes of environmental assessments and how to achieve them. It includes environmental risks to humans as well as nonhuman populations and ecosystems, and most types of environmental assessments. Drawing upon the author’s extensive experience in the field, first as a senior research staff member in the Environmental Sciences Division at Oak Ridge Laboratory and then as science advisor in the United States Environmental Protection Agency’s National Center for Environmental Assessment, the book explains fundamental principles and basic techniques and illustrates them with example applications which carry through multiple chapters and make this book a practical and hands-on guide. Both the content and the style are inviting and approachable to different levels of students.Features Integrates human health and ecological assessments. Includes epidemiological, risk, causal, impact, and outcome assessments. Focuses on fundamental principles that are applicable in all nations and legal contexts. Employs an engaging style and draws on the author’s practical experience. Explains fundamental concepts in short chapters, making it perfect for beginners in the field. Explains the challenges and rewards of a career in environmental assessment. This book is a practical guide for senior and graduate students in environmental sciences and management, as well as new practitioners of assessment who want to understand the purposes of environmental assessments and how to achieve them. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.
Fundamentals of Evidence Based Medicine
by Kameshwar PrasadThis is a basic book on evidence-based medicine (EBM). It starts with an introduction to the topic. It outlines the relationship between EBM and research and quality of care. Then It goes on to cover the most commonly used modules of EBM, i.e. therapy, diagnosis, prognosis and meta-analysis. Each module starts with an introduction to fundamental concepts, and description of the related research process, and then follows the critical appraisal of related type of research artcle. At the end, it covers the different systems of grading of level of evidence and strength of recommendations. The book also has three examples of critical appraisal on diagnosis, therapy, and meta-analysis.
Fundamentals of Evidence-Based Health Care and Translational Science
by Francesco ChiappelliComparative effectiveness research - the conduct and synthesis of systematic research in order to compare the benefits and harms of alternative treatment options - is of critical importance in enabling informed health care decisions to be made. This user-friendly, practical handbook examines in depth how best to perform such comparative effectiveness research. A wide range of topics and methods are discussed, including research synthesis, sampling analysis, assessment of evidence design, systematic evaluation of statistical analysis, and meta-analysis. The discussion extends well beyond the fundamentals by encompassing "complex" systematic reviews, "cumulative" meta-analyses, and logic-based versus utility-based decision making. Health care providers, researchers, instructors, and students will all find this to be an invaluable reference on the compelling current issues and important analytical tools in comparative effectiveness research.
Fundamentals of Frontline Surgery
by Mansoor KhanFundamentals of Frontline Surgery is an easy to read text, written by world class faculty, that provides clinicians with succinct and didactic information about what to do in high intensity, resource limited situations.With global conflicts and humanitarian emergencies on the rise, there has been a dramatic uptake in the number of volunteers for both military and humanitarian operations. This manual aids best practice and fast decision making in the field.
Fundamentals of General Surgery
by Francesco Palazzo Michael J PucciThis book provides a comprehensive guide to the surgical skills required during general surgery. General Concepts are covered with descriptions of basic terminology, the logic behind specific approaches, limitations of specific skills, technical and practical considerations, and safety of using specific approaches and skills. More advanced topics including gastro-intestinal anastomosis, exploring a patient after a major trauma, and managing crisis situations are also discussed, as well as current controversies and future directions within general surgery.Fundamentals of General Surgery is relevant to trainees in general surgery and its subspecialties, and aims to give them an easy to access resource that contains real life examples, iconography, and recommended further reading.
Fundamentals of Hand Therapy: Clinical Reasoning and Treatment Guidelines for Common Diagnoses of the Upper Extremity (2nd Edition)
by Cynthia CooperPerfect for hand therapy specialists, hand therapy students, and any other professional who encounters clients with upper extremity issues, Fundamentals of Hand Therapy, 2nd Edition contains everything you need to make sound therapy decisions. Coverage includes hand anatomy, the evaluation process, and diagnosis-specific information. Expert tips, treatment guidelines, and case studies round out this comprehensive text designed to help you think critically about each client’s individual needs. <p><p> "Overall, a very clear readable style is adopted throughout, with theory supported by various anecdotal case studies. Excellent use is made of illustrations, and many chapters contain the helpful addition of ‘clinical pearls’ or ‘tips from the field’, which are an attempt to make transparent the links between theory and practice. In conclusion, this is an excellent core text for reference purposes." Reviewed by: British Journal of Occupational Therapy Date: Aug 2014 <p> Clinical Pearls and Precautions highlight relevant information learned by the experienced author and contributors that you can apply to clinical practice.<br> Case examples included in the diagnoses chapters in Part Three demonstrate the use of clinical reasoning and a humanistic approach in treating the client.<br> Diagnosis-specific information in the final section of the book is well-organized to give you quick access to the information you need.<br> Special features sections such as Questions to Discuss with the Physician, What to Say to Clients, Tips from the Field, and more help readers find their own clinical voices.<br> Online sample exercises give you a pool to pull from during professional practice.<br> NEW! Chapters on yoga and pilates provide guidance into new ways to treat upper extremity problems.<br> NEW! Chapter on wound care gives you a thorough foundation on how wounds impact therapeutic outcomes.<br> NEW! Chapter on orthotics has been added to cover basic splinting patterns.<br> NEW! Online resources help assess your understanding and retention of the material
Fundamentals of Health Care Financial Management
by Steven BergerIn this thoroughly revised and updated third edition of Fundamentals of Health Care Financial Management, consultant and educator Steven Berger offers a practical step-by-step approach to understanding the fundamental theories and relationships guiding financial decisions in health care organization. Set in a fictional mid-sized hospital, the book is written in diary form, taking the reader into the inner workings of the finance executive's office. This introduction to the most-used tools and techniques of health care financial management includes health care accounting and financial statements; managing cash, billings and collections; making major capital investments; determining cost and using cost information in decision-making; budgeting and performance measurement; and pricing. As in the previous editions, this book introduces key practical concepts in fundamental areas of financial management.
