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Kernel Ridge Regression in Clinical Research
by Ton J. Cleophas Aeilko H. ZwindermanIBM (international business machines) has published in its SPSS statistical software 2022 update a very important novel regression method entitled Kernel Ridge Regression (KRR). It is an extension of the currently available regression methods, and is suitable for pattern recognition in high dimensional data, particularly, when alternative methods fail. Its theoretical advantages are plenty and include thekernel trick for reduced arithmetic complexity,estimation of uncertainty by Gaussians unlike histograms,corrected data-overfit by ridge regularization,availability of 8 alternative kernel density models for datafit.A very exciting and wide array of preliminary KRR research has already been published by major disciplines (like studies in quantum mechanics and nuclear physics, studies of molecular affinity / dynamics, atomisation energy studies, but also forecasting economics studies, IoT (internet of things) studies for e-networks, plant stress response studies, big data streaming studies, etc). In contrast, it is virtually unused in clinical research. This edition is the first textbook and tutorial of kernel ridge regressions for medical and healthcare students as well as recollection / update bench, and help desk for professionals. Each chapter can be studied as a standalone, and, using, real as well as hypothesized data, it tests the performance of the novel methodology against traditional regression analyses. Step by step analyses of over 20 data files stored at Supplementary Files at Springer Interlink are included for self-assessment. We should add that the authors are well qualified in their field. Professor Zwinderman is past-president of the International Society of Biostatistics (2012-2015) and Professor Cleophas is past-president of the American College of Angiology (2000-2002). From their expertise they should be able to make adequate selections of modern KRR methods for the benefit of physicians, students, and investigators. The authors have been working and publishing together for 24 years and their research can be characterized as a continued effort to demonstrate that clinical data analysis is not mathematics but rather a discipline at the interface of biology and mathematics.
Kernenergie: Kraftwerkstypen, Entwicklungen und Risiken
by Hartmut FreyDie Nachfrage nach fossilen Brennstoffen steigt stetig an. Zugleich produzieren sie in der Stromgestehung aufgrund der Oxidationsprozesse Kohlendioxid, das dann in die Atmosphäre entweicht und dort als Treibhausgas die Wärmestrahlung adsorbiert und remittiert. Seit geraumer Zeit werden in einigen Ländern neue Kernkraftwerke gebaut. Die weltweite Akzeptanz der Stromerzeugung durch Kernenergie hat durch die Katastrophen von Tschernobyl und Fukushima gelitten, wobei Tschernobyl auf menschliches Versagen beruhte, während die Reaktorblöcke in Fukushima optimal auf Erdbeben ausgelegt waren, nicht aber auf den eines Tsunami. Das Buch fasst den Stand der Technik zusammen, berücksichtigt Beteiligungsprozesse der Öffentlichkeit sowie absehbare Entwicklungen in den Lebensgewohnheiten und politische Vorgaben.
Kernicterus
by David W. MccandlessKernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy. It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment. In the absence of treatment kernicterus can produce devastating sequelae and death. The present volume will examine the biochemistry and physiology of bilirubin as well as its hepatic metabolism and renal excretion. Chapters will elaborate bodily disposition of bilirubin and its neuropathology. Both early treatments and current therapy will be discussed in detail. Phototherapy will be presented, and its efficacy and influence on incidence thoroughly examined.
Ketamine: From Abused Drug to Rapid-Acting Antidepressant
by Kenji Hashimoto Soichiro Ide Kazutaka IkedaThis book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants.
Ketamine (The MIT Press Essential Knowledge series)
by Bita MoghaddamThe emergence of ketamine--previously known as a combat anesthetic and club drug--as a treatment for depression.Ketamine, approved in 2019 by the Food and Drug Administration for the treatment of depression, has been touted by scientists and media reports as something approaching a miracle cure. This volume in the MIT Press Essential Knowledge series chronicles the ascent of a drug that has been around for fifty years--in previous incarnations, a Vietnam-era combat anesthetic and a popular club drug--that has now been reinvented as a treatment for depression. Bita Moghaddam, a leading researcher in neuropharmacology, explains the scientific history and the biology of ketamine, its clinical use, and its recently discovered antidepressant effects, for the nonspecialist reader.
