- Table View
- List View
It's All Analytics, Part III: The Applications of AI, Analytics, and Data Science
by Gary Miner Scott BurkProfessionals are challenged each day by a changing landscape of technology and terminology. In recent history, especially the last 25 years, there has been an explosion of terms and methods born that automate and improve decision-making and operations. One term, called "analytics," is an overarching description of a compilation of methodologies. But artificial intelligence (AI), statistics, decision science, and optimization, which have been around for decades, have resurged. Also, things like business intelligence, online analytical processing (OLAP) and many, many more have been born or reborn. How is someone to make sense of all this methodology, terminology? Extending on the foundations introduced in the first book, this book illustrates how professionals in healthcare, business, and government are applying these disciplines, methods, and technologies. The goal of this book is to get leaders and practitioners to start thinking about how they may deploy techniques outside their function or industry into their domain. Application of modern technology into new areas is one of the fastest, most effective ways to improve results. By providing a rich set of examples, this book fosters creativity in the application and use of AI and analytics in innovative ways.
It's All in Your Mouth: Biological Dentistry and the Surprising Impact of Oral Health on Whole Body Wellness
by Dominik NischwitzThe future of medicine—and the key to a healthier life—starts in your mouthAmerican dentists are beginning to discover what some of their European counterparts have long understood: Many common chronic conditions—obesity, inflammation, stroke, diabetes, Alzheimer&’s, heart disease, and cancer, among others—often have their origins in the mouth. In a groundbreaking new work, German dentist Dr. Dominik Nischwitz presents the principles of biological dentistry along with emerging scientific research on the mouth&’s vital role in the body&’s microbiome—a key to whole body wellness.Challenging conventional dental wisdom that views the teeth as separate from the rest of the body, and conventional dental practices that often cause more harm than good, It&’s All in Your Mouth delivers:The latest research on the microbiome and the mouthCritical information on the dangers of root canals and amalgam fillingsThe important role of nutrition in oral health and hygieneA clarion call for a new approach to dentistrySensible, holistic, and humane, It&’s All in Your Mouth offers a necessary new approach to natural immunity to chronic disease and integrating dental hygiene into whole body health.
It's Just Nerves: Notes on a Disability
by Kelly DavioWith equal parts wit and empathy, lived experience and cultural criticism, Kelly Davio's It's Just Nerves: Notes on a Disability explores what it means to live with an illness in our contemporary culture, whether at home or abroad. "When the body attacks itself, the crisis is not just of bones and blood, but of beauty and boundaries. 'Strange men have had their hands on me for days, ' Kelly Davio observes during a plasma treatment. Her skillful portrait of myasthenia gravis does not exist in a vacuum. It's Just Nerves is in keen dialogue with the world around us--critiquing modern health care, pub seating etiquette, alarming election outcomes, smarmy meditation culture, and caricatures of illness in ads and on screen. 'Oxygen is delicious, ' Davio reminds us, before the fire breaks out. A brisk, funny, and at times startlingly poetic memoir." --Sandra Beasley, author of Don't Kill the Birthday Girl: Tales from an Allergic Life. "Kelly Davio's It's Just Nerves feels like the book I've been waiting for all my life. If you want to know what it feels like to be a person with a disability in the 21st century, read this book. From mindfulness to yoga pants, Davio skewers ableist fabrications and brings us to a vital, ebullient, and sometimes terrifying reckoning with our real and shared human experience. She is a very funny writer and also a fearless one. Once I started reading these essays, I couldn't put them down; they resounded through me like poetry or truth." --Sheila Black, author of House of Bone and Love/Iraq. "Kelly Davio's got so much incredible stuff brewing together on every page of these nimble, shapeshifting essays: meditations on the politics of illness, the body in crisis, the spirit in bloom, David Bowie--all of it filtered, carefully, through the lithe sensibility of a poet. The results are equal parts witty and wise, heartrending and rapturous. Man, I loved this book." --Mike Scalise, author of The Brand New Catastrophe.
