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Hepatocellular Carcinoma: Translational Precision Medicine Approaches (Molecular and Translational Medicine)
by Yujin HoshidaThis book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.
Hepatocyte Transplantation
by Bruno Christ Peggy StockThis volume features up-to-date protocols for the isolation, preservation, and validation of various cell sources comprising large and small animal models, examining the impact of cell transplantation on acute and chronic liver diseases. Hepatocyte Transplantation: Methods and Protocols guides readers through laboratory protocols for the generation of humanized livers for the assessment of biological actions in vivo and techniques to monitor cell engraftment after cell transplantation in vivo are described and procedures for computational analyses of hepatocyte transplantation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Hepatocyte Transplantation: Methods and Protocols is an essential resource for researchers and clinicians to assess the biological as well as the therapeutic potential of hepatocyte transplantation.
Hepatocyte and Kupffer Cell Interactions (CRC Press Revivals)
by Timothy R. Billiar Ronald D. CurranHepatocyte and Kupffer Cell Interactions presents a comprehensive discussion of historical and recent information regarding this diverse field of research. The role of Kupffer cells and hepatoctyes in normal physiology, nonseptic pathological states, and in sepsis is examined. Microanatomy and methods of experimental study are covered as well. In each of the book's chapters, the role of the Kupffer cell and hepatocyte interaction is placed in context with information on particular liver functions or disease states. Hepatocyte and Kupffer Cell Interactions is an essential reference for leukocyte specialists, gastroenterologists, immunologists, and other researchers working in this fascinating field.
Hepatocytes
by Patrick MaurelHepatocytes account for approximately 80% of the liver mass and play a significant role in various aspects of liver physiopathology, exhibiting unrivaled complexity and diversity of functions. In Hepatocytes: Methods and Protocols, expert researchers provide the reader with methods, technical protocols, and review chapters focusing on selected areas of hepatocyte biology including isolation, culture, differentiation and stem cells, and hepatocyte use in clinical, basic, and applied research. With a specific emphasis on human hepatocytes, the volume presents chapters covering subjects including hepatocyte culture models, cryopreservation methods, differentiation assessment, liver ontogenesis, production of hepatocytes from stem cells, drug/xenobiotic metabolism, toxicity and transport, bile acid and blood coagulation factor production, infection by HBV and HCV, humanized animals, biortificial liver devices, hepatocyte transplantation. As a volume in the highly successful Methods in Molecular BiologyTM series, protocol chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Hepatocytes: Methods and Protocols will be useful to all those who are currently using or planning to use human, or animal, hepatocytes to investigate any aspect of liver physiopathology or who are interested in liver development or liver stem cells and liver biotherapy.
Hepatocytes: Methods and Protocols (Methods in Molecular Biology #2544)
by Naoki TanimizuThis volume details experimental protocols to study structure and function of hepatocytes in vivo and in vitro, and for characterizing heterogeneity and plasticity of hepatocytes in healthy and in injured liver. Chapters guide readers through separating hepatocyte subfractions, characterizing the heterogeneity, novel culture systems, hepatocyte-like cells from human pluripotent stem cells, analyzing drug metabolism, monitoring protein sorting, manipulating gene expression, and methods for expanding primary hepatoblastoma and identifying hepatocellular carcinoma subtypes. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Hepatocytes: Methods and Protocols aims to provide techniques to further understand molecular mechanisms involved in the regulating hepatocyte functions and underlying liver diseases.
Hepatology
by E. Jenny HeathcoteThis book will be an affordable, highly practical handbook on hepatology, aimed at residents/trainees in gastroenterology, GI nurses, and recently qualified consultants to use as a quick reference when managing patients presenting with possible or overt liver disease.It will be of particular use for those GI internists/residents who have an interest specifically in hepatology. It does not aim to be a specialist textbook, but a shorter, 250pp guide that provides key clinical information on each area of hepatology in an accessible form. Extracting relevant material from large reference textbooks can be very time consuming and for this reason, information in this handbook will be presented succinctly in a style suitable for quick reference and easy understanding.The chief emphasis will be on the clinical assessment and management of these patients, and all the major areas of liver disease will be covered, from liver cirrhosis to viral hepatitis, to autoimmune liver failure.Chapters will use a variety of structural features and colour coded boxes to increase the accessibility for residents. These include: key points/take-home points, case history, practice points and management algorithm/flow-charts. Each chapter will also contain sample multiple choice questions that the reader will be able to test themselves on.
