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Heartsounds: The Story of a Love and Loss
by Martha Weinman LearThe national bestseller and undying testament of a wife&’s love for her husband as he embarks on the fight of his life. On a story assignment in France for the New York Times Magazine, Martha Weinman Lear has just escaped tourist-infested Cannes for a quiet pension in the hills behind the Riviera when she gets the call from New York. Her husband has suffered a massive heart attack and is in the hospital. Harold Lear, a fifty-three-year-old urologist and leader in the field of human sexuality research, suddenly finds himself in the helpless role of the patient. Ripping into the Lears&’ lives and marriage, Hal&’s coronary disease sends them on a journey through New York City&’s medical maze. With bittersweet poignancy, Lear chronicles her husband&’s valiant efforts to combat his sickness as more heart attacks and devastating postsurgical complications befall him. A stunning work of medical drama and journalism, Heartsounds is above all the gripping story of a passionate, enduring love.
Heat Advisory: Protecting Health on a Warming Planet
by Alan H. LockwoodClimate change affects not just the planet but the people who live on it. In this book, physician Alan Lockwood describes how global warming will be bad for our health. Drawing on peer-reviewed scientific and medical research, Lockwood meticulously details the symptoms of climate change and their medical side effects. Our global ecosystems create webs of interdependence that support life on the planet. Lockwood shows how climate change is affecting these ecosystems and describes the resulting impact on health. For example, rising temperatures create long-duration heat waves during which people sicken and die. Climate change increases the risk for certain infectious diseases, including malaria, dengue fever, West Nile virus, Zika, and Lyme disease. Extreme weather and poor soil conditions cause agricultural shortfalls, leading to undernutrition and famine. There is even evidence that violence increases in warmer weather -- including a study showing that pitchers throw "beanballs" (balls thrown with the intention of hitting the batter) significantly more often in hot weather.Climate change is real and it is happening now. We must use what we know to adapt to a warmer world and minimize adverse health effects: make city buildings cooler with air conditioning and "cool roofs," for example, and mobilize resources for predicted outbreaks of disease. But, Lockwood points out, we also need prevention. The ultimate preventive medicine is reducing greenhouse gas emissions and replacing energy sources that depend on fossil fuels with those that do not.
Heat Advisory: Protecting Health on a Warming Planet
by Alan H. LockwoodHow climate change can affect our health, from heat-related illnesses to extreme weather events.Climate change affects not just the planet but the people who live on it. In this book, physician Alan Lockwood describes how global warming will be bad for our health. Drawing on peer-reviewed scientific and medical research, Lockwood meticulously details the symptoms of climate change and their medical side effects. Our global ecosystems create webs of interdependence that support life on the planet. Lockwood shows how climate change is affecting these ecosystems and describes the resulting impact on health. For example, rising temperatures create long-duration heat waves during which people sicken and die. Climate change increases the risk for certain infectious diseases, including malaria, dengue fever, West Nile virus, Zika, and Lyme disease. Extreme weather and poor soil conditions cause agricultural shortfalls, leading to undernutrition and famine. There is even evidence that violence increases in warmer weather—including a study showing that pitchers throw “beanballs” (balls thrown with the intention of hitting the batter) significantly more often in hot weather.Climate change is real and it is happening now. We must use what we know to adapt to a warmer world and minimize adverse health effects: make city buildings cooler with air conditioning and “cool roofs,” for example, and mobilize resources for predicted outbreaks of disease. But, Lockwood points out, we also need prevention. The ultimate preventive medicine is reducing greenhouse gas emissions and replacing energy sources that depend on fossil fuels with those that do not.
Heat Shock Proteins and Whole Body Physiology
by Alexzander A. Asea Bente K. PedersenHeat Shock Proteins and Whole Body Physiology is an exciting new book in the Heat Shock Proteins series which provides the most up-to-date review on novel mechanisms insights into the important role played by heat shock proteins in human physiology. Written by leaders in the field of heat shock protein exercise physiology, neuroscience and aging, the chapters systematically and in a step wise fashion takes the reader through the fascinating mechanisms by which heat shock proteins modulate human disease and pathophysiology and provides answers as to its biological significance to the host. Section I, introduces the readers to the role played by heat shock proteins in various diseases and disorders (Heat Shock Proteins and Disease). Section II, addresses the role heat shock proteins play in psychological disorders including post traumatic stress disorders and learning (Heat Shock Proteins and Psychological Stress). Section III, present a detailed review of the role played by heat shock proteins in exercise physiology (Heat Shock Proteins and Exercise Physiology). This book is a must read for heat shock protein researchers, graduate and postgraduate fellows in the field of Medicine in general and specialities in Excersie Physiology, Neuroscience, Immunology, Aging and Pathology.
