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Ibuprofen
by K. D. RainsfordIbuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti-inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor-in-Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology. Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in both humans and animals. Includes molecular, pharmacological and toxicological studies, and discusses the safety and efficacy of non-prescription ibuprofen, including its side effects. Ibuprofen: Discovery, Development & Therapeutics provides a definitive reference on all the main aspects of the chemical and pharmaceutical properties, mechanisms of action and therapeutic uses of ibuprofen including its role in the prevention and treatment of rheumatic conditions, cancer and neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. The book has its origins in a volume first published in 1999, since when there have been considerable advances in research and clinical studies on ibuprofen in the treatment of many inflammatory and even non-inflammatory states. This book will prove invaluable to scientists, clinicians, pharmacists and all those who need to know about the actions and uses of anti-inflammatory and analgesic drugs.
Ibuprofen: Pharmacology, Therapeutics and Side Effects
by K. D. RainsfordIbuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.
Ice Bound: A Doctor's Incredible Battle for Survival at the South Pole
by Jerri Nielsen Maryanne VollersDr. Jerri Nielsen accepts an assignment as a physician for the American research base in Antarctica. This is the story of her discovery that she has breast cancer, and a risky air lift of Nielsen for treatment.
Ice Cold (Rizzoli and Isles #8)
by Tess GerritsenThis eBook includes the full text of the novel plus the following additional content: Rizzoli & Isles, In Their Own Words: learn more about the lead characters in these special essays written by the author Rizzoli & Isles TV Pilot script: A spur-of-the-moment ski trip becomes a bone-chilling nightmare when a wrong turn leaves Boston medical examiner Maura Isles marooned- far from home and help--in the snowbound Wyoming mountains. Seeking shelter from the cold, she and her traveling companions stumble upon Kingdom Come- a remote village of identical houses that seems to have become a ghost town overnight. But the abandoned hamlet has dark secrets to tell, and Maura's party may not be as alone as they think. Days later, word reaches Boston homicide cop Jane Rizzoli that Maura's charred remains have been found at the scene of a car crash. But the shocking news leaves Jane with too many questions, and only one way to get answers. Determined to dig up the truth, she heads for the frozen desolation of Kingdom Come, where gruesome discoveries lie buried, and a ruthless enemy watches and waits.
Ich bin gern mit mir zusammen: Für Menschen, die eine gute Beziehung mit sich wünschen
by Eva-Maria BauerWie wäre das, wenn ich immer wieder mit voller Überzeugung zu mir sagen könnte: Ich bin gern mit mir zusammen! Wie ist es mir möglich, mich selbst und das, was ich täglich tue, wertschätzend anzunehmen? Wie kann ich bei all den Herausforderungen meines Alltags innerlich immer wieder voller Kraft und neuer Hoffnung sein? Dieser Ratgeber unterstützt alle, die sich gleichzeitig innere Stabilisierung und hilfreiche Neuorientierung wünschen. Anhand von wirkungsvollen inneren Bildern, Anstößen zur Selbstreflexion und praktischen Übungen kommen Lesende sich wohltuend nah. So öffnet sich ein hilfreicher Zugang zu all den Möglichkeiten, die in jedem und jeder von uns stecken. Aus dem Inhalt: Der Ratgeber nimmt die Lesenden an die Hand auf einer wohltuenden Reise zu mehr Selbstannahme und Selbststärkung. Er ermöglicht eine Neuorientierung beim Umgang mit eigener Unzufriedenheit, Unsicherheit und Selbstzweifeln. Er regt zur Selbstreflexion an, begleitet beim Finden neuer hilfreicher Sichtweisen auf sich selbst und stärkt so die Handlungsfähigkeit und Selbstfürsorge. So fühlt sich das Eintauchen in das Buch an wie eine liebevolle Umarmung durch sich selbst. Über die Autorin: Psychologin und Coachin Dr. Eva-Maria Bauer teilt ihren reichen Erfahrungsschatz zu Selbstannahme, Selbstfürsorge und positivem Denken. Sie macht das in jahrelanger Arbeit mit ihren Klient:innen gesammelte Wissen den Lesenden auch für die Selbststärkung zugänglich.