Hepatology
by Kathryn Nash Indra Neil GuhaHepatology is an important specialty with diseases and complications related to viral hepatitis and alcohol being the main reason for seeking specialist advice. On most general medical rotations and on most surgical wards there are patients with hepatological problems. Hepatology: Clinical Cases Uncovered contains clinical presentations with real-life patient cases and outcomes as seen on the wards and in exams, and leads students through a practical approach to diagnosis and management of hepatological disease. Following a question and answer approach, including self-assessment material and a 'refresher' section on the basic science, Hepatology: Clinical Cases Uncovered features investigations and the treatment options available for patients presenting with hepatological problems. Difficult concepts are clarified and relevant links are made between pathology and clinical presentation. Hepatology: Clinical Cases Uncovered is ideal for medical students, junior doctors on the Foundation Programme, GP trainees, residents, specialist nurses and nurse practitioners. The book is also an ideal refresher for hepatology or gastroenterology trainees at the beginning of their specialist training programme
Hepatology and Transplant Hepatology
by Jawad AhmadHepatology and Transplant Hepatology: A Case Based Approach presents a collection of interesting cases in liver disease seen at a very busy and large liver transplant center in the United States. These cases cover the full range of pathology that an internist or gastroenterologist may expect to see in a lifetime of taking care of patients with acute or chronic liver disease, before or after liver transplant. Each case is presented as you would see it in a clinical situation where a patient presents a complaint or something is noted on exam or blood work. The question/answer format will help one through the problem of making a diagnosis or in considering a differential diagnosis and also point to the best way to manage each condition. The volume is divided into pre-transplant and post-transplant hepatology. Each case is 3 pages with the first page presenting the case and pertinent lab data and 3-4 questions (i.e. differential diagnosis, tests to order, x-rays/CT required).The second page illustrates the tests, scans, biopsies and asks for the pertinent findings. The third page provides the diagnosis and what may have been expected with other diagnoses. Here is a single source dealing with questions specific for patients with complications of advanced liver disease and also clinical situations seen in transplant hepatology. Hepatology and Transplant Hepatology: A Case Based Approach will have great appeal to anyone in hepatology/transplant hepatology and also to residents/fellows and internists interested in gastroenterology.
Hepatology and Transplant Hepatology Board Review
by Jawad Ahmad Shahid M. MalikHepatology and Transplant Hepatology Board Review Hepatology and Transplant Hepatology: Board Review with Multiple Choice Questions is the only source you will need to pass the American Board of Internal Medicine (ABIM) transplant hepatology examination. Written by two highly experienced hepatologists, this indispensable study guide covers all the main topics tested on the exam: pre-transplant, perioperative, post-transplant, and transplant immunology. 261 multiple-choice questions with answers, including questions based on the authors’ real-life cases, are designed to mimic the clinical scenarios you will encounter in hepatology practice. Questions testing your medical knowledge, clinical insight, and management skills are supported by brief topic overviews, key references, high-quality images, pathology slides, and cholangiograms. Throughout the book, “Pearls” and “Must-Know Facts” sections emphasize testable points that are likely to appear on the ABIM board examination. The first hepatology-specific study aid of its kind, Hepatology and Transplant Hepatology: Board Review with Multiple Choice Questions is a must-have for medical professionals preparing for the hepatology boards, as well as practicing gastroenterologists and hepatologists who want to refresh their knowledge and test their proficiency in both fundamental and advanced hepatology topics.