Heat Shock Proteins in Inflammatory Diseases (Heat Shock Proteins #22)
by Alexzander A. A. Asea Punit KaurThe book Heat Shock Proteins in Inflammatory Diseases provides the most comprehensive highlight and insight of the expression, function and therapeutic activity of Heat Shock Proteins in inflammatory diseases including sepsis, psoriasis, neurodegenerative diseases, cancers, viral infection and autoimmune rheumatic diseases. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in inflammatory diseases.Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Heat Shock Proteins in Veterinary Medicine and Sciences: Published under the Sponsorship of the Association for Institutional Research (AIR) and the Association for the Study of Higher Education (ASHE) (Heat Shock Proteins #12)
by Alexzander A. A. Asea Punit KaurThis books provides up-to-date reviews on current advances of the role of HSP in veterinary medicine and research. Key basic and clinical research laboratories from major universities, veterinary hospitals and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into sections on HSP in the following aspects of Veterinary Medicine, including, I - Domestic Animals, II - Poultry, III - Aquatic and IV - Parasites. The book is a must read for heat shock protein researchers in general and specifically those involved in clinical and research in veterinary medicine.
Heat Shock Proteins in the Immune System
by Robert J. Binder Pramod K. SrivastavaExperts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.
Heat Shock Proteins of Malaria
by Addmore Shonhai Gregory L. BlatchThis book describes the role of heat shock proteins in the life cycle of malaria parasites. The work includes a general introduction on the structural and functional features of heat shock proteins. The main focus is on the role of heat shock protein families from Plasmodium falciparum, their role in protein folding and in the development of malaria pathology. The functions of individual families of heat shock proteins from plasmodium species and their cooperation in functional networks is described. Subcellular and extracellular organelles such as the apicoplast and the Maurer's Clefts which are associated with plasmodium species, are discussed in detail. The role of heat shock proteins in the development and function of these organelles structures are highlighted. Although conceding that heat shock proteins may not be ideal antimalarial drug targets, prospects of targeting heat shock proteins in antimalarial drug discovery either directly and/or in combination therapies are explored.
Heat Shock Proteins of Malaria (Advances in Experimental Medicine and Biology #1340)
by Addmore Shonhai Gregory L. Blatch Didier PicardThis new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies.Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer’s Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.
Heat Stress and Animal Productivity
by Anjali Aggarwal Ramesh UpadhyayDr. Anjali Aggarwal is working as a Senior Scientist at National Dairy Research Institute, Karnal (India). She holds a PhD degree in Animal Physiology and is involved in research and teaching at post-graduate level. Her area of research work is stress and environmental physiology. She has more than 50 publications, two technical bulletins, four manuals and many book chapters to her credit. She has successfully guided many post-graduate and PhD students. Her major research accomplishments are on microclimatic modification for alleviation of heat and cold stress, mist and fan cooling systems for cows and buffaloes, and use of wallowing tank in buffaloes. Her work involves the use of technology of supplementing micronutrients during dry period and early lactation to crossbred and indigenous cows for alleviating metabolic and oxidative stress and improved health and productivity. Studies are also done in her lab on partitioning of heat loss from skin and pulmonary system of cattle and buffaloes as a result of exercise or exposure to heat stress. Dr. R.C. Upadhyay is working as Head, Dairy Cattle Physiology Division at National Dairy Research Institute, Karnal (India). He graduated in Veterinary Sciences and obtained his PhD degree in Animal Physiology. His area of recent research is climate change, stress, and environmental physiology. His major research accomplishment is on climate change impact assessment of milk production and growth in livestock. His work also involves studying methane conversion and emission factors for Indian livestock and use of IPCC methodology of methane inventory of Indian livestock. Heat shock protein-70 expression studies in cattle and buffaloes are also done in his lab. Draught animal power evaluation, fatigue assessment, work-rest cycle and work limiting factors form the highlights of his work. Studies on partitioning of heat loss from skin and pulmonary system of cattle and buffaloes and electrocardiographic studies in cattle, buffalo, sheep and goat are also undertaken in his lab. He has more than 75 research papers, four books and several book chapters to his credit. Technologies developed and research done by him include methodology of methane measurement: open and closed circuit for cattle and buffaloes; inventory of methane emission from livestock using IPCC methodology; livestock stress index: thermal stress measurement based on physiological functions; and draught power evaluation system and large animal treadmill system. He received training in Radio-nuclides in medicine at Australian School of Nuclear Technology, Lucas heights, NSW, Australia in 1985 and Use of radioisotopes in cardiovascular investigations at CSIRO, Prospect, NSW, Australia, during 1985-86. He has guided several post-graduate and PhD students. He is recipient of Hari Om Ashram Award-1990 (ICAR) for outstanding research in animal sciences.
