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Leukemia
by Chi Wai SoRecent advances in molecular and cellular biology techniques have significantly improved our ability to detect, monitor, model and study the underlying molecular basis and pathogenesis of leukemia, yet we are still in an early discovery stage and much more work is needed in order to develop better strategies to diagnose, classify and treat this biologically and clinically diverse disease. In Leukemia: Methods and Protocols, expert researchers bring together a wide range of state-of-the-art laboratory methods and detailed protocols that are useful for both clinical and basic research scientists working on the disease. The volume provides techniques for prenatal backtracking of leukemic clone, molecular diagnosis, detection of genome-wide genetic abnormalities and profiling, identification of unknown fusion genes, monitoring of minimal residual diseases, disease modeling using murine and human primary hematopoietic cells, studying of normal and malignant hematopoiesis, identification of interacting partners with leukemia associated oncoproteins, and global characterization of genome-wide epigenetic changes in leukemic cells. Written in the highly successful Methods in Molecular BiologyTM series format, the convenient chapters contain brief introductions, lists of the necessary materials, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Leukemia: Methods and Protocols will help researchers to advance knowledge and have a better understanding of the disease, which will ultimately facilitate development of anti-cancer therapy and improve quality of life for patients.
Leukemia Stem Cells in Hematologic Malignancies (Advances in Experimental Medicine and Biology #1143)
by Shaoguang Li Haojian ZhangThis book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.
Leukemia Stem Cells: Methods and Protocols (Methods in Molecular Biology #2185)
by César Cobaleda Isidro Sánchez-GarcíaThe detailed volume aims to provide a comprehensive hands-on manual covering all the techniques involved in the cellular and molecular identification and characterization of both normal hematopoietic and leukemic stem cells, both from human patients and from mouse models of human leukemia. The book also covers the most frequently used experimental approaches for the generation of such stem cell-based models of human leukemia. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Leukemia Stem Cells: Methods and Protocols serves as an ideal guide for researchers, both expert and novice, seeking to further our knowledge of this vital avenue of cancer research.
Leukemia and Related Disorders
by Fred R. Appelbaum Elihu H. EsteyFrom the world renowned Fred Hutchinson Cancer Research Center, this book is written for all physicians who treat patients with acute or chronic leukemias or myelodysplasia. It is designed to answer questions about treatment approaches that commonly arise in day-to-day practice. In keeping with the Center's groundbreaking research in bone marrow transplantation, the book provides exceptional coverage of the role of allogeneic transplant in treatment. It also addresses the important issues of supportive care and long-term complications of successful treatment. *Edited and written by experts at the Fred Hutchinson Cancer Research Center *Clinically focused and comprehensive coverage of treatment approaches *Allogeneic transplant addressed in detail *Separate chapters on supportive care and long-term complications
Leukemias
by Stefan Faderl Hagop KantarjianEdited by experts from one of the world's largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials.Topics include:Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors)Ras inhibitorsEpigenetic therapy (hypomethylaters and histone deacetylase inhibitors)Lenalidomide analogsNew chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesineCombinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib)New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40)Thrombopoietic agentsLeukemias: Principles and Practice of TherapyIncludes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory diseaseIncorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area
Level 4: Virus Hunters of the CDC
by Joseph Mccormick Leslie A. Horvitz Susan Fisher-Hoch"Sublimely equipped to survive, to propagate, to conquer, the virus is neither really alive nor really dead. Its dimensions are measured in molecules. It attacks by dismantling its human targets cell by cell." "Level 4: Virus Hunters of the CDC is an intense, personal account of more than a quarter-century on the front lines - in the ultra high-tech "hot zone" lab that McCormick was instrumental in creating at the Centers for Disease Control headquarters in Atlanta, as well as in the most primitive places on the planet, where the local climate, terrain, and politics can kill just as surely as any disease." "Told in intimate detail by two of the world's best-known virologists - colleagues, collaborators, husband and wife - Level 4 is a journey across the world and into many strange new worlds: from the seductive beauty of equatorial Africa - a limitless reservoir of infection - to the confines of the all-but-invisible field of the electron microscope. While other books have offered hot zones, sick monkeys, and grim statistics, Level 4 brings home from the world of the virus the human stories of those who lived, and those who died."--BOOK JACKET. Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
Level 5 Diploma in Leadership for Health and Social Care 2nd Edition
by Tina Tilmouth Jan QuallingtonReflect on how best practice can be managed in care settings, develop your leadership skills and achieve your career goals with this new edition of Level 5 Diploma in Leadership for Health and Social Care.This new edition of Level 5 Diploma in Leadership for Health and Social Care has been fully updated to reflect the changes to the structure of the qualification. Covering all of the mandatory units in an easy-to-follow and thorough manner, this book is perfect for anyone looking to progress in their management career and for existing care setting managers as an invaluable reference guide. -Covers all the information in the qualification thoroughly and in an easy to follow manner with a new and updated design.-Updated to match the Level 5 qualification's integration into the higher apprenticeship programme including the new 'undertake a research project' unit.-Encourage learners to think more about the theory aspect of the qualification and how it is applied in the workplace with 'In Practice' features.-Explore and understand the different methods of assessment and how to prepare using relevant activities.
