- Table View
- List View
Localization Of Putative Steroid Receptors: Volume I: Experimental Systems
by Louis P. PertschukThese volumes represent the "state-of-the-art" in morphological methods for detection of steroid receptors. In Volume I we have attempted to collect current available methods and experimental approahes which might be useful in solving present enigmas. The background and recent advances presented are intended to stimulate further experimentation and new innovations, and spur clinical trials by all investigators with an interest in steroid hormones, cell biology, and clinical oncology.
Localization Of Putative Steroid Receptors: Volume II: Clinically Oriented Studies
by PertschukThese volumes represent the "state-of-the-art" in morphological methods for detection of steroid receptors. Some physician authors have applied many of the new methodologies in clinical research projects deisgned to improve medical practice, and these attempts have been placed in Volume II. The Background and recent advances presented here are intended to stimulate further experimentation and new innovations, and spur clinical trials by all investigators with an interest in steroid hormones, cell biology, and clinical oncology.
Localization and Its Discontents: A Genealogy of Psychoanalysis & the Neuro Disciplines
by Katja GuentherPsychoanalysis and neurological medicine have promoted contrasting and seemingly irreconcilable notions of the modern self. Since Freud, psychoanalysts have relied on the spoken word in a therapeutic practice that has revolutionized our understanding of the mind. Neurologists and neurosurgeons, meanwhile, have used material apparatus—the scalpel, the electrode—to probe the workings of the nervous system, and in so doing have radically reshaped our understanding of the brain. Both operate in vastly different institutional and cultural contexts. Given these differences, it is remarkable that both fields found resources for their development in the same tradition of late nineteenth-century German medicine: neuropsychiatry. In Localization and Its Discontents, Katja Guenther investigates the significance of this common history, drawing on extensive archival research in seven countries, institutional analysis, and close examination of the practical conditions of scientific and clinical work. Her remarkable accomplishment not only reframes the history of psychoanalysis and the neuro disciplines, but also offers us new ways of thinking about their future.
Localization in Clinical Neurology
by Jose Biller Paul W. Brazis Joseph C. MasdeuAnatomical localization skills based in physical examination are essential for any clinician caring for patients with neurologic disease processes. Now fully revised and up to date, Localization in Clinical Neurology, 8th Edition, uses easy-to-read descriptions, full-color illustrations and videos to help readers understand and locate the source of a patient’s signs and symptoms. This gold standard text now features dozens of clinical videos that help clinicians improve diagnostic accuracy and avoid unnecessary testing.
Localizing the Moral Sense
by Jan VerplaetseDue to the current revolution in brain research the search for the "moral brain" became a serious endeavour. Nowadays, neural circuits that are indispensable for moral and social behaviour are discovered and the brains of psychopaths and criminals - the classical anti-heroes of morality - are scanned with curiosity, even enthusiasm. How revolutionary this current research might be, the quest for a localisable ethical centre or moral organ is far from new. The moral brain was a recurrent theme in the works of neuroscientists during the 19th and 20th century. From the phrenology era to the encephalitis pandemic in the 1920s a wide range of European and American scientists (neurologists, psychiatrists, anthropologists and criminologists) speculated about and discussed the location of a moral sense in the human cortex. Encouraged by medical discoveries and concerned by terrifying phenomena like crime or "moral insanity" (psychopathy) even renowned and outstanding neurologists, including Moritz Benedikt, Paul Flechsig, Arthur Van Gehuchten, Oskar Vogt or Constantin von Monakow, had the nerve to make their speculations public. This book presents the first overview of believers and disbelievers in a cerebral seat of human morality, their positions and arguments and offers an explanation for these historical attempts to localise our moral sense, in spite of the massive disapproving commentary launched by colleagues.
Locating Health: Historical and Anthropological Investigations of Place and Health (Studies for the Society for the Social History of Medicine #2)
by Erika Dyck Christopher FletcherThe essays in this collection focus on the dynamic relationship between health and place. Historical and anthropological perspectives are presented – each discipline having a long tradition of engaging with these concepts. The resulting dialogue should produce a new layer of methodology, enhancing both fields.
