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Lone Wolf: the unputdownable story of one family’s impossible decision by the number one bestselling author of A Spark of Light
by Jodi PicoultTHE SUNDAY TIMES BESTSELLER'A gripping human story' Mail on SundayFollowing a terrible accident, Luke Warren lies comatose in a hospital bed. His family have been told he might never wake up. After seven years of estrangement, Edward has come to face his father for what he believes to be one final time before he discontinues his life support. To Edward, this is a painful but necessary decision which his father would have approved of.However, this one decision throws the Warren family into bitter conflict and soon, long-held secrets will be forced into the light.'Picoult's pitch and pace are masterly' Financial TimesTHE BOOK OF TWO WAYS, Jodi's stunning new novel about life, death and missed opportunities is available to pre-order now.
Loneliness in Europe: Determinants, Risks and Interventions (Population Economics)
by Sylke V. Schnepf Béatrice D’Hombres Caterina MauriThis open-access volume accompanies the microdata release of the EU Loneliness Survey. Loneliness, often referred to as the ‘epidemic of the 21st century’, has emerged as a grave public health concern. For years, a lack of comprehensive European cross-national data hindered a thorough examination of this issue. In 2022, the European Commission's Joint Research Centre conducted the inaugural EU Loneliness Survey, covering around 30,000 individuals in 27 European nations. The book sheds light on who is most affected by loneliness, identifies contributing experiences and behaviours, addresses the stigmatisation of loneliness and discusses its societal impact. Furthermore, it emphasises the importance of interventions to combat loneliness. Finally, the book discusses the challenges of survey design and offers valuable insights for the monitoring of loneliness in Europe in the future. This makes the book a must-read for scholars and academics interested in population economics, public health and social well-being.
Lonely Children and Adolescents
by Malka MargalitFrom texting and social networking sites to after-school activities, young people have many opportunities to interact with one another, and yet loneliness and isolation trouble today's youth in increasing numbers. Many children and teens report feeling lonely even in the midst of family and friends, and childhood loneliness is a prime risk factor for adult alienation. Lonely Children and Adolescents: Self-Perceptions, Social Exclusion, and Hope illuminates seldom-explored experiences of social isolation among young people as well as the frustrations of the parents and teachers who wish to help. This groundbreaking book conceptualizes loneliness not simply as the absence of social connections, but as a continuum of developmental experience, often growing out of the conflict between opposite needs: to be like one's peers yet be one's unique self. The author draws clear distinctions between loneliness and solitude and identifies genetic and environmental characteristics (i.e., social, psychological, familial, and educational) that can be reinforced to help children become more resilient and less isolated. In addition, therapeutic approaches are described that challenge loneliness by encouraging empowerment, resilience, and hope, from proven strategies to promising tech-based interventions. Highlights include: * Developmental perspectives on loneliness. * Schools and the role of teachers, from preschool to high school. * Peer relations (e.g., cliques, bullies, exclusion, and popularity). * Lonely children, lonely parents: models of coping. * Loneliness in the virtual world. * Prevention and intervention strategies at home, at school, in therapy. Asking its readers to rethink many of their assumptions about social competence and isolation, this volume is essential reading for researchers and professionals in clinical child, school, developmental, and educational psychology; allied education disciplines; social work; and social and personality psychology.
Long Acting Animal Health Drug Products: Fundamentals and Applications (Advances in Delivery Science and Technology)
by Michael J. Rathbone Arlene McdowellLong acting veterinary formulations play a significant role in animal health, production and reproduction within the animal health industry. Such technologies offer beneficial advantages to the veterinarian, farmer and pet owner. These advantages have resulted in them growing in popularity in recent years. The pharmaceutical scientist is faced with many challenges when innovating new products in this demanding field of controlled release. This book provides the reader with a comprehensive guide on the theories, applications, and challenges associated with the design and development of long acting veterinary formulations. The authoritative chapters of the book are written by some of the leading experts in the field. The book covers a wide scope of areas including the market influences, preformulation, biopharmaceutics, in vitro drug release testing and specification setting to name but a few. It also provides a detailed overview of the major technological advances made in this area. As a result this book covers everything a formulation scientist in industry or academia, or a student needs to know about this unique drug delivery field to advance health, production and reproduction treatment options and benefits for animals worldwide.
Long Acting Injections and Implants
by Jeremy C. Wright Diane J. BurgessLong acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability. An intriguing variety of technologies have been developed to provide long acting injections and implants. Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient. This book surveys and summarizes the field. Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants. This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants. This book will also be ideal as a graduate textbook.