The Ketogenic Kitchen: Low carb. High fat. Extraordinary health.
by Patricia Daly Domini KempCancer survivors Domini Kemp and Patricia Daly offer the first comprehensive ketogenic cookbook based on the most exciting new research on nutritional approaches to the prevention and management of cancer. For decades, the ketogenic diet--which shifts the body's metabolism from burning glucose to burning fat, lowering blood sugar and insulin and resulting in a metabolic state known as ketosis--has been used to successfully manage pediatric epilepsy. More recently, it has been used by the Paleo community as a weight loss strategy. Now emerging research suggests that a ketogenic diet, in conjunction with conventional treatments, also offers new hope for those coping with cancer and other serious disease. With endorsements from leading researchers and oncologists such as Dr. Thomas Seyfried (Cancer as a Metabolic Disease), The Ketogenic Kitchen offers more than 250 recipes, as well as meal plans and comprehensive scientific information about the benefits of a ketogenic diet, with sensible advice to help readers through periods of illness, recovery, and treatment. This North American paperback edition has been updated to include U.S. customary units of measure appearing side-by-side with metric measures.
Kevin Guest House (Images of Modern America)
by Gerald L. Halligan Denis GarveyWhile unknown to many living in western New York, the Kevin Guest House has served thousands of critically ill individuals and their families for over 40 years. Quietly nestled within the expanding Buffalo Niagara Medical Campus of Buffalo, New York, the demand for the facility continues to increase. The opening chapter is a testimony to the Speyser-Beer family, who originally owned the property. The second and third chapters memorialize the founders of the Kevin Guest House, the Garvey family of Sharon, Pennsylvania. The remaining chapters provide a virtual tour of the grounds and building expansions of 2016.
Key Account Controlling in der pharmazeutischen Industrie
by Sabine RinauerDas deutsche Gesundheitssystem ist ein komplexes Regulierungsgefüge. Damit die Marktteilnehmer die Konsequenzen ihres Handelns einschätzen können, werden die Kenntnis von Interdependenzen und die frühzeitige Information über Veränderungen der Rahmenbedingungen immer wichtiger. Durch die Konsolidierung der Nachfragestrukturen gewinnt die Fokussierung auf die zentralen Schlüsselkunden für die Arzneimittelhersteller an strategischer Bedeutung. Die damit verbundene Veränderung im absatzwirtschaftlichen Geschäftsmodell verändert den Informations- und Koordinationsbedarf maßgeblich und stellt somit neue Anforderungen an das Controlling. Neue praxistaugliche Instrumente zur Entscheidungsunterstützung und Verhaltenssteuerung im pharmazeutischen Key Account Management werden benötigt.
Key Account Management Excellence in Pharma & Medtech
by Mike MoormanKey Account Management Excellence in Pharma & Medtech is designed to help life sciences practitioners develop and execute innovative and effective key account management (KAM) strategies and capabilities. Pharmaceutical and medtech companies are increasingly pursuing KAM in response to the rapid rise of large, sophisticated and complex healthcare provider and payer systems and groups. Those that invest the time to get KAM right will protect their business and grow with these rising customers. This book is groundbreaking in both its scope and its tailoring of leading KAM practices specifically for life sciences. The central theme is that "key account management is an organization-wide business strategy, not just a role or a sales-specific initiative." KAM is a strategy focused on providing unique offerings and value through an orchestrated, cross-functional, go-to-market model designed specifically to address the needs and engagement preferences of a unique segment of customers. The insights and practices shared in this book are designed to be a valuable reference at every stage of the KAM journey. The book has been designed to facilitate a common language and deep understanding of KAM issues and leading practices organization-wide—particularly for life sciences leaders, account managers and cross-functional team members responsible for building, transforming and supporting their organization’s KAM strategies and capabilities.
Key Concepts and Issues in Nursing Ethics
by P. Anne ScottShort case studies, based on real stories from the health care arena, ensure that each chapter of this book is rooted in descriptions of nursing practise that are grounded, salient narratives of nursing care. The reader is assisted to explore the ethical dimension of nursing practice: what it is and how it can be portrayed, discussed, and analysed within a variety of practice and theoretical contexts. One of the unique contributions of this book is to consider nursing not only in the context of the individual nurse - patient relationship but also as a social good that is of necessity limited, due to the ultimate limits on the nursing and health care resource. This book will help the reader consider what good nursing looks like, both within the context of limitations on resources and under conditions of scarcity. Indeed, any discussion of ethical issues in nursing should be well grounded in a conceptualisation of nursing that nursing students and practising nursing can recognise, accept and engage with. Nursing, like medicine, social work and teaching has a clear moral aim - to do good. In the case of nursing to do good for the patient. However it is vital that in the pressurised, constrained health service of the 21st century, we help nurses explore what this might mean for nursing practice and what can reasonably be expected of the individual nurse in terms of good nursing care.