Level 5 Diploma in Leadership for Health and Social Care 2nd Edition
by Tina Tilmouth Jan QuallingtonReflect on how best practice can be managed in care settings, develop your leadership skills and achieve your career goals with this new edition of Level 5 Diploma in Leadership for Health and Social Care.This new edition of Level 5 Diploma in Leadership for Health and Social Care has been fully updated to reflect the changes to the structure of the qualification. Covering all of the mandatory units in an easy-to-follow and thorough manner, this book is perfect for anyone looking to progress in their management career and for existing care setting managers as an invaluable reference guide. -Covers all the information in the qualification thoroughly and in an easy to follow manner with a new and updated design.-Updated to match the Level 5 qualification's integration into the higher apprenticeship programme including the new 'undertake a research project' unit.-Encourage learners to think more about the theory aspect of the qualification and how it is applied in the workplace with 'In Practice' features.-Explore and understand the different methods of assessment and how to prepare using relevant activities.
Level 5 Diploma in Leadership for Health and Social Care 2nd Edition
by Tina Tilmouth Jan QuallingtonReflect on how best practice can be managed in care settings, develop your leadership skills and achieve your career goals with this new edition of Level 5 Diploma in Leadership for Health and Social Care.This new edition of Level 5 Diploma in Leadership for Health and Social Care has been fully updated to reflect the changes to the structure of the qualification. Covering all of the mandatory units in an easy-to-follow and thorough manner, this book is perfect for anyone looking to progress in their management career and for existing care setting managers as an invaluable reference guide. -Covers all the information in the qualification thoroughly and in an easy to follow manner with a new and updated design.-Updated to match the Level 5 qualification's integration into the higher apprenticeship programme including the new 'undertake a research project' unit.-Encourage learners to think more about the theory aspect of the qualification and how it is applied in the workplace with 'In Practice' features.-Explore and understand the different methods of assessment and how to prepare using relevant activities.
Level Set Method in Medical Imaging Segmentation
by Jasjit S. Suri Ayman El-BazLevel set methods are numerical techniques which offer remarkably powerful tools for understanding, analyzing, and computing interface motion in a host of settings. When used for medical imaging analysis and segmentation, the function assigns a label to each pixel or voxel and optimality is defined based on desired imaging properties. This often includes a detection step to extract specific objects via segmentation. This allows for the segmentation and analysis problem to be formulated and solved in a principled way based on well-established mathematical theories. Level set method is a great tool for modeling time varying medical images and enhancement of numerical computations.
Levels of Organization in the Biological Sciences (Vienna Series in Theoretical Biology)
by Daniel S. Brooks, James DiFrisco, and William C. WimsattScientific philosophers examine the nature and significance of levels of organization, a core structural principle in the biological sciences.This volume examines the idea of levels of organization as a distinct object of investigation, considering its merits as a core organizational principle for the scientific image of the natural world. It approaches levels of organization--roughly, the idea that the natural world is segregated into part-whole relationships of increasing spatiotemporal scale and complexity--in terms of its roles in scientific reasoning as a dynamic, open-ended idea capable of performing multiple overlapping functions in distinct empirical settings.The contributors--scientific philosophers with longstanding ties to the biological sciences--discuss topics including the philosophical and scientific contexts for