Ich bin nicht dick, ich habe nur schwere Gene: Die Macht unseres Erbguts und wo sie endet
by Nicolai PeschelGehören Sie auch zu den Menschen, die einen Donut nur betrachten müssen, um 3 Kilo mehr auf der Waage zu haben – wohingegen andere den ganzen Tag essen können, ohne ein Gramm zuzunehmen? Haben Sie sich auch schon einmal gefragt, was schuld daran ist, dass Sie keinen Alkohol vertragen, beim lustigen Karaoke Abend ausgebuht werden, mit 30 schon eine Glatze haben oder so ein Morgenmuffel sind? Eine einfache Antwort auf diese Fragen wäre: Das habe ich von meinen Eltern geerbt - das liegt alles nur an meinen Genen! Aber stimmt das wirklich? Auf vergnügliche Weise erklärt das Buch „Ich bin nicht dick, ich habe nur schwere Gene“ die Macht und Wirkung der Gene auf unseren Körper, unser Verhalten und unsere Persönlichkeit. Erfahren Sie mehr darüber, wie selbstbestimmt wir Menschen unter dem Einfluss der Gene sind. Welche unserer Charaktereigenschaften sind erblich und unseren Genen geschuldet – und wo haben Umwelt, soziales Umfeld und wir selbst den größeren Einfluss?
Ich und Selbst: Ein Leitfaden für die psychotherapeutische Praxis (Psychotherapie: Praxis)
by Marie-Luise AlthoffDieses Buch hilft Psychotherapeuten, Psychiatern und Supervisoren, ihre Patienten und Klienten bei ihrer Identitätssuche und Selbstfindung zu unterstützen. Als Ausgangspunkt der Überlegungen werden die Theorien der Ich- und selbstpsychologischen sowie der relationalen psychodynamischen Richtungen dargestellt. Die Selbst- und Identitätsbildung als Suchbewegung von Klienten und Therapeuten steht im Zentrum der Fragestellungen. Die Autorin gibt fundierte und hilfreiche Antworten – in dem Wissen, dass Antworten nie ein für alle Mal gelten und doch zufriedenstellend sein können. Wir transformieren uns fortwährend und können uns letztlich nie auf etwas Eigentliches zurückführen. Fragen aus dem Inhalt: Menschen sagen: „Ich suche mich“, „Ich finde mich“, „Ich erfinde mich neu.“ Wer oder was ist eigentlich dieses Ich, wer oder was ist dieses Mich, und was machen die beiden da, wenn sie sich suchen, finden oder erfinden? Machen die beiden das stets und ständig und beeinflussen sie sich wechselseitig? „Ich kann mich selbst so schwer verstehen?“ Wer oder was ist denn dieses Selbst? Also ist da noch ein Dritter im Bunde, wie immer? In diesem Buch werden Antworten auf diese Fragen gesucht. Die Autorin: Dr. phil. Marie-Luise Althoff ist Analytikerin, Dozentin, Supervisorin und Lehrtherapeutin und diskutiert mit Blick auf Psychotherapie und Supervision die Konzeptualisierung einer Beeinflussung des Ich- und Selbsterlebens.