Hepatology at a Glance (At a Glance)
by Deepak Joshi Margaret G. Keane Jeremy NayagamThe market‐leading at a Glance series is popular among healthcare students and newly qualified practitioners, for its concise and simple approach and excellent illustrations. Each bite‐sized chapter is covered in a double‐page spread with clear, easy‐to‐follow diagrams, supported by succinct explanatory text. Covering a wide range of topics, books in the at a Glance series are ideal as introductory texts for teaching, learning and revision, and are useful throughout university and beyond. Everything you need to know about Hepatology… at a Glance! Develop a basic understanding of liver disease in this accessible, beautifully illustrated introduction to an increasingly important specialty Hepatology is the field of research and medicine which deals with diseases of the liver. As liver problems are encountered with increasing frequency in the medical profession, accessible information for medical staff and allied health care professionals is essential to support patient care. Hepatology at a Glance meets this need with a highly readable volume designed to bridge the gap between introductory gastroenterology textbooks and materials for hepatology specialists. It covers essential areas such as the development, structure, and function of the liver, transplantation, common liver disorders, and much more. Now fully updated for its second edition, it is a must-own for medical practitioners looking for a working reference on a vital category of medical conditions. Readers of the second edition of Hepatology at a Glance will also find: Updates in most chapters, incorporating new research and best practicesSix entirely new chapters covering subjects like adolescent care, radiology in liver disease, endo-hepatology, and moreAn international authorial team Hepatology at a Glance is ideal for those working within British Society of Gastroenterology guidelines and has been expanded for an American audience. To receive automatic updates on Wiley books and journals, join our email list. Sign up today at www.wiley.com/email
Hepatotoxicology
by Robert G. Meeks Steadman HarrisonThis book is destined to serve as a classic reference source to which researchers can turn for a historical perspective and basic information on the physiology, biochemistry, and pathology of the liver. Major areas covered in the book include histological organization, classification of chemical-induced injury, stages of cellular injury, and xenobiotic metabolism. Chapters discussing the use of biochemical methods to determine liver damage, the effects of various chemical agents of the liver, and hepatocarcinogenesis are also presented. Toxicologists, physiologists, physicians, biochemists, industrial hygienists, and others interested in the effects of chemical agents on the structure and function will find this book to be an indispensable source of information.
Her Baby Out of the Blue
by Alison RobertsA drop-dead gorgeous man walking into the hospital with a newborn baby in his arms should be all in a day's work for emergency pediatric surgeon Jane Walters. But this isn't work-related--this tiny little girl is the daughter Jane never knew she had!When Jane donated her eggs to a friend, she thought all the IVF attempts had failed. Apparently not. Now her friend has died, and the baby's uncle, gorgeous Dylan McKenzie, Is here to tell Jane that what newborn Sophie really needs is for the three of them to come together as a family. . . .
Her Christmas Baby Bump
by Robin GiannaOne Christmas night with consequences! Talented midwife Hope Sanders's dream of holding a baby of her own is finally coming true! She's just weeks away from beginning her fertility treatment-and then meeting gorgeous hotshot fertility doc Aaron Cartwright throws a holly sprig in her plans... Aaron's mistletoe kisses might be dazzling, but after they spend one magical Christmas night together, Hope never expects to end up pregnant! Now she's faced with telling Aaron her surprise baby news...but has she finally found the man of her dreams, too? Midwives On-Call at Christmas
Her Doctor's Christmas Proposal (Midwives On-Call at Christmas #4)
by Louisa GeorgeReunited at Christmas... Obstetrician Isabel Delamere is tired of running from the past. Especially when her childhood sweetheart, Sean Anderson, has already followed her halfway around the world! But sharing her deepest secret with Sean means reliving the heartbreak of losing their baby... Sean is devastated to learn that he was once a father-and that Isabel went through it alone. Now that they are together again, Sean knows his heart will always belong to Isabel...and with a little bit of Christmas magic he's determined to convince her that their love is worth fighting for!
Her Dr. Wright
by Meredith WebberSaving Dr. Wright Rowena knew she was in love with her sexy boss, Dr. David Wright, and was beginning to suspect he felt the same way. David’s wife mysteriously disappeared over three years ago and when her twin suddenly appeared, intent on digging up the past, David was placed under suspicion. He was in crisis and Rowena desperately wanted to comfort him. David refused to let Rowena get involved. He couldn’t offer her a future with his past hanging over him. Except he was finding it hard to envisage a future without her.
Her Emergency Knight
by Alison RobertsComing soon! Her Emergency Knight by Alison Roberts will be available Aug 15, 2016.
Her Family for Keeps
by Molly EvansRebel without a home! Being a traveling nurse suits Rebel Taylor just fine-no ties, no relationships, no dating! With the Huntington's gene in her family, what can she possibly offer a guy anyway? But Duncan McFee, Albuquerque's hottest and most single doc, disagrees. He's determined to tempt this stunning, wonderful woman-and when he does, her story is enough to make him risk his own heart. He can give her all the love and family she could want. All he needs to do is persuade Rebel!