Fundamentals of Health Promotion for Nurses (Fundamentals)
by Jane WillsFundamentals of Health Promotion for Nurses is a concise, accessible introduction to health promotion and public health for pre-registration nursing students and newly qualified nurses. Promoting the health and wellbeing of patients is a vital part of the nursing role, and the updated second edition of this user-friendly book discusses the foundations for health promotion practice using practical examples, activities and discussion points to encourage readers to reflect on their values, debate the issues and apply their knowledge and understanding to practice.
Fundamentals of Health at Work
by C. WilkinsonFundamentals of Health at Work is an engaging re-assessment of workplace health, with particular emphasis on the neglected issues of the social context of the working environment and the impact on individuals of their workplaces. In looking at the historical context of the subject and at the concepts of health and illness, a selective series of tho
Fundamentals of Hearing: Fifth Edition
by William YostAn introductory text on hearing sciences, this book includes auditory, anatomy, physiology, psychoacoustics, and perception content. Illustrated with over 200 figures, it contains a complete Glossary of terms from the American Standards Institute, a combined subject/author index, and a comprehensive bibliography.
Fundamentals of Hernia Radiology
by Jeffrey A. Blatnik Eric M. Pauli Salvatore Docimo Jr.This book offers a complete focus on the radiographic analysis of the abdominal wall and hernias. An estimated 20 million hernias are repaired annually throughout the world. As the technology utilized to complete hernia repairs becomes more complex, surgeons are required to have a more thorough understanding of the radiographic anatomy and diagnostic modalities used to evaluate hernias. Furthermore, the amount that now goes into the preoperative planning of hernias for complex repairs (such robotic and open transversus abdominis muscle release procedures) requires an understanding of radiology and the ability to identify nuances of anatomy offered by the imaging. The use of mesh and extent of re-do hernia repairs has also complicated radiographic evaluation of hernias. The text is a comprehensive review of abdominal wall imaging broken down into individual types of hernia. Each hernia type is discussed with consideration to the best type of imaging evaluation, unique radiographic findings and considerations prior to repair. Representative images, diagrams and videos are used to point out anatomy and features of the hernia. This text offers the first-of-its-kind standardized approach to evaluating hernias radiographically. Most importantly, each hernia and chapter is approached with the surgeon in mind, meaning, authors explain the radiology based on anatomy and with a plan for surgical repair on the horizon. Select chapters include illuminating videos to give context to the text. This is an ideal guide for practicing surgeons and trainees treating patients with hernias.
Fundamentals of High-Resolution Lung CT: Common Findings, Common Patterns, Common Diseases and Differential Diagnosis
by Brett M. Elicker W. Richard WebbPublisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. In clear and concise language, Fundamentals of High-Resolution Lung CT, provides a straightforward guide to understanding the high-resolution lung CT (HRCT) assessment of diffuse lung diseases. You will learn to accurately interpret HRCT findings, and how those findings can translate into the correct diagnosis or appropriate differential diagnosis. This volume includes over 600 images we consider classic, many of which have been updated and improved to facilitate easier reading and more precise interpretation.
