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Immunology of Behçet's Disease
by Manfred Zierhut Shigeaki OhnoBeh's Disease (BD) is one of the most-studied systemic disorders characterized by an occlusive vasculopathy of multiple organs. The etiology and pathogenesis of BD are still unclear, but there is evidence for genetic, immunologic and infectious factors in the onset and throughout the course of the disease. This book summarizes our knowledge regarding the most important factors that induce or trigger BD. After an epidemiological overview, the clinical presentation of ocular and non-ocular symptoms of BD is summarized. The immunopathological changes reflect a chronic vasculitis of arterioles, venules, and capillaries. The book covers the role of T-cells, NK-T-cells, secreted cytokines, and neutrophils as well as immune reactions against various microbial heat shock proteins. It shows that the pathogenic gene involved in the development of BD is pinpointed to HLA-B51. It also discusses the treatment of BD, including anti-TNF-alpha-antibodies and interferon-alpha.
Immunology of the Female Genital Tract
by Ernst Rainer Weissenbacher Monika Wirth Ioannis Mylonas Klinik Für Geburtshilfe William J. Ledger Steven S. WitkinThis book systematically reviews and discusses recent studies and articles on the immunology of female genital tract tissue. The scope is broad, encompassing innate immune responses, adaptive (humoral and cell-mediated) immunity, the immunology of menstruation, the immunology of viral and bacterial infections, the immunology of normal and abnormal pregnancy, and immunological infertility. Throughout, tables and illustrations are judiciously used to facilitate understanding. Immunology of the Female Genital Tract will serve as an invaluable source of up-to-date information for all with an interest in this subject.
Immunology of the Fungal Diseases
by Rebecca A. CoxThis informative text is divided into eight chapters, each of which presents a comprehensive review of natural and acquired host defense mechanisms in a major mycotic disease. The chapters are written by distinguished scientists whose studies have contributed significantly to the understanding of the immunology of the mycoses. This text should provide a valuable reference for researchers, practicing clinicians, and new investigators entering this expanding field.
Immunology of the Lymphatic System
by Laura SantambrogioThis book will be a comprehensive study of the lymphatic system and its immunological role. It will begin with lymphatic capillaries, their origin and development. It will treat lymph circulation, in general, with a special emphasis on lymph circulation in parenchymal organs. The next section will address lymph nodes, subcortical circulation and the conduit system. It will discuss organs with no lymphatic system, such as the brain. Finally, it will cover lymph composition and cells in the lymph. While primarily basic research, the volume will touch upon elements of the clinical, as well, broadening its scope and appeal.
Immunology of the Skin
by Kenji KabashimaThis book reviews the role of each cell subset in the skin, providing the basics for understanding skin immunology and the mechanisms of skin diseases. The skin is one of the immune organs and is continually exposed to foreign antigens and external stimuli that must be monitored and characterized for possible elimination. Upon exposure to foreign antigens, the skin can elicit a variety of immune responses in harmony with skin components that include keratinocytes, dendritic cell subsets, mast cells, basophils, fibroblasts, macrophages, gamma-delta T cells, neutrophils, myeloid-derived suppressor cells, vascular and lymphatic cells, hair follicles, platelets, and adipose tissues, among others. In the past 10 years, knowledge of immunology has expanded drastically in areas such as innate immunity (Toll-like receptors, C-type lectins), and host defenses to bacteria and viruses, and this increased knowledge has led to the development of more effective treatment of psoriasis and other skin diseases. This book provides updates on the mechanisms of skin diseases including contact dermatitis, atopic dermatitis, psoriasis, urticaria, drug eruption, bullous diseases, anaphylaxis, graft-versus-host disease, rosacea, lymphoma, photodermatology, and collagen vascular diseases. Understanding the basics of skin immunology will help clinicians and dermatologists use new therapeutics such as biologics efficiently. Serving as an intermediary between basic science and clinical medicine, this book gives readers the opportunity to understand and marvel at the mystery and fascination of skin immunology.
