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Introductory Textbook of Psychiatry (Fifth Edition)
by Donald W. Black Nancy C. AndreasenLearn more about psychiatric diagnosis and therapy.
Introduzione alla Meccanica dei Fluidi per Applicazioni Cardiovascolari
by Gianni Pedrizzetti Federico DomenichiniQuesto libro parte da una descrizione degli elementi fondamentali della meccanica dei fluidi nei grandi vasi sanguigni. A questo fine, viene introdotto un rigoroso background fisico accompagnato da esempi applicati alla circolazione, presentando risultati classici e sviluppi recenti relativi allo studio della dinamica sanguigna nella fisiologia cardiovascolare. Esplora poi argomenti più avanzati per una comprensione dei fenomeni, effettivamente riscontrati in cardiologia clinica, fondata sull’utilizzo delle leggi di conservazione della meccanica. Il testo si presenta come una risorsa di apprendimento ideale per fisici e ingegneri che si occupano di dinamica dei fluidi cardiovascolare, operatori nel settore delle tecnologie biomediche, studenti in biofluidodinamica. Il libro fornisce un filo conduttore tra i campi distanti della meccanica dei fluidi e della cardiologia clinica. Ben radicato nella teoria della dinamica dei fluidi, guida il lettore attraverso scenari progressivamente più realistici fino alla complessità delle applicazioni mediche di routine. Basato su oltre 25 anni di collaborazioni dell'autore con i cardiologi, aiuta gli ingegneri a imparare a comunicare con i clinici, mantenendo al contempo il rigore delle discipline scientifiche. Scritto in uno stile conciso, è un libro di testo accessibile a un ampio pubblico di lettori, tra cui studenti, fisici e ingegneri, offrendo un punto di ingresso a questo campo multidisciplinare. Include concetti chiave esemplificati da illustrazioni che utilizzano tecniche di analisi di immagini all'avanguardia e da riferimenti a metodi di modellazione e misurazione, e contiene intuizioni originali uniche.
Introvision bei Stress- und Angstbewältigung: Kurz-Manual für Psychotherapeuten, Coaches und Berater (essentials)
by Melanie Neumann Kathrin HeckMelanie Neumann und Kathrin Heck präsentieren die vielfältigen Möglichkeiten, die die verhaltenstherapeutisch orientierte Methode der Introvision Praktikern aus den Bereichen Psychotherapie, Coaching und Beratung bietet. Das essential vermittelt anschaulich, wie die Introvision bei stress- und angstassoziierten Erkrankungen angewendet werden kann, und zeigt, dass es sich dabei um eine wirksame Therapiemethode handelt, die problemlos mit anderen psychotherapeutischen Verfahren kombiniert werden kann. Zahlreiche Fallbeispiele, Arbeitsbausteine und Anleitungen ermöglichen eine einfache Umsetzung der Introvision in die Praxis.
Intubating the Critically Ill Patient: A Step-by-Step Guide for Success in the ED and ICU
by Rachel GarvinIntubating critically ill patients is a process that requires a well-thought-out, step-by-step plan, specific to each patient. This book teaches the steps necessary to predict, prepare, perform, and provide pre and post-intubation care. The focus of the book is not on how to intubate, but rather all the steps leading up to and after the tube goes in. From the EMS stretcher to the ICU bed, this book has easily accessible, practical information for these tenuous patients, and answers the who, what, where, when and how of airway management. Included are specific chapters on special patient populations outlining the process of intubating patients with neurologic injury, cardiovascular compromise, sepsis, trauma and those with obesity Intubating the Critically Ill Patient: A Step-by-Step Guide for Success in the ED and ICU is an essential resource for physicians, medical students, and allied health professionals in emergency medicine and intensive care settings.
