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Human Subjects Research after the Holocaust
by Sheldon Rubenfeld Susan Benedict"An engaging, compelling and disturbing confrontation with evil . . . a book that will be transformative in its call for individual and collective moral responsibility. " - Michael A. Grodin, M. D. , Professor and Director, Project on Medicine and the Holocaust, Elie Wiesel Center for Judaic Studies, Boston University Human Subjects Research after the Holocaust challenges you to confront the misguided medical ethics of the Third Reich personally, and to apply the lessons learned to contemporary human subjects research. While it is comforting to believe that Nazi physicians, nurses, and bioscientists were either incompetent, mad, or few in number, they were, in fact, the best in the world at the time, and the vast majority participated in the government program of "applied biology. " They were not coerced to behave as they did--they enthusiastically exploited widely accepted eugenic theories to design horrendous medical experiments, gas chambers and euthanasia programs, which ultimately led to mass murder in the concentration camps. Americans provided financial support for their research, modeled their medical education and research after the Germans, and continued to perform unethical human subjects research even after the Nuremberg Doctors' Trial. The German Medical Association apologized in 2012 for the behavior of its physicians during the Third Reich. By examining the medical crimes of human subjects researchers during the Third Reich, you will naturally examine your own behavior and that of your colleagues, and perhaps ask yourself "If the best physicians and bioscientists of the early 20th century could do evil while believing they were doing good, can I be certain that I will never do the same?"
Human Temperature Control: A Quantitative Approach
by Eugene H. WisslerThe principal objective of this book is to provide information needed to define human thermal behavior quantitatively. Human thermal physiology is defined using mathematical methods routinely employed by physicists and engineers, but seldom used by physiologists. Major sections of the book are devoted to blood flow, sweating, shivering, heat transfer within the body, and heat and mass transfer from skin and clothing to the environment. Simple algebraic models based on experimental data from a century of physiological investigation are developed for bodily processes. The book offers an invaluable source of information for physiologists and physical scientists interested in quantitative approaches to the fascinating field of human thermoregulation.
Human Tissue in Transplantation and Research
by David PriceDeficiencies and shortfalls in the supply of human organs for transplantation and human tissue for research generate policy dilemmas across the world and have often given rise to major and deleterious controversies, such as those relating to organ and tissue retention practices following post-mortem examination. They also create an environment in which illegitimate commercial activities flourish. At the same time, patients are denied the therapy they desperately require and researchers are impeded from carrying out vital work into the causes of, and efficacious treatments for, major illnesses and diseases. David Price sets out a clear and integrated legal and policy framework which emanates from the tissue source but protects the interests of donors and relevant professionals through tailored property entitlements, but without presupposing rights to trade in 'original' materials.
Human Tooth Crown and Root Morphology
by Scott Joel D. G. Richard IrishThis guide to scoring crown and root traits in human dentitions substantially builds on a seminal 1991 work by Turner, Nichol, and Scott. It provides detailed descriptions and multiple illustrations of each crown and root trait to help guide researchers to make consistent observations on trait expression, greatly reducing observer error. The book also reflects exciting new developments driven by technology that have significant ramifications for dental anthropology, particularly the recent development of a web-based application that computes the probability that an individual belongs to a particular genogeographic grouping based on combinations of crown and root traits; as such, the utility of these variables is expanded to forensic anthropology. This book is ideal for researchers and graduate students in the fields of dental, physical, and forensic anthropology and will serve as a methodological guide for many years to come.
Human Touch in Healthcare: Textbook for Therapy, Care and Medicine
by Claudia Winkelmann Martin Grunwald Stephanie Margarete MuellerThis textbook presents the essential research findings on human touch and haptic perception in a concise manner for students and health professionals. Focusing on anatomical, neural and physiological as well as psychological, social and clinical aspects, the scope of this book ranges from the fetus in the womb to the older adult in need of care. The chapters can be read individually or consecutively, and cross-chapter content is indicated by chapter references. Key learning points are highlighted at the end of each section, and figures, illustrations, and references facilitate the learning process. The quality of the presented study results has been critically analyzed and only randomized controlled studies are reported, which gives the reader a critical representation of the current state of knowledge. The textbook also provides valuable suggestions for future research by noting blind spots in existing research, and by pointing to methodological challenges in the implementation of high quality studies. Hence, this textbook is not only a representation of current knowledge, but also an epistemological analysis of the research process. There has been a surge of research about the sense of touch in the past ten years, which is incorporated in this book. This textbook will be an invaluable tool for physiotherapists, occupational therapists, nurses and other health professionals in everyday professional life.