Immunology: A Short Course
by Richard CoicoImmunology: A Short Course provides an overview of the physiology of the immune system and the pathophysiology of a broad range of immune-mediated diseases, offering accessible and comprehensive guidance to the basic concepts and clinical approaches in the discipline. Now in its eighth edition, this bestselling textbook has been fully updated to reflect our expanded knowledge of how the immune system develops and functions, and the ways in which these physiological phenomena can fail or be compromised. New chapters examine cells and organs of the immune system, organization and expression of lymphocyte antigen receptor genes, experimental systems and methods, and B- and T-cell development activation. Helping students gain an integrated understanding of immunology, this textbook: Offers substantial new and revised material, expanded clinical coverage, enhanced pedagogical features, and updated figures, tables, and references Features recent research advances and therapeutic successes in the field of immunology Includes a companion website containing multiple choice questions, electronic flashcards, downloadable figures, PowerPoint slides, and sample cases Can be supplemented with the Clinical Cases in Immunology companion book The eighth edition of Immunology: A Short Course is an ideal resource for life and health science students, dental and nursing students seeking a short course text, and basic scientists and clinical researchers looking to refresh their knowledge in the subject.
Immunology: A Short Course (Short Course Ser.)
by Richard Coico Geoffrey SunshineImmunology: A Short Course, Seventh Edition introduces all the critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs.This new edition of Immunology: A Short Course: * Has been fully revised and updated, with a brand new art program to help reinforce learning* Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area * Highlights important therapeutic successes resulting from targeted antibody therapies* Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical applications
Immunology: An Illustrated Outline
by David MaleImmunology: An Illustrated Outline is both a guide to the essential principles of immunology and a concise dictionary of immunological terms. The book can be used to consolidate understanding in preparation for course exams and medical licensing exams, or as a refresher when immunology is encountered in related life sciences, such as microbiology, virology, and zoology. The book is organized into five sections that represent the major topics in basic and clinical immunology. The Sixth Edition has been comprehensively revised to highlight the latest understanding of the field, particularly in the areas of innate immune defenses and antibody-based therapeutics. Concise explanations of immunological terms Full-color illustrations and micrographs to reinforce the text Each topic is set out in single- or double-page spreads Tables collate and summarize detailed information
Immunology: Overview and Laboratory Manual
by Tobili Y. Sam-YelloweA two-in-one text providing teaching lab students with an overview of immunology as well as a lab manual complete with current standard exercises. Section I of this book provides an overview of the immune system and immunity, and includes review questions, problem sets, case studies, inquiry-based questions, and more to provide students with a strong foundation in the field. Section II consists of twenty-two lab exercises focused on key concepts in immunology, such as antibody production, cell separation, cell function, immunoassays, Th1/Th2 cytokine detection, cell and tissue culture methods, and cell and molecular biology techniques. Appendices include safety information, suggested links and readings, and standard discipline processes, protocols, and instructions.
Immunometabolism: Methods and Protocols (Methods in Molecular Biology #2184)
by Suresh MishraThis detailed book showcases the tremendous effort and progress made in developing techniques and protocols for the study of immunometabolism, and in utilizing recent technological advances for probing and manipulating adipose and immune cells, and subsequently, their functions and immunometabolic consequences. Written by experts in the field, many chapters use macrophages as a model immune cell type, due to their prominence in the innate immune system and the exhaustive study of their traits. Protocols using adipocytes, dendritic cells, and T cells as model cell lines, as well as measurement of glucose metabolism at the systemic level, have also been included. Written for the highly successful Methods in Molecular Biology book series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immunometabolism: Methods and Protocols serves as a vital guide for researchers working at the important interface of immunology and metabolism.
Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines
by Yvonne Perrie Darren R. FlowerThis volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.
Immunomodulators and Biologics in Dermatologic Treatment: Turning Theory into Practice
by Neal BhatiaThis title provides a practically applicable guide to the use of immunomodulators and biologics to treat cutaneous diseases. Chapters cover the mechanisms, applications and safety concerns pertaining to the latest systemic therapies. Extensive guidance is provided on how to design lab monitoring schedules, manage patient follow-up visits, develop tapering plans and assess adverse outcomes. The book also reviews how to initiate off-label applications and establish methods of matching mechanisms for a range of diseases to the mechanisms of the available therapies. The latest updates in the development and utility of systemic immunomodulators, biologics and JAK Inhibitors from clinical trials and updated guidelines are also discussed. Immunomodulators and Biologics in Dermatologic Treatment comprehensively describes the use of a range of systemic therapies for immunomodulation in dermatology and how best to incorporate these into practice. It therefore represents a valuable resource for novice readers and experienced dermatologists involved in the management of these patients.
