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Innate Immune System of Skin and Oral Mucosa
by Nava Dayan Philip W. WertzAn in-depth look at cutting-edge research on the body's innate immune systemInnate immunity is the body's first line of protection against potential microbial, viral, and environmental attacks, and the skin and oral mucosa are two of the most powerful barriers that which we rely on to stay well. The definitive book on the subject, Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products provides a comprehensive overview of these systems, including coverage of antimicrobial peptides and lipids and microbial challenges and stressors that can influence innate immunity.Designed to help experts and newcomers alike in fields like dermatology, oral pathology, cosmetics, personal care, and pharmaceuticals, the book is filled with suggestions to assist research and development. Looking at the many challenges facing the innate immune system, including the impact of topically applied skin products and medications, Innate Immune System of Skin and Oral Mucosa paves the way for next generation treatment avenues, preventative approaches, and drug development.
Innate Immunity
by Eric Vivier Jonathan EwbankThis volume contains chapters dealing with the isolation and functional characterization of cells involved in innate immunity in mouse and man, including mast cells and eosinophils, and with several chapters focusing on natural killer cells. These approaches and models are being used to dissect the complex interplay between hosts and pathogens, and contribute to developing strategies to help fight infection.
Innate Lymphoid Cells (Advances in Experimental Medicine and Biology #1365)
by Xiao-Hong SunThis book aims to systemically summarize the key findings about Innate lymphoid cells (ILCs) and present the consensus of current views and prospective. ILCs are a class of newly recognized immune cells which play an instructive role in shaping immunity in physiological and pathological conditions. This book discusses the differentiation of ILC, the relation of ILCs with respiratory function, inflammation in the gut, skin disorders, cancer, neurobiology and microbes. The knowledge included in this book is valuable for both basic immunologists and clinicians in understanding the heterogenetic immune responses in disease and health.
Innate Tolerance in the CNS
by Miguel A. Perez-Pinzon John H. Zhang Jeffrey M. GiddayCerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain - or inducing endogenous protective mechanisms after the initial injury - can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.
The Inner Apprentice: An Awareness-Centred Approach to Vocational Training for General Practice, Second Edition
by Roger NeighbourHighly Commended in the 2005 BMA Medical Book Competition The first edition of The Inner Apprentice proved to be a landmark publication. Now in its second edition, it includes an additional chapter in which questions the assumptions about the relevance of awareness-based teaching in the overcrowded curriculum of contemporary vocational training – and suggests that the curiosity they engender is more important than ever. This book offers many new ideas, techniques and educational tools, and will be of interest to general practice trainers and trainees, and anyone involved in an individual teaching relationship.
An Inner Approach to Cranial Osteopathy
by Timothy MarrisThis book is for the current Cranial Osteopathic practitioner. It looks into Cranial Osteopathy from a more profound 'inner' approach to help the practitioner to understand Cranial Osteopathy from a deeper and broader perspective. The book starts by taking the reader on an 'inner' journey of understanding more about themselves as the practitioner, discussing the 'osteopathic toolbox', and the need to be 'inner centred' when diagnosing and treating. It then looks at aspects of diagnosis - of tissue and fluid states - giving the reader several 'inner' considerations which they should apply when assessing a patient. The book then looks at the whole body and using an 'inner' approach to assess and treat each area. Each chapter gives an overview of the relevant anatomy and discusses the osteopathic relevance and new ways of working. Case studies/clinical experiences are described and 'hands on' exercises, which can be accessed via audio files, are given for the reader to practise. These exercises should be done 'at the treatment table' and will prepare the reader to use the approaches described with their patients. The audio leads the listener through a 'guided tour' of the anatomy and explains the exercise while they use their hands to feel what the author is describing.This guide will help Cranial Osteopathic practitioners enhance their skills, knowledge and understanding to a much-advanced level.
The Inner Consultation: How to Develop an Effective and Intuitive Consulting Style, Second Edition (Radcliffe Ser.)
by Roger NeighbourThe Inner Consultation, Second Edition sets out the author’s thoughts on how consulting skills, and methods of teaching them, have evolved in the 17 years since the book’s first publication. It also develops the theme of ‘curiosity’ as the key requirement for patient-centred consulting and provides a practical consultation model with five checkpoints to work to, advice for developing skills, and suggestions for doctors to ensure they know the cues in the consultation that require their full attention. All general practitioners, GP registrars, and medical professionals will find this book essential and thought-provoking reading.