It's Not About the Hair: And Other Certainties of Life and Cancer
by Debra JarvisDebra Jarvis works as a chaplain supporting patients at Seattle's Cancer Care Alliance (the clinic founded by the world-famous Fred Hutchinson Cancer Research Institute). In that capacity she meets daily with patients in at many points along the path of living with cancer, from diagnosis to treatment to recovery and facing death. So in one of those ironic twists of fate, Jarvis was diagnosed with breast cancer herself. It's Not About the Hair is the account of her time with cancer. As she says, the first thing people ask when they learn you have cancer is whether you are going to lose your hair. But what they really mean to ask is whether you are going to lose your life. Debra Jarvis is able to write honestly and humorously about her experience with cancer because she has had the unique experience of having witnessed and having guided so many cases of cancer. And she brings all of that perspective and context and wisdom to the story of her own breast cancer. As an ordained minister she considers her voice to be a combination of Mr. Miyagi from The Karate Kid" and Martha Stewart (pre-felon, that is), a persona she labels Mr. Martha Miyagi. It's mystical and practical. Debra Jarvis manages to channel a humor that is reminiscent of Nora Ephron. This is a cancer story that won't give you the creeps, but it will guide you to think deeply about the serious stuff like ingrained views on health and disease, life and death, the time we have and how we want to live it.
It's Not All in Your Head
by Steven Taylor Gordon AsmundsonWhere do you go for help when no one believes you're really sick? The doctors can't explain your symptoms, but you know there's something wrong because you can sense it in your body. Living with the specter of an unresolved health issue isn't just painful, it's isolating. The preoccupation and stress it causes can disrupt your career or interfere with personal relationships. If you continually experience symptoms of illness, or worry a lot about disease, you may be suffering from health anxiety--a condition that can produce physical effects of its own, including muscle tension, nausea, and a quickened heart rate. In this compassionate and empowering book, noted psychologists Gordon J. G. Asmundson and Steven Taylor provide simple and accurate self-tests designed to help you understand health anxiety and the role it might be playing in how you feel. Concrete examples and helpful exercises show you how to change thought and behavior patterns that contribute to the aches, pains, and anxiety you're experiencing. The authors also explain how to involve friends and family--and when to seek professional help--as you learn to stay well without worry.
It's Not Yet Dark: A Memoir
by Simon FitzmauriceAn international bestselling memoir about an Irishman who chose to live life to the fullest after his diagnosis of ALS.In 2008, Simon Fitzmaurice was diagnosed with Lou Gehrig&’s disease. He was given four years to live. In 2010, in a state of lung-function collapse, Simon knew with crystal clarity he was not ready to die. Against all prevailing medical opinion, he chose life. Despite the loss of almost all motor function, thanks to miraculous technology, he continued to work, raise his five children, and write this astonishing memoir. It&’s Not Yet Dark is a journey into a life that, though brutally compromised, was lived more fully than most, revealing the potent power of love, of art, and of the human spirit. Written using an eye-gaze computer, this is an unforgettable book about relationships and family, about what connects and separates us as people, and, ultimately, about what it means to be alive.International Bestseller A Barnes & Noble Discover Pick A Barnes & Noble Best Biography of the Year An iBooks Best Book of the MonthAn Amazon Best Memoir of the Month&“A fiercely eloquent testament to making the most out of every moment we&’re given.&”—People, Book of the Week &“Vibrant.&”—Minneapolis Star Tribune&“Beautifully written. Utterly life-affirming.&”—Alan Rickman &“A beautiful love story—in its essence that's what this is. Survival stories are not about surviving, they're inherently about what makes a survivor push through. A desire to remain in the light of all creation, even as a darkening is taking place. A darkening which happens to us all.&”—Colin Farrell
It's Not Your Fault!
by Dr Joseph BaroneMillions of children over the age of five wet their beds every night. Many parents think they must be doing something wrong when their five-year-old is still in diapers while their friends' children are perfectly trained by eighteen months of age. This undoubtedly is a very embarrassing and frustrating problem for both the parent and child, and can interfere with family dynamics and a child's ability to enjoy ordinary social situations. It's Not Your Fault! offers evidence-based strategies for parents who need assistance with toilet training and helping their child with urinary control issues. Dr. Joseph Barone, M.D., provides proven techniques that bring bedwetting to a happy conclusion. Frequently, parents are misguided by bad advice from friends, TV talk shows, the Internet, or parenting books. With many years of clinical experience, Dr. Barone shares valuable, practical information for parents to guide them through the basics of toilet training and bedwetting, and presents management plans to resolve any difficulties that occur. A comprehensive guide, this book covers everything parents need to know about normal toilet training and bedwetting, as well as step-by-step solutions based on testing and research in a real-world setting to help children suffering from delayed toilet training, bed wetting, and daytime urinary wetting.It's Not Your Fault! provides hope and guidance to those desperate to help their children overcome urinary control and toilet training problems. Dr. Barone sets parents on a course that makes things better for both themselves and their children.