Immunomodulators and Human Health
by Anil K. Sharma Raj K. Keservani Rajesh K. KesharwaniThis book focuses on a broad range of immunomodulators, including both natural and synthetic ones. It highlights their role in human health. The book discusses nanotechnology-based immunomodulators with special emphasis on different types of formulation to boost the immune system. It highlights the role of immunomodulators against different microbes. This book describes important topics such as Classification and uses of various immunomodulators; Potential role of herbs and spices on immune system; Immune booster activity of prebiotics; Recent advances of nutraceutical and functional foods in Immune health; Antioxidants and immunomodulation; Nanotechnology and immunomodulators in cancer; Immunomodulatory role for the treatment and management of tuberculosis; Immunomodulation in autoimmune disorders; Herbal immunomodulators and COVID-19; Role of Cytokines as Immunomodulators and Immunomodulatory effects of endocrine disrupting chemicals. This book covers various aspects of product innovation, development, and launching of nutritional and pharmaceutical products with reference to immunomodulators. This book is meant for researchers and students in the field of immunology and pharmaceutical sciences.
Immunomodulators in Aquaculture and Fish Health
by Preetham Elumalai Sreeja Lakshmi Mehdi SoltaniThis reference book provides updated information about different immunomodulators for managing fish health and sustainable aquaculture. Immunomodulators are dietary additives that enhance innate defense mechanisms and increase resistance against specific pathogens and diseases. The book covers the different types of immunostimulants, their modes of action, and their efficacies. It also reviews safety concerns, ethical regulations, limitations, and outreach to farmers. It discusses the application of herbal immunomodulators, antioxidants, pre- and pro-biotics, in disease management. Features:• Reviews the pressing topic of reduction of antibiotic use in aquaculture • Discusses herbal immunomodulators, nutrients, antioxidants and pre- and pro-biotics • Covers the topic of progressive immunomodulation using nanotechnology • Discusses fish health management in the ever-growing aquaculture industry • Includes natural and synthetic immunomodulators The book is meant for researchers and industry experts in aquaculture, fisheries science, and veterinary medicine.
Immunomodulatory Biomaterials for Cell Therapy and Tissue Engineering: Recent Advancements (Synthesis Lectures on Biomedical Engineering)
by Sudip Mukherjee Boram Kim Andrea HernandezThis book presents the recent developments in immunomodulatory biomaterials for cell-based therapies in various diseases, including diabetes, cancer, cardiovascular disease, and bone regeneration. The authors first cover the fundamentals of conventional immunology and immunomodulation, before focusing on the history, advantages, and challenges of cell therapies. Biological cell therapy has gained immense attention for various diseases due to unique advantages it has over chemical drugs regarding cost, ease of production, toxicity, and therapeutic efficacy. However, these cell-based therapies need an inert delivery system that can locally deliver cells and minimally elicit foreign body response. The book discusses the foreign body response to the immunomodulatory biomaterials as well as the current and future strategies for potential mitigation of considerable immune responses toward immunomodulatory biomaterials and devices.
Immunonutrition: Interactions of Diet, Genetics, and Inflammation
by David Heber Bharat B. AggarwalThe interaction of immune function and nutrition underlies the low-grade chronic inflammation involved in the etiology of many common obesity-associated and age-related chronic disease conditions. This close interaction is the genesis of the term immunonutrition, which represents a new interdisciplinary field of nutritional and medical research. Im
Immunopathology in Toxicology and Drug Development
by George A. ParkerThis book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system-based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.
Immunopathology in Toxicology and Drug Development
by George A. ParkerThis book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.
Immunopatient: The New Frontier of Curing Cancer
by Peter RooneyWhen an X-ray of a sore arm quickly leads to a diagnosis of Stage IV kidney cancer—one which would soon affect his bones, his lungs, lymph nodes, and brain—Peter Rooney’s life will never be the same. Faced with the prognosis of an incurable disease and armed only with the will to fight back, Immunopatient chronicles Peter’s desperate quest for hope and healing, and the experimental treatment that will give him a chance to strike back at his disease. Detailing both the medical breakthroughs that provided Peter with cutting-edge treatment and his inspirational quest to conquer both his fear and his illness through mindfulness and positive visualization, Immunopatient is a gripping memoir, one that offers new hope to cancer patients everywhere to never give up looking for answers. Peter’s story, both humble and human, showcases the heights of medical science and the depths of human endurance, proving that anything is possible as long as you keep moving forward.