The Inner Life of the Dying Person
by Allan KellehearThis unique book recounts the experience of facing one's death solely from the dying person's point of view rather than from the perspective of caregivers, survivors, or rescuers. Such unmediated access challenges assumptions about the emotional and spiritual dimensions of dying, showing readers that -- along with suffering, loss, anger, sadness, and fear -- we can also feel courage, love, hope, reminiscence, transcendence, transformation, and even happiness as we die.A work that is at once psychological, sociological, and philosophical, this book brings together testimonies of those dying from terminal illness, old age, sudden injury or trauma, acts of war, and the consequences of natural disasters and terrorism. It also includes statements from individuals who are on death row, in death camps, or planning suicide. Each form of dying addressed highlights an important set of emotions and narratives that often eclipses stereotypical renderings of dying and reflects the numerous contexts in which this journey can occur outside of hospitals, nursing homes, and hospices. Chapters focus on common emotional themes linked to dying, expanding and challenging them through first-person accounts and analyses of relevant academic and clinical literature in psycho-oncology, palliative care, gerontology, military history, anthropology, sociology, cultural and religious studies, poetry, and fiction. The result is an all-encompassing investigation into an experience that will eventually include us all and is more surprising and profound than anyone can imagine.
The Inner Life of the Dying Person
by Allan KellehearThis unique book recounts the experience of facing one's death solely from the dying person's point of view rather than from the perspective of caregivers, survivors, or rescuers. Such unmediated access challenges assumptions about the emotional and spiritual dimensions of dying, showing readers that -- along with suffering, loss, anger, sadness, and fear -- we can also feel courage, love, hope, reminiscence, transcendence, transformation, and even happiness as we die.A work that is at once psychological, sociological, and philosophical, this book brings together testimonies of those dying from terminal illness, old age, sudden injury or trauma, acts of war, and the consequences of natural disasters and terrorism. It also includes statements from individuals who are on death row, in death camps, or planning suicide. Each form of dying addressed highlights an important set of emotions and narratives that often eclipses stereotypical renderings of dying and reflects the numerous contexts in which this journey can occur outside of hospitals, nursing homes, and hospices. Chapters focus on common emotional themes linked to dying, expanding and challenging them through first-person accounts and analyses of relevant academic and clinical literature in psycho-oncology, palliative care, gerontology, military history, anthropology, sociology, cultural and religious studies, poetry, and fiction. The result is an all-encompassing investigation into an experience that will eventually include us all and is more surprising and profound than anyone can imagine.
The Inner Physician: Why And How To Practise Big Picture Medicine
by Roger NeighbourIn this final volume of his best-selling 'Inner' trilogy, Roger Neighbour explores the relationship between a doctor's professional and private selves. He suggests that the mind of every doctor retains an untrained 'ordinary human being' part - their Inner Physician - which makes an important, though often neglected, contribution to medical practice. This 'Inner Physician', which he also describes as the 'amateur within' or the 'expert minus the expertise', plays a major role in diagnosis and treatment, and is the chief source of insight, empathy and clinical acumen. Roger shows that skilled use of the Inner Physician is one thing that distinguishes the generalist from the specialist.
The Inner Power of Stillness: A practical guide for therapists and practitioners
by Alexander Filmer-Lorch Margaret Anne Gill Caroline BarrowThe Inner Power of Stillness is not just another book about therapeutic presence, mindfulness and meditation. It explores and highlights the next evolutionary step, leading us beyond the already well-researched teachings of these topics, by looking at the multidimensional scale of stillness from an entirely different point of view.The focal point is the inner development by therapists, practitioners and teachers of the mainly dormant potential of stillness and the storage capacity of stillness-stimulus and imprints in our tissue/fascia, as well as their benefits, use and application in a treatment or teaching environment.The Inner Power of Stillness endeavours to illuminate the lost value of stillness for the therapist and practitioner both as a person and as a professional. The authors anchor the possibility of this inner evolution of the power of stillness to the latest research into tissue and cell memory.They introduce the concept of a potential new modality called 'stillness-memory', and build upon this new understanding a logical and practical framework in which science and philosophy truly inform each other.This opens up access to a much larger scale of new ideas and possibilities which, providing the transformative teachings they embody are put into practice, carry the potential for practitioners to be the best person and the best professional they can be, without compromising their own overall health and wellbeing.In-depth knowledge of how to arrive at this promising new modality, as well as how to apply it in everyday work and life, is at the heart of the book. It covers