It's Okay to Laugh: (Crying Is Cool Too)
by Nora McInerny Purmort“Thank you for the perfect blend of nostalgia-drenched humor, wit, and heartbreak, Nora.” — Mandy Moorecomedy = tragedy + time/roséTwenty-seven-year-old Nora McInerny Purmort bounced from boyfriend to dopey “boyfriend” until she met Aaron—a charismatic art director and comic-book nerd who once made Nora laugh so hard she pulled a muscle. When Aaron was diagnosed with a rare form of brain cancer, they refused to let it limit their love. They got engaged on Aaron’s hospital bed and had a baby boy while he was on chemo. In the period that followed, Nora and Aaron packed fifty years of marriage into the three they got, spending their time on what really matters: Buffy the Vampire Slayer, each other, and Beyoncé. A few months later, Aaron died in Nora’s arms. The obituary they wrote during Aaron’s hospice care revealing his true identity as Spider-Man touched the nation. With It’s Okay to Laugh, Nora puts a young, fresh twist on the subjects of mortality and resilience. What does it actually mean to live your “one wild and precious life” to the fullest? How can a joyful marriage contain more sickness than health? How do you keep going when life kicks you in the junk? In this deeply felt and deeply funny memoir, Nora gives her readers a true gift—permission to struggle, permission to laugh, permission to tell the truth and know that everything will be okay. It’s Okay to Laugh is a love letter to life, in all its messy glory; it reads like a conversation with a close friend, and leaves a trail of glitter in its wake.This book is for people who have been through some shit.This is for people who aren’t sure if they’re saying or doing the right thing (you’re not, but nobody is). This is for people who had their life turned upside down and just learned to live that way. For people who have laughed at a funeral or cried in a grocery store. This is for everyone who wondered what exactly they’re supposed to be doing with their one wild and precious life. I don’t actually have the answer, but if you find out, will you text me?
It's Only Temporary
by Evan HandlerWhat if you were supposed to die, but you didn't? And what if, years later, your precious second chance didn't turn out anything like you thought it would? That's the journey Evan Handler experiences, and the one he explores in It's Only Temporary: The Good News and the Bad News of Being Alive. In a collection of funny, offbeat, and poignant autobiographical essays, Handler moves beyond the supposedly "incurable" illness he triumphed over in his mid-twenties--only to tumble through his thirties and forties in search of ever elusive love and happiness.From bold attempts to rekindle his acting career to hapless efforts to run faster around New York's Central Park reservoir, from bizarre Internet dates to twenty-seven breakups (involving only ten women), Handler careens through his against-all-odds existence. Always searching for meaning in his unlikely survival, he shares stories of sadistic junior high school gym teachers, bullying wannabe Hollywood moguls, returned engagement rings, and Europeans' fascination with American bathroom habits.Picking up ten years after his first book, Time on Fire, Handler again uses what the New York Times calls his "laceratingly funny and revealing" storytelling skills to weave twenty-one new tales into a defiantly unconventional memoir. Consistently witty and insightful, Handler's stories shift effortlessly from the comedic to the profound, musing with equal intensity on the existence of God and his experiences with TV stardom. Then, just when it seems he's failed to make the most of his astonishing second chance, Handler finds his way to miracles even greater than the ones that saved his life. His memoir describes his journey from darkness to light, from yearning to gratitude, and in so doing succeeds as both a stirring love story and a classic coming-of-age tale. It's Only Temporary celebrates the transformation of a boy to man--even if it look Handler more than forty years to get there.
It's Probably Nothing
by Beach CongerIt's Probably Nothing continues the tale woven by Dr. Beach Conger in his first book, Bag Balm and Duct Tape. This new collection sees Conger and his wife yearning for new challenges and relocating to the suburbs of Philadelphia after 25 years in mythical Dumster, Vermont. Conger gamely takes a job in a teaching hospital in the poorest part of the city and gets to experience urban bureaucratized medicine and its trials-a far cry from the more idiosyncratic and hands-on version he practiced in Vermont. After 5 years Conger and his wife move back to Dumster, where he rediscovers more about his patients' capacity to both cope and cherish one another than he expected. Each of the tightly constructed chapters is centered around a particular patient or particular theme in medicine. It's Probably Nothing is both funny and poignant, and showcases both Conger's irreverent view into medicine and his profound empathy for the characters he encounters along the way. His experience highlights how medicine-and problems with our current medical system-can remain the same and yet be vastly different across class, race, and region. Among the people the reader meets are urban drag queens, small-town farmers and other heroes, Vermont celebrities, and the occasional reclusive author.