Ich will, also bin ich: Wie der freie Wille uns zu dem macht, was wir sind
by Ruth MettenDieses Buch appelliert an Sie, Ihren freien Willen zu gebrauchen. Denn allen wissenschaftlichen Unkenrufen zum Trotz: wir haben – wie gezeigt wird – tatsächlich einen freien Willen; wir haben einen Zugriff auf unsere Freiheit. Das ist sogar von allerhöchster Bedeutung: denn unser Selbst scheint erst durch Willensakte zustande zu kommen. Verhält es sich aber so, dann täten wir gut daran, unseren Willen zu bilden, wie es die alten Meditationsschulen empfehlen. Und wodurch gelingt das? Indem wir uns in Achtsamkeit und Selbsthypnose üben, wozu der letzte Teil des Buches anleiten will. Mit einem Geleitwort von Dr. Burkhard Peter. Aus dem Inhalt: Der freie Wille – eine Illusion? – Leben gedeiht in Freiheit – Rückschläge – Mit vielen Beispielen, Übungen und Aha-Momenten. Mit Hörübungen zum Download. Über die Autorin: Dr. med. Ruth Metten ist als Fachärztin für Psychiatrie und Psychotherapie in Kempen niedergelassen, beschäftigt sich mit Sterbebegleitung, Achtsamkeit und Selbsthypnose und hält zum Thema dieses Buches Vorträge und Seminare.
Icons of Life: A Cultural History of Human Embryos
by Lynn M. MorganThis book takes up the question of how embryos-- as ideas, images, symbols, and tiny bits of human tissue-- are generated, circulated, and enlivened by social and political discourse and shows how embryological view of development intersects with the social and material history of human embryo collecting.
Idea of Consciousness: Synapses and the Mind
by Max R. BennettThe Idea of Consciousness examines the problem of how the working of synaptic connections might give rise to consciousness, and describes the current neuroscientific concepts and techniques used to identify and explore those parts of the brain that may be involved. This book will serve as an invaluable and stimulating introduction to the subject. Beautifully illustrated, it is a must for anyone who is curious about consciousness.
Ideas and Practices in the History of Medicine, 1650–1820 (Variorum Collected Studies #1038)
by Adrian WilsonAlthough articles in this volume fall into three thematic clusters, each of those groups exemplifies three general themes: micro-social processes; innovations and the question of continuity versus discontinuity; and the relationship between ideas and practice. Most of these essays touch upon, and some of them are exclusively concerned with, small scale social processes: e.g. the routines of the all-female early-modern childbirth ritual, the different ways that male practitioners were summoned to such occasions, the functioning of voluntary hospitals, the protocols underlying patient records. Such social practices are well worth studying as both the sites and drivers of larger-scale historical change. Whenever there comes into being something new - whether an institution (a hospital), a social practice (the summoning of men as midwives) or a concept (a new approach to disease) - the question arises as to its relationship with what went before. This concept resonates throughout these essays, but is most to the fore in the chapters on early Hanoverian London (which asks explanatory questions) and on Porter versus Foucault (who represent the extremes of continuity and discontinuity respectively). A couple of generations ago, the ’history of ideas’ was pursued largely without reference to practice; in recent times, the danger has appeared of the very reverse taking place. This book ranges across a broad spectrum in this respect, the emphasis being sometimes upon practice (Eleanor Willughby’s work as a midwife) and sometimes upon ideas (concepts of pleurisy across the centuries); but in every case there is at least the potential for relating the two to one another. None of these themes is specific to medical history; on the contrary, they are the bread-and-butter of historical reconstruction in general.
Ideas and the Pace of Change
by Katherine BootheCanada is the only OECD country that has universal, comprehensive public hospital and medical insurance but lacks equivalent pharmaceutical coverage. In Ideas and the Pace of Change, Katherine Boothe explains the reasons for this unique situation. Using archival, interview, and polling data, Boothe compares the policy histories of Canada, the United Kingdom, and Australia in order to understand why Canada followed a different path on pharmaceutical insurance.Boothe argues that pace matters in policy change. Quick, radical change requires centralized political institutions, an elite consensus, and an engaged, attentive electorate. Without these prerequisites, states are far more likely to take a slower, incremental approach. But while rapid policy change reinforces the new consensus, incremental progress strengthens the status quo, letting development stall and raising the bar for achieving change.An important contribution to the study of comparative political economy, Ideas and the Pace of Change should be required reading for anyone seeking to understand why health care reforms succeed or fail.
