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In His Loving Care
by Jennifer TaylorA child to call her own... On discovering he has a daughter, Lewis Cole's life is changed in an instant, from single city surgeon to single father and country G.P. He's determined to give little Kristy all of the love and attention she needs, but somehow he finds there is also room in his heart for beautiful Dr. Helen Daniels. When she's around it feels like they are a family. Lewis can see her as the perfect wife and mother for Kristy, but Helen needs something more--a child of her own. How can Lewis fulfill her dreams when he's still discovering how to be a dad?
In My Blood: Six Generations of Madness & Desire in an American Family
by John SedgwickWhile working on his second novel, John Sedgwick spiraled into a depression so profound that it very nearly resulted in suicide. An author acclaimed for his intimate literary excursions into the rarified, moneyed enclave of Brahmin Boston, he decided to search for the roots of his malaise in the history of his own storied family—one of America's oldest and most notable. Following a bloodline that travels from Theodore Sedgwick, compatriot of George Washington and John Adams, to Edie Sedgwick, Andy Warhol's tragic muse, John Sedgwick's very personal journey of self-discovery became something far greater: a spellbinding study of the evolution of an extraordinary American family.
In My Hands: Compelling Stories from a Surgeon and His Patients Fighting Cancer
by Steven A. CurleyIn IN MY HANDS, surgical oncologist Dr. Steven Curley shares the empowering lessons he's learned over 25 years from his cancer patients' unique stories of struggle, perseverance, and triumph. As Chief of Surgical Oncology at Baylor College of Medicine, Dr. Steven Curley has worked with cancer patients for over two decades. While his life's work has been to help his patients live longer lives, he found that they helped him in ways he never could have expected. IN MY HANDS is a rare, often emotional look at some of Dr. Curley's real patients and real situations in modern cancer care. These stories of resilience, hope, and determination changed and inspired Dr. Curley, and he uses these same stories to encourage patients dealing with the fear and uncertainty coupled with a diagnosis of cancer. Every story in the book has a theme inspired by his patients: Hope, Courage, Strength, Determination, Wonder, Cooperation, Creativity, Diligence, Service, Perseverance, Wisdom, Grace, Consideration, Gratitude, Discernment, Reverence, Resourcefulness, Faith, Beauty, Acceptance, and Empathy. Some are positive messages, reminding us of the importance of maintaining balance between family, work, and leisure activities. Others are examples of the remarkable resilience of the human spirit when facing the reality of and the surgical risks that accompany a cancer diagnosis. Realistically, despite remarkable advances in multidisciplinary cancer care, some remind us cancer is still a potentially lethal and destructive disease affecting patients and the family and friends supporting them. While many people are told that there is no hope in their situation, Dr. Curley's patients taught him to always provide hope, to push the envelope and give people a chance, and that hope is a critical component of treatment and care. IN MY HANDS is medical narrative at its finest, and provides insight into medicine and patient care along with fascinating details about one of our most feared diseases.
In Our Control: The Complete Guide to Contraceptive Choices for Women
by Jennifer Baumgardner Laura EldridgeThe efficacy and risks of different birth control options are dramatically different today from what they once were thanks to scientific advances and increased awareness of STDs and other factors. In the most comprehensive book on birth control since the 1970s, women's health activist Laura Eldridge discusses the history, scientific advances, and practical uses of everything from condoms to the male pill to Plan B.Do diaphragms work? Should you stay on the Pill? What does fertility awareness really mean? Find these answers and more in In Our Control, the definitive guide to modern contraceptive and sexual health. Eldridge presents her meticulous research and unbiased consideration of our options in the intimate and honest tone of a close friend. Eldridge goes on to explore large-scale issues that might factor into women's birth control choices, urging her readers to consider the environmental impacts of each method and to take part in a dialogue on how international reproductive health issues affect us all.Whether you're looking for your first birth control method or want to know more about your current contraceptive choice, In Our Control offers the cutting edge information and practical wisdom you'll need to make empowered decisions about your sexual health.