Long COVID Fatigue: Clinical Sciences, Artificial Intelligence and the Future of Brain Health
by Thorsten RudroffThis book offers the first comprehensive analysis of long COVID fatigue using advanced neuroimaging and artificial intelligence (AI). It bridges the gap between basic science and patient care in post-viral syndromes. The volume guides readers from fundamental concepts to future innovations, making complex neurobiological mechanisms accessible to researchers and clinicians. Each chapter builds on the previous, connecting molecular mechanisms to clinical manifestations. The integration of AI in diagnosis and treatment is a pioneering approach in long COVID literature. The book provides detailed analysis of brain metabolic patterns in long COVID fatigue, insights into protective mechanisms like metabolic heterogeneity in the basal ganglia, practical guidelines for AI-enhanced diagnostic and treatment approaches, and pathways for translating research into clinical practice. It combines rigorous scientific analysis with practical applications, serving as both a reference and a roadmap for future developments in long COVID research and treatment. The main objectives are to provide a comprehensive understanding of long COVID fatigue mechanisms, present evidence-based approaches for diagnosis and treatment, showcase innovative AI applications in medical imaging, establish a framework for future research, and offer practical clinical management guidelines. This book is tailored for neurologists, neuroscientists, COVID-19 specialists, radiologists, healthcare providers, AI researchers, and graduate students in related fields.
Long Lever Techniques: An Illustrated Guide for Practitioners to Treat Neuro-Musculoskeletal Pain
by Bobby Nourani Richard HuffA full-color introductory guide to a revolutionary new osteopathic treatment: a direct manual medicine approach for reestablishing cranial rhythmic impulse, improving primary respiration mechanism, and restoring potency at the site of dysfunction.In the first book to discuss the long lever technique, Bobby Nourani, DO, introduces a manual medicine treatment for treating somatic dysfunction, reducing pain, and manipulating the body for effective and efficient healing. Written for professionals--osteopaths, physicians, bodyworkers, physical therapists, occupational therapists, craniosacral therapists, and other practitioners who want to integrate osteopathic techniques into an existing practice--Long Lever Techniques focuses on how we can mobilize interconnected structures to positively restore the body to better health and function. The long lever approach--using the arm or leg as lever and fulcrum to mobilize an area of somatic dysfunction--is a manual application of corrective force that can be applied once or multiple times. It has wide-ranging applications, from pain reduction to autonomic rebalancing to improved respiration rate, and is presented with full-color photos and illustrations so that medical professionals can put it into practice quickly. Readers will learn about: • The history and development of long lever techniques • Its clinical applications to cervical, thoracic, rib, lumbar, sacral, and pelvic dysfunction • Coccyx and craniococcygeal anatomy, evaluation, indications, and informed consent and documentation • How to integrate long lever techniques in practice
Long Life Strategy: A Guide for Living a Longer, Healthier, and More Fulfilling life
by Ronald M. CaplanThe second edition of Long Life Strategy builds upon the practical tips and knowledge in the first edition by providing readers with an outline to living a longer, healthier, more enjoyable life and late life. The book elaborates on three major areas, which include what you can do to live a long life, what your doctor should be doing to help you achieve this goal, and what society, of which we are all part, should be doing to better accommodate a growing number of older people in the coming decades. Dr. Caplan begins by introducing what it means to live a longer life and explaining the current research on delaying, preventing, and reversing aging in our cells. The next chapters detail how to prevent diseases and conditions commonly associated with aging, including diabetes, cancer, osteoporosis, mental health decline, sexual dysfunction, and heart disease. The author provides instruction for good diet and exercise choices. The concluding chapters provide useful advice for managing a fixed income, becoming a grandparent, dealing with the sickness and loss of a life partner, and how to maintain social relationships into late life. No matter where you are on life’s journey, Long Life Strategy can provide a roadmap to living a longer, healthier, and more fulfilling life.
Long Non-Coding RNAs
by Durdica UgarkovicLong non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.
Long Non-Coding RNAs in Cancer (Methods in Molecular Biology #2348)
by Alfons NavarroThis volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. <P><P> Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.
Long Non-Coding RNAs: Methods and Protocols (Methods in Molecular Biology #2372)
by Lin Zhang Xiaowen HuThis second edition provides a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Chapters guide readers through studies used to circular RNAs, RNA splicing, and findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Long Non-Coding RNAs: Methods and Protocols,Second Edition aims to ensure successful results in the further study of this vital field.
Long Noncoding RNA: Mechanistic Insights and Roles in Inflammation (Advances in Experimental Medicine and Biology #1363)
by Susan CarpenterThis book brings together what is currently known in terms of basic research in the field of long noncoding RNAs (lncRNAs) and builds on this to delve more deeply in the specific roles that lncRNAs are playing during inflammation. The book provides readers with basic knowledge on lncRNAs: from understanding the complexity of the transcriptome, conservation, structure and the tools used to investigate these aspects, to how we use this information to study lncRNAs in a specific biological context. The volume covers the emerging roles of lncRNAs in the initial stages of inflammation as well as their roles in specific inflammatory diseases including arthritis, lupus, diabetes and cardiovascular disease. The book also shows the emerging interest in using lncRNAs as a therapeutic target and how this could impact our ability to diagnose and treat inflammatory diseases in the future.