an inquiry into levels; whether the concept can actually deliver on its organizational promises; the role of levels in the development and evolution of complex systems; conditional independence and downward causation; and the extension of the concept into the sociocultural realm. Taken together, the contributions embrace the diverse usages of the term as aspects of the big picture of levels of organization.ContributorsJan Baedke, Robert W. Batterman, Daniel S. Brooks, James DiFrisco, Markus I. Eronen, Carl Gillett, Sara Green, James Griesemer, Alan C. Love, Angela Potochnik, Thomas Reydon, Ilya Tëmkin, Jon Umerez, William C. Wimsatt, James Woodward
Leven met ADHD
by M. Beenackers W. Brugge F. KatOmschrijvingTot voor kort werd ADHD voornamelijk als een aandoening bij kinderen beschouwd. Ook volwassenen kampen met ADHD. Het is een stoornis waarmee je geboren wordt, dat niet zomaar overgaat bij het ouder worden. ADHD kenmerkt zich door aandachtsproblemen, hyperactiviteit en impulsiviteit. Deze kenmerken uiten zich bij iedereen anders en er zijn daarom verschillende typen ADHD. Voor mensen met deze aandoening is het filteren van informatie en het remmen van gedrag moeilijk. Ze lopen hierdoor in nhet dagelijks leven tegen veel problemen aan. In Leven met ADHD geven Maura Beenackers, Fiona Kat en Willemijn ter Brugge antwoord op vragen als: Wat er is met mij aan de hand? Wat betekent ADHD voor mij en mijn omgeving? En: Wat kan ik er zelf aan doen? De auteurs geven praktische tips en bruikbare adviezen over het veranderen van leefgewoonten en het aanleren van nieuwe vaardigheden. Ook de diverse behandelmogelijkheden binnen de GGZ komen aan bod. De auteurs geven praktische tips en bruikbare adviezen over het veranderen van leefgewoonten en het aanleren van nieuwe vaardigheden. Ook de diverse behandelmogelijkheden binnen de GGZ komen aan bod. Leven met ADHD is bedoeld voor mensen met ADHD en hun directe omgeving. Het boek is tevens bruikbaar in de hulpverlening: voor psychologen, psychotherapeuten, huisartsen en maatschappelijk werkers die mensen met ADHD behandelen of begeleiden.
Leven met angst voor ernstige ziektes
by Sjef PeetersVrijwel iedereen maakt zich wel eens zorgen over een pijntje, een vlekje of een slepende vermoeidheid. En dat is maar goed ook. Deze symptomen kunnen namelijk wijzen op een ziekte die om behandeling vraagt. Maar vaak blijkt er helemaal niets aan de hand te zijn. Een geruststellend bericht van de arts is dan voldoende om de angst te laten te verdwijnen, ook als de pijn voortduurt. Wie zich dan toch zorgen blijft maken en niet ophoudt artsen te vragen zich over de klachten te buigen, lijdt waarschijnlijk aan hypochondrie: angst voor het hebben of het krijgen van een ernstige ziekte zonder dat daar medisch gezien aanleiding toe is. Hypochondrie is een veel voorkomende psychische aandoening. Eén tot vijf procent van de bevolking lijdt eraan. Gelukkig zijn de klachten goed te behandelen.
Leven met autisme
by M. Gottmer M. F. DelfosMensen met autisme hebben veel moeite met alledaagse sociale contacten. Dit kan behoorlijk lastig zijn, voor zowel hen zelf als de mensen om hen heen. Het is niet altijd eenvoudig autisme te herkennen, doordat niet iedereen met een autistische stoornis dezelfde autistische kenmerken en in eenzelfde mate vertoont. Dat is jammer, want als je weet dat er autisme in het spel is, zijn er speciale manieren om de communicatie te verbeteren. In Leven met autisme schetsen Martine Delfos en Marijke Gottmer wat autisme betekent voor de mensen zelf en hun omgeving. Zij beschrijven op respectvolle en heldere wijze de kracht en de kwetsbaarheid van mensen met een autistische stoornis. Hierbij worden waardevolle tips gegeven voor het omgaan met de problematische kanten van het leven met autisme. Ook in deze tweede druk is recent onderzoek verwerkt en zijn commentaren van lezers ter harte genomen. Onder andere wordt er op verzoek nog meer aandacht besteed aan het vermijden van moeilijke worden en worden er veel woorden uitgelegd. Vanwege de grote rol van internet en de computer in deze huidige tijd is er informatie over de betekenis van de computer bij autisme opgenomen.
Leven met een Piekerstoornis.
