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Glaucoma Drainage Devices: A Practical Illustrated Guide
by Monica Gandhi Shibal BhartiyaThis book offers a comprehensive guide to the use of glaucoma drainage devices (GDDs) in various clinical settings, and covers aspects ranging from the basics to managing complications. The aim of this work is to provide readers with a practical go-to desktop book to assist in and enhance their surgical competence with glaucoma drainage devices. Starting with the history of GDDs, it addresses various devices, their models and modifications, and highlights their advantages and disadvantages through numerous illustrations. The indications for the drainage devices are discussed in detail, using patient cases with photographs. The book describes the techniques for all devices in detail, which are explained further in accompanyin videos. After covering the basic techniques, the book provides extensive notes on modifications that may be required in various case presentations such as congenital glaucoma, post-penetrating keratoplasty with extensive peripheral synechiae, and procedure through pars plans etc. Complications and their management are subsequently addressed. The book is an essential guide to help surgeons match patients to the most suitable device, and to support patients from preparation through post-operative care. Primarily intended for glaucoma surgeons, it offers a valuable resource for fellows in training, and all who have an interest in glaucoma surgery.
Glaucoma Imaging
by Antonio FerrerasThis atlas offers a truly comprehensive update on the use of imaging technologies for the diagnosis and follow-up of glaucoma. In addition to standard automated perimetry, gonioscopy, fundus photography, and stereophotography, other advanced, high-resolution methods for imaging the eye in glaucoma are explained in detail, including ultrasound biomicroscopy, confocal scanning laser ophthalmoscopy, scanning laser polarimetry, and spectral domain optical coherence tomography. The role of the various tests and the keys to optimizing their use in clinical practice are detailed with the aid of high-quality figures in order to enable the reader to achieve the best possible performance when applying these tools. The risk of developing visual disability and blindness as a consequence of glaucoma varies widely among affected individuals. Personalized testing strategies and tailored therapeutic interventions are required to effectively reduce visual impairment due to glaucoma. Glaucoma Imaging will assist residents, researchers, and clinicians in improving their ability to understand and integrate the information obtained using traditional techniques with the reports provided by computer-assisted image instruments.
Glaucoma Surgery
by Luigi Caretti Lucio BurattoThis book illustrates effective surgical techniques for treating glaucoma in a practical and easy to follow format. Within the various chapters the different steps for all surgical procedures are clearly described to guide the reader through each clinical presentation. There are many drawings with detailed explanations regarding incisional surgical techniques such as trabeculectomy, shunts and non perforating techniques, canaloplasty and modern Microinvasive Glaucoma Surgeries (MIGSs). Surgical anatomy, different anesthetic techniques, medical therapy, laser treatments and choice of treatment to contrast glaucoma are also explained throughout the book. Finally there are three chapters on the most modern and effective surgical procedures, drawn up by leading internationally renowned ophthalmologists. This book will be an essential clinical resource for a wide range of readers including ophthalmologists in training, experienced surgeons and glaucoma specialists.
Glaucoma: A Guide from Dr. Harry Quigley
by Harry QuigleyIf you or a member of your family has been told that you have glaucoma, or, if you have glaucoma and want to be sure that the treatment you're receiving is right for you, this patient-oriented guide was designed to answer the many questions you may have. The guide gives authoritative answers, easily understood explanations, helpful suggestions, and life-style advice. It won't matter if you are not a medical specialist, since it is written in plain English. Most glaucoma patients retain good vision and live a normal life. The solutions given can take the stress out of dealing with glaucoma and should maximize the chance that no further injury to your ability to see will occur. There is good evidence that patients who try to learn more about their medical care do better in the long run. The author is Dr. Harry A. Quigley, Director of the Glaucoma Center of Excellence of the Wilmer Ophthalmological Institute, Johns Hopkins School of Medicine. He has 40 years' experience caring for glaucoma, researching its treatments, and has performed 10,000 medical and surgical procedures for this disease. His 350 published papers on glaucoma represent the work that is most quoted by other eye doctors in the last 30 years. He was the Editor-in-Chief of the premier vision research journal, Investigative Ophthalmology and Visual Science. No other living ophthalmologist has received the Friedenwald Award (ARVO), the Doyne Medal (Oxford Ophthalmological Congress), the Jackson Lectureship (AAO), and the American Glaucoma Society Lectureship. The guide has quick "Take Home" summaries at the start of each section with the most important information. For those wishing to know much more, detailed explanations, drawings and photographs follow. The sections are designed to answer the questions that patients ask, as well as the questions that they should have asked. For those who know little about their glaucoma, it begins with a simple introduction to the disease. However, those who want in depth information will find discussions of how the disease is diagnosed, what the treatment options are, and how to live a normal life with glaucoma. There are not perfect answers to every question about glaucoma. Where there is controversy, the different sides of the issue are presented to help you and your doctor to make the better choice. There is consideration given to alternative approaches to therapy. There is no cure for glaucoma, and we cannot yet restore vision once it is lost. The guide presents ways to continue life at a high level, whatever the stage of glaucoma.
