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Increasing the Therapeutic Ratio of Radiotherapy
by Philip J. Tofilon Kevin CamphausenCurrent cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations. Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection). Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.
Incurable Me: Why the Best Medical Research Does Not Make It into Clinical Practice
by Kenneth StollerIn Incurable Me, a maverick physician brings transparency to some of medicine's most closely guarded secrets. As he establishes a link between commerce and medical research, K. P. Stoller also explains how to treat some of the most worrisome diseases and conditions afflicting humans today-including Lyme disease, brain trauma, dementia, and autism.Dr. Stoller maintains that the best evidence in medical research is not incorporated into clinical practice unless the medical cartel has the potential to make large amounts of money promoting the results of the research. Stoller takes his provocative argument a step further, maintaining that if specific research conflicts with a powerful entity's financial interests, the likely result will be an effort to suppress or distort the results. Stoller cites numerous examples, including corporate influence on GMO labeling and public health.Stoller also explores how "revolving-door-employment" between the Centers for Disease Control and large pharmaceutical companies can affect research results-as well as our health. Written in an accessible style that is thoroughly appropriate for a lay audience, Incurable Me is a must-read for anyone interested in the state of modern medicine.
Incurable Optimist: Living with Illness and Chronic Hope
by Jennifer Cramer-Miller2024 International Impact Book Awards Winner: Family and Medical Book of Excellence Award Winner: Family Publishers Weekly, starred review, PW Book of the Week, August 2023 At twenty-two, Jennifer Cramer-Miller was thrilled with her new job, charming boyfriend, and Seattle apartment. Then she received a devastating autoimmune diagnosis—and suddenly, rather than planning for a bright future, she found herself soaking a hospital pillow with tears and grappling with words like “progressive” and “incurable.” That day, Cramer-Miller unwillingly crossed over from wellness to chronic illness—from thriving to kidney failure. Her chances of survival hinged upon on the expertise of doctors, the generosity of strangers, and the benevolence of loved ones. But what kind of life would that be? Spanning two-plus decades, this family love story explores loss and acceptance, moving forward with uncertainty, and forging a path to joy. Four kidney transplants later, Cramer-Miller is here to shine a bright light on people helping people in difficult times with a story that will make you want to hug the humans you love. Because sometimes it’s the sorrows that threaten to pull us apart that ultimately unite us in hope.
Indacaterol
by Alexandre TrifilieffChronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available. This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled β2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.
Indentation Testing of Biological Materials (Advanced Structured Materials #91)
by Gennady Mishuris Ivan ArgatovThis book presents a comprehensive and unifying approach to analytical identification of material properties of biological materials. Focusing on depth-sensing indentation testing, pipette aspiration testing, and torsion of soft tissues, it discusses the following important aspects in detail: damping, adhesion, thickness effect, substrate effect, elastic inhomogeneity effect, and biphasic effect. This book is intended for advanced undergraduate and graduate students, researchers in the area of biomechanics as well as for biomedical engineers interested in contact problems and involved in inverse materials parameters prediction analysis.
Independence Training for Visually Handicapped Children
by Doris ToozeFirst published in 1981, this book was written to help parents and teachers to participate in child-based mobility programmes, covering the needs of visually-handicapped children from pre-school to adulthood. It gives insight into ways in which these figures can make the world meaningful to young children, as well as making them aware of the special training that is necessary to develop the social skills of daily living that a sighted child acquires through imitation. Travel techniques must be learnt to enable these children to move independently and the book describes various methods that can be used by the blind traveller. It also examines the role of physical education and dance, both of particular importance for the visually-handicapped child at school age.
Independent Advocacy and Spiritual Care
by Geoff MorganThis book explores the profession of independent advocacy through a history of the practice, and provides an empirical study of its emergence in London. While advocacy has long been associated with professions such as social work and mental health nursing, this book delivers a unique perspective of advocacy through the lens of faith and culture. Using real life examples and insights from service users, advocates and spiritual care practitioners in the advocacy and chaplaincy sectors, the fascinating results offer proposals for enhanced theory, training and practice in independent advocacy. It will be of great interest for students and professionals engaged in advocacy or spiritual care.