by S. J. Swaen J. Kragten Vogelbescheming Nederland W. A. SterkMensen met een chronische piekerstoornis (gegeneraliseerde angststoornis) leven onder voortdurende hoogspanning. Het overmatige piekeren gaat samen met aanhoudende angst, (over)vermoeidheid of andere lichamelijke en psychische klachten. Meestal is er ook sprake van besluiteloosheid, uitstel- en vermijdingsgedrag. Leven met een piekerstoornis behandelt op heldere en toegankelijke wijze behandelingsmethoden en nieuwe veelbelovende zelfhulptechnieken voor deze angststoornis. Naast informatie over gezonde en ongezonde vormen van angst ligt de focus van dit boek vooral op het geleidelijk zelf leren doorbreken van de piekergewoonte. Getoond wordt welke vaardigheden kunnen bijdragen aan meer evenwicht, zelfacceptatie en mentale rust. Leven met een piekerstoornis verschijnt in de reeks Van A tot ggZ. De boeken uit deze reeks zijn zowel voor de professional als voor de cliënt uiterst bruikbaar om meer inzicht te krijgen in diverse stoornissen
Leven met een afhankelijke persoonlijkheidsstoornis
by S. J. Swaen Vogelbescheming Nederland W. A. Sterk E. W. BerrettyIn dit zelfhulpboek beschrijft auteur Ed Berretty in romanvorm het verhaal van Anne Bloem (48). Naast mevrouw Bloem spelen daarin haar man, haar inwonende dochter van 22 en haar psychotherapeut een belangrijke rol. Aan het einde van elk hoofdstuk wordt de aangereikte kennis in overzichtelijke punten op een rij gezet, aangevuld met bruikbare tips. De lezer krijgt door dit verhaal inzicht in de symptomen van de afhankelijke persoonlijkheidsstoornis en de mogelijkheden om daar iets aan te doen. Mevrouw Bloem kiest in overleg met haar therapeut voor een combinatie van cognitieve therapie en gedragstherapie. Cognitieve therapie maakt je bewust van negatieve basisgedachten, zodat je deze kunt veranderen in neutrale of positieve basisideeën. De levensechte beschrijving van de gesprekken van mevrouw Bloem met haar therapeut en de heldere opdrachten die zij mee naar huis krijgt, zullen voor sommige mensen al voldoende zijn om op eigen kracht van hun persoonlijke afhankelijkheidsstoornis af te komen. Voor anderen kan dit boek de drempel wegnemen om bij de professionele hulpverlening aan te kloppen
Leven met een psychisch zieke ouder
by S. Van GamerenNederland telt meer dan 850. 000 ouders met een psychische stoornis. Zo'n ziekte heeft uiteraard invloed op de jeugd van hun kinderen. Een groot deel van deze kinderen groeit desondanks op tot evenwichtige volwassenen, terwijl een ander deel vroeg of laat in het leven te maken krijgt met de uiteenlopende gevolgen van hun jeugdervaringen. In dit boek komen de factoren die hierbij een rol spelen ruimschoots aan bod. In Leven met een psychisch zieke ouder laat gezondheidspsycholoog Sandra van Gameren zien hoe je deze kinderen - ook wel aangeduid met 'koppers' (kopp kinderen van ouders met psychiatrische problemen) - kunt helpen hun veerkracht te behouden. Aan de hand van een tiental ervaringsdeskundigen weet zij een goed beeld te schetsen van de realiteit van een kopp-jeugd en de uitwerking die zo'n jeugd kan hebben op de rest van iemands volwassen leven. Het boek laat zien hoe, naast de zieke en gezonde ouder, andere volwassenen een kopper tijdens zijn/haar jeugd kunnen bijstaan en er zo voor kunnen zorgen dat het kind een manier vindt om met de thuissituatie om te gaan.
Leven met het restless legs syndroom
by Joke Jaarsma Roselyne M. Rijsman"In dit boek komen de diverse aspecten van RLS aan de orde. Wat is de oorzaak, hoe stel je de diagnose, hoe vaak en bij wie komt het voor, kan RLS behandeld of genezen worden, wat kun je in eerste instantie zelf doen, wat betekent het voor je omgeving? Duidelijk is dat RLS niet alleen het leven van de patiënt zelf ingrijpend kan verstoren, maar ook dat van de naaste omgeving. Het boek biedt dan ook handvatten om de kwaliteit van leven te verbeteren." Naast het informeren van patiënten over RLS is dit boek ook geschreven om behandelaars en begeleiders informatie te bieden waarmee zij hun behandeling en benadering van de patiënt kunnen optimaliseren.
Leven met snurken en apneu
by Piet Heijn Mechelen Nico De VriesNieuwe herziene editie van Leven met snurken. Geheel geactualiseerd en aangevuld met de nieuwste ontwikkelingen.
