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Handbook of Sepsis

by W. Joost Wiersinga Christopher W. Seymour

This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is international in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.

Handbook of Service User Involvement in Nursing and Healthcare Research

by Elizabeth Morrow Sally Brearley Fiona Mary Ross Annette Boaz

This book fills an important niche in the market providing practical expert advice on the involvement of service users - patients, carers and the public - in nursing and healthcare research. An invaluable guide for anyone working or involved in nursing and healthcare research, this book provides a step-by-step guide to the principles and process of involvement, including understanding the rationale for involvement, designing involvement, working with service users, and evaluating what has been achieved. With illustrations, worked examples and tool sheets throughout, this evidence-based guide uses real life examples from recent research studies in health and social care research, thus relating theory to practice in a meaningful way. The Handbook of Service User Involvement in Nursing & Healthcare Research introduces a wide range of key issues, including: Why? Why should researchers involve service users? How? How can researchers and service users work together successfully and productively? Who? Who chooses to become involved in research? How are issues of representation and diversity addressed? When? At what stage should service users be involved in the research process?

Handbook of Settings-Based Health Promotion

by Sami Kokko Michelle Baybutt

This book's central focus is to provide academics, students, policy-makers, and practitioners with a unique insight into a wide variety of perspectives on settings-based health promotion. It offers clarity amidst different interpretations and ideological understandings of what applying a settings-based approach means. Emphasis is given to a salutogenic focus, exploring how the creation of wellbeing and fostering of potential in settings to best enable individuals and populations to flourish implies that the setting itself must be the entry point for health promotion. Building on this, the text explores how the settings approach to health promotion strives for changes in the structure and ethos of the setting – detailing how changes and developments in people's health and health behavior are easier to achieve if health promoters focus on settings rather than solely on individuals. The book comprises 15 chapters organized in three sections:In Part I, Evolution, Foundations and Key Principles of the Settings-Based Approach, the first four chapters present the determinants, theoretical basis, and generic commonalities that are consistent over various settings initiatives and formulate the grounds for the settings-based health promotion approach.In Part II, Applying the Settings-Based Approach to Key Settings, Chapters 5-13 introduce the key settings initiatives – both traditional and non-traditional (new and contemporary) – with their developments and specific features. In Part III, Gaia – The Ultimate Setting for Health Promotion, the last two chapters consider the settings approach in the context of future challenges and explore possible directions for further development.Handbook of Settings-Based Health Promotion has novel information and perspectives on the topic that provide readers with up-to-date specialist knowledge and application of global developments to develop and enhance a common understanding and generate new thinking in relation to contemporary settings. This timely tome will engage the academic community in the fields of health promotion and public health including students, teaching staff, and researchers. Additionally, it is a useful resource for policy-makers and practitioners in these fields.

Handbook of Sexual Dysfunction

by Richard Balon R. Taylor Segraves

Offering an authoritative collection of chapters from clinicians and researchers in the United States, Canada, and Europe, this reference comprehensively covers the latest understanding in the etiology, pathophysiology, diagnosis, and treatment of sexual dysfunction.