Independent Mental Health Advocacy - The Right to Be Heard: Context, Values and Good Practice
by Karen Newbigging Konstantina Poursanidou Karen Machin Toby Brandon Stephanie De Haye Julie Ridley Laura Able Mick Mckeown Kaaren Cruse June Sadd Kris ChasteyIndependent mental health advocacy is a crucial means of ensuring rights and entitlements for people sectioned under the Mental Health Act. This book takes an appreciative but critical view of independent mental health advocacy, locating the recent introduction of Independent Mental Health Advocates (IMHAs) within a broader historical, social and policy context, and anticipates future developments. The text includes the voices of service users throughout, both as authors and research participants. Drawing on their research, the authors provide a historical overview of mental health advocacy, independent mental health advocacy in relation to the law, the role and responsibilities of IMHAs, essential values, knowledge and skills required of advocates, relationships with service providers, commissioning, measuring advocacy outcomes, and how IMHA services can be made accessible and appropriate to diverse groups. This will be essential reading for advocates, social work professionals, academic staff and trainers and will provide mental health professionals with an understanding of, and critical reflection on, the IMHA role. It will also be of particular general interest to survivors and mental health service users, and their families and carers.
Independent and Supplementary Prescribing
by Molly Courtenay Matt Griffiths June Crown CbeThe second edition of Independent and Supplementary Prescribing builds on the success of this classic text by providing a unique resource for prescribing and medicines management for both new and experienced prescribers. This is an essential resource for anyone undertaking the non-medical prescribing programme. The book explores a number of key areas for prescribers, including the ethical and legal issues surrounding prescribing, prescribing within a public health context, evidence-based prescribing, basic pharmacology, medication safety, monitoring skills and drug calculations. Each chapter has been updated for the second edition and an additional chapter 'Minimising the risk of prescribing error' has been added. Written by a group of multi-professional authors working at all stages of the medication management process, this book will be essential reading for all nurses, midwives, pharmacists and allied health professionals qualified to prescribe as independent and/or supplementary prescribers.
Independent and Supplementary Prescribing At a Glance (At a Glance (Nursing and Healthcare))
by Ian PeateIndependent and Supplementary Prescribing At a Glance The market-leading at a Glance series is popular among healthcare students and newly qualified practitioners for its concise, simple approach and excellent illustrations. Each bite-sized chapter is covered in a double-page spread with clear, easy-to-follow diagrams, supported by succinct explanatory text. Covering a wide range of topics, books in the at a Glance series are ideal as introductory texts for teaching, learning and revision, and are useful throughout university and beyond. Everything you need to know about Independent and Supplementary Prescribing  at a Glance! Independent and Supplementary Prescribing At a Glance is an accessible and practical resource for healthcare students looking to become independent and supplementary prescribers. Each part of the book is mapped against a recognised prescribing framework published by the Royal Pharmaceutical Society (RPS) for all Registered Healthcare Professionals, and addresses NMC and HCPC regulatory body requirements. The text presents full-colour images, a user-friendly approach to key prescribing topics, and a structure that allows readers to dip-in and out as needed, appealing to a variety of learning styles. Topics include: Professional, legal, and ethical prescribing considerations; independent and supplementary prescribing; critical thinking and clinical reasoning; exploring interventions and differential diagnosis Non-pharmacological approaches and pharmacological treatment options; prescribing reference guides, medication selection and how to prescribe Holistic assessment, quality of life, and evidence-based practice; public health, infection prevention and control; consultation models and principles of history taking and physical examination skills Building relationships, inclusive prescribing and informed choices; medicine optimisation, adverse reactions, and prescribing generic products Independent and Supplementary Prescribing At a Glance is a comprehensive and complete learning and study resource for Registered Nurses, Registered Midwives, Physician Associates and Healthcare Professionals who want to become independent prescribers within the UK. For more information on the complete range of Wiley nursing and health publishing, please visit: www.wiley.com To receive automatic updates on Wiley books and journals, join our email list. Sign up today at www.wiley.com/email All content reviewed by students for students Wiley nursing books are designed exactly for their intended audience. All of our books are developed in collaboration with students. This means that our books are always published with you, the student, in mind. If you would like to be one of our student reviewers, go to www.reviewnursingbooks.com to find out more. This new edition is also available as an e-book. For more details, please see www.wiley.com/buy/9781119837916