Key Concepts in Health Studies (SAGE Key Concepts series)
by Dr Iain Crinson Chris Yuill Eilidh DuncanKey Concepts in Health Studies provides a much needed guide to the central concepts used across the subject, and offers the reader a comprehensive overview of the core topics, theories and debates. Drawing together the fundamentals within the disciplines of health, nursing, and social policy this book is an ideal text both for students studying health in a range of academic fields, and for health and social care practitioners. From ageism to public health, and gender to obesity, the book offers an exciting guide to the multidisciplinary field. Each entry features: -A snapshot definition of the concept -A wider discussion of the main issues -Case studies illustrating the application of theory to practice -Examples of further reading Highly readable, with clear indexing, and cross-referencing between entries, this is not only a student-friendly textbook that will enable the reader to dip into and update their knowledge of a particular key concept, but a valuable resource to anyone practicing in the health care field.
Key Concepts in Healthcare Education (SAGE Key Concepts series)
by Elizabeth Mason-Whitehead Jan Gidman Annette Mcintosh-ScottKey Concepts in Healthcare Education is a guide to the key theories, issues and practical considerations involved in healthcare education in the 21st century. It is aimed at those studying to be educators in both academic and practice settings, as well as supporting the continuing professional development of more experienced lecturers and practice educators. The book can be used as a reference source, a platform for further study and an essential text. The book comprises 40 succinct chapters each covering a topic and featuring - a definition of the concept - key points - discussion of the main issues - a case study to illustrate the application to practice, and - suggestions for further reading. For those developing or enhancing their knowledge and skills in education and mentorship in healthcare, Key Concepts in Healthcare Education is the ideal companion to learning.
Key Concepts in Mental Health (SAGE Key Concepts series)
by David PilgrimA classic and long-trusted resource that provides short summaries of all the key theories, concepts and terminology associated with mental health. Each entry is neatly summarised and thoroughly referenced giving the reader an immediate and thorough entry point to the subject. Structured into four sections, the text starts with entries related to Mental Health and Mental Abnormality, before moving onto Mental Health Services and Society. The new edition offers: 70 concise chapters including new entries on social networks and loneliness Updates across all chapters to align with contemporary, critical debates in mental health Appropriate consideration of the intersection of Covid-19 and mental health An essential guide for students of mental health studies, health, nursing, social work, education, psychology, counselling and psychotherapy.
Key Concepts in Mental Health (SAGE Key Concepts series)
by David PilgrimA classic and long-trusted resource that provides short summaries of all the key theories, concepts and terminology associated with mental health. Each entry is neatly summarised and thoroughly referenced giving the reader an immediate and thorough entry point to the subject. Structured into four sections, the text starts with entries related to Mental Health and Mental Abnormality, before moving onto Mental Health Services and Society. The new edition offers: 70 concise chapters including new entries on social networks and loneliness Updates across all chapters to align with contemporary, critical debates in mental health Appropriate consideration of the intersection of Covid-19 and mental health An essential guide for students of mental health studies, health, nursing, social work, education, psychology, counselling and psychotherapy.
Key Concepts in Mental Health
by David Pilgrim"This book wins on two levels: not only is there an extensive range of concepts presented (including some that are unexpected yet clearly relevant), there is also a succinct, thorough and critical dissection of each. Recommended, if not essential, reading for all student mental health professionals. " - Dr Steven Pryjmachuk, Head of Mental Health Division, School of Nursing, Midwifery and Social Work, University of Manchester Mental health is an area that new students and trainee practitioners often find bewildering. This book cuts through the stigma associated with this topic. It delivers bite-sized chunks of information that cover the central concepts and debates which shape contemporary views about mental health and illness. As this book shows, these key concepts not only influence our understanding of mental health, but also govern the provision of services for people with mental-health problems. Drawing together perspectives from sociology, psychiatry, psychology and ethics, the vital topics in mental health are examined in three parts: - PART ONE: Mental Health and Mental-Health Problems explores theories and understandings of mental health and illness - PART TWO: Mental Health Services looks at the structure and organization of mental health service delivery, past and present - PART THREE: Mental Health and Society studies the social context. This new edition adds 10 new concepts as well as updating the previous entries. New topics include childhood adversity, recovery, spirituality, well-being, social and cultural capital, quality of mental-health services, evidence-based practice, and work and mental health. This book will be invaluable for trainee health professionals, including clinical psychologists, social workers, nurses, counsellors and psychotherapists.