Handbook of Single-Cell Technologies

by Fan-Gang Tseng Tuhin Subhra Santra

This book provides a brief overview of single-cell analysis using recent advanced technologies. The different sections cover different aspect of single cell analysis and applications with their advantages, limitations, and future challenges. The book has covered how different physical energies such as optical, electrical, and mechanical energy have been applied for single cell therapy and analysis. The recent advanced micro/nanofluidic devices have been employed for single-cell counting, manipulation, cultivation, separation, isolation, lysis, printing and patterning and host-viral interaction at single-cell level. Various chemical approaches for single-cell analysis have been discussed, such as liposome mediated materials transfer at single-cell and their analysis, discovery of antibody via single-cell, high-throughput screening of antigen-specific antibody-secreting cells, and biomolecular secretion analysis of individual cells. Moreover, different single-cell omics such as genomics, proteomics and transcriptomics have been discussed using microfluidic technologies as well as conventional approaches. The role of single cell analysis in system biology and biocatalysis have been discussed in detail. The book describes single-cell phenotyping of heterogeneous tissue, stimulation, and instant reaction quenching technology for biochemical kinetic analysis, large scale single-cell assay for the identification of biocatalysts and analytical techniques for single-cell studies in microbiology. The role of single-cell analysis in cancer, such as single-cell adhesion and cancer progression, single-cell technologies for cancer therapy, analytical technology for single cancer cell analysis, and biophysical markers for cancer cell analysis have been discussed. The flow cytometry based high throughput single-cell analysis have been well emphasized. Finally this book has covered single-cell electrophysiology, single-cell sensing and size measurement using mechanical and microwave resonators, molecular force spectroscopy for cell adhesion measurement, micro-tweezers and force microscopy techniques for single-cell mechanobiological analysis, mass spectrometry and acoustic tweezers for single-cell manipulation and analysis. This book is intended for academic and industrial researchers, undergraduate and graduate students in the fields of biomedical engineering, bio-micro/nanoengineering, and bio-micro/nano fabrication for single-cell analysis. It can be used for courses on bio-MEMS/bio-NEMS, biomicrofluidics, bio-micro/nanofabrications, micro/nanofluidics, biophysics, single cell analysis, bionanotechnology, drug delivery systems and biomedical microdevices. Collective contributions from respected experts, have brought diverse aspects of single-cell technologies in a single hand book. This will benefit researchers and practitioners in the biotechnology industry for different diseases analysis, therapeutics, diagnostics, drug discovery, drug screening etc. In addition to hard copies, the book will be available online and will often be updated by the authors.

Handbook of Skin Disease Management

by Zainab Jiyad Carsten Flohr

Handbook of Skin Disease Management Learn the essential information necessary to manage patients with skin diseases in this brand-new compact handbook Skin diseases severely impact quality of life and management of these conditions can be exceptionally challenging, particularly when first and second-line treatments have failed. The Handbook of Skin Disease Management is the first handbook specifically developed with the focus on the management aspect of dermatological conditions. It is designed to be used by busy clinicians who need relevant information quickly and includes an A-Z format with succinct entries loaded with essential information. Incorporating evidence bases and success rates for each potential treatment, it includes everything clinicians need to rapidly familiarize themselves with the different treatment options. Handbook of Skin Disease Management readers will also find: Treatment of over 40 conditions, listed alphabetically for easy reference A visually enhanced guide to prescribing systemics Over 20 key lists, such as differentials for blistering diseases, telangiectasia, and more Handbook of Skin Disease Management is a vital reference for clinicians working with dermatological patients, particularly trainees and junior doctors. “What a refreshing change to see such a succinct book full of useful practical advice that can be used in the clinic. Zainab Jiyad and Carsten Flohr succeed in that difficult task of bridging the gap between evidence and practice.” —Hywel Williams, OBE, NIHR Senior Investigator Emeritus, FMedSci Professor of Dermato-Epidemiology and Co-Director, Centre of Evidence-Based Dermatology Centre of Evidence-Based Dermatology, University of Nottingham, UK “I wish I had such a useful handbook during my early career! Zainab Jiyad and Carsten Flohr have produced a great guide on the management of common skin diseases for dermatology trainees, consultants and GPs, packed with the latest evidence from guidelines and systematic reviews.”—Phyllis Spuls, Professor of Evidence-Based Dermatology, Amsterdam University Medical Centers, The Netherlands

Handbook of Sleep Disorders

by Clete A. Kushida

Now in its second edition, Handbook of Sleep Disorders is the classic all-inclusive reference for sleep professionals around the world. Contributed by leading authorities, this new edition continues to provide a well-organized guide to the diagnosis and treatment of the six major categories of sleep disorders-insomnia, circadian

Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications (Imaging in Medical Diagnosis and Therapy)

by George C. Kagadis Nancy L. Ford Dimitrios N. Karnabatidis George K. Loudos

The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans. Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research. The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.