Heat Stress in Sport and Exercise: Thermophysiology of Health and Performance
by Julien D. Périard Sébastien RacinaisThe book is designed to provide a flowing description of the physiology of heat stress, the illnesses associated with heat exposure, recommendations on optimising health and performance, and an examination of Olympic sports played in potentially hot environmental conditions. In the first section the book examines how heat stress effects performance by outlining the basics of thermoregulation and how these responses impact on cardiovascular, central nervous system, and skeletal muscle function. It also outlines the pathophysiology and treatment of exertional heat illness, as well as the role of hydration status during exercise in the heat. Thereafter, countermeasures (e.g. cooling and heat acclimation) are covered and an explanation as to how they may aid in decreasing the incidence of heat illness and minimise the impairment in performance is provided. A novel and particular feature of the book is its inclusion of sport-specific chapters in which the influence of heat stress on performance and health is described, as well as strategies and policies adopted by the governing bodies in trying to offset the deleterious role of thermal strain. Given the breadth and scope of the sections, the book will be a reference guide for clinicians, practitioners, coaches, athletes, researchers, and students.
Heat and Mass Transfer: A Biological Context, Second Edition
by Ashim K. DattaThis substantially revised text represents a broader based biological engineering title. It includes medicine and other applications that are desired in curricula supported by the American Society of Agricultural and Biological Engineers, as well as many bioengineering departments in both U.S. and worldwide departments. This new edition will focus
Heatherdale's Shy Nurse
by Abigail GordonHow to mend a broken heart...Heartbroken, Leonie Mitchell is throwing herself into her work. Saving her little patients in a new countryside hospital seems like the best way to deal with the loss of her baby and her relationship. But Leonie hasn't counted on her charismatic new boss, surgeon Callum Warrender. She can't deny her attraction to Callum, nor can she ignore the comfort she finds in his arms.... Could he be the key to healing this shy nurse's broken heart?
Heatwaves: Causes, Consequences and Responses (Biometeorology #6)
by Glenn McGregorDistinctively, this book brings together an end-to-end understanding of heatwaves, that is, a consideration of their causes, consequences for human and natural systems and societal responses to them in the form of adaptation and mitigation actions. It advocates for recognizing "the heatwave imperative" and emphasizes that “heatwaves matter”. Together, the individual chapters make the point that “knowing heatwaves” from a holistic interdisciplinary perspective will assist with efforts towards heatwave risk reduction and building resilience to what is probably the most pervasive of a range of climate hazards. The book will be of interest to upper level undergraduate and taught postgraduate students and researchers in geography, climatology, environmental, atmospheric and population health sciences as well as climate and health researchers, urban planners, policy makers and the informed public with an interest in climate and society issues.
Heaven and Hell: Garven Wilsonhulme takes on all comers in the jungle of modern competition
by Carl DouglassHeaven and Hell is a novel of a man's driven life, one of overarching ambition. Here, Garven Wilsonhulme, would-be neurosurgeon, enters medical school and learns about the grim realities of competing for his place in a class where 50% of the students will be gone by the time of graduation. He makes life-long friends and enemies and faces for the first time what it is to be a student of the human condition and what life as a physician will hold for him. He learned a mnemonic ditty for the bones of the wrist: "Never Lower Tillie's Pants, Grandmother Might Come Home" and how to save a boy dying from meningitis. In Heaven and Hell, Garven is first introduced to the gripping world of neurosurgery by the man who becomes his mentor. That meeting proves to be life changing.