Intuition in Medicine: A Philosophical Defense of Clinical Reasoning
by Braude Hillel D.Intuition is central to discussions about the nature of scientific and philosophical reasoning and what it means to be human. In this bold and timely book, Hillel D. Braude marshals his dual training as a physician and philosopher to examine the place of intuition in medicine. Rather than defining and using a single concept of intuitionOCophilosophical, practical, or neuroscientificOCoBraude here examines intuition as it occurs at different levels and in different contexts of clinical reasoning. He argues that not only does intuition provide the bridge between medical reasoning and moral reasoning, but that it also links the epistemological, ontological, and ethical foundations of clinical decision making. In presenting his case, Braude takes readers on a journey through AristotleOCOs "Ethics"OCohighlighting the significance of practical reasoning in relation to theoretical reasoning and the potential bridge between themOCothen through current debates between regulators and clinicians on evidence-based medicine, and finally applies the philosophical perspectives of Reichenbach, Popper, and Peirce to analyze the intuitive support for clinical equipoise, a key concept in research ethics. Through his phenomenological study of intuition Braude aims to demonstrate that ethical responsibility for the other lies at the heart of clinical judgment. aBraudeOCOs original approach advances medical ethics by using philosophical rigor and history to analyze the tacit underpinnings of clinical reasoning and to introduce clear conceptual distinctions that simultaneously affirm and exacerbate the tension between ethical theory and practice. His study will be welcomed not only by philosophers but also by clinicians eager to justify how they use moral intuitions, and anyone interested in medical decision making. a
Intuitive Acupuncture
by John HamweeThe role of intuition is seldom identified in acupuncture training as one of the keys to effective practice. John Hamwee here explores its paramount importance in diagnosis and treatment, showing how development of the intuitive sense, and its appropriate use in the treatment room, is vital to building the most effective individual practice. Through discussion of theory, clinical example, and the experiences of leading acupuncturists, the author shows how intuition, or the grasping of subliminal clues, can be developed, based on the practitioner's growing `storeroom' of clinical experience and why it is so useful for this to become a conscious and rigorously examined process. He discusses the process of testing intuition against objective observation of the patient, and how an intuitive leap can provide a shortcut across an innumerable series of diagnostic steps, and lead to diagnostic and treatment decisions that make complete sense of the observable phenomena. He suggests that learning to trust the intuitive faculty, while still fully interrogating conclusions, is the basis of better patient outcomes and significantly advanced practice. This thoughtful and engaging book will be one that acupuncturists will want to read and reread, and will speak to all therapists, counsellors, and health practitioners.
Intuitive Biostatistics: A Nonmathematical Guide to Statistical Thinking
by Harvey MotulskyIntuitive Biostatistics takes a non-technical, non-quantitative approach to statistics and emphasizes interpretation of statistical results rather than the computational strategies for generating statistical data. This makes the text especially useful for those in health-science fields who have not taken a biostatistics course before. <P><P> The text is also an excellent resource for professionals in labs, acting as a conceptually oriented and accessible biostatistics guide. With an engaging and conversational tone, Intuitive Biostatistics provides a clear introduction to statistics for undergraduate and graduate students and also serves as a statistics refresher for working scientists.
Inulin for Pharmaceutical Applications: A Versatile Biopolymer
by Neeraj Mishra Wasim Akram Tanweer HaiderThis book explores the different uses of inulin in pharmaceutical formulations, its potential therapeutic benefits, and the regulatory considerations involved in developing inulin-based pharmaceutical products. The book covers topics such as the physical and chemical properties of inulin, its use in drug delivery and controlled release systems, therapeutic applications in managing metabolic disorders, gastrointestinal disorders, immune function, bone health, and brain health, as well as the regulatory considerations involved in developing inulin-based pharmaceutical products. The book aims to provide a complete understanding of the various applications of inulin in the pharmaceutical industry, making it relevant and significant for pharmaceutical professionals seeking to develop new drugs and drug delivery systems. Additionally, it provides valuable information for researchers and scientists working on inulin-based treatments and formulations. It appears to be a comprehensive guide for scientists, researchers, and pharmaceutical professionals interested in understanding the various applications of inulin in the pharmaceutical industry.
Inulin-Type Fructans: Functional Food Ingredients (Modern Nutrition)
by Marcel RoberfroidInulin and oligofructose are naturally occurring resistant carbohydrates that have a variety of uses as functional food ingredients. In addition to their role as prebiotics that selectively stimulate the growth of beneficial bacteria in the intestines, these inulin-type fructans act as dietary fiber in the digestive system and have applications as
Invariant Measurement with Raters and Rating Scales: Rasch Models for Rater-Mediated Assessments
by Stefanie Wind George Engelhard Jr.The purpose of this book is to present methods for developing, evaluating and maintaining rater-mediated assessment systems. Rater-mediated assessments involve ratings that are assigned by raters to persons responding to constructed-response items (e.g., written essays and teacher portfolios) and other types of performance assessments. This book addresses the following topics: (1) introduction to the principles of invariant measurement, (2) application of the principles of invariant measurement to rater-mediated assessments, (3) description of the lens model for rater judgments, (4) integration of principles of invariant measurement with the lens model of cognitive processes of raters, (5) illustration of substantive and psychometric issues related to rater-mediated assessments in terms of validity, reliability, and fairness, and (6) discussion of theoretical and practical issues related to rater-mediated assessment systems. Invariant measurement is fast becoming the dominant paradigm for assessment systems around the world, and this book provides an invaluable resource for graduate students, measurement practitioners, substantive theorists in the human sciences, and other individuals interested in invariant measurement when judgments are obtained with rating scales.