In Our Own Right: Black Australian Nurses' Stories
by Sally S. Goold Kerrynne LiddleThe intimate, private, and heart wrenching stories told in this book, the first of its kind in Australia, will penetrate the hearts and souls of even the most hardened reader. Told with incredible dignity and humility, each of the individual and deeply personal stories recounted is a powerful testimony to the gross inhumanity and brutal capacity of white people in Australia - colonists who selectively destroy and humiliate, without remorse, the lives and souls of their fellow black Australians. In Our Own Right: Black Australian Nurses' Stories provides a powerful catalyst for questioning and calling into question the taken-for-granted humanity of us all.
In Pain: A Bioethicist’s Personal Struggle with Opioids
by Travis RiederA bioethicist’s eloquent and riveting memoir of opioid dependence and withdrawal—a harrowing personal reckoning and clarion call for change not only for government but medicine itself, revealing the lack of crucial resources and structures to handle this insidious nationwide epidemic.Travis Rieder’s terrifying journey down the rabbit hole of opioid dependence began with a motorcycle accident in 2015. Enduring half a dozen surgeries, the drugs he received were both miraculous and essential to his recovery. But his most profound suffering came several months later when he went into acute opioid withdrawal while following his physician’s orders. Over the course of four excruciating weeks, Rieder learned what it means to be “dope sick”—the physical and mental agony caused by opioid dependence. Clueless how to manage his opioid taper, Travis’s doctors suggested he go back on the drugs and try again later. Yet returning to pills out of fear of withdrawal is one route to full-blown addiction. Instead, Rieder continued the painful process of weaning himself.Rieder’s experience exposes a dark secret of American pain management: a healthcare system so conflicted about opioids, and so inept at managing them, that the crisis currently facing us is both unsurprising and inevitable. As he recounts his story, Rieder provides a fascinating look at the history of these drugs first invented in the 1800s, changing attitudes about pain management over the following decades, and the implementation of the pain scale at the beginning of the twenty-first century. He explores both the science of addiction and the systemic and cultural barriers we must overcome if we are to address the problem effectively in the contemporary American healthcare system. In Pain is not only a gripping personal account of dependence, but a groundbreaking exploration of the intractable causes of America’s opioid problem and their implications for resolving the crisis. Rieder makes clear that the opioid crisis exists against a backdrop of real, debilitating pain—and that anyone can fall victim to this epidemic.
In Pursuit of Memory: The Fight Against Alzheimer's
by Joseph JebelliFor readers of Atul Gawande, Siddhartha Mukherjee, and Henry Marsh, a riveting, gorgeously written biography of one of history's most fascinating and confounding diseases--Alzheimer's--from its discovery more than 100 years ago to today's race towards a cure.SHORTLISTED FOR THE ROYAL SOCIETY SCIENCE BOOK PRIZE 2017Named "Science Book of the Month" by BooksellerAlzheimer's is the great global epidemic of our time, affecting millions worldwide -- there are more than 5 million people diagnosed in the US alone. And as our population ages, scientists are working against the clock to find a cure.Neuroscientist Joseph Jebelli is among them. His beloved grandfather had Alzheimer's and now he's written the book he needed then -- a very human history of this frightening disease. But In Pursuit of Memory is also a thrilling scientific detective story that takes you behind the headlines. Jebelli's quest takes us from nineteenth-century Germany and post-war England, to the jungles of Papua New Guinea and the technological proving grounds of Japan; through America, India, China, Iceland, Sweden, and Colombia. Its heroes are scientists from around the world -- many of whom he's worked with -- and the brave patients and families who have changed the way that researchers think about the disease.This compelling insider's account shows vividly why Jebelli feels so hopeful about a cure, but also why our best defense in the meantime is to understand the disease. In Pursuit of Memory is a clever, moving, eye-opening guide to the threat one in three of us faces now.