Heavenly Stems and Earthly Branches - TianGan DiZhi: The Keys to the Sublime
by Zhongxian Wu Karin Taylor Taylor WuTianGan (Heavenly Stems) and DiZhi (Earthly Branches), commonly abbreviated to GanZhi, originated in the ancient Chinese cosmological sciences and is a complex calendrical system which was created to codify the patterns of life and of the universe itself. The ten symbols of Gan express the Yin or Yang perspective of Five Elements and embody the Way of Heaven. The 12 symbols of Zhi, made manifest in the 12 animals of the Chinese zodiac, hold the root of each Element and embrace the Way of Earth.This set of study cards beautifully presents the key characteristics of each of the 22 GanZhi symbols, making it a unique learning tool and reference guide. The Chinese character of each Stem or Branch is shown, and for calligraphers and those who want to draw the characters correctly the stroke order is clearly illustrated on separate cards. This accessible learning tool offers essential information on the fundamental building blocks upon which Chinese classical texts, classical Chinese medicine, Fengshui, Chinese astrology, traditional Chinese cosmology, Qigong, Neigong, Taiji, and other inner cultivation practices are built. These cards provide a key starting point for the beginning student and offer invaluable information for the seasoned practitioner to deepen their practice.A companion book (9781848191518), also published by Singing Dragon, is available.
Heavy Metal Remediation: Sustainable Nexus Approach (Earth and Environmental Sciences Library)
by Nitish KumarHeavy metals, in general trace elements, are one of the major environmental problems. Nowadays, increasing environmental and global public health concerns related with environmental contamination by heavy metals are well known. Moreover, human exposure has risen dramatically because of an exponential increase of their use in several activities such as agricultural, industrial, technological and urban applications. They are presented in soils, water and atmosphere and they are a serious risk for the food chain.Approximately 10 million contaminated sites have been reported globally, occupying approximately 49.42 million acres of land, of which >50% is contaminated with toxic heavy metals. This situation warrants immediate attention to limit the introduction of heavy metals into soil systems and to remove the prevailing heavy metals from polluted soils. However, the majorities of existing heavy-metal-removal technologies are expensive, inefficient, or generate secondary pollutants. Therefore, it is of great importance to develop cheaper, environmentally friendly and sustainable approaches (including the development of new immobilizing agents) to manage and rehabilitate heavy-metal-contaminated soils. In the light of the aforementioned facts, this book sheds light on this global environmental issue, and proposes solutions to contamination through multi-disciplinary approaches and case studies from different parts of the world. It addresses sustainable heavy metal contamination remediation strategies using the potential applications of recent biological technology such as biotechnology, bioremediation, phytoremediation, biochar, absorbent, genetic engineering, and nanotechnology approaches. This book is of interest to researchers, teachers, environmental scientists, environmental engineers, environmentalists, and policy makers. Also, the book serves as additional reading material for undergraduate and graduate students of environmental microbiology, biotechnology, eco-toxicology, environmental remediation, waste management, and environmental sciences as well as the general audience.
Heavy Metal Toxicity: Human Health Impact and Mitigation Strategies (Environmental Science and Engineering)
by Nitish KumarThis edited book brings together a diverse group of environmental science, sustainability, and health researchers to address the challenges posed by global mass poisoning caused by heavy metals contamination of soil and plants. In recent years, contamination of the environment by heavy metals has become a major concern. Their multiple industrial, domestic, agricultural, medical, and technological applications have led to their wide distribution in the environment, raising concerns over their potential effects on human health and the environment. Owing to their toxic, non-degradable, and bio-accumulative nature, the health burden on the population has increased significantly. Heavy metals such as arsenic, lead, mercury, cadmium, and uranium do not play a significant role in metabolism in the human body and are thus toxic. Their exposure in high concentration can cause acute toxicity resulting in acute health conditions, which is easy to observe and regulate, while similar is not visible for immediate action when their exposure is in trace amounts over the years. Heavy metals enter in the food chain through consumption of plant material. A high concentration of heavy metals has been found to be harmful to vegetation. As the heavy metals concentration in plants increases, it adversely affects several biological parameters and eventually renders the soil barren.The book sheds light on this global environmental issue and proposes solutions to contamination through multi-disciplinary approaches and case studies from different parts of the world. This book is a valuable resource to students, academicians, researchers, and environmental professionals who are doing field work on heavy metals contamination throughout the world.
Hedgehog Signaling Protocols
by Jamila I. HorabinIntended for Molecular Biologists, Biochemists, and Geneticists interested in manipulating and analyzing the Hedgehog Signaling Pathway, this volume offers various detailed chapters on experimental description, including anecdotal pointers and notes.