Invariant Measurement: Using Rasch Models in the Social, Behavioral, and Health Sciences
by George Engelhard Jr.This introductory text describes the principles of invariant measurement, how invariant measurement can be achieved with Rasch models, and how to use invariant measurement to solve measurement problems in the social, behavioral, and health sciences. Rasch models are used throughout but a comparison of Rasch models to other item response theory (IRT) models is also provided. Written with students in mind, the manuscript was class tested to help maximize accessibility. Chapters open with an introduction and close with a summary and discussion. Numerous examples and exercises demonstrate the main issues addressed in each chapter. Key terms are defined when first introduced and in an end-of-text glossary. All of the book’s analyses were conducted with the Facets program. The data sets used in the book, sample syntax files for running the Facets program, Excel files for creating item and person response functions, links to related websites, and other material are available at www.GeorgeEngelhard.com. Highlights include: A strong philosophical and methodological approach to measurement in the human sciences Demonstrations of how measurement problems can be addressed using invariant measurement Practical illustrations of how to create and evaluate scales using invariant measurement A history of measurement based on test-score and scaling traditions Previously unpublished work in analyzing rating data, the detection and measurement of rater errors, and the evaluation of rater accuracy A review of estimation methods, model-data fit, indices used to evaluate the quality of rater-mediated assessments, rater error and bias, and rater accuracy. Intended as a supplementary text for graduate or advanced undergraduate courses on measurement or test theory, item response theory, scaling theory, psychometrics, advanced measurement techniques, research methods, or evaluation research taught in education, psychology, and the social and health sciences, the book also appeals to practitioners and researchers in these fields who develop or use scales and instruments. Only a basic mathematical level is required including a basic course in statistic.
Invariant Measurement: Using Rasch Models in the Social, Behavioral, and Health Sciences
by George Engelhard, Jr. Jue WangThis is the second edition of an introductory text that describes the principles of invariant measurement; how invariant measurement can be achieved using Rasch measurement theory; and how to use invariant measurement to solve a variety of measurement problems in the social, behavioral, and health sciences. Rasch models are used throughout the text, but brief comparisons of Rasch models to other item response theory (IRT) models are also provided.Written with students in mind, this new edition was class-tested to help maximize accessibility. Chapters open with an introduction and close with a discussion and summary. All chapters have been updated from the first edition, and a new chapter on explanatory Rasch models has been added. Features include numerous examples and exercises to demonstrate the main issues addressed in each chapter. Key terms are defined when first introduced and included in a helpful end-of-text glossary.This book also benefits from online materials which include the data sets used in the book, sample syntax files for running the Facets program, Excel files for creating item and person response functions, and links to related websites.This book will act as a supplementary text for graduate or advanced undergraduate courses on measurement or test theory, IRT, scaling theory, psychometrics, advanced measurement techniques, research methods, or evaluation research taught in education, psychology, and other social and health sciences. It will also appeal to practitioners and researchers in these fields who develop or use scales and instruments. Only a basic mathematical level is required, including a basic course in statistics, ensuring it is an accessible resource for students and researchers alike.
Invariant Natural Killer T-Cells: Methods and Protocols (Methods in Molecular Biology #2388)
by Chaohong LiuThis detailed book focuses on various aspects of Invariant Natural Killer T-Cells (iNKT), which are known to contribute to homeostasis and autoimmunity and can also cause various pathological responses such as allergy, infection, excessive autoimmune response, and cancer. The volume explores techniques for identification and isolation of iNKT cells, iNKT cell activation and transformation, as well as proliferation and differentiation and much more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Invariant Natural Killer T-Cells: Methods and Protocols is an ideal guide for researchers working with and studying iNKT cells, perhaps to provide a deeper knowledge of the human immune system.