In Pursuit of Memory: The Fight Against Alzheimer's: Shortlisted for the Royal Society Prize
by Dr Joseph JebelliWhen Joseph Jebelli was twelve, his beloved grandfather began to act very strangely. It started with inexplicable walks, and gradually his bright smiles were replaced by a fearful, withdrawn expression. Before long, he didn't recognise his family any more. Dr Jebelli has dedicated his career to understanding Alzheimer's disease, which affects millions worldwide and 850,000 people in the UK alone. In this, his first book, Jebelli explores the past, present and future of Alzheimer's disease starting from the very beginning - the first recorded case more than one hundred years ago - right up to the cutting-edge research being done today. It is a story as good as any detective novel, taking us to nineteenth-century Germany and post-war England; to the jungles of Papua New Guinea and the technological proving grounds of Japan; to America, India, China, Iceland, Sweden, and Colombia; and to the cloud-capped spires of the most elite academic institutions. Its heroes are expert scientists from around the world - but also the incredibly brave patients and families who have changed the way scientists think about Alzheimer's, unveiling a pandemic that took us centuries to track down, and above all, reminding everyone never to take memory - our most prized possession - for granted. Based upon years of meticulous research, In Pursuit of Memory is a compelling insider's account of this terrible disease and the scientists who are trying to find a cure against the clock.
In Pursuit of Memory: The Fight Against Alzheimer's: Shortlisted for the Royal Society Prize
by Dr Joseph JebelliWhen Joseph Jebelli was twelve, his beloved grandfather began to act very strangely. It started with inexplicable walks, and gradually his bright smiles were replaced by a fearful, withdrawn expression. Before long, he didn't recognise his family any more. Dr Jebelli has dedicated his career to understanding Alzheimer's disease, which affects millions worldwide and 850,000 people in the UK alone. In this, his first book, Jebelli explores the past, present and future of Alzheimer's disease starting from the very beginning - the first recorded case more than one hundred years ago - right up to the cutting-edge research being done today. It is a story as good as any detective novel, taking us to nineteenth-century Germany and post-war England; to the jungles of Papua New Guinea and the technological proving grounds of Japan; to America, India, China, Iceland, Sweden, and Colombia; and to the cloud-capped spires of the most elite academic institutions. Its heroes are expert scientists from around the world - but also the incredibly brave patients and families who have changed the way scientists think about Alzheimer's, unveiling a pandemic that took us centuries to track down, and above all, reminding everyone never to take memory - our most prized possession - for granted. Based upon years of meticulous research, In Pursuit of Memory is a compelling insider's account of this terrible disease and the scientists who are trying to find a cure against the clock.(P)2017 John Murray Press
In Search of Mary Seacole: The Making of a Black Cultural Icon and Humanitarian
by Helen RappaportFrom New York Times bestselling author Helen Rappaport comes a superb and revealing biography of Mary Seacole that is testament to her remarkable achievements and corrective to the myths that have grown around her.Raised in Jamaica, Mary Seacole first came to England in the 1850s after working in Panama. She wanted to volunteer as a nurse and aide during the Crimean War. When her services were rejected, she financed her own expedition to Balaclava, where her reputation for her nursing—and for her compassion—became almost legendary. Popularly known as &‘Mother Seacole&’, she was the most famous Black celebrity of her generation—an extraordinary achievement in Victorian Britain. She regularly mixed with illustrious royal and military patrons and they, along with grateful war veterans, helped her recover financially when she faced bankruptcy. However, after her death in 1881, she was largely forgotten. More recently, her profile has been revived and her reputation lionised, with a statue of her standing outside St Thomas's Hospital in London and her portrait—rediscovered by the author—now on display in the National Portrait Gallery. In Search of Mary Seacole is the fruit of almost twenty years of research and reveals the truth about Seacole's personal life, her "rivalry" with Florence Nightingale, and other misconceptions. Vivid and moving, In Search of Mary Seacole shows that reality is oftem more remarkable and more dramatic than the legend.