Hedgehog Signaling: Methods and Protocols (Methods in Molecular Biology #2374)
by Xiaochun LiThis detailed book explores the technical breakthroughs with biophysical and cell biological approaches that have advanced the study of molecular mechanisms underlying the generation and transduction of the hedgehog (HH) signal, indicating the important role of sterols in this pathway. Within its pages, the volume examines techniques involving several key protein components in this pathway, including HH, the signaling ligand; Dispatched, a HH secretion regulator; Patched, the receptor of HH; Smoothened, the signal transducer used to transduce the HH signal across the plasma membrane; and GLI, the transcription factor to turn on HH target genes. Written in the highly successful Methods in Molecular Biology series format, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Hedgehog Signaling: Methods and Protocols provides researchers in clinical and basic science with a fresh and reliable reference for analyzing HH signal transduction through cell biological, biochemical, and biophysical approaches.
Hedgehog signaling activation in human cancer and its clinical implications
by Jingwu XieUnderstanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.
Heidegger, Reproductive Technology, & The Motherless Age
by Dana S. BeluDana S. Belu combines Heidegger's phenomenology of technology with feminist phenomenology in order to make sense of the increased technicization of women's reproductive bodies during conception, pregnancy, and birth.
Heidelberger Medizinergespräche: Chefärzte und ihre Karrierewege
by Christoph JaschinskiWie werde ich ein guter und erfolgreicher Mediziner?In diesem Buch berichten einige der bekanntesten Mediziner Deutschlands über ihren Werdegang. Im persönlichen Gespräch erzählen sie offen und zugleich unterhaltsam über die Erlebnisse, Erfolge, aber auch Misserfolge, die sie dahin gebracht haben, wo sie heute stehen. Weiterhin beantworteten diese Koryphäen der modernen Medizin, was sie heutigen Medizinstudierenden für deren Lebensweg raten würden. In fünf Interviews sammelt sich so ein breites Spektrum, das sowohl internistische als auch chirurgische Werdegänge, deutsche wie amerikanische Lebenswege sowie medizinspezifische als auch außerhalb des Fachlichen liegende Erfahrungen umfasst. Eine Pflichtlektüre für jeden Medizinstudierenden!
Heilfasten für Dummies (Für Dummies)
by Sebastian Bartning Carola BartningMöchten Sie sich und Ihrem Körper mit Heilfasten etwas Gutes tun und für eine Weile im Alltag innehalten und entschleunigen? Ballast abwerfen, vielleicht ein paar Pfunde verlieren, zur Ruhe kommen? Beim Heilfasten nach Dr. Buchinger wird mehrere Tage auf feste Nahrung verzichtet: Es gibt Tees, Basenbrühen und Säfte. Dieses Buch führt Sie Schritt-für Schritt durch alle Phasen hindurch - von den Entlastungstagen über das eigentliche Fasten, das Fastenende bis zu den Aufbautagen. Sie erfahren, wie Sie Fastenkrisen bewältigen und das Fasten mit Entspannungstechniken und Meditation begleiten, damit die Zeit des Fastens für Sie bereichernd und gesundend ist.
Heilpflanzen der Traditionellen Europäischen Medizin
by Angelika PrentnerDieses Buch widmet sich umfassend und anschaulich dem Einsatz von heimischen Pflanzen zur Therapie und Prävention von häufigen Krankheitsbildern. Ein kurzer Grundlagenteil führt dabei zu Beginn in die wesentlichen Kernpunkte der Traditionellen Europäischen Medizin (TEM) mit ihrem breit gefassten Verständnis von Gesundheit ein. Außerdem werden die unterschiedlichen Zubereitungsarten von Heilpflanzen vorgestellt. Der weitaus größere Teil bietet eine gute Übersicht zur Wirkung und Anwendung von heimischen Heilpflanzen geordnet nach verschiedenen Organsystemen. Zu den einzelnen Krankheitsbildern und häufigen Indikationen werden heimische Heilpflanzen in Wort und Bild mit ihrer Wirkung, Anwendung und Zubereitungsmöglichkeit vorgestellt. Als Besitzerin einer traditionsreichen Naturapotheke verfügt die Autorin über ein großes Wissen an bewährten zum Teil sehr alten Rezepturen. Das praxisnahe Buch wendet sich an Ärzte und Pharmazeuten, die sich mit der Traditionellen Europäischen Medizin beschäftigen möchten sowie an alle an dem Thema Interessierten.