Identically Different: Why You Can Change Your Genes
by Professor Tim Spector'This is not simply a book of ideas, it is also a book of stories, most astounding, many heartbreaking' - Bryan Appleyard, SUNDAY TIMESSince the discovery of DNA, scientists have believed that genes are fixed entities that cannot be changed by environment - we inherit them, pass them on to our children and take them with us when we die.Professor Tim Spector reveals how the latest genetic research and his own pioneering studies on epigenetics are rewriting everything we thought we knew about genes, identity and evolution. Conceptually, he explains, our genes are not fixed entities but more like plastic, able to change shape and evolve, and these changes can be passed on to future generations.Tim Spector's dazzling guide to the hidden world of our genes reveals the complex role they play in shaping our identities, and will make you think again about everything from sexuality to religion, cancer to autism, politics to pubic hair, clones to bacteria, and what it is that makes us all so unique and quintessentially human.
Identically Different: Why You Can Change Your Genes
by Professor Tim Spector'This is not simply a book of ideas, it is also a book of stories, most astounding, many heartbreaking' - Bryan Appleyard, SUNDAY TIMESSince the discovery of DNA, scientists have believed that genes are fixed entities that cannot be changed by environment - we inherit them, pass them on to our children and take them with us when we die.Professor Tim Spector reveals how the latest genetic research and his own pioneering studies on epigenetics are rewriting everything we thought we knew about genes, identity and evolution. Conceptually, he explains, our genes are not fixed entities but more like plastic, able to change shape and evolve, and these changes can be passed on to future generations.Tim Spector's dazzling guide to the hidden world of our genes reveals the complex role they play in shaping our identities, and will make you think again about everything from sexuality to religion, cancer to autism, politics to pubic hair, clones to bacteria, and what it is that makes us all so unique and quintessentially human.
Identically Different: Why You Can Change Your Genes
by Tim Spector'This is not simply a book of ideas, it is also a book of stories, most astounding, many heartbreaking' - Bryan Appleyard, SUNDAY TIMESSince the discovery of DNA, scientists have believed that genes are fixed entities that cannot be changed by environment - we inherit them, pass them on to our children and take them with us when we die.Professor Tim Spector reveals how the latest genetic research and his own pioneering studies on epigenetics are rewriting everything we thought we knew about genes, identity and evolution. Conceptually, he explains, our genes are not fixed entities but more like plastic, able to change shape and evolve, and these changes can be passed on to future generations.Tim Spector's dazzling guide to the hidden world of our genes reveals the complex role they play in shaping our identities, and will make you think again about everything from sexuality to religion, cancer to autism, politics to pubic hair, clones to bacteria, and what it is that makes us all so unique and quintessentially human.
Identifiability and Observability in Epidemiological Models: A Primer (SpringerBriefs on PDEs and Data Science)
by Alain Rapaport Nik Cunniffe Frédéric Hamelin Abderrahman Iggidr Gauthier SalletThis book introduces the concepts of identifiability and observability in mathematical epidemiology, as well as those of observers’ constructions. It first exposes and illustrates on several examples the mathematical definitions and properties of observability and identifiability. A chapter is dedicated to the well-known Kermack McKendrick model, for which the complete analysis of identifiability and observability is not available in the literature. Then, several techniques of observer constructions, in view of online estimation of state and parameters, are presented and deployed on several models. New developments relevant for applications in epidemiology are also given. Finally, practical considerations are discussed with data and numerical simulations related to models previously analysed in the book. The book will be appealing to epidemiological modellers and mathematicians working on models in epidemiology.This book contributes to Sustainable Development Goal 3 (SDG3): Good Health and Well Being.