In Search of Medicine's Moral Compass (In Search Of Medicine's Moral Compass Ser.)
by Rob TeneryA veteran physician shares his opinion on the state of health care in America and what needs to be done to change it. In an age where uncertainty rules the day, Dr. Rob Tenery explains how health care has evolved into a $2.6 trillion enterprise. He does this with carefully researched histories and a series of challenging and thought-provoking commentaries on the most important issues of the day. Dr. Tenery&’s book focuses on a time when doctors and patients worked together to determine the best course of treatment—solutions now being ceded to large corporations and the federal government. He relates, as only a physician can, the challenges, fulfillment, and ethical dilemmas of caring for patients and making the best decisions for their health and well-being. Whether contemplating what doctors can do when nothing can be done, or thinking about the state of the medical profession, his insights are based on real-life experiences with his patients and colleagues. Dr. Tenery brings a perspective and a set of values gained from his father and grandfather, who, together with the author, represent over a century of caring for patients. This book gives you the opportunity to step into the shoes of a dedicated third-generation physician and to see the changing nature of health and medical care through his eyes. This physician of over thirty-seven years is sharing his collected writing for a better understanding of why medicine is a profession and not just another business.
In Search of Perfumes: A lifetime journey to the sources of nature's scents
by Dominique Roques'[An] immersive debut... with detailed accounts of his trips and vivid descriptions of the scents ... [Roques'] rich travelogue will transport readers' Publishers Weekly (Starred Review)In Search of Perfumes is a fragrant journey across the world, revealing the beauty and mysteries of the perfume trade.Fruits, flowers, spices, bark, leaves, and branches are just some of the natural ingredients from the plant world that are used in the creation of perfume. Dominique Roques, travelling from Andalusia to Somaliland by way of Bulgaria, Laos, El Salvador, Indonesia and Egypt, describes his search to find the best natural ingredients, precious to perfumers everywhere.In Search of Perfumes demonstrates how the prestigious multi-million-pound perfume industry may begin its life as a single plant harvested by producers surviving on ancestral traditions and techniques and often risking their lives in the process as they combat the rising threat of climate change. Roques reveals the beauty and mysteries of a familiar trade; a return to the source of the world's scents.
In Search of Perfumes: A lifetime journey to the sources of nature's scents
by Dominique Roques'[An] immersive debut... with detailed accounts of his trips and vivid descriptions of the scents ... [Roques'] rich travelogue will transport readers' Publishers Weekly (Starred Review)In Search of Perfumes is a fragrant journey across the world, revealing the beauty and mysteries of the perfume trade.Fruits, flowers, spices, bark, leaves, and branches are just some of the natural ingredients from the plant world that are used in the creation of perfume. Dominique Roques, travelling from Andalusia to Somaliland by way of Bulgaria, Laos, El Salvador, Indonesia and Egypt, describes his search to find the best natural ingredients, precious to perfumers everywhere.In Search of Perfumes demonstrates how the prestigious multi-million-pound perfume industry may begin its life as a single plant harvested by producers surviving on ancestral traditions and techniques and often risking their lives in the process as they combat the rising threat of climate change. Roques reveals the beauty and mysteries of a familiar trade; a return to the source of the world's scents.
In Search of Sexual Health: Diagnosing and Treating Syphilis in Hot Springs, Arkansas, 1890–1940
by Elliott BowenHow did beliefs about syphilis shape the kinds of treatment people with this disease received? The story of how a town in the Ozark hinterlands played a key role in determining standards of medical care around syphilis.During the late 1800s and early 1900s, the central Arkansas city of Hot Springs enjoyed a reputation as one of the United States' premier health resorts. Throughout this period, the vast majority of Americans who traveled there did so because they had (or thought they had) syphilis—a disease whose incidence was said to be dramatically on the rise all across the country. Boasting an impressive medical infrastructure that included private clinics, a military hospital, and a venereal disease clinic operated by the United States Public Health Service, Hot Springs extended a variety of treatment options. Until the antibiotic revolution of the 1940s, Hot Springs occupied a central position in the country's struggle with sexually transmitted disease.Drawing upon health-seekers' firsthand accounts, clinical case files, and the writings of the city's privately practicing specialists, In Search of Sexual Health examines the era's "venereal peril" from the standpoint of medical practice. How, Elliott Bowen asks, did people with VD understand their illnesses, and what therapeutic strategies did they employ? Highlighting the unique role that resident doctors, visiting patients, and local residents played in shaping Hot Springs' response to syphilis, Bowen argues that syphilis's status as a stigmatized disease of "others" (namely prostitutes, immigrants, and African Americans) had a direct impact on the kinds of treatment patients received, and translated into very different outcomes for the city's diverse clientele—which included men as well as women, blacks as well as whites, and the poor as well as the rich.Whereas much of the existing scholarship on the history of sexually transmitted diseases privileges the actions of medical elites and federal authorities, this study reveals Hot Springs, a remote and fairly obscure town, as a local node with a significant national impact on American medicine and public health. Providing a richer, more complex understanding of a critical chapter in the history of sexually transmitted diseases, In Search of Sexual Health will prove valuable to historians of medicine, public health, and the environment, in addition to scholars of race, gender, sexuality.