Human Toxicology of Pesticides (Routledge Revivals)
by Fina P. Kaloyanova M. A. El BatawiFirst Published in 1991, this book conducts a systematic analysis of existing information regarding the toxicological effects of pesticides on humans. The book identifies the negative health effects related to exposure to pesticides and the biological changes required to undertake biological monitoring. The book also discusses the importance and magnitude of the problem for different kinds of pesticide applications in different parts of the world, explains the toxicodynamics and clinical picture of acute and chronic intoxications resulting from exposure to different groups of pesticides and selected individual substances, and evaluates existing methods and limitations for assessing human exposure to pesticides. Pesticide manufacturers, occupational health professionals, epidemiologists, environmentalists, government agencies and others concerned with the effects of pesticides on human populations should consider this book essential reading.
Human Traces: A Novel (Vintage International Ser.)
by Sebastian FaulksSixteen-year-old Jacques Rebière is living a humble life in rural France, studying butterflies and frogs by candlelight in his bedroom. Across the Channel, in England, the playful Thomas Midwinter, also sixteen, is enjoying a life of ease-and is resigned to follow his father's wishes and pursue a career in medicine. A fateful seaside meeting four years later sets the two young men on a profound course of friendship and discovery; they will become pioneers in the burgeoning field of psychiatry. But when a female patient at the doctors' Austrian sanatorium becomes dangerously ill, the two men's conflicting diagnosis threatens to divide them--and to undermine all their professional achievements. From the bestselling author of Birdsong comes this masterful novel that ventures to answer challenging questions of consciousness and science, and what it means to be human.From the Trade Paperback edition.
Human Trafficking Is a Public Health Issue: A Paradigm Expansion in the United States
by Makini Chisolm-Straker Hanni StoklosaThis clear-sighted reference examines the public health dimensions of labor and sex trafficking in the United States, the scope of the crisis, and possibilities for solutions. Its ecological lifespan approach globally traces risk and protective factors associated with this exploitation, laying a roadmap towards its prevention. Diverse experts, including survivors, describe support and care interventions across domains and disciplines, from the law enforcement and judicial sectors to community health systems and NGOs, with a robust model for collaboration. By focusing on the humanity of trafficked persons, a public health paradigm broadens our understanding of and ability to address trafficking while adding critical direction and resources to the criminal justice and human rights structures currently in place. Among the topics covered:Children at Risk: Foster Care and Human TraffickingLGBTQ Youth and Vulnerability to Sex TraffickingPhysical Health of Human Trafficking Survivors: Unmet EssentialsResearch Informing Advocacy: An Anti-Human Trafficking ToolCaring for Survivors Using a Trauma-Informed Care FrameworkThe Media and Human Trafficking: Discussion and Critique of the Dominant NarrativeHuman Trafficking Is a Public Health Issue is a sobering read; a powerful call to action for public health professionals, including social workers and health care practitioners providing direct services, as well as the larger anti-trafficking community of advocates, prosecutors, taskforce members, law enforcement agents, officers, funders, and administrators. “An extraordinary collection of knowledge by survivors, academics, clinicians, and advocates who are experts on human trafficking. Human Trafficking is a Public Health Issue is a comprehensive offering in educating readers on human trafficking through a multi-pronged public health lens.”Margeaux Gray: Survivor, Advocate, Artist, Public Speaker
Human Trafficking: Perspectives from Nursing, Criminal Justice, and the Social Sciences
by Donna Sabella Mary De ChesnayThis book presents various forms of human trafficking, a growing trend in the exploitation of large numbers of people with concurrent public health, socio-cultural, and economic costs to countries burdened with the consequences of the COVID-19 pandemic. Edited by psychiatric-mental health nurses and an applied anthropologist, this volume covers all forms of human trafficking: sex trafficking, forced labor, forced marriage, baby trafficking, organ trafficking, child marriage, and child soldiers with a global public health and policy focus. As such, it fills a gap in human trafficking knowledge and is built on courses springing up around the United States in multiple disciplines. Medical, mental health, and social work interventions are included as well as information about programs with documented outcomes. Each chapter includes state of the art of knowledge with case studies illustrating specific focal ideas, discussion, questions and exercises in order to help readers retain and reinforce chapter material. This textbook will be useful in the disciplines of nursing, medicine, public health, social work, and policy making, as well as in disciplines in which human trafficking is a current interest, such as law, criminal justice, and education.