Identifiability and Regression Analysis of Biological Systems Models: Statistical and Mathematical Foundations and R Scripts (SpringerBriefs in Statistics)
by Paola LeccaThis richly illustrated book presents the objectives of, and the latest techniques for, the identifiability analysis and standard and robust regression analysis of complex dynamical models. The book first provides a definition of complexity in dynamic systems by introducing readers to the concepts of system size, density of interactions, stiff dynamics, and hybrid nature of determination. In turn, it presents the mathematical foundations of and algorithmic procedures for model structural and practical identifiability analysis, multilinear and non-linear regression analysis, and best predictor selection.Although the main fields of application discussed in the book are biochemistry and systems biology, the methodologies described can also be employed in other disciplines such as physics and the environmental sciences. Readers will learn how to deal with problems such as determining the identifiability conditions, searching for an identifiable model, and conducting their own regression analysis and diagnostics without supervision. Featuring a wealth of real-world examples, exercises, and codes in R, the book addresses the needs of doctoral students and researchers in bioinformatics, bioengineering, systems biology, biophysics, biochemistry, the environmental sciences and experimental physics. Readers should be familiar with the fundamentals of probability and statistics (as provided in first-year university courses) and a basic grasp of R.
Identifiability and Regression Analysis of Biological Systems Models: Statistical and Mathematical Foundations and R Scripts (SpringerBriefs in Statistics)
by Paola LeccaThis richly illustrated book presents the latest techniques for the identifiability analysis and standard and robust regression analysis of complex dynamical models, and looks at their objectives. It begins by providing a definition of complexity in dynamic systems, introducing the concepts of system size, density of interactions, stiff dynamics, and the hybrid nature of determination. The discussion then turns to the mathematical foundations of model structural and practical identifiability analysis, multilinear and non-linear regression analysis, and best predictor selection, and their algorithmic procedures. Although the featured examples mainly focus on applications to biochemistry and systems biology, the methodologies described can also be employed in other disciplines such as physics and the environmental sciences. Readers will learn how to determine identifiability conditions, how to search for an identifiable model, and how to conduct their own regression analysis and diagnostics without supervision. This new edition includes a concise, yet comprehensive treatment of the main artificial intelligence methods which can be used for parameter inference in models of complex dynamic biological systems. It emphasizes the most efficient solutions for generating synthetic data that augment the training data and which are indispensable for machine learning procedures. Featuring a wealth of real-world examples, exercises, and R codes, the book addresses the needs of doctoral students and researchers in bioinformatics, bioengineering, systems biology, biophysics, biochemistry, the environmental sciences and experimental physics. Familiarity with the fundamentals of probability and statistics (as provided in first-year university courses) and a basic grasp of R are assumed.
Identification and Characterization of Neural Progenitor Cells in the Adult Mammalian Brain
by Sara Gil-Perotín Jose Manuel Garcia-Verdugo Arturo Alvarez-BuyllaAdult neurogenesis has been questioned for many years. In the early 1900s, a dogma was established that denied new neuron formation in the adult brain. In the last century however, new discoveries have demonstrated the real existence of proliferation in the adult brain, and in the last decade, these studies led to the identification of neural stem cells in mammals. Adult neural stem cells are undifferentiated cells that are present in the adult brain and are capable of dividing and differentiating into glia and new neurons. Newly formed neurons terminally differentiate into mature neurons in the olfactory bulb and the dentate gyrus of the hippocampus. Since then, a number of new research lines have emerged whose common objective is the phenotypical and molecular characterization of brain stem cells. As a result, new therapies are successfully being applied to animal models for certain neurodegenerative diseases or stroke. At present, and in years to come, this finding extends to the adult human brain, and gives reason and hope to all the previous studies.
Identification of Biomarkers, New Treatments, and Vaccines for COVID-19 (Advances in Experimental Medicine and Biology #1327)
by Paul C. GuestThe novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just one year. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are profound, and has required extreme social distancing measures across the globe in order to prevent overwhelming the healthcare services and hospitals. COVID-19 appears to have the greatest effects on elderly individuals and those who have co-morbid diseases, such as diabetes and obesity. As the cases and death rate remain high, there are justified fears of this virus remaining for several months or years to come. To address this, a rapid and unprecedented worldwide mobilization effort has begun to identify effective treatments and develop vaccines. As these begin to be deployed and administered across the globe, many now feel the virus will be brought under control and lives will eventually return to normal. This new volume will increase readers’ understanding of the ongoing COVID-19 pandemic through a series of chapters that address these concerns. Leading experts will discuss new treatment approaches, vaccine development, mental health aspects of the pandemic, and convey the results of survey studies. The book will be an excellent resource for researchers studying virology, metabolic diseases, respiratory disorders, and clinical scientists, physicians, drug companies, and healthcare services and workers.