In Search of the Good
by Daniel CallahanDaniel Callahan helped invent the field of bioethics more than forty years ago when he decided to use his training in philosophy to grapple with ethical problems in biology and medicine. Disenchanted with academic philosophy because of its analytical bent and distance from the concerns of real life, Callahan found the ethical issues raised by the rapid medical advances of the 1960s--which included the birth control pill, heart transplants, and new capacities to keep very sick people alive--to be philosophical questions with immediate real-world relevance. In this memoir, Callahan describes his part in the founding of bioethics and traces his thinking on critical issues including embryonic stem cell research, market-driven health care, and medical rationing. He identifies the major challenges facing bioethics today and ruminates on its future. Callahan writes about founding the Hastings Center--the first bioethics research institution--with the author and psychiatrist Willard Gaylin in 1969, and recounts the challenges of running a think tank while keeping up a prolific flow of influential books and articles. Editor of the famous liberal Catholic magazine Commonweal in the 1960s, Callahan describes his now-secular approach to issues of illness and mortality. He questions the idea of endless medical "progress" and interventionist end-of-life care that seems to blur the boundary between living and dying. It is the role of bioethics, he argues, to be a loyal dissenter in the onward march of medical progress. The most important challenge for bioethics now is to help rethink the very goals of medicine.
In Search of the Good: A Life in Bioethics (Basic Bioethics)
by Daniel CallahanOne of the founding fathers of bioethics describes the development of the field and his thinking on some of the crucial issues of our time. Daniel Callahan helped invent the field of bioethics more than forty years ago when he decided to use his training in philosophy to grapple with ethical problems in biology and medicine. Disenchanted with academic philosophy because of its analytical bent and distance from the concerns of real life, Callahan found the ethical issues raised by the rapid medical advances of the 1960s—which included the birth control pill, heart transplants, and new capacities to keep very sick people alive—to be philosophical questions with immediate real-world relevance. In this memoir, Callahan describes his part in the founding of bioethics and traces his thinking on critical issues including embryonic stem cell research, market-driven health care, and medical rationing. He identifies the major challenges facing bioethics today and ruminates on its future.Callahan writes about founding the Hastings Center—the first bioethics research institution—with the author and psychiatrist Willard Gaylin in 1969, and recounts the challenges of running a think tank while keeping up a prolific flow of influential books and articles. Editor of the famous liberal Catholic magazine Commonweal in the 1960s, Callahan describes his now-secular approach to issues of illness and mortality. He questions the idea of endless medical “progress” and interventionist end-of-life care that seems to blur the boundary between living and dying. It is the role of bioethics, he argues, to be a loyal dissenter in the onward march of medical progress. The most important challenge for bioethics now is to help rethink the very goals of medicine.