Locating Medical History: The Stories and Their Meanings
by Frank Huisman and John Harley WarnerThe issues constituting the history of medicine are consequential: how societies organize health care, how individuals or states relate to sickness, how we understand our own identity and agency as sufferers or healers. In Locating Medical History: The Stories and Their Meanings, Frank Huisman, John Harley Warner, and other eminent historians explore and reflect on a field that accommodates a remarkable diversity of practitioners and approaches.At a time when medical history is facing profound choices about its future, these scholars explore the discipline in the distant and recent past in order to rethink its missions and methods today. They discuss such issues as the periodic estrangement of medical history from medicine, the influence of Foucault on the writing of medical history, and the shifts from social to cultural history and back again. Chapters explore the early history of the field, its transformations since the 1970s, and its prospects for the future.With diverse constituencies, a multiplicity of approaches, styles, and aims is both expected and desired. This volume locates medical history within itself and within larger historiographic trends, to provide a springboard for discussions about what the history of medicine should be, and what aims it should serve.Contributors: Olga Amsterdamska, University of Amsterdam; Warwick Anderson, University of Wisconsin, Madison; Allan M. Brandt, Harvard Medical School; Theodore M. Brown, University of Rochester; Roger Cooter, University College London; Martin Dinges, Institut für Geschichte der Medizin der Robert Bosch Stiftung; Alice Domurat Dreger, Michigan State University; Jacalyn Duffin, Queen's University; Elizabeth Fee, National Library of Medicine; Mary E. Fissell, The Johns Hopkins University; Danielle Gourevitch, École Pratique des Hautes Études; Anja Hiddinga, University of Amsterdam; Ludmilla Jordanova, University of East Anglia; Alfons Labisch, Heinrich-Heine-University; Hans-Uwe Lammel, University of Rostock; Sherwin B. Nuland, Yale University; Vivian Nutton, University College London; Roy Porter, formerly University College London; Susan M. Reverby. Wellesley College; David Rosner, Columbia University; Thomas Rütten, University of Newcastle upon Tyne; Heinz-Peter Schmiedebach, University of Greifswald; Christiane Sinding, Institut National de la Santé et de la Recherche Médicale
Lockdown: India Under Siege from Corona
by Sunil SharanThe respected Times of India journalist reveals the truths and consequences of the country&’s unprecedented COVID-19 lockdown. On March 24, 2020, with approximately five hundred reported COVID-19 cases reported and only hours notice, India&’s Prime Minister Narendra Modi ordered the most stringent national lockdown the world has ever seen. Two months later, Modi announced the fourth phase of national lockdown with some relaxations. Now in phase five of lockdown—and as restrictions are loosened even more—all everyone knows for sure is what is unknown: What happens to the virus as India reopens? What happens to the Indian economy? And what happens to Modi? Lockdown brings you inside an event that will affect the world around us perhaps for decades to come.
Locked In Locked Out: Surviving a Brainstem Stroke
by Shawn JenningsCan there be life after a brainstem stroke? After Dr. Shawn Jennings, a busy family physician, suffered a brainstem stroke on May 13, 1999, he woke from a coma locked inside his body, aware and alert but unable to communicate or move. Once he regained limited movement in his left arm, he began typing his story, using one hand and a lot of patience. With unexpected humour and tender honesty, Shawn shares his experiences in his struggle for recovery and acceptance of his life after the stroke. He affirms that even without achieving a full recovery life is still worth it.