Fundamentals of Human Physiology
by Giovanni CavagnaThis textbook explores the fundamental qualitative and quantitative aspects of human physiology. It approaches biological and physiological processes and phenomena from a quantitative perspective, revealing how physiological problems can be mathematically formulated starting from simple laws of physics. The book addresses a broad range of topics, including: the statics and dynamics of circulation; muscle and sarcomere force-length and force-velocity relations, together with their mechanisms and functional consequences; subdivisions and meaning of the heat produced by muscle; locomotion, statics and dynamics of respiration; diffusion of gases and acid base equilibrium; phonation; general functions of the kidney and of the different sections of the nephron; changes in clearance with a substance’s plasmatic concentration; pH regulation and the kidney; Donnan’s equilibrium and its consequences; and the Nernst equation. The book offers the ideal learning resource for students of human physiology courses in medicine and biomedicine, as well as biomedical engineering and biophysics graduate students. An elementary grasp of mathematics and physics is sufficient to understand the content.
Fundamentals of Human Resources in Healthcare, Second Edition (Gateway to Healthcare Management)
by Bruce FriedInstructor Resources: Test Bank, Instructor’s ManualHuman resources are the bedrock of healthcare organizations. Yet healthcare faces severe staffing shortages, both as a result of the aging population and workforce and because of wide disparities in the geographic distribution of workers. To attract and retain this increasingly scarce resource—and to inspire the best from their employees—healthcare managers must know how to develop, nurture, and coach their staff for success. Fundamentals of Human Resources in Healthcare takes a back-to-basics approach to workforce management. It sets forth fundamental concepts that will help healthcare managers succeed at the most important and challenging part of their job: managing people. Unlike books that peddle the latest oversimplified solution or quick-fix cure-all for workforce challenges, this book presents proven best practices and evidence-based strategies for successfully working with employees. This new edition puts human resources in the context of today’s healthcare environment, with all of its rapid, ongoing, and unprecedented changes. Thoroughly revised and updated, it includes:• A new chapter on enhancing diversity and inclusion in healthcare organizations• Expanded material on physician compensation, including changes in incentives; compensation practices in patient-centered medical homes and accountable care organizations; and challenges in measuring physician productivity• Revised and updated content on the legal and regulatory environment of human resources management, including sexual harassment, electronic monitoring and workplace searches, and termination• A new chapter on human resources management practices that support quality improvement and patient safety initiatives• Current developments in union organizing and union membership in healthcare organizationsWritten for current and aspiring managers throughout a healthcare organization—not just those employed in the human resources department—this book establishes a vision in which everyone is a human resources manager.
Fundamentals of Implant Dentistry
by Gerard ByrneFundamentals of Implant Dentistry is a basic guide to foundational knowledge and skills and their application in clinical practice. More comprehensive than a procedural atlas and more accessible than a specialist reference, this text is an indispensable tool for dental students and clinicians beginning work with dental implants.Fundamentals of Implant Dentistry provides a concise yet comprehensive look at the basic background and science of implantology and includes practical, evidence-based instruction on common procedures such as single implant crowns, bridges and overdentures. Well-illustrated with clear line drawings and clinical photos, the book serves as the perfect introduction to this exciting area of dentistry.
Fundamentals of Infection Prevention and Control
by Debbie WestonReviews of first edition:"This book tells every healthcare professional all they need to know about infection control... A user-friendly, valuable source of knowledge on a subject that can be confusing and complicated." Nursing Standard"A valuable contribution within any health or social environment." Journal of Community NursingInfection prevention and control is an essential component of nursing care, and a crucially important subject area for both nursing students and qualified nurses. Fundamentals of Infection Prevention and Control gives readers a firm grasp of the principles of infection control, how they relate to clinical practice and the key issues surrounding the subject. It provides a comprehensive guide to the prevention, management and control of healthcare associated infections, and the basic elements of microbiology, immunology and epidemiology that underpin them.Thoroughly revised in line with current policy, this new edition contains brand-new chapters on a range of topics including the role of the Infection Prevention and Control Team, audit and surveillance, and the management of outbreaks. Also incorporating a range of case studies and examples as well as additional online content, it is essential reading for all nursing students as well as qualified nursing and healthcare professionals.Explores both principles and practice of a crucial subject areaAccessible and user-friendly, with a range of features to help study including key definitions, links back to clinical practice, and chapter learning outcomes and summariesAccompanied by an online resource centre featuring MCQs, weblinks, case scenarios and downloadable fact sheetsFeatures an increased clinical focus, with more application to practiceThis title is also available:as a Wiley E-Text, powered by VitalSource: an interactive digital version of the book featuring downloadable text and images, highlighting and note-taking facilities, book-marking, cross-referencing, in-text searching, and linking to references and glossary termsinstantly on CourseSmart at www.coursesmart.co.uk/9781118306659. CourseSmart offers extrafunctionality, as well as an immediate way to review the text. For more details, visit www.coursesmart.com/instructors or www.coursesmart.com/students
Fundamentals of Inflammation
by Charles N. Serhan Peter A. Ward Derek W. Gilroy Charles N. Serhan Peter A. WardThe acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.