Human Virology in Latin America
by Juan Ernesto Ludert Flor H. Pujol Juan ArbizaThis book is a compilation of some of the most remarkable contributions made by scientists currently working in Latin America to the understanding of virus biology, the pathogenesis of virus-related diseases, virus epidemiology, vaccine trials and antivirals development. In addition to recognizing the many fine virologists working in Latin America, Human Virology in Latin America also discusses both the state-of-the-art research and the current challenges that are being faced in the region, in hopes of inspiring young scientists worldwide to become eminent virologists.
Human Viruses: The New Insights
by Shamim I. AhmadThis book discusses current evidence on human viruses and provides an extensive coverage of newly emerged viruses and current strategies for treatment. Offering a new perspective in view of the re-emergence of Ebola in African countries and Dengue in India and Pakistan, the contents include chapters on emergence, pathogenicity, epidemiology and vaccine uptake. Human Viruses: Diseases, Treatments and Vaccines: The New Insights discusses a range of viruses from the most common such as Influenza and Hepatitis to Zika, Poliomyelitis and Chikungunya among many others. It is authored by a team of experts on viral disease and will be of immense use to virologists, public health experts and clinicians.
Human and Animal Filariases: Landscape, Challenges, and Control (Drug Discovery in Infectious Diseases)
by Paul M. SelzerHuman and Animal Filariases The rational approach to controlling human and animal diseases caused by nematodes Filariae are a family of parasitic worms which infect animals and humans, causing severe diseases such as elephantiasis (lymphatic filariasis) and river blindness (onchocerciasis) in humans, as well as heartworm disease (dirofilariasis) in dogs and cats. While the human diseases are rarely fatal, the blindness and disfiguration resulting from these infections constitute a severe burden for the affected individuals and to the healthcare systems in many tropical countries. In 2017, the World Health Organization classified several filariases as neglected tropical diseases and announced a new program seeking to eradicate these infections, which has in turn sparked a new push to develop antifilarial drugs. Considering the current and future import of this topic, Human and Animal Filariases takes a comprehensive look at infections by filarial parasites in humans and in animals. It begins by reviewing the current state of diagnosis and chemotherapy, before addressing the increasing resistance to available antifilarial drugs. This is followed by strategies and approaches for the discovery of novel drugs and finally by looking at alternative and supplementary approaches to combat the parasites, including vector control and vaccination. Human and Animal Filariases readers will find: A comprehensive approach that integrates current chemotherapy with recent advances in antifilarial drug discovery Practical information on assay development, target validation, and required drug product profiles Insights from global experts from leading academic institutions as well as from pharma and healthcare companies Human and Animal Filariases is a unique reference for parasitologists, veterinarians, as well as professionals in the pharmaceutical industry and in public health agencies.
Human and Animal Relationships (The Mycota #6)
by Axel A. Brakhage Peter F. Zipfel Olaf KniemeyerEstimates based on sequencing data suggest that there are around 5.1 million species of fungi. Yet only a small number of fungi are harmful to animals, including humans. In addition to host-pathogen interactions, there are also mutualistic interactions between fungi and animals. Diseases caused by pathogenic fungi range from allergic reactions and superficial infections to invasive mycoses, and have a significant impact on human and animal life. Fungi are also cultivated by animals as a food source in highly developed relationships or are even involved in gut mutualism. This 3rd edition of Volume 6 of The Mycota highlights exemplary interactions between fungal pathogens and their host(s). The book is organized in three parts: Part 1 summarizes our current understanding of important pathogenic fungi such as Candida species, Malassezia yeasts, Aspergillus fumigatus and fungi of the order Mucorales. Part 2 addresses the characterization of the host response towards pathogenic fungi. It focuses on RNA as a mediator of host-pathogen interactions, the human gut mycobiome, the role of the innate immune system in fighting infections, pattern recognition receptors involved in fungal infections, and a summary of established infection models for studying host-fungal-pathogen interactions. Part 3 provides insights into the impact transcriptomics and proteomics technologies have on the research of human-pathogenic fungi. The up-to-date reviews by experts in the field provide the reader with a comprehensive overview of the various research topics in the field of human and animal relationships with fungi and will hopefully help researchers to find inspiration for their own research.