Key Concepts in Mental Health
by David PilgrimThis is the only text to give you a complete, concise overview of mental health and all the issues that surround it from a theoretical and practical point of view. Split into three sections, the book defines mental health and mental illness, examines the services and settings in which mental health care takes place and discusses the societal issues surrounding mental health. Made up of 63 bite-sized chapters, the book offers: · Definitions of the key concepts · Key points that you need to know for your study and practice · Further reading to help you expand your knowledge It will be essential reading for students of health, nursing, mental health, social work and social care. It is also valuable reading for students of counselling and psychotherapy.
Key Concepts in Mental Health (SAGE Key Concepts series)
by Professor David PilgrimNow in its 4th edition, this text continues to give you a complete and concise overview of mental health and all the issues that surround it from a theoretical and practical perspective. Restructured into 4 sections, the book starts by defining mental health and mental abnormality before examining the mental health services and the place mental health takes in society. Fully updated, the book offers: 66 bite-sized chapters including new ones on the Biopsychosocial Model, trauma and mindfulness Key points summarising what you need to know for study and practice Examples of further reading to help you expand your knowledge It is essential reading for students of health, nursing, mental health, social work and social care. It is also valuable reading for students of counselling and psychotherapy.
Key Concepts in Mental Health (SAGE Key Concepts series)
by Professor David PilgrimNow in its 4th edition, this text continues to give you a complete and concise overview of mental health and all the issues that surround it from a theoretical and practical perspective. Restructured into 4 sections, the book starts by defining mental health and mental abnormality before examining the mental health services and the place mental health takes in society. Fully updated, the book offers: 66 bite-sized chapters including new ones on the Biopsychosocial Model, trauma and mindfulness Key points summarising what you need to know for study and practice Examples of further reading to help you expand your knowledge It is essential reading for students of health, nursing, mental health, social work and social care. It is also valuable reading for students of counselling and psychotherapy.
Key Concepts in Mental Health (SAGE Key Concepts series)
by Professor David PilgrimNow in an updated fifth edition, this book provides readers with overviews of all the key theories, concepts and terminology associated with mental health, summarising them succinctly in a series of easily digestible yet expertly written entries. Structured into four sections, the text starts with entries related to Mental Health and Mental Abnormality, before moving onto Mental Health Services and Society. The new edition offers: 68 concise chapters including new entries on ADHD, Secondary Prevention, Challenges for Practitioners, and The Impact of Social Media on Mental Health. Updates across all chapters to make the content more in-line with contemporary critical debates in mental health, including new terminology and references to modern mental health services. A new contextualising introduction on the sticky subject of mental health terminology. Additional further reading examples and suggestions An essential guide for students of mental health studies, health, nursing, social work, psychology, counselling and psychotherapy.
Key Concepts in Mental Health (SAGE Key Concepts series)
by Professor David PilgrimNow in an updated fifth edition, this book provides readers with overviews of all the key theories, concepts and terminology associated with mental health, summarising them succinctly in a series of easily digestible yet expertly written entries. Structured into four sections, the text starts with entries related to Mental Health and Mental Abnormality, before moving onto Mental Health Services and Society. The new edition offers: 68 concise chapters including new entries on ADHD, Secondary Prevention, Challenges for Practitioners, and The Impact of Social Media on Mental Health. Updates across all chapters to make the content more in-line with contemporary critical debates in mental health, including new terminology and references to modern mental health services. A new contextualising introduction on the sticky subject of mental health terminology. Additional further reading examples and suggestions An essential guide for students of mental health studies, health, nursing, social work, psychology, counselling and psychotherapy.
Key Concepts in MIN - Intracerebral Hemorrhage Evacuation: Volume 1: Basics (Key-Concepts in MIN #1)
by Klaus Dieter ReschThis is the first of four volumes that together elaborate on an advanced minimally invasive neurosurgery (MIN) technique for cerebral hemorrhages, which makes it possible to prevent secondary injury by the hematoma and to preserve neurological function and accelerate neuropsychological recovery after the evacuation.It describes in detail the theoretical, technical and training procedures necessary to carry out successful intracerebral hemorrhage evacuations using MIN techniques. A combination of mouth-tracked microsurgery, neuro-sonography, neuro-endoscopy, LASER and sealing makes highly effective, minimally invasive evacuation of all types of hematomas possible. The MIN Key Concept, an advanced new model based on the Keyhole Concept and MIN techniques is also presented. Lastly, the scientific basics of MIN are discussed and summarized. A historical curriculum vitae is included in memory of the main pioneer of innovative MIN techniques, Prof. Axel Perneczky, to whom this book is dedicated.