In Shock: My Journey from Death to Recovery and the Redemptive Power of Hope
by Rana AwdishA riveting first-hand account of a physician who's suddenly a dying patient and her revelation of the horribly misguided standard of care in the medical worldDr. Rana Awdish never imagined that an emergency trip to the hospital would result in hemorrhaging nearly all of her blood volume and losing her unborn first child. But after her first visit, Dr. Awdish spent months fighting for her life, enduring consecutive major surgeries and experiencing multiple overlapping organ failures. At each step of the recovery process, Awdish was faced with something even more unexpected: repeated cavalier behavior from her fellow physicians—indifference following human loss, disregard for anguish and suffering, and an exacting emotional distance. Hauntingly perceptive and beautifully written, In Shock allows the reader to transform alongside Awidsh and watch what she discovers in our carefully-cultivated, yet often misguided, standard of care. Awdish comes to understand the fatal flaws in her profession and in her own past actions as a physician while achieving, through unflinching presence, a crystalline vision of a new and better possibility for us all. As Dr. Awdish finds herself up against the same self-protective partitions she was trained to construct as a medical student and physician, she artfully illuminates the dysfunction of disconnection. Shatteringly personal, and yet wholly universal, she offers a brave road map for anyone navigating illness while presenting physicians with a new paradigm and rationale for embracing the emotional bond between doctor and patient.
In Sickness and In Health
by Richard K. ThomasThe increasing importance of sickness and disability data across health-related disciplines is the focus of this concise but comprehensive resource. It reviews the basics of morbidity at the population level by defining core concepts, analyzing why morbidity has overtaken mortality as central to demographic study, and surveying ways these data are generated, accessed, and measured. Subsequent chapters demonstrate how this knowledge can be used to better understand--and potentially solve--critical public health issues, benefitting not only populations served, but also areas such as health services planning, resource allocation, and health policy-setting. To make this material useful to the most readers, this reference: Explains why and how morbidity data are categorized by health professionals and other data users. Examines various methods of identifying and measuring morbidity data. Identifies demographic and non-demographic factors associated with morbidity. Describes and evaluates sources of U. S. morbidity data. Reviews the current state of morbidity in the U. S. , and what it means for healthcare and society in general. Suggests future uses of morbidity data in reducing health disparities and improving population health. In Sickness and In Health is uniquely relevant to demographers and demography students, public health professionals, and epidemiologists. Its presentation of concepts and applications makes the book a valuable classroom text and a useful guide for those addressing challenges facing U. S. healthcare.
In Sight: My Life in Science and Health Innovation
by Julia LevyIn Sight is a memoir about how a love of science and discovery drove Julia Levy, a celebrated scholar and biotech CEO, to work her way through gender bias in order to achieve academic and professional recognition. Her story traces the unconventional invention of a breakthrough drug treatment from its development from laboratory research to its application as a medical treatment for vision loss. Told from a female perspective, In Sight is a unique and personal story covering Levy’s early years as a refugee, her university training in the UK and her appointment as professor at the University of British Columbia. Years spent as an academic led the author to unexpected exposure to the biotechnology industry and a chance meeting with colleagues that led to the formation of a lucrative biotechnology company, known today as QLT Inc. The bulk of the book covers the years spent building the company, and Levy’s surprising transition from chief scientific officer to CEO. In Sight is an honest description of the trials of drug development, the tensions inherent in the commercialization of health innovations, and the truly remarkable hurdles faced by women in the scientific community.
In Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future
by Brian S. HilbushLearn how AI and data science are upending the worlds of biology and medicine In Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future delivers an illuminating and fresh perspective on the convergence of two powerful technologies: AI and biotech. Accomplished genomics expert, executive, and author Brian Hilbush offers readers a brilliant exploration of the most current work of pioneering tech giants and biotechnology startups who have already started disrupting healthcare. The book provides an in-depth understanding of the sources of innovation that are driving the shift in the pharmaceutical industry away from serendipitous therapeutic discovery and toward engineered medicines and curative therapies. In this fascinating book, you'll discover: An overview of the rise of data science methods and the paradigm shift in biology that led to the in silico revolution An outline of the fundamental breakthroughs in AI and deep learning and their applications across medicine A compelling argument for the notion that AI and biotechnology tools will rapidly accelerate the development of therapeutics A summary of innovative breakthroughs in biotechnology with a focus on gene editing and cell reprogramming technologies for therapeutic development A guide to the startup landscape in AI in medicine, revealing where investments are poised to shape the innovation base for the pharmaceutical industry Perfect for anyone with an interest in scientific topics and technology, In Silico Dreams also belongs on the bookshelves of decision-makers in a wide range of industries, including healthcare, technology, venture capital, and government.