Handbook of Small Animal MRI

by Ian Elliott Geoff Skerritt

Handbook of Small Animal MRI will help you make the most of one of the greatest advancements in veterinary practice in recent years, magnetic resonance imaging. Those using the services of mobile scanners dedicated to veterinary use, as well as those in practices with their own MRI machine, will benefit from this book. It provides a clear and comprehensive account of how this important diagnostic tool works. In addition this easy reference handbook provides guidance on the interpretation of images of common clinical conditions. The book includes: • An overview of the basic principles, explaining exactly how and why MRI works and how images are produced • Easy-to-understand diagrams to explain the theory of MRI • Safety procedures • A Glossary of terms • Over 100 annotated images of MRI scans to aid diagnosis • An additional atlas of normal anatomy for MRI interpretation Written by two pioneering experts in the field with a combined experience of over 20,000 MRI studies of veterinary patients. Suitable for small animal veterinarians and veterinary students. Ian Elliott trained as a Radiographer and first became involved with MRI in late 1980s. He has worked exclusively in MRI since 1991 and, following an extensive spell scanning human patients, helped pioneer the use of the technique in veterinary practice. Ian has been involved exclusively in veterinary MRI since 2000 and has scanned many thousands of cases during this time. He currently works for Burgess Diagnostics providing MRI services to veterinary surgeons throughout UK and Ireland. Geoff Skerritt is an RCVS Recognised Specialist in Veterinary Neurology, Diplomate of the European College of Veterinary Neurology and former President of the ECVN. In 1997 Geoff was one of the founders of VetMRI, the first mobile veterinary MRI facility in Europe. He is the founder and director of ChesterGates Animal Referral Hospital, a leading multi-discipline veterinary referral centre in the UK.

Handbook of Small Animal Regional Anesthesia and Analgesia Techniques

by Phillip Lerche Turi Aarnes Fernando Martinez Taboada Gwen Covey-Crump

This is a concise visual guide to the major techniques of regional anesthesia and analgesia for small animal practitioners, with complete coverage of the relevant physics, physiology, and pharmacology. Provides straightforward advice and easy-to-implement strategies for general veterinary practitioners without specialist training who want to incorporate regional anesthesia into their practice Features an accessible design with plenty of diagrams and photos and a convenient and robust spiral-bound format that lays flat for use during procedures Broken into sections which explain techniques by limb or body part and by species Details important anatomy (nerves, bones, and vessels), as well as possible side effects and complications

Handbook of Smart Homes, Health Care and Well-Being

by Eveline J.M. Wouters Joost Van Hoof George Demiris

Featuring the insights of engineers and healthcare professionals, this book shows how 'smart' homes can help modern societies cope with the healthcare needs of an ageing population. It includes critical assessments of a number of real-life projects.

Handbook of Social Inclusion: Research and Practices in Health and Social Sciences

by Pranee Liamputtong

Addresses the social inclusion/social exclusion paradigm Highlights important theoretical frameworks relating to social inclusion, including social exclusion, social determinants, social justice, human rights, stigma and discrimination, cultural humility, cultural competence, the capability approach, and occupational justice Covers research methodologies that enhance social inclusion, including participatory action research and other inclusive/innovative research methods Includes main research methodologies that researchers can use to promote social inclusion including qualitative research, quantitative methods, mixed methods research, ethics in research, and research dissemination Provides examples of research and programs/interventions that lead to social inclusion of people and communities <P><P><i>Advisory: Bookshare has learned that this book offers only partial accessibility. We have kept it in the collection because it is useful for some of our members. Benetech is actively working on projects to improve accessibility issues such as these.</i>