Locking Plates in Veterinary Orthopedics (AVS Advances in Veterinary Surgery)
by Matthew D. Barnhart Karl C. MaritatoLocking Plates in Veterinary Orthopedics is a comprehensive and state-of-the-art guide to all aspects of using locking plates to treat orthopedic conditions in dogs, cats, and large animals. • Offers a proven approach to using locking plates in veterinary practice • Highlights practical clinical applications with illustrative clinical cases • Includes information on the history, principles, and materials as well as specific techniques • Presents data on both traumatic and non-traumatic applications • Provides instructive color photographs to demonstrate the procedures
Lockout-Tagout: Verriegelung Von Stellgliedern Zur Umfassenden Wartungssicherung Von Maschinen (essentials)
by Lars Schnieder Tim-Colin UhdeDas Inverkehrbringen und der Betrieb von Maschinen erfordern, das Einhalten von (Sicherheits-)Anforderungen zu dokumentieren, in Gefährdungsbeurteilungen das Risiko zu ermitteln, Schutzmaßnahmen abzuleiten und umzusetzen. Trotz des einheitlichen Rechtsrahmens kommt es gerade bei Instandhaltungsarbeiten weiterhin zu schweren Arbeitsunfällen, z.B. durch unkontrolliert austretende Energien wegen deaktivierter Schutzmechanismen. Die Autoren führen in den Rechtsrahmen der Maschinen- und Betriebssicherheit ein und leiten daraus die wichtige Absicherung unkontrollierter Energiequellen während der Instandhaltung ab. Mit Lockout-Tagout stellen sie ein anerkanntes Verfahren zur Verbesserung der Betriebssicherheit vor. Hierzu kombinieren die Autoren Verfahrensanweisungen, technische Maßnahmen und Schulungen mit einer kontinuierlichen Überwachung der Wirksamkeit der Maßnahmen.Die AutorenDr.-Ing. Lars Schnieder verantwortet in einer Software-Entwicklungsfirma das Geschäftsfeld Sicherheitsbegutachtung. Er ist international als Sachverständiger für die Maschinen- und Betriebssicherheit tätig.Tim-Colin Uhde ist in dieser Firma als Sachverständiger für die Maschinen- und Betriebssicherheit tätig.
Lockout-Tagout: Verriegelung von Stellgliedern zur umfassenden Wartungssicherung von Maschinen (essentials)
by Lars Schnieder Tim-Colin UhdeDas Inverkehrbringen und der Betrieb von Maschinen erfordern, das Einhalten von (Sicherheits-)Anforderungen zu dokumentieren, in Gefährdungsbeurteilungen das Risiko zu ermitteln, Schutzmaßnahmen abzuleiten und umzusetzen. Trotz des einheitlichen Rechtsrahmens kommt es gerade bei Instandhaltungsarbeiten weiterhin zu schweren Arbeitsunfällen, z.B. durch unkontrolliert austretende Energien wegen deaktivierter Schutzmechanismen. Die Autoren führen in den Rechtsrahmen der Maschinen- und Betriebssicherheit ein und leiten daraus die wichtige Absicherung unkontrollierter Energiequellen während der Instandhaltung ab. Mit Lockout-Tagout stellen sie ein anerkanntes Verfahren zur Verbesserung der Betriebssicherheit vor. In der 2. Auflage dieses Buches wurde die systematische Vorgehensweise zur Umsetzung eines Programms zur Gefährdungsbeherrschung von Betreibern von Maschinen grundlegend erweitert und ergänzt. Hierzu kombinieren die Autoren Verfahrensanweisungen, technische Maßnahmen und Schulungen mit einer kontinuierlichen Überwachung der Wirksamkeit der Maßnahmen.