Glaucoma: Basic And Clinical Perspectives (Current Practices in Ophthalmology)
by Parul IchhpujaniThis book covers all the latest aspects of what’s happening in all the micro-fields of glaucoma. The chapters cover pathogenesis, structural and functional tests, and medical, laser and surgical therapies. An entire chapter is devoted to the future of glaucoma management. All the chapters are supported with illustrations to enhance understanding of the developments.A lot of innovations are happening in the field of basic research, pharmacology, surgical devices and imaging equipment for glaucoma.As part of the series “Current Practices in Ophthalmology” this volume is meant for residents, fellows-in-training, generalist ophthalmologists and specialists alike.
Glaucoma: Methods and Protocols (Methods in Molecular Biology #2858)
by Tatjana Jakobs Paloma B. LitonThis second edition volume expands on the previous edition with an update on the latest methodologies used to study the neurodegeneration of glaucoma. This book notably features a focus on ocular hypertension as an important factor in the pathogenesis of glaucoma, and the relationship between elevated intraocular pressure and neurodegeneration. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Glaucoma: Methods and Protocols, Second Edition is a valuable resource for anyone interested in glaucoma research. This book will encourage innovation and facilitate progress toward improving our understanding and treatment of glaucoma.
Glenohumeral Osteoarthritis in the Young Patient: Evaluation and Management
by Joseph A. Abboud Brian M. Grawe J. Gabriel HorneffThe management of glenohumeral arthritis in the young patient remains a challenging problem for the treating clinician. The activity demands seen in such patient populations require a unique understanding of what the goals of treatment are to ensure satisfied and sustainable outcomes. In addition, younger patients have a longer life expectancy and more active lifestyles, which can negatively impact the longevity of arthroplasty implants that are traditionally used in the older patient population. As such, the discovery and implementation of novel and anatomy preserving techniques continue to evolve to meet the demand of younger patients without compromising their outcomes. This practical text serves to educate the treating clinician on how to recognize and categorize glenohumeral osteoarthritis in young patients and offers insight into the various operative and non-operative treatment options. Opening chapters examine the prevalence and burden, etiology and evaluation of the condition, followed by chapters discussing the current non-invasive and non-operative approaches to treatment, such as injection therapy. The main complement of chapters are detailed descriptions of surgical approaches, from arthroscopy and cartilage reconstruction to total and reverse shoulder arthroplasty, stemless approaches and arthrodesis. A final chapter expands on future management strategies. Radiographs and intraoperative photos are provided to enhance the text.Presenting the state of the art for this increasingly common condition, Glenohumeral Osteoarthritis in the Young Patient is an ideal resource for orthopedic surgeons and sports medicine specialists alike.
Glial Cell Engineering in Neural Regeneration
by Li YaoThis book focuses on current applications of glial cells in neural regeneration, especially in spinal cord repair. It introduces the application of a few types of glial cells including oligodendrocyte, astrocyte, Schwann cells, and stem cell derived glial cells in neural regeneration. The latest glial cell research with biomaterials, gene modification, and electrical signals is also summarized. This is an ideal book for undergraduate and research students in tissue engineering, neurobiology, and regenerative medicine as well as researchers in the field.
Glial Cells in Health and Disease of the CNS
by Rommy Von BernhardiA timely overview covering the three major types of glial cells in the central nervous system - astrocytes, microglia, and oligodendrocytes. New findings on glia biology are overturning a century of conventional thinking about how the brain operates and are expanding our knowledge about information processing in the brain. The book will present recent research findings on the role of glial cells in both healthy function and disease. It will comprehensively cover a broad spectrum of topics while remaining compact in size.
Glial Physiology and Pathophysiology
by Alexei Verkhratsky Arthur Morgan ButtGlial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells.Coverae includes:the morphology and interrelationships between glial cells and neurones in different parts of the nervous systemsthe cellular physiology of the different kinds of glial cellsthe mechanisms of intra- and inter-cellular signalling in glial networksthe mechanisms of glial-neuronal communicationsthe role of glial cells in synaptic plasticity, neuronal survival and development of nervous systemthe cellular and molecular mechanisms of metabolic neuronal-glial interactionsthe role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson'sNeuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it.An up-to-date and fully referenced text on the most numerous cells in the human brainDetailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous systemDescribes the role og glial cells in neuropathologyFocus boxes highlight key points and summarise important factsCompanion website with downloadable figures and slides
Glial-Neuronal Signaling in Neuroendocrine Systems (Masterclass in Neuroendocrinology #11)
by Jeffrey G. Tasker Jaideep S. Bains Julie A. ChowenThis volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today. Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication. Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems. This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.