It's Probably Nothing...*
by Micki MyersDaring, sly, and unlike any other book you've read, this memoir-in-poems tackles cancer with a bawdy wit guaranteed to make you laugh your wig off.As a vibrant woman in her early forties, mother of two, poet, artist, and teacher, Micki Myers decided to confront her cancer diagnosis head on with the sharpest tools in her arsenal: namely, her sense of humor and unbridled poetic license. The result is a charming, poignant, laugh-out-loud collection that hits all the highs (morphine) and lows (everything else) of being a cancer patient and surviving with your spirit intact (even if your boobs are not). It's Probably Nothing... is the perfect gift for a friend in crisis, providing laughter, wisdom, and much-needed perspective. From losing your hair (even, ahem, down there) and gaining two bouncy silicone strangers, to the pitfalls of marijuana therapy and the endless chemo-room muzak "that makes you think/survival might be overrrated," Myers reminds you that you're not alone and that it's okay to laugh.
It's Probably Nothing: The Stress-Less Guide to Dealing with Health Anxiety, Wellness Fads, and Overhyped Headlines
by Casey GuerenFrom stress-induced symptom searching and "miracle cures" to the wellness fads filling your social media timeline, health journalist Casey Gueren digs into why we're so anxious about our health and how to separate medical facts from fiction. Surrounded by &“health hacks&” and clickbait headlines, it&’s easy to feel overwhelmed and underprepared when it comes to taking care of your health. But despite what the wellness industry told you, you don&’t need another cleanse, detox, or supplement—you need a crash course in separating hype from health.In It's Probably Nothing you&’ll find a health journalist&’s tools and tips to. . . Fine-tune your B.S. detector and spot the wellness industry&’s sneaky tricksGet answers to your health questions without spiraling down search holesManage health stress and learn to listen to your body (just enough)Decode the latest overhyped health headlinesFind compassionate, evidence-based care that works for youAnd so much more Packed with illuminating information, funny personal anecdotes, concrete strategies for coping, quotes from dozens of medical experts, and a foreword by New York Times-bestselling author of The Vagina Bible Dr. Jen Gunter, this book is the perfect companion for navigating our wellness-obsessed world with a little less stress and a lot more information.
Italian Consensus for the Classification and Reporting of Thyroid Cytology
by Lucio Palombini Fulvio Basolo Anna Crescenzi Guido Fadda Andrea Frasoldati Francesco Nardi Enrico Papini Alfredo PontecorviThis updated edition of the Italian Consensus for Classification and Reporting of Thyroid Cytology (ICCRTC) integrates the evolution in the field of thyroid pathology and the new approaches in the management of thyroid diseases. The five categories defined in the 2014 Consensus edition, with the separation of indeterminate nodules into TIR3A and TIR3B subcategories, are retained due to their effective stratification of malignancy risk. The 2024 Consensus update has been developed by pathologists and endocrinologists with recognised expertise in thyroid disease and has been endorsed by their respective scientific societies: Società Italiana di Anatomia Patologica e Citologia Diagnostica (SIAPeC-IAP), Associazione Italiana Tiroide (AIT), Associazione Medici Endocrinologi (AME), Società Italiana di Endocrinologia (SIE). This book includes chapters on sampling techniques, ultrasound imaging, molecular testing, oncocytes and translatability between major reporting systems. Enhanced with videos of WSI from cytology slides explaining morphological criteria for category selection, and with interactive self-assessment flashcards, this book will help pathologists to report thyroid cytology diagnoses, and endocrinologists to correctly interpret cytology reports for patient management.
Italian Doctor, Full-Time Father
by Dianne DrakeDante has never shied away from a challenge, but winning Catherine back will be the greatest he's ever faced... Dr. Catherine Brannon knows her cool reserve will be tested by her new patient, surgeon-turned-racing-driver Dante Baldassare--her ex-fiance! Dante the sports star is reputed to enjoy fast cars and fast women. But Dante the father, devoted to a small boy, is a different story indeed. Family means everything to Dante--which is why he became a single dad to his orphaned nephew, and lost Catherine in the process. Despite their past, passion sizzles between them, and Dante realizes they have something too precious to lose again. If this is a second chance, he'll stop at nothing to win back Catherine's love.