Immunopharmacology
by Manzoor M. KhanDuring the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
Immunopharmacology and Inflammation
by Ekaterini Tiligada Carlo Riccardi Francesca Levi-SchafferA comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.
Immunophenotyping for Haematologists: Principles and Practice
by Mike Leach Barbara J. BainOffers clear and concise instruction on running, reporting and interpreting immunophenotyping studies Written by two well-known haematology educators and experts on the topic, Immunophenotyping for Haematologists contains an introduction to running, reporting and interpreting immunophenotyping studies. The book offers a unique approach to the topic by putting the focus on clinical and laboratory haematologists who are not routinely involved in running and reporting on immunophenotyping studies. Immunophenotyping using flow cytometry has become the method of choice in identifying and sorting cells within complex populations, for example, the analysis of immune or neoplastic cells in a blood sample. The text reviews the purpose and principles of immunophenotyping and includes an introduction and explanation of the principles and the role of immunophenotyping. The authors examine immunophenotypic characteristics of the disease groups commonly encountered and identify the features that differentiate malignant cells from normal cells. To enhance understanding, the book contains multiple choice and extended matching questions which integrates immunophenotyping with clinicopathological features and the results of other investigations to mimic everyday practice. This important book: Provides a concise introduction to running, reporting and interpreting immunophenotyping studies Contains a list of all the antibody specificities currently widely used in diagnosis and disease monitoring Presents an ideal reference for use in laboratories, including immunophenotyping laboratories Aids in the interpretation by covering immunophenotypic characteristics of commonly encountered disease groups Identifies the features that differentiate malignant cells from their normal counterparts Written for haematologists working in both laboratory and clinical haematology, Immunophenotyping for Haematologists is a much-needed reference for understanding and interpreting immunophenotyping studies.
Immunophenotyping: Methods and Protocols (Methods in Molecular Biology #2032)
by J. Philip McCoyThis volume presents the latest collection of immunophenotypic techniques and applications used in research and clinical settings. Chapters in this book cover topics such as constructions of high dimensions fluorescence and mass cytometry panels; fluorescence barcoding; using dried or lyophilized reagents; and immunophenotypic examples of specific cell types. The book concludes with a discussion on the critical roles of quality control and immunophenotyping in the clinical environment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Immunophenotyping: Methods and Protocols is a valuable resource for any researchers, clinician, or scientist interested in learning more about this evolving field.
Immunoproteomics: Methods and Protocols
by Kelly M. Fulton Susan M. TwineProviding current diverse approaches and techniques used to study the immunoproteome, Immunoproteomics: Methods and Protocols collects chapters from key researchers that deliver information to be used in diagnostics, disease progression, and vaccine correlates of protection analysis, to name but a few. This detailed volume includes techniques used for the study of the antibody targets of bacterial pathogens, viruses, and cancer, mass spectrometry-based approaches to characterize T-cell epitopes, chapters on detection and relative quantification of cytokines in serum, as well as in silico prediction of epitopes using sequence-based or modeling approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Immunoproteomics: Methods and Protocols aids researchers in transferring these techniques to their own laboratories in addition to providing a reference to guide researchers toward appropriate techniques.
Immunoproteomics: Methods and Protocols (Methods in Molecular Biology #2024)
by Kelly M. Fulton Susan M. TwineThis second edition volume expands on the previous edition with new sections describing the characterization of peptides bound to major histocompatibility complexes (MHC) on the surface of the cell. Chapters also cover topics such as using SERPA for antigen identification; antigen content of electroimmunoprecipitates; whole genome-phage display libraries; antigens in immune complexes; and immunoproteomic biomarkers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Immunoprotemics: Methods and Protocols, Second Edition is a valuable resource that presents novice and expert researchers with techniques that are easily transferrable to laboratories and provides enhanced hands-on insights into this evolving field.