Glioblastoma:
by Swapan K. RayGlioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.
Glioblastoma: Methods and Protocols (Methods in Molecular Biology #1741)
by Dimitris G. PlacantonakisThis volume details cutting-edge protocols on the characterization of the genome, epigenome, proteome, metabolome and single-cell transcriptome of tumors and tumor-derived cultures. Chapters focus on subpopulations of cells with stem-like properties, laser capture microdissection, and modeling human glioma with human embryonic stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Glioblastoma: Methods and Protocols aims to support researchers seeking new and refined protocols to better decrypt this tumor.
Glioma Cell Biology
by Aleksi Sedo Rolf MentleinGliomas are fatal diseases, but also represent good models for tumor research with the aim to eventually discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorigenesis (tumor stem cell theory versus "classical" opinions), tumor angiogenesis (since they are highly vascularized) and tumor invasion (since they grow without limits). In addition, they have a very special microenvironment (the brain) and limited tumor stroma cells (mainly microglia and endothelial cells). This book addresses the molecular mechanisms of the various tumor stages, describes the interaction with the tumor microenvironment and furthermore depicts experimental models for Glioma research and future therapeutic concepts. The book is composed and written for Scientists and Medical Doctors in Oncology, Neurosciences and Molecular Biology.
Glioma Imaging: Physiologic, Metabolic, and Molecular Approaches
by Whitney B. PopeThis book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice. The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn: current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapythe theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learningabout the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trialsof the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits
Glioma Signaling
by Jolanta BarańskaGlioma Signaling is a text reference on cellular signaling processes focused on the mechanism of nucleotide receptors activation by exogenic nucleotides and the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration changes, cellular growth, progression and invasion, as well as presents perspective concerning potential targets for glioma therapy.
Glioma Signaling (Advances in Experimental Medicine and Biology #1202)
by Jolanta BarańskaGliomas, developing in the brain from the transformed glial cells, are a very special kind of tumor, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. This book is a reference on cellular signaling processes regulating gliomas physiology and invasiveness. The work is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides and formation of complex signaling cascades induced by growth factors, cytokines and cannabinoids. The second edition of the book enriched in new chapters provides a framework explaining how signal transduction elements may modulate numerous genetic and epigenetic alterations, describes the role of local microenvironment in cellular growth, progression and invasion and, in the light of extensive new results, presents perspectives concerning potential targets for gliomas therapy.
Glissonean Pedicles Approach in Minimally Invasive Liver Surgery
by Benedetto Ielpo Edoardo Rosso Alessandro AnselmoAim of this book is to present the main minimally invasive approaches to the Glissonean pedicles. This kind of technique for hepatectomy has been gaining interest in recent years and may represent the ideal method to achieve anatomical liver resections. Currently the most performed procedure for liver surgery is still the classic intrafascial approach in which, after entering the Glissonean sheath, the portal triad elements are singularly dissected and isolated. However, this is a quite challenging technique to pursue in a minimally invasive setting. Nowadays the laparoscopic and robotic approach for liver resections are increasing worldwide and the intra or extra hepatic Glissonean approach, in which the portal triad elements are dissected and isolated “en bloc” without entering the Glissonean sheath, can facilitate the surgical technique. Furthermore this strategy allows better identification of the ischemic area and could decrease blood loss during dissection, as the liver inflow is kept under control. This book includes a step-by-step description of each pedicle isolation and section, with original laparoscopic and robotic pictures and videos. HPB surgeons who are interested in this technique may find these pages, written in cooperation with some of the most prominent worldwide experts, to be highly informative and valuable.
Global Applications of Culturally Competent Health Care: Guidelines for Practice
by Marilyn “Marty” Douglas Dula Pacquiao Larry PurnellThis book is unique in its global approach to applying the Guidelines for Culturally Competent Nursing Practice that were recently endorsed by the International Council of Nurses (ICN) and distributed to all of its 130 national nursing associations. The purpose of this book is to illustrate how these guidelines can be put into clinical practice and to show how practitioners from different countries with diverse populations can implement them. The first chapter provides the conceptual basis for Culturally Competent Health Care and describes how the guidelines were developed. Each of the next 10 sections presents a chapter describing a specific guideline followed by three or four chapters with detailed case studies to illustrate how the guideline was implemented in a particular cultural setting. All case studies follow a similar format and are written by international authors with clinical expertise and work experience in the culture being presented. This book will be useful for advanced practice nurses, healthcare students, clinicians, administrators, educators, researchers, and those who provide community health or population-based care.