Invariants of Behavior
by Mario NegrelloThe study of the brain and behavior is illuminated with the discovery of invariances. Experimental brain research uncovers constancies amidst variation, with respect to interventions and transformations prescribed by experimental paradigms. Place cells, mirror neurons, event related potentials and areas differentially active in fMRI, all illustrate the pervasive role of invariances in neural systems in relation to their function.
Invasion of the Body: Revolutions in Surgery
by Nicholas L. TilneyIn 1913, the Peter Bent Brigham Hospital in Boston admitted its first patient, Mary Agnes Turner, who suffered from varicose veins in her legs. The surgical treatment she received, under ether anesthesia, was the most advanced available at the time. At the same hospital fifty years later, Nicholas Tilney—then a second-year resident—assisted in the repair of a large aortic aneurysm. The cutting-edge diagnostic tools he used to evaluate the patient’s condition would soon be eclipsed by yet more sophisticated apparatus, including minimally invasive approaches and state-of-the-art imaging technology, which Tilney would draw on in pioneering organ transplant surgery and becoming one of its most distinguished practitioners. In Invasion of the Body, Tilney tells the story of modern surgery and the revolutions that have transformed the field: anesthesia, prevention of infection, professional standards of competency, pharmaceutical advances, and the present turmoil in medical education and health care reform. Tilney uses as his stage the famous Boston teaching hospital where he completed his residency and went on to practice (now called Brigham and Women's). His cast of characters includes clinicians, support staff, trainees, patients, families, and various applied scientists who push the revolutions forward. While lauding the innovations that have brought surgeons' capabilities to heights undreamed of even a few decades ago, Tilney also previews a challenging future, as new capacities to prolong life and restore health run headlong into unsustainable costs. The authoritative voice he brings to the ancient tradition of surgical invasion will be welcomed by patients, practitioners, and policymakers alike.
Invasion of the Prostate Snatchers: An Essential Guide to Managing Prostate Cancer for Patients and Their Families
by Ralph H. Blum Mark ScholzAn indispensable map through the medical minefield of prostate cancer, revised and updated with the latest developments in treatment options. Every year almost a quarter of a million confused and frightened American men are tossed into a prostate cancer cauldron stirred by salespeople representing a multibillion-dollar industry. Patients are too often rushed into a radical prostatectomy, a major operation that rarely prolongs life and more than half the time leaves them impotent. Invasion of the Prostate Snatchers argues that close monitoring—active surveillance rather than surgery or radiation—should be the initial treatment approach for many men at the low- and intermediate-risk stages. In a unique collaboration, doctor and patient provide a wholly new perspective on managing this disease. Ralph Blum&’s account of his personal struggle, together with Dr. Mark Scholz&’s presentation of new scientific advances, offers convincing evidence that this noninvasive approach can be crucial in preventing tens of thousands of men from being overtreated each year. This revised and updated second edition: -Highlights the latest prostate cancer treatment options that preserve erectile and urinary function while prolonging lifespan -Establishes updated protocol for how to accurately interpret high prostate-specific antigen (PSA) while avoiding the invasive, dangerous random biopsy -Recounts true patient stories that accurately represent the hurdles today&’s patients face while navigating a prostate cancer diagnosis -Introduces the latest evidence in the radiation vs. radical prostatectomy debate -Presents the latest thinking on diet and exercise for men with prostate cancer
Invasion of the Prostate Snatchers: No More Unnecessary Biopsies, Radical Treatment or Loss of Sexual Potency
by Ralph H. Blum Mark ScholzRadical prostatectomy is still the most widely recommended treatment for prostate cancer. Yet, according to a recent study, only one out of every forty-eight men who undergo this debilitating procedure survives longer than those who forgo surgery. Invasion of the Prostate Snatchers reports the latest thinking on prostate cancer management in clear, easy-to-understand prose. In a unique collaboration, a patient and his doctor provide a new perspective on living with this disease. Ralph Blum’s surprisingly entertaining twenty-year journey and eventual decision to treat his cancer as a “chronic condition,” together with Dr. Mark Scholz’s presentation of the newest scientific evidence, will liberate thousands of newly diagnosed men to pursue a noninvasive approach and thereby preserve normal sexual and urinary function.