Lever's Dermatopathology: Histopathology of the Skin
by Misha Rosenbach Adam I. Rubin David E. Elder Rosalie Elenitsas George F. Murphy John T. Seykora Xiaowei XuUsed by generations of physicians who encounter patients with dermatological diseases, Lever’s Dermatopathology: Histopathology of the Skin comprehensively covers skin disease in which histopathology plays an important role in diagnosis. The updated 12th Edition, edited by Drs. David E. Elder, Rosalie Elenitsas, George F. Murphy, Misha Rosenbach, Adam I. Rubin, John T. Seykora, and Xiaowei Xu, maintains the proven, clinicopathologic classification of cutaneous disease while incorporating a “primer” on pattern-algorithm diagnosis. It features larger images throughout, as well as thoroughly revised content with new diseases and new information on pathophysiology and molecular pathogenesis—all in an easy-to-navigate, highly readable format.
Leveraging Culture to Address Health Inequalities
by Institute of Medicine Steve Olson Karen M. Anderson Board on Population Health and Public Health Practice Roundtable on the Promotion of Health Equity and the Elimination of Health DisparitiesLeveraging Culture to Address Health Inequalities: Examples from Native Communities is the summary of a workshop convened in November 2012 by the Roundtable on the Promotion of Health Equity and the Elimination of Health Disparities of the Institute of Medicine. The workshop brought together more than 100 health care providers, policy makers, program administrators, researchers, and Native advocates to discuss the sizable health inequities affecting Native American, Alaska Native, First Nation, and Pacific Islander populations and the potential role of culture in helping to reduce those inequities. This report summarizes the presentations and discussion of the workshop and includes case studies that examine programs aimed at diabetes prevention and management and cancer prevention and treatment programs. In Native American tradition, the medicine wheel encompasses four different components of health: physical, emotional, mental, and spiritual. Health and well-being require balance within and among all four components. Thus, whether someone remains healthy depends as much on what happens around that person as on what happens within. Leveraging Culture to Address Health Inequalities addresses the broad role of culture in contributing to and ameliorating health inequities.
Leveraging Data Science for Global Health
by Maimuna S. Majumder Leo Anthony Celi Patricia Ordóñez Juan Sebastian Osorio Kenneth E. Paik Melek SomaiThis open access book explores ways to leverage information technology and machine learning to combat disease and promote health, especially in resource-constrained settings. It focuses on digital disease surveillance through the application of machine learning to non-traditional data sources. Developing countries are uniquely prone to large-scale emerging infectious disease outbreaks due to disruption of ecosystems, civil unrest, and poor healthcare infrastructure – and without comprehensive surveillance, delays in outbreak identification, resource deployment, and case management can be catastrophic. In combination with context-informed analytics, students will learn how non-traditional digital disease data sources – including news media, social media, Google Trends, and Google Street View – can fill critical knowledge gaps and help inform on-the-ground decision-making when formal surveillance systems are insufficient.
Leveraging Food Technology for Obesity Prevention and Reduction Effort: Workshop Summary
by The National Academy of SciencesObesity is a major public health challenge. More than one-third of the U. S. adult population is considered obese, a figure that has more than doubled since the mid-1970s. Among children, obesity rates have more than tripled over the same period. Not only is obesity associated with numerous medical complications, but it incurs significant economic cost. At its simplest, obesity is a result of an energy imbalance, with obese (and overweight) people consuming more energy (calories) than they are expending. During the last 10-20 years, behavioral scientists have made significant progress toward building an evidence base for understanding what drives energy imbalance in overweight and obese individuals. Meanwhile, food scientists have been tapping into this growing evidence base to improve existing technologies and create new technologies that can be applied to alter the food supply in ways that reduce the obesity burden on the American population. Leveraging Food Technology for Obesity Prevention and Reduction Effort examines the complexity of human eating behavior and explores ways in which the food industry can continue to leverage modern food processing technologies to influence energy intake. The report also examines the opportunities and challenges of altering the food supply--both at home and outside the home--and outlines lessons learned, best practices, and next steps.
Leveraging Lean in Ancillary Hospital Services: Creating a Cost Effective, Standardized, High Quality, Patient-Focused Operation
by Charles Protzman Joyce Kerpchar George MayzellThis book is part of a series of titles that are a spin-off of the Shingo Prize-winning book Leveraging Lean in Healthcare: Transforming Your Enterprise into a High Quality Patient Care Delivery System. Each book in the series focuses on a specific aspect of healthcare that has demonstrated significant process and quality improvements after a Lean
Leveraging Lean in Medical Laboratories: Creating a Cost Effective, Standardized, High Quality, Patient-Focused Operation
by Charles Protzman Joyce Kerpchar George MayzellThis book is part of a series of titles that are a spin-off of the Shingo Prize-winning book Leveraging Lean in Healthcare: Transforming Your Enterprise into a High Quality Patient Care Delivery System. Each book in the series focuses on a specific aspect of healthcare that has demonstrated significant process and quality improvements after a Lean