Identification of Ligand Binding Site and Protein-Protein Interaction Area
by Irena Roterman-KoniecznaThis volume presents a review of the latest numerical techniques used to identify ligand binding and protein complexation sites. It should be noted that there are many other theoretical studies devoted to predicting the activity of specific proteins and that useful protein data can be found in numerous databases. The aim of advanced computational techniques is to identify the active sites in specific proteins and moreover to suggest a generalized mechanism by which such protein-ligand (or protein-protein) interactions can be effected. Developing such tools is not an easy task - it requires extensive expertise in the area of molecular biology as well as a firm grasp of numerical modeling methods. Thus, it is often viewed as a prime candidate for interdisciplinary research.
Identification of Pathogenic Fungi
by Elizabeth M. Johnson Colin K. Campbell David W. WarnockSince the first edition of Identification of Pathogenic Fungi, there has been incredible progress in the diagnosis, treatment and prevention of fungal diseases: new methods of diagnosis have been introduced, and new antifungal agents have been licensed for use. However, these developments have been offset by the emergence of resistance to several classes of drugs, and an increase in infections caused by fungi with innate resistance to one or more classes.Identification of Pathogenic Fungi, Second Edition, assists in the identification of over 100 of the most significant organisms of medical importance. Each chapter is arranged so that the descriptions for similar organisms may be found on adjacent pages. Differential diagnosis details are given for each organism on the basis of both colonial appearance and microscopic characteristics for the organisms described.In this fully updated second edition, a new chapter on the identification of fungi in histopathological sections and smears has been added, while colour illustrations of cultures and microscopic structures have been included, and high quality, four colour digital images are incorporated throughout.
Identifying Future Disease Hot Spots: Infectious Disease Vulnerability Index
by Paul Christopher Melinda Moore Adeyemi Okunogbe Bill GelfeldRecent high-profile outbreaks such as Ebola and Zika have illustrated the transnational nature of infectious diseases. Countries that are most vulnerable to outbreaks may be higher priorities for technical support. RAND's Infectious Disease Vulnerability Index should help U.S. government and international agencies identify these countries and inform programming to preemptively mitigate the spread and effects of potential transnational outbreaks.
Identifying and Addressing Childhood Food Insecurity in Healthcare and Community Settings (SpringerBriefs in Public Health)
by Hans B. Kersten Andrew F. Beck Melissa KleinThis salient resource offers clinicians a comprehensive multi-tiered framework for identifying, addressing, and reducing food insecurity among children and their families. Reinforcing the importance of food insecurity as a key social determinant of health, this monograph reviews the epidemiology and presents in-depth guidelines for screening for food insecurity and hunger. Recommendations for screening in a busy clinical setting as well as the strengths and limitations of widely-used instruments are discussed. The monograph also outlines a variety of clinic-level interventions, potential community-based resources, and opportunities for clinical-community partnerships to improve families’ food access and security. Further, contributors provide workable plans for large-scale advocacy through greater engagement with professional and community resources as well as policymakers. The monograph concludes with an outline of the critical steps to implement a food insecurity screening process and the key components to train the next generation of provider-advocates. Included in the coverage: Epidemiology and pathophysiology of food insecurity Screening tools and training Scope of interventions to address food insecurity Creation and evaluation of the impact of food insecurity-focused clinical-community partnerships on patients and populations Development of an action plan to fight food insecurityIdentifying and Addressing Childhood Food Insecurity in Healthcare and Community Settings will find an engaged audience among physicians and other clinicians who want to address food insecurity in their healthcare and/or community setting. Institutions that are starting to address social determinants of health, including food insecurity, will find guidance on screening tools, processes and evaluation of impact.