Handbook of Social Sciences and Global Public Health

by Pranee Liamputtong

This handbook highlights the relevance of the social sciences in global public health and their significantly crucial role in the explanation of health and illness in different population groups, the improvement of health, and the prevention of illnesses around the world. Knowledge generated via social science theories and research methodologies allows healthcare providers, policy-makers, and politicians to understand and appreciate the lived experience of their people, and to provide sensitive health and social care to them at a time of most need. Social sciences, such as medical sociology, medical anthropology, social psychology, and public health are the disciplines that examine the sociocultural causes and consequences of health and illness. It is evident that biomedicine cannot be the only answer to improving the health of people. What makes social sciences important in global public health is the critical role social, cultural, economic, and political factors play in determining or influencing the health of individuals, communities, and the larger society and nation. This handbook is comprehensive in its nature and contents, which range from a more disciplinary-based approach and theoretical and methodological frameworks to different aspects of global public health. It covers: Discussions of the social science disciplines and their essence, concepts, and theories relating to global public health Theoretical frameworks in social sciences that can be used to explain health and illness in populations Methodological inquiries that social science researchers can use to examine global public health issues and understand social issues relating to health in different population groups and regionsExamples of social science research in global public health areas and concerns as well as population groups The Handbook of Social Sciences and Global Public Health is a useful reference for students, researchers, lecturers, practitioners, and policymakers in global health, public health, and social science disciplines; and libraries in universities and health and social care institutions. It offers readers a good understanding of the issues that can impact the health and well-being of people in society, which may lead to culturally sensitive health and social care for people that ultimately will lead to a more equitable society worldwide.

Handbook of Social Work Practice with Vulnerable and Resilient Populations

by Alex Gitterman

Every day, social workers deal with individuals, families, and groups struggling with problems that are often chronic, persistent, acute, and/or unexpected. When community and family support systems are weak or unavailable, and when internal resources fail, these populations become vulnerable to physical, cognitive, emotional, and social deterioration.Yet despite numerous risk factors, a large number of vulnerable people do live happy and productive lives. This best-selling handbook examines not only risk and vulnerability factors in disadvantaged populations but also resilience and protective strategies for managing and overcoming adversity. This third edition reflects new demographic data, research findings, and theoretical developments and accounts for changing economic and political realities and immigration and health care policy reforms. Contributors have expanded their essays to include practice with individuals, families, and groups, and new chapters consider working with military members and their families, victims and survivors of terrorism and torture, bullied children, and young men of color.

Handbook of Social Work Practice with Vulnerable and Resilient Populations

by Alex Gitterman

When community and family support systems are weak or unavailable, and when internal resources fail, populations that struggle with chronic, persistent, acute, and/or unexpected problems become vulnerable to physical, cognitive, emotional, and social deterioration. Yet despite numerous risk factors, a large number of vulnerable people do live happy and productive lives. This best-selling handbook examines not only risk and vulnerability factors in disadvantaged populations but also resilience and protective strategies for managing and overcoming adversity. This third edition reflects new demographic data, research findings, and theoretical developments and accounts for changing economic and political realities, including immigration and health care policy reforms. Contributors have expanded their essays to include practice with individuals, families, and groups, and new chapters consider working with military members and their families, victims and survivors of terrorism and torture, bullied children, and young men of color.

Handbook of Socialization, Second Edition

by Joan E. Grusec Paul D. Hastings

This highly regarded handbook remains the leading reference and advanced text on socialization. Bringing together foremost authorities, the volume reviews the breadth of current knowledge on socialization processes across the lifespan. Contributors present cutting-edge theories and findings pertaining to family, peer, school, community, media, and other influences on individual development. Genetics and biology, cultural psychology, and affective science are given particular attention. Three themes guide the book: the interdependence of biology and experience, the bidirectionality of socialization processes, and the many contributing factors that interact to produce multiple socialization processes and pathways. New to This Edition *Revised structure reflects the diversity of socializing relationships in multiple contexts across the lifespan. *Chapters on adolescence, socialization in the workplace, moral development, culture, and neuroscience. *Many new authors and extensively revised chapters.