Human and Machine Hearing: Extracting Meaning From Sound
by Richard F. LyonHuman and Machine Hearing is the first book to comprehensively describe how human hearing works and how to build machines to analyze sounds in the same way that people do. Drawing on over thirty-five years of experience in analyzing hearing and building systems, Richard F. Lyon explains how we can now build machines with close-to-human abilities in speech, music, and other sound-understanding domains. He explains human hearing in terms of engineering concepts, and describes how to incorporate those concepts into machines for a wide range of modern applications. The details of this approach are presented at an accessible level, to bring a diverse range of readers, from neuroscience to engineering, to a common technical understanding. The description of hearing as signal-processing algorithms is supported by corresponding open-source code, for which the book serves as motivating documentation.
Human and Mosquito Lysozymes
by Mauro PratoMalaria remains an alarming emergency in developing countries. It is thus urgent to identify any parasite or host molecules that can serve as new affordable markers for early diagnosis of disease complications or as new targets for vector control. In this context, human and mosquito lysozymes are good candidate molecules, as their involvement in malaria has been recently reported by several independent groups. This book reviews the grounded knowledge on malaria etiology and physiopathology, as well as the current approaches for diagnosis, therapy, and vector control. In addition, the emerging evidence on the involvement of human and mosquito lysozymes in malaria from available experimental models and clinical studies is thoroughly discussed, as is the potential use of other antimicrobial peptides against malaria. Intriguingly, the contributors propose that old well-known molecules such as lysozymes might be used as new targets for cost-effective strategies to fight malaria.
Human and Organizational Dynamics in E-Health
by David Bangert Robert DoktorNurses are key to building effective teams in primary care, but it has proved difficult to develop 'teams' in a service based on a small-business model. Current organisational arrangements fragment the different clinical professionals into tribes who have different employers and managers. This book brings together the work of pioneers in the field, to provide models for the future. As the need to define the primary care team becomes more urgent, this book is essential reading for all nursing professionals in primary care, nursing management, general practitioners, and primary care leaders at health authorities and Primary Care Organisations. 'The authors present an understanding of the context within which change is taking place, the elements to be addressed in the change process and a challenge for the future direction and pace of change.' From the Foreword by Marion Bull, Chief Nursing Officer, Welsh Office
Human iPS Cells in Disease Modelling
by Keiichi FukudaHuman iPS cells have a great potential to be cell sources forregenerative medicine because of the promise of infinite self-renewal and thecapability to differentiate into multiple cell types. This book focuses onanother great potential of human iPS cells, which is the establishment of humandisease models using patient-specific iPS cells. Human iPS cells can be easilyobtained from a patient's somatic cells and provide the entire information on thepatient's genome. Accordingly, we can generate disease models for inheritablediseases in cell culture dishes using iPS cells. This is a quite new techniquebut holds tremendous potential for our increased understanding of pathogenesis,and will then be the basis for novel drug development industries. All theauthors are leading researchers in this field and they have reported many kindsof patient-derived iPS cells. In this book, they introduce the aspects thatcould be recapitulated in terms of disease modelling as well as furtherinnovative findings such as novel pathogenetic insights and novel therapies.
Human iPSC-derived Disease Models for Drug Discovery (Handbook of Experimental Pharmacology #281)
by Wei Zhu Markus H. KuehnSince their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has been lost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.
Human-Centered Service Design for Healthcare Transformation: Development, Innovation, Change
by Mario A. PfannstielThis book explores the use of human-centered service design. Through a variety of case studies and best practices, it highlights ways to systematically improve the provision of healthcare services to different target and age groups in order to understand customer expectations and needs. The book also offers new insights into the dyadic relationship between service provider and customer, each of which has their own set of goals, purposes, and benefits and must cope with a scarcity of resources and opportunities to optimize and design. Written by recognized experts, scholars, and practitioners, this book demonstrates how, where, and when to successfully apply human-centered service design at multiple levels, including corporate, departmental, and product/service. Value-added services are not only assessed in terms of their effectiveness, efficiency, and productivity, but also bearing in mind human emotions, interactions, and communication techniques as an important part of service provision. Accordingly, the book will appeal to scholars and practitioners in the hospital and healthcare sector, and to anyone interested in organizational development, service business model innovation, customer involvement and perceptions, and the service experience.