Locomotion and Posture in Older Adults
by Fabio Augusto Barbieri Rodrigo VitórioThis book is an attempt to advance the discussion and improve our understanding about the effects of aging and movement disorders on motor control during walking and postural tasks. Despite these activities are performed daily, there is a high requirement of motor and neural systems in order to perform both tasks efficiently. Both walking and posture require a complex interaction of musculoskeletal and neural systems. However, the mechanisms used to control these tasks, as well as how they are planned and coordinated, are still a question of discussion among health professionals and researchers. In addition, this discussion is more interesting when the effects of aging are included in the context of locomotion and the postural control. The number of older individuals is 841 million in 2015, which is four times higher than the 202 million that lived in 1950. Aging causes many motor, sensorial and neural deficits, which impair locomotion and postural control in the elderly. The severity of this framework is worsened when the aging goes along with a movement disorder, such as Parkinson disease, Chorea, Dystonia, Huntington disease, etc. Therefore, the aim of this book is to highlight the influence of different aspects on planning, controlling and performing locomotion and posture tasks. In attempting to improve current knowledge in this field, invited authors present and discuss how environmental, sensorial, motor, cognitive and individual aspects influence the planning and performance of locomotor and postural activities. The major thrust of the book is to address the mechanisms involved in controlling and planning motor action in neurological healthy individuals, as well as in those who suffer from movement disorders or face the effects of aging, indicating the aspects that impair locomotion and postural control. In addition, new technologies, tools and interventions designed to manage the effects of aging and movement disorders are presented in the book.
Locomotion and Posture in Older Adults: The Role of Aging and Movement Disorders
by Fabio Augusto Barbieri Rodrigo Vitório Paulo Cezar Rocha dos SantosThis book sheds new light on the effects of aging and movement disorders on movement control during walking and postural tasks. Understanding these dynamics is more important than ever as we face a future where the number of older adults is projected to double by 2050. The severity of this framework is exacerbated when aging is accompanied by movement disorders such as Parkinson's disease, Chorea, Multiple Sclerosis, Dystonia, and Huntington's disease. The book explores how complex interactions between musculoskeletal and neural systems are required for efficient execution of daily activities like walking and maintaining posture. The chapters in this comprehensive volume address the multifaceted challenges posed by aging and movement disorders in gait and postural control, including innovative rehabilitation strategies and the role of artificial intelligence. Expert contributors examine how environmental, sensorial, motor, cognitive, and individual factors influence locomotor and postural activities. Readers will discover cutting-edge research findings that address critical questions about planning, performance, and impairment in these essential functions. This book is a must-read for anyone seeking to understand and reduce the effects of aging and movement disorders on gait and posture. This book is an invaluable resource for clinicians, physical therapists, occupational therapists, psychologists, biologists, researchers, health professionals, as well as those involved in physical education and sports medicine. It highlights the mechanisms involved in controlling and planning postural and gait tasks in both neurologically healthy older individuals and those who suffer from movement disorders, offering new perspectives on interventions and technologies designed to improve understanding or delay impairments due to aging or movement disorders on gait and posture. Whether you're a practitioner or researcher in related fields, this book equips you with the essential knowledge to enhance the quality of life for older adults facing these challenges.
Locoregional Radionuclide Cancer Therapy: Clinical and Scientific Aspects
by Franklin C. L. WongThis book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach.Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed.This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.
Locoregional Tumor Therapy
by Eric Van Cutsem Thomas J. Vogl Franco Orsi Alberto SobreroRecent years have witnessed a renaissance in the use of locoregional tumor therapy as part of a multimodal therapeutic approach to a variety of solid tumors, and attempts are underway to define its value in the overall therapeutic strategy for individual tumor entities. This flourishing of interest in locoregional tumor therapy derives from a series of important new developments concerning methodology, drug treatments, and instrumentation. The resulting approaches include not only optimized locoregional chemotherapy and chemoembolization for hepatocellular carcinoma and other tumors, but also other "targeted" therapies such as stereotactic radiosurgery, radiofrequency ablation, intra-arterial administration of radiopharmaceuticals, and complex new methods of chemoembolization of liver metastases involving the use of multiagent chemotherapy in combination with targeted drugs, drug-eluting beads/microspheres, or nanoparticles. In addition, intraperitoneal and intrapleural therapies, e. g. , cytoreduction plus hyperthermic intraperitoneal chemotherapy, are now a standard element of the strategy for a range of tumors. It is vital that practitioners have the necessary expertise in the use of these locoregional treatment methods and understand how to combine them optimally with modern systemic therapies. With that goal in mind, this book presents, in condensed form, the clinical results achieved using various locoregional tumor therapies. In so doing, it will allow the reader to rapidly retrieve the information on indications and effectiveness that is required for optimal integration of these highly effective therapies into modern, yet more complex treatment strategies.