Invasive Cardiology: A Manual for Cath Lab Personnel with Navigate Advantage Access
by Sandy Watson Kenneth A Gorski4 Stars from Doody's Book Review (on the Third Edition)! “It is excellent reading for students, healthcare professionals considering the cath lab as an adventure, as well as novice and expert cath lab professionals.” Completely revised and updated, the fourth edition of Invasive Cardiology: A Manual for Cath Lab Personnel, is written specifically for nurses, technologists, and allied health personnel working in the catheterization laboratory. Topics cover all aspects of the catheterization laboratory including cardiovascular anatomy, radiography, angiography, technical duties of the staff, right and left heart catheterization, PCI, invasive ultrasound, valvuloplasty, hemostasis, pediatric interventions, pharmacology, emergency procedures, and many others. Every new print copy includes Navigate Advantage Access that unlocks a complete, interactive eBook, student practice activities, learning analytics reporting tools, and more! Now focused on being a training and assessment resource rather than just a reference book, the book is divided into parts for better pedagogical organizationStunning 4-color graphics depicting anatomy, physiology, and invasive cardiology devices and proceduresEach chapter now includes learning objectives, summaries, relevant case studies, and self-assessment questionsUpdated to reflect the Society of Invasive Cardiovascular Professionals' (SICP) 2015 Educational Guidelines for Invasive Cardiovascular Technology Personnel in the Cardiovascular Catheterization LaboratoryIncludes information on endovascular treatment of pulmonary embolism New eBook available with additional online case studies Printable step-by-step procedures © 2023 | 625 pages
Invasive Diagnostics and Therapy (Advances in Experimental Medicine and Biology #1374)
by Mieczyslaw PokorskiThe book is an update on contentious or unsettled issues concerning invasive diagnostic and therapeutic challenges in cancer and related disorders, focusing on the surgical approach. Topics include recommendations for the best practice in using the surgery safety checklist, surgical strategies in a variety of thoracic cancers, renal cell carcinoma, tumors of parathyroid glands, mesothelioma, and bariatric surgeries. The focus is on the diagnostic and therapeutic challenges of aggressive cancerous entities, choosing the most beneficial modes for optimal outcomes and patient survival. Chapters also address radioimaging and therapy outcomes in different intracranial lesions leading to severe neurological disabilities. The areas of medical practice addressed are still veiled in uncertainty, yet-unresolved pathogenetic background, and have a substantial component of empirical rather than evidence-based clinical approach. Pursuing and sharing new ideas and innovations is essential for improving the management and outcome. The book endeavors to disseminate and deliberate on the latest medical knowledge, studies, and advancements in surgical and diagnostic dealing with cancer. The book is addressed to physicians and surgeons, and all allied health care professionals engaged in patient care and therapy.
Invasive Electrophysiology for Beginners
by Leon Iden Martin Borlich Philipp SommerWhat lies behind IAP, IVP, AH, HV, and LAVA? How can a SVT be differentiated through stimulation maneuvers? How is the mapping of complex arrhythmias achieved? The techniques of invasive electrophysiology are rapidly evolving and becoming increasingly sophisticated. This book explains the essential fundamentals of the field in an understandable manner, richly illustrated and with many practical tips. It specifically targets beginners who are seeking an overview of all aspects of invasive electrophysiology and wish to understand the connections. From the Content Electrophysiological mechanisms of cardiac arrhythmias Energy sources for ablation and their mechanisms of action Setup, puncture techniques, 3D mapping systems Diagnosis and therapy of cardiac arrhythmias, including typical and atypical atrial flutter, atrial fibrillation, idiopathic PVCs, VT in ischemic and non-ischemic cardiomyopathy Management of complications Practical Plus: Numerous video contributions on individual arrhythmias, mapping techniques, and diagnostic maneuvers, as well as a glossary with the most important technical terms
Invasive Elektrophysiologie für Einsteiger
by Leon Iden Martin Borlich Philipp SommerWas verbirgt sich hinter IAP, IVP, AH, HV und LAVA? Durch welche Stimulationsmanöver lässt sich eine SVT differenzieren? Wie gelingt das Mapping komplexer Arrhythmien? Die Techniken der invasiven Elektrophysiologie entwickeln sich rasant und werden immer anspruchsvoller. Das Buch erklärt verständlich formuliert, reich bebildert und mit vielen Tipps für die Praxis die wesentlichen Grundlagen des Faches. Dargestellt werden die technischen, apparativen und logistischen Voraussetzungen elektrophysiologischer Eingriffe, ebenso wie die anatomischen Grundlagen, die Diagnostik und Therapie der einzelnen Herzrhythmusstörungen. Besonderes Highlight sind Filmbeiträge zu einzelnen Arrhythmien, Mappingtechniken und diagnostischen Manövern. Das Buch wendet sich explizit an Einsteiger, die einen Überblick zu allen Aspekten der invasiven Elektrophysiologie suchen und Zusammenhänge verstehen möchten.