In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications
by Claudio N. CavasottoIn Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design. Its main aims are to introduce the theoretical framework and algorithms, discuss the range of validity, strengths and limita
In Silico Methods for Predicting Drug Toxicity
by Emilio BenfenatiThis detailed volume explores in silico methods forpharmaceutical toxicity by combiningthe theoretical advanced research with the practical application of the tools. Beginning with a section covering sophisticated models addressing the bindingto receptors, pharmacokinetics and adsorption, metabolism, distribution, andexcretion, the book continues with chapters delving into models for specifictoxicological and ecotoxicological endpoints, as well as broad views of themain initiatives and new perspectives which will very likely improve our way ofmodelling pharmaceuticals. Written for the highly successful Methods in Molecular Biology series,chapters include the kind of detailed implementation advice that is key forachieving successful research results. Authoritative and practical, In Silico Methods for Predicting DrugToxicity offers the advantage of incorporating data and knowledge fromdifferent fields, such as chemistry, biology, -omics, and pharmacology, toachieve goals in this vital area of research.
In Silico Methods for Predicting Drug Toxicity (Methods in Molecular Biology #2425)
by Emilio BenfenatiThis fully updated book explores all-new and revised protocols involving the use of in silico models, particularly with regard to pharmaceuticals. Divided into five sections, the volume covers the modeling of pharmaceuticals in the body, toxicity data for modeling purposes, in silico models for multiple endpoints, a number of platforms for evaluating pharmaceuticals, as well as an exploration of challenges, both scientific and sociological. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and implementation advice necessary for successful results. Authoritative and comprehensive, In Silico Methods for Predicting Drug Toxicity, Second Edition aims to guide the reader through the correct procedures needed to harness in silico models, a field which now touches a wide variety of research specialties.
In Silico Modeling of Drugs Against Coronaviruses: Computational Tools and Protocols (Methods in Pharmacology and Toxicology)
by Kunal RoyThis essential volume explores a variety of tools and protocols of structure-based (homology modeling, molecular docking, molecular dynamics, protein-protein interaction network) and ligand-based (pharmacophore mapping, quantitative structure-activity relationships or QSARs) drug design for ranking and prioritization of candidate molecules in search of effective treatment strategy against coronaviruses. Beginning with an introductory section that discusses coronavirus interactions with humanity and COVID-19 in particular, the book then continues with sections on tools and methodologies, literature reports and case studies, as well as online tools and databases that can be used for computational anti-coronavirus drug research. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of practical detail and implementation advice that ensures high quality results in the lab. Comprehensive and timely, In Silico Modeling of Drugs Against Coronaviruses: Computational Tools and Protocols is an ideal reference for researchers working on the development of novel anti-coronavirus drugs for SARS-CoV-2 and for coronaviruses that will likely appear in the future.
In Silico Models for Drug Discovery
by Sandhya KortagereInfectious diseases caused by viruses, parasites, bacteria, and fungi are the number one cause of death worldwide. Although new technologies have improved diagnosis of infectious diseases, the efficacy of all known current anti-infective agents is threatened by the spread of drug-resistant forms of the pathogens. Hence, there remains an urgent need to develop anti-infective agents that target drug-resistant pathogens. In Silico Models for Drug Discovery presents a comprehensive look at the role in silico models play in understanding infectious diseases and in developing novel therapeutics to treat them. Written by leading experts in the field, chapters cover topics such as techniques to derive novel antimicrobial targets, methods of interpreting polypharmacology-based drug target networks, and molecular dynamics techniques used to compute binding energies of drugs to their target proteins, to name a few. Written in the successful Methods in Molecular BiologyTM series or in review article format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, In Silico Models for Drug Discovery seeks to serve both professionals and novices involved in the study and treatment of infectious diseases.