Locoregional Tumor Therapy
by Eric Van Cutsem Thomas J. Vogl Franco Orsi Alberto SobreroThis book presents, in condensed form, the clinical results achieved by means of various locoregional tumor therapies employed for different indications. In so doing, it will allow the reader to rapidly retrieve the information on indications and effectiveness that is required for optimal integration of these highly effective therapies into modern, complex treatment strategies. The renaissance in locoregional tumor therapies is an ongoing process. New chemotherapeutic schedules, especially for liver and lung tumors, have been developed during the past few years. Other targeted therapies, such as radioembolization, microwave ablation, and HIFU techniques, and new pharmaceuticals for intra-arterial therapy have been developed and implemented in clinical practice. Furthermore, the advantages of unlimited combination of starch microspheres with various antitumor agents, supported by effective ischemia, have been increasingly exploited. The second edition of this book reflects these advances and includes entirely new chapters on the role of intraperitoneal perfusion in treating peritoneal carcinomatosis and the use of limb perfusion. Locoregional Tumor Therapy will be invaluable for all practitioners who work with cancer patients.
Log-Linear Models and Logistic Regression (Springer Texts in Statistics)
by Ronald ChristensenThis book examines statistical models for frequency data. The primary focus is on log-linear models for contingency tables but also includes extensive discussion of logistic regression. Topics such as logistic discrimination, generalized linear models, and correspondence analysis are also explored. The treatment is designed for readers with prior knowledge of analysis of variance and regression. It builds upon the relationships between these basic models for continuous data and the analogous log-linear and logistic regression models for discrete data. While emphasizing similarities between methods for discrete and continuous data, this book also carefully examines the differences in model interpretations and evaluation that occur due to the discrete nature of the data. Numerous data sets from fields as diverse as engineering, education, sociology, and medicine are used to illustrate procedures and provide exercises. A major addition to the third edition is the availability of a companion online manual providing R code for the procedures illustrated in the book. The book begins with an extensive discussion of odds and odds ratios as well as concrete illustrations of basic independence models for contingency tables. After developing a sound applied and theoretical basis for frequency models analogous to ANOVA and regression, the book presents, for contingency tables, detailed discussions of the use of graphical models, of model selection procedures, and of models with quantitative factors. It then explores generalized linear models, after which all the fundamental results are reexamined using powerful matrix methods. The book then gives an extensive treatment of Bayesian procedures for analyzing logistic regression and other regression models for binomial data. Bayesian methods are conceptually simple and unlike traditional methods allow accurate conclusions to be drawn without requiring large sample sizes. The book concludes with two new chapters: one on exact conditional tests for small sample sizes and another on the graphical procedure known as correspondence analysis.
Logan Turner's Diseases of the Nose, Throat and Ear: Head and Neck Surgery, 12th Edition
by S. Musheer Hussain Quentin GardinerThis classic ENT textbook has been updated and expanded to reflect the increasing sophistication of diagnostic and management skills. All sub-specialities are covered, with the content grouped into five major sections: Rhinology, Head and Neck, Otology, Paediatric Otorhinolaryngology, Imaging.New material includes:- A new chapter on middle ear devices- Information on recent technical advances, including implant devices, immunotherapy and monoclonal antibodies- Updated coverage of imaging and diagnostic techniquesEach chapter includes key learning points, up-to-date references and suggestions for further reading. Many chapters benefit from updated figures which provide clarity and enhance the effectiveness of the text. ENT trainees and other practitioners with an interest in otorhinolaryngology will find this all-purpose textbook ideal for a thorough understanding of the specialty.From the Foreword by the President of the Royal College of Surgeons of England‘This iconic ENT textbook has guided generations of aspiring ENT surgeons around the world, as well as practitioners from other disciplines seeking a general grounding in the specialty.’