Italian Doctor, Sleigh-Bell Bride
by Sarah MorganUSA Today–Bestselling Author: A dream date with a doctor makes her feel like a princess—but is true love just a fairy tale for an overworked single mom?Liv Winchester has avoided men and sex since her ex left her with a baby. But new, wealthy trauma consultant Stefano Lucarelli is stunned by her curves and natural nursing talent.Stefano wants to make this overworked single mom feel like the beautiful woman she is again. He gives her two tickets to the Snow Ball, pampering treatments, a designer dress, diamonds, and a babysitter for the night . . . and Liv feels like a princess.Their Snow Ball date is magical. But it’s going to take even more to convince Liv that she’s ready to be Stefano’s for real . . . Praise for the novels of Sarah Morgan“Sweet, sexy and emotionally layered.” —Kirkus Reviews“Morgan masterfully introduces a cast of endearing supporting characters. This touching Christmas tale will [remain] a reader favorite for years to come.” —Publishers Weekly (starred review)
Italian Surgeon to the Stars
by Melanie Milburne"You think you can erase what we had?" Celebrity heart surgeon Dr. Alessandro Lucioni might be gorgeous, but I will never forget what we shared in Paris five years ago...or how he broke my heart! And now he's standing in front of me, asking for my help with his young niece-and determined to pick up where we left off! But this time I won't be his consolation prize. I will remain strong. Yet with memories of those magical blazing nights swirling through my mind, he's just so very hard to resist...
Itch and Pain: Similarities, Interactions, and Differences
by Gil Yosipovitch Lars Arendt-Nielsen Hjalte AndersenProviding for the first time a comprehensive overview of the common and different pathways and mechanisms of itch and pain, this unique title explores these two distinct and still somehow similar sensory experiences and utilize the cross-fertilization between the two fields to develop better treatments for patients. Itch and Pain: Similarities, Interactions and Differences is the only available, up-to-date guide to current information in this important area, ideal for basic scientists as well as clinicians in dermatology, pain, neurology, medicine, psychology, or other specialties.
Itch: Basic Mechanisms and Therapy (Basic and Clinical Dermatology)
by Gil Yosipovitch Francis McGlone Malcolm W. GreavesOffering details on the pharmacology of itch, techniques of itch evaluation, and neurogenic itch, this reference presents new concepts in the neurophysiology and central mechanisms of itch, animal models of itch, and processing of histamine itch in the human cerebral cortex. The text clarifies itch in systemic and skin disease, exploring renal itch
Itch: Mechanisms and Treatment (Frontiers in Neuroscience)
by E. Carstens Tasuku AkiyamaAdvances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direc
Item Writing for Nurse Educators
by Vicki MoranThe book provides guidance and direction for any nurse educator teaching in the professional environment and must write questions to evaluate learning. It covers the basics of item writing and leveling of items using Bloom's taxonomy to the learner. In addition, the book provides stem examples and new types of questions expected on the National Council Licensure Examination for both the registered and practical nurse. Finally, case study development and item analysis are presented.Evaluation of student performance by examination is critical in nursing education, from undergraduate to continuing education programs. Many faculty have reported learning the item writing process in graduate programs, but it is often lost or not reused. Recent research reports nursing faculty using textbook questions that have not been validated and security of the questions have been compromised. A nursing education profession should have the ability to develop items to validate that learning has occurred. The skill is essential to any professional to evaluate the effectiveness of learning.Critical thinking is a skill necessary for licensure examinations, and students often need assistance to learn this skill to pass the licensure examination and practice as a nurse. Therefore, faculty need a source to facilitate their development of the learned item writing process to assist learners and prepare them for practice.This book is unique in that it addresses the basics and the advanced components. In addition, the book provides a substantial list of stems and case study ideas. Finally, the book describes how to use a knowledge-based item and develop an item to a higher level of Blooms' taxonomy and assists those nursing programs that educate international students to adequately prepare for the student to pass the national licensing examination required to practice in the US and Canada.