Index of Medical Imaging
by Jonathan McConnellThe ‘Index of Medical Imaging' is the must-have companion for diagnostic radiography students and newly qualified imaging practitioners, designed to allow easy access to descriptions and discussions of many aspects of medical imaging such as radiographic projections, positioning, procedures and clinical examinations. The Index consists of multiple lists, tables and discussions linked to (amongst others) radiography, CT, MRI and components such as radiological contrast agents, responses to contrast reactions, MRI safety. There is a glossary of terms and definitions plus a list of abbreviations that may be encountered within radiology. Tables are given that suggest the order and type of examination that should be performed as defined by the UK Royal College of Radiologists. FEATURES • Supports clinical decision-making • Glossary of key terms and abbreviations • Unique format that consists of multiple lists, tables and discussions
Index of Variant Human Fibrinogens
by Ray F. EbertWhether you're a clinician concerned with patient management, a technician involved in diagnostic testing, or an investigator studying fibrinogen structure and function, you'll find that the 1994 Index of Variant Human Fibrinogens. is a valuable resource. It contains not only the most comprehensive compilation of the world literature and research on dyfibrinogenemia, but also includes a synopsis for health professionals and expert guidance for the diagnosis and treatment of dysfibrinogenemia, the study of genetically abnormal human fibrinogens. Furthermore, this book provides the latest DNA and protein sequences (including the AaE chain) and listings of available PCR primers and anti-fibrinogen antibodies. Add to this a set of 263 Dysfibrinogen Reports tracking more than 30 different characteristics for each variant, plus 9 summary tables and a comprehensive bibliography, and the result is an authoritative companion for the diagnosis and management of this multifaceted and complex disease.Compare your patient's laboratory profile, clinical manifestations, or molecular defect with virtually all others in the literature. Consider all the options for treating bleeding or thrombotic complications. Determine if your data from a newly identified variant are unique. Spend an hour with this book and see if it doesn't save many hours of literature searching and summarizing!
India Migration Report 2022: Health Professionals' Migration (India Migration Report)
by S. Irudaya RajanIndia Migration Report 2022 is one of the first volumes to focus comprehensively on Indian health professionals’ migration. The essays in the volume discuss the reasons, challenges and opportunities that daunt and prompt health professionals to migrate within and outside India. This volume: • Explores the history of migration of health professionals, especially nurses from India; • Focuses in economic and social drivers of migration among health professionals; • Examines shifting patterns in migration as well as emergence of new destinations for migrants; • Studies the economic and social impact of COVID-19 among migrant health professionals; • Highlights the influence of remittances on rural economies in India. Timely, data-driven and drawing on exhaustive fieldwork, the volume looks at Indian health professionals in North America, Middle East, Asia Pacific and South Asia. It will be of interest to scholars and researchers of development studies, public health, public policy, economics, demography, sociology and social anthropology, and migration and diaspora studies.
India and the Patent Wars: Pharmaceuticals in the New Intellectual Property Regime (The Culture and Politics of Health Care Work)
by Murphy HalliburtonIndia and the Patent Wars contributes to an international debate over the costs of medicine and restrictions on access under stringent patent laws showing how activists and drug companies in low-income countries seize agency and exert influence over these processes. Murphy Halliburton contributes to analyses of globalization within the fields of anthropology, sociology, law, and public health by drawing on interviews and ethnographic work with pharmaceutical producers in India and the United States.India has been at the center of emerging controversies around patent rights related to pharmaceutical production and local medical knowledge. Halliburton shows that Big Pharma is not all-powerful, and that local activists and practitioners of ayurveda, India’s largest indigenous medical system, have been able to undermine the aspirations of multinational companies and the WTO. Halliburton traces how key drug prices have gone down, not up, in low-income countries under the new patent regime through partnerships between US- and India-based companies, but warns us to be aware of access to essential medicines in low- and middle-income countries going forward.
India's Historical Demography: Studies in Famine, Disease and Society (Routledge Library Editions: Health, Disease and Society #12)
by Tim DysonWhen this book was originally published in 1989 here had been virtually no studies of the country’s historical demography. This volume was significant for 3 reasons: it contributed greatly to the knowledge of India’s population history; it had major implications for the work of social and economic historians of India; and lastly the Indian context provides an excellent laboratory in which to investigate certain large-scale demographic phenomena – among others the experience of bubonic plague, influenza, cholera and famine.