Global Approach in Safety Testing
by Joseph J Degeorge Jan Willem van der LaanThis volume will consider one of ICH's major categories, Safety i.e. topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but even after ICH6 no explanations have been given during a formal Congress about the background of the ICH Guidance documents. Even more important than what has been written, might have been those thoughts of the experts that are not included in the Guidance documents. Why has the guideline been written as it is written, and why have some aspects been deleted. These and other related questions are the contents of this book, written by experts who were involved in the ICH process. Furthermore, the chapters will contain discussions on the "lessons learnt" and "future developments".
Global Bioethics: Building on the Leopold Legacy
by Van Rensselaer PotterThis book on Bioethics discusses regarding the Leopold legacy, human survival, dilemmas in ecological Bioethics, two kinds of bioethics, dilemmas in medical bioethics, the control of human fertility and global bioethics defined. Appendix includes the Leopold heritage and a bioethical creed for individuals.
Global Bioethics: The Impact of the UNESCO International Bioethics Committee
by Jonathan D. Moreno Alireza Bagheri Stefano SempliciThe UNESCO International Bioethics Committee is an international body that sets standards in the field of bioethics. This collection represents the contributions of the IBC to global bioethics. The IBC is a body of 36 independent experts that follows progress in the life sciences and its applications in order to ensure respect for human dignity and freedom. Currently, some of the topics of the IBC contributions have been discussed in the bioethics literature, mostly journal articles. However, this is a unique contribution by the scholars who developed these universal declarations and reports. The contributors have not only provided a scholarly up to date discussion of their research topics, but as members of the IBC they have also discussed specific practical challenges in the development of such international documents. This book will be suited to academics within bioethics, health care policy and international law.
Global COVID-19 Research and Modeling: A Historical Record (Data Analytics)
by Longbing CaoThis book provides answers to fundamental and challenging questions regarding the global response to COVID-19. It creates a historical record of COVID-19 research conducted over the four years of the pandemic, with a focus on how researchers have responded, quantified, and modeled COVID-19 problems. Since mid-2021, we have diligently monitored and analyzed global scientific efforts in tackling COVID-19. Our comprehensive global endeavor involves collecting, processing, analyzing, and discovering COVID-19 related scientific literature in English since January 2020. This provides insights into how scientists across disciplines and almost every country and regions have fought against COVID-19. Additionally, we explore the quantification of COVID-19 problems and impacts through mathematics, AI, machine learning, data science, epidemiology, and domain knowledge. The book reports findings on publication quantities, impacts, collaborations, and correlations with the economy and infectionsglobally, regionally, and country-wide. These results represent the first and only holistic and systematic studies aimed at scientifically understanding, quantifying, and containing the pandemic. We hope this comprehensive analysis will contribute to better preparedness, response, and management of future emergencies and inspire further research in infectious diseases. The book also serves as a valuable resource for research policy, funding management authorities, researchers, policy makers, and funding bodies involved in infectious disease management, public health, and emergency resilience.
Global Cardiac Surgery Capacity Development in Low and Middle Income Countries (Sustainable Development Goals Series)
by Jacques KpodonuThis book provides a focused resource on how cardiac surgery capacity can be developed and how it assists in the sustainable development and strengthening of associated health systems. Background is provided on the extent of the problems that are experienced in many nations with suggestions for how suitable frameworks can be developed to improve cardiac healthcare provision. Relevant aspects of governance, financial modelling and disease surveillance are all covered. Guidance is also given on how to found and nurture cardiac surgery curriculum and residency programs. Global Cardiac Surgery Capacity Development in Low and Middle Income Countries provides a practically applicable resource on how to treat cardiac patients with limited resources. It identifies the key challenges and presents strategies on how these can be managed, therefore making it a critical tool for those involved in this field.
Global Catastrophic Biological Risks (Current Topics in Microbiology and Immunology #424)
by Thomas V. Inglesby Amesh A. AdaljaThis volume focuses on Global Catastrophic Biological Risks (GCBRs), a special class of infectious disease outbreaks or pandemics in which the combined capacity of the world’s private and government resources becomes severely strained. These events, of which the 1918 influenza pandemic is emblematic, cause severe disruptions in the normal functioning of the world, exact heavy tolls in terms of morbidity and mortality, and lead to major economic losses. GCBRs can be caused by any type of microorganism, and myriad contextual factors can influence their impact. Additionally, there are cascading questions that arise in connection with GCBR prediction, preparation, and response. This book gathers contributions from thought leaders who discuss the multi-faceted approaches needed in order to address this problem. From understanding the special characteristics of various microbes to financing challenges, the volume provides an essential primer on a neglected but highly relevant topic. Physicians, scientists, policymakers, public health practitioners and anyone with an interest in the field of pandemics, emerging infectious disease, biosecurity, and global health security will find it a valuable and insightful resource.