Iterative Learning Control for Electrical Stimulation and Stroke Rehabilitation
by Chris T. Freeman Eric Rogers Jane H. Burridge Ann-Marie Hughes Katie L. MeadmoreIterative learning control (ILC) has its origins in the control of processes that perform a task repetitively with a view to improving accuracy from trial to trial by using information from previous executions of the task. This brief shows how a classic application of this technique - trajectory following in robots - can be extended to neurological rehabilitation after stroke. Regaining upper limb movement is an important step in a return to independence after stroke, but the prognosis for such recovery has remained poor. Rehabilitation robotics provides the opportunity for repetitive task-oriented movement practice reflecting the importance of such intense practice demonstrated by conventional therapeutic research and motor learning theory. Until now this technique has not allowed feedback from one practice repetition to influence the next, also implicated as an important factor in therapy. The authors demonstrate how ILC can be used to adjust external functional electrical stimulation of patients' muscles while they are repeatedly performing a task in response to the known effects of stimulation in previous repetitions. As the motor nerves and muscles of the arm reaquire the ability to convert an intention to move into a motion of accurate trajectory, force and rapidity, initially intense external stimulation can now be scaled back progressively until the fullest possible independence of movement is achieved.
J Wave Syndromes
by Charles Antzelevitch Gan-Xin YanThis book delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs to be directed. It covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics. J wave syndromes are one of the hottest topics in cardiology today. Cardiac arrhythmias associated with Brugada syndrome (BrS) or an early repolarization (ER) pattern in the inferior or infero-lateral ECG leads are thought to be mechanistically linked to accentuation of transient outward current (Ito)-mediated J waves. Although BrS and ER syndrome (ERS) differ with respect to magnitude and lead location of abnormal J waves, they are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. ERS is divided into three subtypes with the most severe, Type 3, displaying an ER pattern globally in the inferior, lateral and right precordial leads. BrS has been linked to mutations in 19 different genes, whereas ERS has been associated with mutations in 7 different genes. There is a great deal of confusion as to how to properly diagnose and treat the J wave syndromes as well as confusion about the underlying mechanisms. The demonstration of successful epicardial ablation of BrS has provided new therapeutic options for the management of this syndrome for which treatment alternatives are currently very limited, particularly in the case of electrical storms caused by otherwise uncontrollable recurrent VT/VF. An early repolarization pattern is observed in 2-5% of the US population. While it is clear that the vast majority of individuals exhibiting an ER pattern are not at risk for sudden cardiac death, the challenge moving forward is to identify those individuals who truly are at risk and to design safe and effective treatments.
JAK-STAT Signaling in Diseases
by Ritobrata GoswamiJAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis. Features: Details activation and microRNA-mediated regulation of JAK-STAT pathway Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway. An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.
JFK's Secret Doctor: The Remarkable Life of Medical Pioneer and Legendary Rock Climber Hans Kraus
by Susan E.B. SchwartzSet against the grand panorama of twentieth-century world events, it captures the remarkable life and spirit of climbing and medical visionary Hans Kraus (1905-1966). Kraus was taught English by James Joyce, escaped Nazi dominated Europe, and was JFK’s secret back specialist. A legendary rock climber known for hair-raising ascents on two continents, Kraus lived a life filled with tragedy and triumph, intense passion, verve, and a whole lot of guts, glory, and wit. One of the great unsung medical pioneers of the twentieth century, Kraus made headline news throughout the second half of the 1950s, was a guest of honor at Eisenhower’s White House, and was the subject of cover stories in major magazines throughout America, including Sports Illustrated. His pioneering work in muscles and fitness uncovered a shocking truth about a lack of fitness in American children, and his work curing back pain brought him into the Kennedy White House and inner circle of Camelot. Here now is the life of Hans Kraus, including the behind-the-scenes story of Kennedy’s crippling back problems, based on new documentation, including White House medical records and interviews with two Kennedy White House doctors. Skyhorse Publishing, as well as our Arcade imprint, are proud to publish a broad range of books for readers interested in history--books about World War II, the Third Reich, Hitler and his henchmen, the JFK assassination, conspiracies, the American Civil War, the American Revolution, gladiators, Vikings, ancient Rome, medieval times, the old West, and much more. While not every title we publish becomes a New York Times bestseller or a national bestseller, we are committed to books on subjects that are sometimes overlooked and to authors whose work might not otherwise find a home.
JIMD Reports - Case and Research Reports, 2011/2
by SsiemJIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.