Human-Centered Technology for a Better Tomorrow: Proceedings of HUMENS 2021 (Lecture Notes in Mechanical Engineering)
by Mohd Hasnun Arif Hassan Zulkifli Ahmad A Manap Mohamad Zairi Baharom Nasrul Hadi Johari Ummu Kulthum Jamaludin Muhammad Hilmi Jalil Idris Mat Sahat Mohd Nadzeri OmarThis book acts as a compilation of papers presented in the Human Engineering Symposium (HUMENS 2021). The symposium theme, “Human-centered Technology for A Better Tomorrow,” covers the following research topics: ergonomics, biomechanics, sports technology, medical device and instrumentation, artificial intelligence / machine learning, industrial design, rehabilitation, additive manufacturing, modelling and bio-simulation, and signal processing. Fifty-nine articles published in this book are divided into four parts, namely Part 1—Artificial Intelligence and Biosimulation, Part 2—Biomechanics, Safety and Sports, Part 3—Design and Instrumentation, and Part 4—Ergonomics.
Human-Computer Interface Technologies for the Motor Impaired (Rehabilitation Science In Practice Ser.)
by Dinesh K. Kumar Sridhar Poosapadi ArjunanHuman Computer Interface Technologies for the Motor Impaired examines both the technical and social aspects of human computer interface (HCI). Written by world-class academic experts committed to improving HCI technologies for people with disabilities, this all-inclusive book explores the latest research, and offers insight into the current limitat
Human-Environment Interactions
by Emilio F. Moran Eduardo S. BrondízioDrawing on research from eleven countries across four continents, the 16 chapters in the volume bring perspectives from various specialties in anthropology and human ecology, institutional analysis, historical and political ecology, geography, archaeology, and land change sciences. The four sections of the volume reflect complementary approaches to HEI: health and adaptation approaches, land change and landscape management approaches, institutional and political-ecology approaches, and historical and archaeological approaches.
Human-Insect Interactions
by Sergey GovorushkoThis book presents a 360-degree picture of the world of insects and explores how their existence affects our lives: the "good, bad, and ugly" aspects of their interactions with humankind. It provides a lucid introductory text for beginning undergraduate students in the life sciences, particularly those pursuing beginner courses in entomology, agriculture, and botany.
Human-animal Medicine: Clinical Approaches To Zoonoses, Toxicants And Other Shared Health Risks
by Lisa Conti Peter RabinowitzHuman-Animal Medicine is an innovative reference exploring the unprecedented convergence of human, animal, and environmental health, triggering global pandemics and requiring new clinical paradigms. The "One Health" approach calls for greater communication and cooperation between human health care providers, public health professionals, and veterinarians to better address vital issues of emerging diseases and environmental change. This incredibly timely book provides, for the first time, practical guidelines for "One Health" collaborations in a wide range of clinical human-animal health issues, including the H1N1 virus, zoonotic diseases, the human-animal bond, animal allergy, bites and stings, and animals as "sentinels" for toxic environmental health hazards.
Human/Animal Relationships in Transformation: Scientific, Moral and Legal Perspectives (The Palgrave Macmillan Animal Ethics Series)
by Augusto Vitale Simone PolloThe ethics of human/animal relationships is a growing field of academic research and a topic for public discussion and regulatory interventions from law-makers, governments and private institutions. Human/animal relationships are in transformation and understanding the nature of this process is crucial for all those who believe that the enlargement of moral and legal recognition to nonhuman animals is part of contemporary moral and political progress. Understanding the nature of this process means analysing and critically discussing the philosophical, scientific and legal concepts and arguments embedded in it. This book contributes to the discussion by bringing together the ideas and reflections of leading experts from different disciplinary backgrounds and with a range of scientific perspectives.This book both provides an up-to-date examination of the transformation of human/animal relationships and presents ideas to foster this process.