Handbook of Socioeconomic Determinants of Occupational Health: From Macro-level to Micro-level Evidence (Handbook Series in Occupational Health Sciences)

by Töres Theorell

This anthology provides readers of scientific literature on socioeconomic factors and working conditions with the newest knowledge in this field. Since our world is subjected to constant change in accelerating speed, scientific reviews and updates are needed. Fortunately, research methodology in epidemiology, physiology, psychology and sociology is also developing rapidly and therefore the scientific community can provide politicians and policy makers with increasingly sophisticated and exact descriptions of societal factors in relation to work. The anthology starts in the macro level sphere – with international perspectives and reviews related to working conditions in relation to political change (the fall of the Soviet Union) gender, age, precarious employment, national economy and retirement. Two chapters relate to national policies and activities in international organizations. The second part of the book relates to the meso level sphere – with reviews on social patterns in distributions of psychosocial and physical risks at work in general as well as reviews on noise, shift work, under/overemployment, occupational physical activity, job intensity (which may be a particularly important problem in low income countries), digitization in modern work, climate change, childhood determinants of occupational health in adult years and theoretical models currently used in occupational epidemiology - demand/control, effort/reward, organizational justice, psychosocial safety climate, conflicts, bullying/harassment. This part of the book ends with two chapters on interventions (one chapter on the use of cultural interventions and one on interventions and their evaluation in general) and two chapters on financial aspects of poor/good work environments and evaluations of interventions. In the third part of the book the micro level is addressed. Here mechanisms translating working conditions into physiology are discussed. This starts in general theory relating basic theories regarding energy storage and release to psychosocial theory (extension of demand control theory). It also includes regeneration physiology, autonomic nervous system function, immunology and adverse behaviour.Sections in the Handbook: Macro-level determinants of occupational health: Akizumi Tsutsumi, Meso-level determinants of occupational health: Morten Wahrendorf and Jian Li, Micro-level determinants of occupational health: Bradley J. Wright

Handbook of Sociology of Aging

by Jacqueline L. Angel Richard A. Settersten Jr.

The Handbook of Sociology of Aging is the most comprehensive, engaging, and up-to-date treatment of developments within the field over the past 30 years. The volume represents an indispensable source of the freshest and highest standard scholarship for scholars, policy makers, and aging professionals alike. The Handbook of Sociology of Aging contains 45 far-reaching chapters, authored by nearly 80 of the most renowned experts, on the most pressing topics related to aging today. With its recurring attention to the social forces that shape human aging, and the social consequences and policy implications of it, the contents will be of interest to everyone who cares about what aging means for individuals, families, and societies. The chapters of the Handbook of Sociology of Aging illustrate the field's extraordinary breadth and depth, which has never before been represented in a single volume. Its contributions address topics that range from foundational matters, such as classic and contemporary theories and methods, to topics of longstanding and emergent interest, such as social diversity and inequalities, social relationships, social institutions, economies and governments, social vulnerabilities, public health, and care arrangements. The volume closes with a set of personal essays by senior scholars who share their experiences and hopes for the field, and an essay by the editors that provides a roadmap for the decade ahead. The Handbook of Sociology of Aging showcases the very best that sociology has to offer the study of human aging.

Handbook of Solubility Data for Pharmaceuticals

by Abolghasem Jouyban

Aqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticals provides an extensive datab

Handbook of Space Pharmaceuticals

by Yashwant V. Pathak Marlise Araujo dos Santos Luis Zea

This handbook, directed at medical professionals and students who are involved in developing the space industry or are academicians doing research in this area, covers current pharmaceutical knowledge about the difference in medication efficacy in space versus on Earth and includes trial results and best practices for the space research and travel industry. The well-known contributors come from an interdisciplinary background and address all aspects of the subject, from the physiological impact of spaceflight to the effects of radiation.As the commercial space industry expands its operations in industry and tourism, the field of space pharmaceuticals is growing commensurately. Existing pharmacological research from space is thoroughly covered in this book, and Earth applications are also described. Potential pharmacological solutions are posed along with the known challenges and examples from existing studies, which are detailed at length. This major reference work is a comprehensive and important medical resource for all space industry players.