Fundamentals of Laboratory Animal Science
by Enqi Liu and Jianglin FanLaboratory animals are becoming increasingly important for biomedical research. It is said that approximately 70% of biomedical research is associated with the use of experimental animals. Laboratory animal research not only expands our knowledge of science, but also greatly improves human and animal health. The field of laboratory animal science is ever-growing and changing as new experimental techniques are developed and new animal models are created. It is essential to know not only the biological features of each laboratory animal but also how to use and care for them responsibly in order to perform high-quality experiments. Courses in beginning Laboratory Animal Science are starting to be offered in many universities throughout the world. However, a practical introductory textbook that contains state-of-the-art techniques is still lacking. Fundamentals of Laboratory Animal Science provides comprehensive information on the principles and practices of using laboratory animals for biomedical research. Each individual chapter focuses on a key sub-discipline of laboratory animal science: animal welfare and best humane care practices in the laboratory; the quality control of laboratory animals; the anatomy, physiology, and husbandry of commonly used species; the principles of creating and using animal models for studying human diseases; practical techniques used for laboratory animal experiments; experimental design; and animal experimentation management. Knowledge of this broad spectrum of concepts and skills will ensure research goes smoothly while greatly reducing animal pain and distress. Well-illustrated and thoroughly referenced, this book will serve not only as a standard textbook but also as a handy guide for veterinarians, researchers, animal care staff, administrators, and other professionals who are involved in laboratory animal science.
Fundamentals of Light Microscopy and Electronic Imaging
by Douglas B. Murphy Michael W. DavidsonFundamentals of Light Microscopy and Electronic Imaging, Second Edition provides a coherent introduction to the principles and applications of the integrated optical microscope system, covering both theoretical and practical considerations. It expands and updates discussions of multi-spectral imaging, intensified digital cameras, signal colocalization, and uses of objectives, and offers guidance in the selection of microscopes and electronic cameras, as well as appropriate auxiliary optical systems and fluorescent tags.The book is divided into three sections covering optical principles in diffraction and image formation, basic modes of light microscopy, and components of modern electronic imaging systems and image processing operations. Each chapter introduces relevant theory, followed by descriptions of instrument alignment and image interpretation. This revision includes new chapters on live cell imaging, measurement of protein dynamics, deconvolution microscopy, and interference microscopy.PowerPoint slides of the figures as well as other supplementary materials for instructors are available at a companion website:www.wiley.com/go/murphy/lightmicroscopy
Fundamentals of Linear Algebra for Signal Processing
by James ReillySignal processing is ubiquitous in many fields of science and engineering. This textbook is tailored specifically for graduate students and presents linear algebra, which is requisite knowledge in these fields, in a form explicitly targeted to signal processing and related disciplines. Written by an experienced author with over 35 years of expertise in signal processing research and teaching, this book provides the necessary foundation in a focused and accessible manner, offering a practical approach to linear algebra without sacrificing rigor. Emphasis is placed on a deeper conceptualization of material specific to signal processing so students may more readily adapt this knowledge to actual problems in the field. Since other emerging areas, such as machine learning, are closely related to signal processing, the book also provides the necessary background in this discipline. The book includes many examples and problems relevant to signal processing, offering explanations and insights that are difficult to find elsewhere. Fundamentals of Linear Algebra for Signal Processing will allow students to master the essential knowledge of linear algebra for signal processing. It is also an essential guide for researchers and practitioners in biomedical, electrical, chemical engineering, and related disciplines.
Fundamentals of Linear Systems for Physical Scientists and Engineers
by N.N. PuriThanks to the advent of inexpensive computing, it is possible to analyze, compute, and develop results that were unthinkable in the '60s. Control systems, telecommunications, robotics, speech, vision, and digital signal processing are but a few examples of computing applications. While there are many excellent resources available that focus on one
Fundamentals of MRI: An Interactive Learning Approach (Series in Medical Physics and Biomedical Engineering)
by Elizabeth Berry Andrew J. BulpittFundamentals of MRI: An Interactive Learning Approach explores the physical principles that underpin the technique of magnetic resonance imaging (MRI).After covering background mathematics, physics, and digital imaging, the book presents fundamental physical principles, including magnetization and rotating reference frame. It describes how relaxation mechanisms help predict tissue contrast and how an MR signal is localized to a selected slice through the body. The text then focuses on frequency and phase encoding. It also explores the spin-echo sequence, its scan parameters, and additional imaging sequences, such as inversion recovery and gradient echo.The authors enhance the learning experience with practical materials. Along with questions, exercises, and solutions, they include ten interactive programs on the accompanying downloadable resources. These programs not only allow concepts to be clearly demonstrated and further developed, but also provide an opportunity to engage in the learning process through guided exercises.By providing a solid, hands-on foundation in the physics of MRI, this textbook helps students gain confidence with core concepts before they move on to further study or practical training.