Key Concepts in MIN - Intracerebral Hemorrhage Evacuation: Volume 2: Basics 2 (Key-Concepts in MIN #2)
by Klaus Dieter ReschThis book adds in chapter 1 and 2 the MIN-key techniques Laser and sealing, completing the 3 MIN-key techniques of the first volume. In chapter 3 the evolution of anatomy to a key-concept of MIN is described, presenting theory and reality of anatomical perspectives that can be used by the MIN-surgeon directly in the OR. Anatomy must be elaborated according to Gestalt-Theory to become a Key of MIN. Still anatomy is the "House of Medicine”, giving a mental place to all knowledge, theories and biological functions.The "surgical simulation concept" of chapter 4 as trainings environment follows, also as a key-concept of MIN. In this chapter we draw the line from Gestalt-Anatomy to a Surgical Simulation Application in Pathological Anatomy exemplified in aneurysm cases.Chapter 5 presents the best preservation technique of anatomical perishable matter, forming durable, dry and odorless specimen of unknown precision and beauty. The scientific value of this unique technique and the benefit for MIN are shown by many examples.With the Plastination gallery of chapter 6 the best head-plastinates and sheet-plastinates of head and brain complete the volume. Many of the specimen have been shown around the globe in the famous exhibitions “body worlds“ (Prof. Dr. G. v. Hagens/Inventor of Plastination).
Key Concepts in Nursing (SAGE Key Concepts series)
by Tom Mason Elizabeth Mason-Whitehead Annette Mcintosh-Scott Mrs Ann BryanNursing can be complex and challenging to new students and trainee practitioners. Key Concepts in Nursing provides a much needed guide to the central topics and debates which shape nursing theory, policy and contemporary practice. From assessment to ethics, and leadership to risk management, the book offers a comprehensive yet concise guide to the professional field. Each entry features: " a snapshot definition of the concept; " a broader discussion addressing the main issues and links to practice; " key points relevant to the entry; " case studies to illustrate the application to practice; " examples of further reading. Highly readable, with clear indexing and cross referencing, this is an ideal book for trainees to turn to for learning more about key issues in nursing practice and education. It meets the validation requirements of all training programmes and will also be invaluable for nurses continuing their professional education, those returning to practice and for mentoring.
Key Concepts in Nursing and Healthcare Research (SAGE Key Concepts series)
by Annette McIntosh-Scott Tom Mason Elizabeth Mason-Whitehead David CoyleResearch presents a dizzying array of terms and concepts to understand. This new book gives an overview of the important elements across nursing and health research in 42 short, straightforward chapters. Drawing on a range of perspectives from contributors with diverse experience, it will help you to understand what research means, how it is done, and what conclusions you can draw from it in your practice. Topics covered range from action research to systematic review to questionnaires. Every chapter includes a case study. It will be invaluable reading for nursing students at pre-registration level, undergraduate allied health students and for qualified practitioners needing a quick guide to the essentials. Annette McIntosh-Scott is Executive Dean in the Faculty of Health and Social Care at the University of Chester. Tom Mason was Professor and Head of Mental Health and Learning Disabilities at the University of Chester. Elizabeth Mason-Whitehead is Professor of Social and Health Care in the Faculty of Health and Social Care at the University of Chester. David Coyle is a Lecturer in the School of Healthcare Sciences at Bangor University.
Key Concepts in Palliative Care (Key Concepts (sage) Ser.)
by Moyra Baldwin Mrs Jan WoodhouseDo you need a succinct introduction to the key theories and principles of palliative care and their application to practice? Key Concepts in Palliative Care provides just this in a compact, fifty-concept guide to the field. Taking account of the government's "End of Life Care Strategy", contributors set out the key issues affecting practice across a range of health and social care contexts. The book covers topics ranging from dying and death to symptom management and spiritual care, backed up with practical examples. Each entry comprises: o a snapshot definition of the topic o key points o a discussion of the main debates o links to practice through thought-provoking case histories, and o suggestions for further reading. Key Concepts in Palliative Care is an ideal text and handy source of reference for health and social care professionals who are developing their knowledge and skills in palliative care.