Handbook of Spatial Epidemiology (Chapman & Hall/CRC Handbooks of Modern Statistical Methods)

by Andrew B. Lawson María Dolores Ugarte Sudipto Banerjee Robert P. Haining

Handbook of Spatial Epidemiology explains how to model epidemiological problems and improve inference about disease etiology from a geographical perspective. Top epidemiologists, geographers, and statisticians share interdisciplinary viewpoints on analyzing spatial data and space-time variations in disease incidences. These analyses can provide imp

Handbook of Speech-Language Therapy in Sub-Saharan Africa: Integrating Research And Practice

by Ulrike M. Lüdtke Edward Kija Mathew Kinyua Karia

This book synthesizes research on language development and communication disability in Sub-Saharan Africa and highlights best practices for providing speech and language therapy services to individuals with language, communication, and hearing disorders across the lifespan. The book brings together a wide range of international contributions from various disciplines, such as speech-language pathology, audiology, developmental psychology, language education, social work, neurology, neuropsychology, pediatrics, linguistics, pedagogy, and phonetics to provide perspectives on problems, challenges, ideas, concepts, and models to serve the people in Sub-Saharan Africa.

Handbook of Speech-Language Therapy in Sub-Saharan Africa: Integrating Research and Practice

by Ulrike M. Lüdtke Edward Kija Mathew Kinyua Karia

This book synthesizes research on language development and communication disability in Sub-Saharan Africa and highlights best practices for providing speech and language therapy services to individuals with language, communication, and hearing disorders across the lifespan. The book brings together a wide range of international contributions from various disciplines, such as speech-language pathology, audiology, developmental psychology, language education, social work, neurology, neuropsychology, pediatrics, linguistics, pedagogy, and phonetics to provide perspectives on problems, challenges, ideas, concepts, and models to serve the people in Sub-Saharan Africa. Key areas of coverage include:Challenges for speech-language therapists in the health sector.Community awareness and the sustainable delivery of services.Culture-specific support of communication and language development in early childhood.Malnutrition, dysphagia, feeding difficulties, pediatric HIV, and related issues.Communication disability treatments, including assessment and intervention, augmentative and alternative communication (AAC), and issues specific to bilingualism and biliteracy.Inclusive education of children with communication disorders with case studies from Rwanda, Tanzania, Kenya, and South Africa. The Handbook of Speech-Language Therapy in Sub-Saharan Africa is an essential reference for researchers, professors, and graduate students as well as clinicians, therapists, and other professionals in developmental psychology, speech-language pathology and therapy, social work, neuropsychology, pediatrics, special education, community based rehabilitation, and all related disciplines.

Handbook of Spinal Cord Injuries and Related Disorders: A Guide to Evaluation and Management

by Hyun-Yoon Ko Sungchul Huh

This easy-to-use handbook is designed to assist in the evaluation and management of spinal cord injuries and the diverse related disorders and conditions. Spinal cord injuries can cause abnormalities in all body systems due to dysfunction of the somatic motor and sensory systems and damage to the autonomic nerve system. The latter gives rise to respiratory and cardiac problems, temperature regulation disorders, endocrine system disorders, and many associated metabolic disorders. Other potential consequences of spinal cord injuries include pressure injuries and various disabilities and obstacles, ranging from physical limitations to social embarrassment. This handbook offers extensive guidance on medical management in different scenarios from the acute phase to long-term care, with a particular focus on information of importance for the solution of clinical problems commonly encountered in daily practice. It will be ideal for practitioners in rehabilitation medicine, neurosurgery, orthopedics, neurology, and other relevant specialties that deal with patients with spinal cord injuries.

Handbook of Sports Medicine and Science, Sports Therapy: Organization and Operations

by James E. Zachazewski David J. Magee

Handbook of Sports Therapy Services: Organization and Operations is a practical guide, appropriate for each member of the multi-disciplinary "Sports Therapy" team, to establishing and effectively delivering the diverse therapy services required for athletes at international, national, and regional sporting events.

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