topics such as working from your inner power of stillness, the insightful self and, most importantly, the practitioner's toolkit.Some thought-provoking themes that might be of great value to therapists, teachers and practitioners who intend to dedicate some of their time to working for the greater good can be found at the end of the book, where consideration is given to a universal view of compassion and the solace that stillness can bring to people who are nearing the end of their life and final departure.The book concludes with a philosophical note acknowledging the timeless nature of ancient wisdom, and the ever more important relevance and role of the philosopher in our modern world today.The Inner Power of Stillness is a comprehensive guide for people working with people. It provides practical knowledge that will revolutionise the way practitioners help others:Working from a greater perspective, being aware of the whole as well as the parts, and responding to the cause and not only the effect.Working from an internal place of stillness.Innovative and practical exercises and techniques to dissolve friction/struggles in sustaining a state of authentic therapeutic presence, mindfulness and meditation.Simple exercises to help clients build long-term memory of stillness as a foundation for successful mindfulness and meditation practice.Includes Forewords from John Matthew Upledger, Lauren Walker and Charles Ridley
The Inner Touch: Archaeology Of A Sensation
by Daniel Heller-RoazenThe Inner Touch presents the archaeology of a single sense: the sense of being sentient. Aristotle was perhaps the first to define this faculty when in his treatise On the Soul he identified a sensory power, irreducible to the five senses, by which animals perceive that they are perceiving: the simple "sense," as he wrote, "that we are seeing and hearing." After him, thinkers returned, time and again, to define and redefine this curious sensation. The classical Greek and Roman philosophers as well as the medieval Arabic, Hebrew, and Latin thinkers who followed them all investigated a power they called "the common sense," which one ancient author likened to "a kind of inner touch, by which we are able to grasp ourselves." Their many findings were not lost with the waning of the Middle Ages. From Montaigne and Francis Bacon to Locke, Leibniz, and Rousseau, from nineteenth-century psychiatry and neurology to Proust and Walter Benjamin, the writers and thinkers of the modern period have turned knowingly and unknowing to the terms of older traditions in exploring the perception that every sensitive being possesses of its life. The Inner Touch reconstructs and reconsiders the history of this perception. In twenty-five concise chapters that move freely among ancient, medieval, and modern cultures, Daniel Heller-Roazen investigates a set of exemplary phenomena that have played central roles in philosophical, literary, psychological, and medical accounts of the nature of animal existence. Here sensation and self-sensation, sleeping and waking, aesthetics and anesthetics, perception and apperception, animal nature and human nature, consciousness and unconsciousness, all acquire a new meaning. The Inner Touch proposes an original, elegant, and far-reaching philosophical inquiry into a problem that has never been more pressing: what it means to feel that one is alive.Winner of the Aldo and Jeanne Scaglione Prize for Comparative Literary Studies
Inner War: A German WWII Survivor’s Journey from Pain to Peace
by Gerda RobinsonIt is sometimes difficult to remember that in war there are innocents on all sides who suffer. German citizens who had no connection to the atrocities committed by their countrymen nonetheless endured great hardships because of them. In The Inner War, author Gerda Hartwich Robinson narrates her story as a German survivor of World War II. She tells how her life’s journey included hunger, fear, neglect, and physical and emotional abuse, and how she carried these injustices in her mind and body for many years, leading to debilitating back pain, headaches, panic attacks, depression, and feelings of inadequacy. In this touching memoir, Robinson shows that the tragedies of war don’t end when the last bomb is dropped or the last prisoner freed; they continue in subtle but devastating ways. Like many German citizens during and after the war, Robinson was simply trying to survive a terrifying situation she had nothing to do with. She describes how her spirit was devastated by hopelessness, and how she entertained thoughts of suicide. The Inner War shares lessons she learned at a chronic pain rehabilitation center that allowed her to start on a path to peace and love.
The Inner Workings of Life
by Eberhard O. VoitLiving systems are dynamic and extremely complex and their behaviour is often hard to predict by studying their individual parts. Systems biology promises to reveal and analyse these highly connected, regulated and adaptable systems, using mathematical modelling and computational analysis. This new systems approach is already having a broad impact on biological research and has potentially far-reaching implications for our understanding of life. Written in an informal and non-technical style, this book provides an accessible introduction to systems biology. Self-contained vignettes each convey a key theme and are intended to enlighten, provoke and interest readers of different academic disciplines, but also to offer new insight to those working in the field. Using a minimum amount of jargon and no mathematics, Voit manages to convey complex ideas and give the reader a genuine sense of the excitement that systems biology brings with it, as well as the current challenges and opportunities.