Invasive Fungal Rhinosinusitis
by Gauri MankekarIncidence of invasive fungal sinusitis has been increasing over the years. The understanding of its pathophysiology has improved with newer serological tests and diagnostic methods helping in earlier diagnosis and reducing patient morbidity. It was believed earlier that invasive fungal sinusitis is seen only in immune compromised patients but clinical reports suggest otherwise. More anti-fungal drugs are being added to improve incidence of patient survival. This book aims to compile all practical information about invasive fungal sinusitis into a single volume. Therefore, busy clinicians would not have to perform exhaustive literature studies to diagnose invasive fungal sinusitis. The book aims to provide an overview of diseases which could be mistaken for invasive fungal sinusitis and discuss how the management is different. Book sections consist of clinical, microbiological, serological, pathological, radiological and pharmacological features of the disease and its management. Each section is important in today's context as it dynamically alters the management of the patient. Early clinical suspicion and rapid microbiological, pathological and radiological diagnosis with aggressive treatment with surgical debridement and medical therapy leads to favorable outcomes.
Invasomes as Drug Nanocarriers for Innovative Pharmaceutical Dosage Forms
by Nina DragićevićThis book details the novel nanocarriers named 'invasomes" and how they are used for dermal and transdermal drug delivery. The text describes their composition, usage of skin as a drug delivery route and liposomes as skin delivery systems. Included are reviewed studies revealing the importance of invasomes in this field.
Inventing Disease and Pushing Pills: Pharmaceutical Companies and the Medicalisation of Normal Life
by Jörg BlechThis is a highly accessible and reassuring account of how the pharmaceutical industry is redefining health, making it a state that is almost impossible to achieve. Many normal life processes – states as natural as birth, ageing, sexuality, unhappiness and death – are systematically being reinterpreted as pathological so creating new markets for their treatments. In this enlightening book, Jörg Blech reveals:how the invention of diseases by pharmaceutical companies is turning us all into patients, and how we can protect ourselves against this how the medical profession has been bullied and co-opted into endorsing profitable cures for people who aren't illfears about how pharmaceutical companies create markets by playing on the general public's concern with their health.A self-help book in the truest sense, Inventing Disease and Pushing Pills reassures us about our own health. It is essential reading for doctors, nurses and patients alike.
Inventing the Thrifty Gene: The Science of Settler Colonialism
by Travis HayThough First Nations communities in Canada have historically lacked access to clean water, affordable food, and equitable health care, they have never lacked access to well-funded scientists seeking to study them. Inventing the Thrifty Gene examines the relationship between science and settler colonialism through the lens of “Aboriginal diabetes” and the thrifty gene hypothesis, which posits that Indigenous peoples are genetically predisposed to type 2 diabetes and obesity due to their alleged hunter-gatherer genes. Hay’s study begins with Charles Darwin’s travels and his observations on the Indigenous peoples he encountered, setting the imperial context for Canadian histories of medicine and colonialism. It continues in the mid-twentieth century with a look at nutritional experimentation during the long career of Percy Moore, the medical director of Indian Affairs (1946–1965). Hay then turns to James Neel’s invention of the thrifty gene hypothesis in 1962 and Robert Hegele’s reinvention and application of the hypothesis to Sandy Lake First Nation in northern Ontario in the 1990s. Finally, Hay demonstrates the way in which settler colonial science was responded to and resisted by Indigenous leadership in Sandy Lake First Nation, who used monies from the thrifty gene study to fund wellness programs in their community. Inventing the Thrifty Gene exposes the exploitative nature of settler science with Indigenous subjects, the flawed scientific theories stemming from faulty assumptions of Indigenous decline and disappearance, as well as the severe inequities in Canadian health care that persist even today.