India's Open-Economy Policy: Globalism, Rivalry, Continuity (Routledge Contemporary South Asia Series #Vol. 14)
by Jalal AlamgirThis book is the first major exploration of Indian political economy using a constructivist approach. Arguing that India’s open-economy policy was made, justified, and continued on the basis of the idea of openness more than its tangible effect, the book explains what sustained the idea of openness, what philosophy, interpretations of history, and international context gave it support, justification, and persuasive force. Drawing on a wide range of contemporary and historical sources, and going as far back as the 19th century, the author reconstructs how Indian policymakers have interpreted economic priorities, perceived success and failure, and evaluated the destiny of their nation. By the 1990s, their imperatives increasingly highlighted a sense of rivalry, especially with China, and globalism, a desire to play a strong role in world affairs. The book shows how a sense of nationalist urgency was created through globalism and rivalry, allowing policymakers to privilege international needs over domestic political demands, replace economic independence with interdependence as a priority, and ensure that the broad basis of India’s openness could not be challenged effectively even though certain policies faced severe opposition. This book will be of interest to those working on International Political Economy, Globalization, Economic History, Public Policy, and South Asian politics.
India's Public Health Care Delivery: Policies for Universal Health Care
by Sanjeev KelkarThis book describes the present awful state of India’s Public Health Care Delivery, its dismal planning and implementation. It argues that it can be remedied comprehensively and effectively, using its ‘own already present’ resources. A radical re-evaluation of some sacrosanct ideas and discarding many of these, especially in Primary Care and its structure is required. It can be done without disadvantage to the last man served. This book starts with the sea change India has undergone and emphasizes new ways of managing health. High quality work force creation and its deployment, an unsolved problem is effectively given a solution. The bulk of the book discusses the entire public health care structure and function and how it can be newly laid out with proper work force allocation, hitherto grossly inadequate, including professionals from other training backgrounds. It is total solution that will help India to achieve the goal of Universal Health Care.
Indian Doctors in Kenya, 1895–1940
by Anna Greenwood Harshad TopiwalaThis ground-breaking book offers unique insights into the careers of Indian doctors in colonial Kenya during the height of British colonialism, between 1895 and 1940. The story of these important Indian professionals presents a rare social history of an important political minority.
Indian Ethnic Rhinoplasty: A Surgical Guide
by Virendra GhaisasEach racial and ethnic population has their own nasal characteristics, which need to be considered when planning rhinoplasty surgery. This book is probably the first of its kind in the Indian context highlighting the goal of maintaining ethnic identity congruent with the patient’s facial features and establishing Indian standards for gauging the success of the surgery. This is important as most of the rhinoplasty books have addressed these issues of the Caucasian or southeast Asian population and Caucasian normative standards of facial analysis. This book provides a broader understanding of ethnically specific features. It highlights the regional variations within India and their implications for rhinoplasty Surgery, thereby filling the void of lack of knowledge of the intricacies of surgery on Indian noses. It deals with important topics such as preoperative evaluations, determining factors such as thickness and texture of skin along with the various complications that may be encountered. It simplifies and facilitates learning with numerous pre-operative, intra-operative, and postoperative photographs. This book provides a systematic approach to Rhinoplasty surgery in Indian patients with an emphasis on addressing the functional aspects along with the cosmetic aspects. This book is a must-have for trainees in rhinoplasty and plastic surgery courses along with facial plastic surgeons, maxillofacial surgeons, and aesthetic surgeons operating on the Indian population across the globe.
Indian Herbal Drug Microscopy
by Shailendra S. Gurav Nilambari S. GuravAdulteration and misidentification of herbal drugs can cause serious health problems to consumers. The first step in quality control of medicinal plants is ensuring the authenticity of the desired species for intended use, with anatomical study playing a critical role in identifying and authenticating medicinal plants. A product of numerous years of experience and research, Indian Herbal Drug Microscopy is a vital resource for identifying and evaluating Indian medicinal plants. Comprised of four concise and comprehensive chapters, the book presents stepwise procedures for sectioning of plant material, histo-chemical staining techniques, and the anatomy of forty well-known and medicinally important plants, including Arjuna, Ashoka, Ashwagandha, Cinchona, Cinnamon, Ginger, Kurchi, Rauwolfia, Turmeric, Tulsi, and Vasaka. The book is also supplemented with color photographs and hand-drawn microscopic images. Written by authorities in the field, Indian Herbal Drug Microscopy is a valuable guide for herbal drug microscopy of Indian medicinal plants.