The Inner World of Medical Students: Listening to Their Voices in Poetry
by Johanna ShapiroThis is a practical and comprehensive guide to communication in family medicine for doctors nurses and staff in the primary healthcare team. It brings together all facets of communication in healthcare including involvement of patients staff and external workers. It shows how to address all aspects of communication in relation to one-to-one situations teaching and groups and encourages the reader to reflect on their own clinical and work experience. Using think boxes exercises and references this is an accessible guide relevant to all members of the practice team.
Innere Medizin
by Wolfgang PiperInnere Medizin ist lernbar! Ganz egal ob im klinischen Studienabschnitt oder im PJ - internistische Fragestellungen und Krankheitsbilder werden Ihnen immer und überall begegnen. Spätestens im Examen müssen Sie fit sein in der Inneren Medizin - und der Piper hilft Ihnen dabei. Dieses Lehrbuch beinhaltet die gesamte Innere Medizin in übersichtlichen, gut gegliederten Texten. Hier wird Verständnis für die Zusammenhänge großgeschrieben - denn Verstehen kommt vor dem Pauken. Deshalb werden auch wichtige physiologische und pathophysiologische Grundlagen wiederholt, bevor es zu Klinik, Diagnostik und Therapie weitergeht. · Mit allen relevanten Krankheitsbildern · Mehr als 600 Fotos, Zeichnungen und Grafiken · Lerntabellen und Übersichten Der ideale Begleiter während des Studiums und in der täglichen Praxis: Innere Medizin zum schnellen Nachschlagen oder konzentriertem Lesen - so wie man es gerade braucht.
Innocent Secret
by Josie MetcalfeLiving on the edge Dr. Joe Faraday is a man who keeps his heart well hidden. Well, Nurse Vicky Lawrence has a secret, too--her feelings for this tender man contributed to the recent breakdown of her engagement. Vicky knows Joe wants her, but every time she gets close, he withdraws. She senses that some emotional trauma is holding him back, but what? They are living on tenterhooks, and Vicky wonders if anything can ever tip Joe into her arms.... And then her safety is threatened....
Innovating for Healthy Urbanization
by Roy Ahn Thomas F. Burke Anita M. McgahanThis powerful resource identifies wide-scale health challenges facing a rapidly urbanizing planet--including key concerns in nutrition, health status, health care, and safety--and strategies toward possible solutions. Theoretical and empirical analysis focuses on maximizing the benefits of urban living and minimizing negative outcomes across areas for improvement (health education, maternal and child health) and threats to well-being (noise pollution, drug counterfeiting). For each challenge, contributors discuss implications for health, specific practices that fuel them, and emerging ideas for solving them efficiently and effectively. Not only are these issues of immediate salience, they will become dangerously urgent in years to come. Included in the coverage: Food fortification and other innovations to address child malnutrition. Anti-trafficking innovations, urbanization, and global health. Innovations to address global climate change in cities. Innovations in disaster preparedness: implications for urbanization and health. Medical diagnostic innovations in urban developing settings. The case for comprehensive, integrated, and standardized measures of health in cities. Recent studies suggest that urban areas will be a large majority in both the developing and developed worlds. Innovations to Address Urbanization & Global Health is a proactive idea book to be read by undergraduates, graduate students and researchers in public and urban health.
Innovating for Patient Safety in Medicine: 9780857257659 (Becoming Tomorrow's Doctors Series)
by Rebecca Lawton Gerry ArmitageThis book helps the next generation of doctors understand how to contribute to making healthcare safer. Patient safety is increasingly important in medical practice today and is becoming a core part of training for medical students and foundation doctors. This book will enable the student or junior doctor to challenge and innovate in practice to improve patient safety and care. It takes a practical approach and explores what patient safety is, why it is important, how to involve patients, the role of education, technology and resources, how to be an innovative practitioner and measuring the impact of patient safety initiatives.