Her Four-Year Baby Secret
by Alison RobertsA father for her son Single mom and paramedic Fiona Murchison will do anything to shield her little boy from the glare of the world's media. No one knows that her late husband, celebrity racing driver Al Stewart, has an heir, and Fiona is determined to keep it that way to keep her child safe... All is at risk, though, when a charming new surgeon arrives in Town, and Fi immediately recognizes him as Al's brother Nick! The time has come for Fi to confess her four-year-old secret. Nick is overjoyed to discover he has a nephew, and Fiona is relieved to know that Nick, too, will do anything to protect this little family from the world--including loving them as if they were his own.
Her Greek Doctor's Proposal
by Robin GiannaThe question he thought he'd never ask... Archaeologist Laurel Evans put her career on hold to care for her younger sisters. Now, close to achieving her goals, she won't let anything distract her. Laurel has come to Delphi to dig up ancient treasures, but she finds a modern-day Greek god instead-local doctor Andros Drakoulias! A devoted single dad, Andros is determined to give his little girl stability. He knows his fling with Laurel can't last, so why is it so hard to imagine a future without her by his side?
Her Holiday Miracle
by Joanna NeilHer Caribbean Escape Talented ER doc Cade Byfield appears to have it all, yet there's always been something missing. When Dr. Rebecca Flynn arrives on his Caribbean island, Cade begins to think that she might be the answer. But the mysterious beauty hides a devastating secret-the family Cade wants is the one thing she can never give him. Until one smoldering kiss in the eye of a storm makes Rebecca question: Could trusting Cade with her past give them both the future they dream of?
Her Honourable Playboy
by Kate HardyFrom E.R. doctor to high-society bride?Registrar Alyssa Ward is not pleased when she wins a date with the E.R. consultant, Honorable Sebastian Radley. She's not in the market for a relationship—especially not with a renowned womanizer like Seb. But, then again, he is devastatingly handsome—and, after all, it's only one date.Seb has never been one for monogamy. So why does he find that one date with Alyssa just isn't enough? There's so much more to her than just another woman he's dated. And when she gives him some life-changing news, he finds himself reassessing who he really wants to be—every woman's honorable playboy, or Alyssa's honorable husband?
Her Hot Highland Doc
by Annie O'NeilA match made in Scotland He might have the good looks of a modern-day Viking, but Dr. Brodie McClellan has brooding down to an art. He's only recently returned to the Isle of Dunregan and already the demons of his past are pushing him to the edge. Running from her own troubled past, this remote posting is heaven-sent for locum Dr. Kali O'Shea. And Brodie makes her long to find her true home in Scotland...in her new boss's arms!
Her Knight Under the Mistletoe: The Nurse's Special Delivery Her New Year Baby Surprise Her Knight Under The Mistletoe (Large Print Medical Romance Ser. #Vol. 928)
by Annie O'NeilAll the single mom wants for Christmas…London ER doctor Matthew Chase is shocked that his new role has become a job share with Dr. Amanda Wakehurst—the last woman he expected to see again.Matthew is also unaware he’s the father of her little boy, until Tristan is critically injured. Yet Matthew is there to support Amanda in her hour of need, and he proves how much he wants to be Tristan’s dad. Dare she hope he still wants her, too? Being together as a family this Christmas would be her ultimate gift…
Her Little Secret
by Carol MarinelliHer Little Secret Eastern Beach Hospital is just the next stop for doctor Nick Roberts hes left broken hearts on every continent! But Nicks funloving attitude is so infectious that his patients and nurse Alison Carter are unwillingly hooked. One night with Nick leaves Alison with a new zest for life and one rather more unexpected gift The Doctors Damsel in Distress Theres something about nurse Madison that has Dr Levi Fielding desperate to have her in his arms. Her girlnextdoor looks and unawakened sex appeal mean he cant resist flustering her! So when Levi saves Madisons life at a hospital picnic, he knows its a white knight moment he ll take full advantage of
Her Man of Honour
by Melanie MilburneTo love, honour and protectIt's Dr. Amy Tanner's first day in the beautiful coastal village of Marraburra. She's here to give her patients the best possible care, and also to uncover the truth behind her cousin's disappearance. Gorgeous sheriff Angus Ford is impressed with the new doctor's feisty courage and unquestionable skill--not to mention her stunning looks. But when Amy finds out the truth about her cousin, Sheriff Ford is determined to protect her.Amy's intention is to settle the past and then head back to her life in the city, but this commanding, caring man has changed her mind. Could her real home be in Marraburra, as the sheriff's wife?