Indian Herbal Medicines: Antioxidant and Antimicrobial Properties (SpringerBriefs in Molecular Science)
by Maria Micali Ramesh Kumar Sharma Rajeev K. Singla Alessandra Pellerito Bhupendra Kumar RanaThis book discusses the scope and limitations of the antimicrobial and antioxidant properties of foods as medicines or medicinal coadjuvants in traditional Indian herbal therapies. The first chapter introduces readers to the relevance of the Ayurveda system, its holistic classification approach, applications of selected herbs and the demonstrable efficacy of herbal extracts in terms of antimicrobial susceptibility. In turn, the second chapter discusses the antimicrobial properties and kinetic mechanisms of inhibition ascribed to selected vegetable extracts. The third chapter addresses the antioxidant power of phenolic compounds from vegetable products and herbal extracts. The book closes with a review of natural antioxidant agents’ role in the treatment of metabolic disorders. Written from an Indian perspective, this book unravels the chemistry of the traditional Indian diet and its impact on health. Further, it can serve as a reference for other traditional products with similar health claims.
Indian Medicinal Plants: Uses and Propagation Aspects
by Akula Ramakrishna Srinath RaoThe demand for medicinal plants is increasing, and this leads to unscrupulous collection from the wild and adulteration of supplies. Providing high-quality planting material for sustainable use and thereby saving the genetic diversity of plants in the wild is important. In this regard, the methods of propagation of some important medicinal plants are provided along with the traditional methods of propagation. Indian Medicinal Plants: Uses and Propagation Aspects offers a unique compendium of more than 270 medicinal plant species from India with detailed taxonomic classifications based on the Bentham and Hooker system of classification. Salient Features: Provides traditional methods of propagation and discusses the propagation of medicinal plants Presents plant properties, plant parts and chemical constituents Describes the medicinal uses of more than 270 medicinal plant species from India This book is of special interest to practitioners of alternative medicine, students of Ayurveda, researchers and industrialists associated with medical botany, pharmacologists, sociologists and medical herbalists.
Indian Psychology Perception: Cognition; Emotion And Will; Epistemology Of Perception (Psychology Ser.)
by Sinha, JadunathFirst Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.
Indian Sisters: A History of Nursing and the State, 1907–2007 (South Asian History and Culture)
by Madelaine HealeyHealth and medicine cannot be understood without considering the role of nurses, both as professionals and as working women. In India, unlike other countries, nurses have suffered an exceptional degree of neglect at the hands of state, a situation that has been detrimental to the quality of both rural and urban health care. Charting the history of the development of nursing in India over 100 years, Indian Sisters examines the reasons why nurses have so consistently been sidelined and excluded from health care governance and policymaking. The book challenges the routine suggestion that nursing’s poor status is mainly attributable to socio-cultural factors, such as caste, limitations on female mobility and social taboos. It argues instead that many of its problems are due to an under-achieved relationship between a patriarchal state on the one hand, and weak professional nursing organisations shaped by their colonial roots on the other. It also explores how the recent phenomenon of large-scale emigration of nurses to the West (leading to better pay, working conditions and career prospects) has transformed the profession, lifting its status dramatically. At the same time, it raises questions about the implications of emigration for the fate of health care system in India. An important contribution to the growing academic genre of nursing history, the book is essential reading for scholars and students of health care, the history of medicine, gender and women’s studies, sociology, and migration studies. It will also be useful to policymakers and health professionals.
India’s Mental Healthcare Act, 2017: Building Laws, Protecting Rights
by Brendan D. Kelly Richard M. DuffyThis book comprehensively discusses the background to the passing of India's revolutionary Mental Healthcare Act, 2017, offering a detailed description of the Act itself and a rigorous analysis in the context of the CRPD and the World Health Organization (WHO) standards for mental health law. It examines the fine balance, between complying with the CRPD while still delivering practical, humane, and implementable legislation. It explores how this legislation was shaped by the WHO standards and provides insights into areas where the Indian legislators deviated from these guidelines and why. Taking India as an example, it highlights what is possible in other low- and middle-income countries. Further it covers key issues in mental health, identifying potential competing interests and exploring the difficulties and limitations of international guidelines.The book is a valuable resource for psychiatrists, nurses, social workers, non-governmental organizations and all mental healthcare workers in India and anyone studying human rights law.