Innovating for the Global South
by Janice Gross Stein Joseph Wong Dilip SomanDespite the vast wealth generated in the last half century, in today's world inequality is worsening and poverty is becoming increasingly chronic. Hundreds of millions of people continue to live on less than $2 per day and lack basic human necessities such as nutritious food, shelter, clean water, primary health care, and education.Innovating for the Global South offers fresh solutions for reducing poverty in the developing world. Highlighting the multidisciplinary expertise of the University of Toronto's Global Innovation Group, leading experts from the fields of engineering, medicine, management, and global public policy examine the causes and consequences of endemic poverty and the challenges of mitigating its effects from the perspective of the world's poorest of the poor.Can we imagine ways to generate solar energy to run essential medical equipment in the countryside? Can we adapt information and communication technologies to provide up-to-the-minute agricultural market prices for remote farming villages? How do we create more inclusive innovation processes to hear the voices of those living in urban slums? Is it possible to reinvent a low-cost toilet that operates beyond the water and electricity grids?Motivated by the imperatives of developing, delivering, and harnessing innovation in the developing world, Innovating for the Global South is essential reading for managers, practitioners, and scholars of development, business, and policy.
Innovating in a Learning Community
by Kai Reimers Xunhua Guo Mingzhi Li Bin Xie Tiantian ZhangHow do firms jointly develop open information infrastructures? To answer this question, this book draws on the results of a longitudinal research project covering the development of the pharmaceutical distribution industry in China from 2004 to 2012, focusing on the emergence and subsequent evolution of industry-wide information infrastructures. How do firms delimit areas of proprietary innovation in open innovation projects? How do firms coordinate, initiate, negotiate and implement the development of innovative infrastructures? How do processes and practices within firms enable and constrain such collective efforts? - This book provides answers to these questions and draws conclusions regarding the challenges and new capabilities that firms will need in a world in which participation in the building of open information infrastructures becomes a necessary task for commercial organizations.
Innovation and Biomedicine
by Mike MichaelWith its focus on the offshore randomized control trials of a Pre-Exposure Prophylactic pill (PrEP) for preventing HIV infection, the volume develops a sustained analysis of the complex, virtual and topological dimensions of the expectations, ethics and evidence that surround the innovation of PrEP.
The Innovation and Evolution of Medical Devices: Vaginal Mesh Kits
by S. Abbas ShobeiriThis text provides a central resource for physicians, entrepreneurs, and the MBA students about how innovation occurs in medical device industry. The book uses the rise and fall of vaginal mesh kits to highlight the evolution of responses by the physicians, patients and the regulatory bodies. There are specific chapters reviewing the US regulatory issues and business practices that were consequential to withdrawal of most vaginal mesh kits from the US market. The book is meant to be concise, evidence-based, and practical for the first time readers to understand the innovation forces. Concise textual information from acknowledged experts is complemented by high-quality diagrams and images to provide a thorough update of this rapidly evolving medical device industry. The case study chapters fully elucidate the anatomical basis that led to conceptualization of vaginal mesh kits, their introduction into the market, medicolegal and business implications followed with innovation that occurred by the surgeons to utilize ultrasound for and innovative surgeries to overcome device complications. With a luxurious number of well-marked pictures, readers will gain a clear understanding of the medical device innovation and evolution. Innovation and Evolution of Medical Devices: The vaginal Mesh Kits provides a rich practical resource written in a simple a step-by- step approach for all readers in their approach to new medical devices and technologies.
Innovation and Invention In Medical Devices: Workshop Summary
by Kathi E. Hanna Peter Bouxsein Frederick J. Manning Andrew PopeThe National Academies Press (NAP)--publisher for the National Academies--publishes more than 200 books a year offering the most authoritative views, definitive information, and groundbreaking recommendations on a wide range of topics in science, engineering, and health. Our books are unique in that they are authored by the nation's leading experts in every scientific field.
Innovation and Marketing in the Pharmaceutical Industry
by Min Ding Jehoshua Eliashberg Stefan StremerschThe pharmaceutical industry is one of today's most dynamic and complex industries, involving commercialization of cutting-edge scientific research, a huge web of stakeholders (from investors to doctors), multi-stage supply chains, fierce competition in the race to market, and a challenging regulatory environment. The stakes are high, with each new product raising the prospect of spectacular success--or failure. Worldwide revenues are approaching $1 trillion; in the U. S. alone, marketing for pharmaceutical products is, itself, a multi-billion dollar industry. In this volume, the editors showcase contributions from experts around the world to capture the state of the art in research, analysis, and practice, and covering the full spectrum of topics relating to innovation and marketing, including R&D, promotion, pricing, branding, competitive strategy, and portfolio management. Chapters include such features as: · An extensive literature review, including coverage of research from fields other than marketing · an overview of how practitioners have addressed the topic · introduction of relevant analytical tools, such as statistics and ethnographic studies · suggestions for further research by scholars and students The result is a comprehensive, state-of-the-art resource that will be of interest to researchers, policymakers, and practitioners, alike.