‘By bringing together recognised experts in their fields, the editors have ensured that this Twelfth Edition of Logan Turner’s Diseases of the Nose, Throat and Ear will remain a definitive text for those working in the UK and also in those many countries around the world in which previous editions of the book have gained popularity.’- Mr Tim MitchellReviews of the Eleventh Edition‘It is a modern, well-illustrated textbook with plenty of illustrations and figures, and the text is clear, well written and broken up into easy-to-read sections. It is also a suitable textbook both for primary and secondary care doctors and has a good depth of coverage. If you want to learn more about ENT and want an established, yet up-to-date book which is not expensive then look no further. It is an excellent general all-purpose ENT textbook which will satisfy a wide audience.’ - Dr Harry Brown
Logan's Illustrated Human Anatomy
by Bari M. LoganThis concise illustrated volume presents a pictorial guide to human anatomy through the meticulous dissections of Bari Logan, assembled during his long career as a distinguished prosector, and representing an unrivalled collection of superb photographic images. Illustrations are fully labelled, and accompanied by brief clinical notes to provide additional guidance for the student. Material covering anatomical preparation and cadaver preservation, orientation and planes of section, the bones, muscles and cranial nerves and an extensive glossary provides supplemental detail. The book will be a convenient photographic companion to all core textbooks of anatomy and ideal during exam preparation.
Logic Synthesis for Genetic Diseases
by Pey-Chang Kent Lin Sunil P. KhatriThis book brings to bear a body of logic synthesis techniques, in order to contribute to the analysis and control of Boolean Networks (BN) for modeling genetic diseases such as cancer. The authors provide several VLSI logic techniques to model the genetic disease behavior as a BN, with powerful implicit enumeration techniques. Coverage also includes techniques from VLSI testing to control a faulty BN, transforming its behavior to a healthy BN, potentially aiding in efforts to find the best candidates for treatment of genetic diseases.
Logic of Discovery and Diagnosis in Medicine (Pittsburgh Series in Philosophy and History of Science)
by Kenneth F. SchaffnerThis title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1985.
Logos Run (Runner #2)
by William C. DietzAfter interstellar courier Jak Rebo agrees to deliver a powerful artificial intelligence named Logos to a distant planet, he quickly comes to realize that it's no ordinary assignment. Logos has the power to not only reactivate the ancient stargates, but to restore interstellar travel, and bring the far flung remnants of humanity back together again.Some, like the members of the ruthless Techno Society, want to harness Logos and control it. Others, including those who fear technology, seek to destroy it.Together with Lonni Norr, the beautiful clairvoyant who can channel spirits from the afterlife, and the bodyguard Hoggles, Rebo will have to outrun his many enemies, and prevent Logos from falling into the wrong hands if he is to prevent humanity from falling into oblivion.With electrifying action, unstoppable heroes and gripping adventure, Logos Run is the thrilling conclusion to Runner by acclaimed military science fiction author William C. Dietz.
London and its Asylums, 1888-1914: Politics and Madness (Mental Health in Historical Perspective)
by Robert EllisThis book explores the impact that politics had on the management of mental health care at the turn of the nineteenth and twentieth centuries. 1888 and the introduction of the Local Government Act marked a turning point in which democratically elected bodies became responsible for the management of madness for the first time. With its focus on London in the period leading up to the First World War, it offers a new way to look at institutions and to consider their connections to wider issues that were facing the capital and the nation. The chapters that follow place London at the heart of international networks and debates relating to finance, welfare, architecture, scientific and medical initiatives, and the developing responses to immigrant populations. Overall, it shines a light on the relationships between mental health policies and other ideological priorities.
London's Most Eligible Doctor
by Annie O'NeilThe talk of the town... When a devastating dancing injury forces prima ballerina Lina Keminsky to walk away from her dreams, she takes a receptionist job to make ends meet. But working for London's most sought after doc, Cole Manning, isn't what she expects... While Cole might not bear physical scars, he's become a pro at hiding wounds that run deep. But working alongside the feisty Lina, Cole sees his guard slowly but surely beginning to crumble. Together, can they mend each other's hearts?