Long Term Care for Activity Professionals, Social Services Professionals, and Recreational Therapists
by Mary Anne Weeks Priscilla Wirth Elizabeth Betsy Best-MartiniThis is the best reference book for activity directors working in long-term care, assisted living, and adult day programs, and it's the most popular text for training new professionals. This book is down to earth, easy to understand, and comprehensive enough to answer your difficult questions about working with different resident groups, meeting standards, working with team and family members, and managing your department. It lets you see how all the parts of your facility can fit together to make an empowering, healthful, person-centered environment for everyone. It shows you how to provide care that satisfies, and even exceeds, health care regulations. And it gives you suggestions on how to stay sane, at least most of the time. <P><P>A great reference book with many excellent activities and reproducible forms, the seventh edition also includes information the new F-Tag codes, changes to the survey process, cultural sensitivity, and details on successful person-centered programming.
Long Term Safety of Assisted Reproduction
by Arianna D’Angelo Kenny A. Rodriguez-Wallberg Daniela NogueiraA much-needed overview of the available information now accumulating to indicate that assisted reproductive technologies are generally safe for both babies and mothers. However, the literature abounds with reports of a higher risk of obstetric and perinatal complications; regarding the long term outcomes for both women and children, the data are still scarce. The chapters summarized in this book review the current knowledge on long term safety of assisted reproduction and indicate the need for continued research to cover the lack of data in some specific patient groups and for recently developed treatments that only have a short period of follow-up.
Long Time, No See
by Beth FinkeLong Time, No See is certainly an inspiring story, but Beth Finke does not aim to inspire. Eschewing reassuring platitudes and sensational pleas for sympathy, she charts her struggles with juvenile diabetes, blindness, and a host of other hardships, sharing her feelings of despair and frustration as well as her hard-won triumphs. Rejecting the label "courageous," she prefers to describe herself using the phrase her mother invoked in times of difficulty: "She did what she had to do. " With unflinching candor and acerbic wit, Finke chronicles the progress of the juvenile diabetes that left her blind at the age of twenty-six as well as the seemingly endless spiral of adversity that followed. First she was forced out of her professional job. Then she bore a multiply handicapped son. But she kept moving forward, confronting marital and financial problems and persevering through a rocky training period with a seeing-eye dog. Finke's life story and her commanding knowledge of her situation give readers a clear understanding of diabetes, blindness, and the issues faced by parents of children with significant disabilities. Because she has taken care to include accurate medical information as well as personal memoir, Long Time, No See serves as an excellent resource for others in similar situations and for professionals who deal with disabled adults or children.
Long for This World: A Novel
by Michael ByersWhile a scientist struggles with medical ethics, his family tackles troubles of their own in this novel by the author of The Cost of Good Intentions.A wise and richly symphonic first novel, Long for This World is a thoroughly contemporary family drama that hinges on a riveting medical dilemma. Dr. Henry Moss is a dedicated geneticist who stumbles upon a possible cure for a disease that causes rapid aging and early death in children. Although his discovery may hold the key to eternal youth, exploiting it is an ethical minefield. Henry must make a painful choice: he can save the life of a critically ill boy he has grown to love—at the cost of his career—or he can sell his findings for a fortune to match the wealth of his dot-com-rich Seattle neighbors. Henry turns to his family for support, and in their intimately detailed lives unfolds a story of unforgettable characters grappling with their own demons.A New York Times Notable Book“This story will move you to tears and make you laugh out loud. It will also probably make you lie in bed at night and think about things that should be thought about: medical ethics, the moral choices in everyday life, the meaning of friendship and love and compassion, the need for connection.” —Elizabeth Berg, New York Times – bestselling author of The Confession Club“A piercing scientific and familial romance . . . also a noisy novel of manners—and money . . . Byers effortlessly conveys the quick pivots and non sequiturs of familial byplay.” —Kerry Fried, New York Times Book Review“A medical-ethical thriller with a warm domestic heart.” —Francine Prose, O, the Oprah Magazine
Long- und Post-Covid-Syndrom: Behandlung in der Physiotherapie und Ergotherapie (essentials)
by Jesko Streeck Dmitry AyzikovDieses essential enthält umfassende Diagnosestrategien und Therapieoptionen für das komplexe Krankheitsbild von Post-Covid-Erkrankungen. Es dient als detaillierter Leitfaden, um die komplexen Krankheitsbilder von Post-Covid und Long-Covid präzise zu differenzieren und typische Stolpersteine in Anamnese und Behandlung zu vermeiden. Das Krankheitsbild Myalgische Enzephalomyelitis/Chronisches Fatigue-Syndrom (ME/CFS) und seine Ähnlichkeiten zu Post-Covid werden klar abgegrenzt, um ein besseres Verständnis dieser Erkrankungen zu fördern. Darüber hinaus wird das Verständnis für die Vielseitigkeit von Covid19 sensibilisiert.
Long-Covid-/Post-Covid-Syndrom aus psychiatrischer Sicht: Ansätze zur psychiatrischen Differentialdiagnostik und Therapie (essentials)
by Katharina GrobholzDer Pathomechanismus von Long-/Post-Covid ist noch nicht endgültig geklärt, in ihrer Wirksamkeit ausreichend erprobte bzw. kurative Therapien stehen bisher nicht zur Verfügung.Die Differentialdiagnose zu psychischen Erkrankungen ist aufgrund der unspezifischen Symptomatik sowie des hohen Anteils psychischer Komorbiditäten oft schwierig. Psychiatrische und therapeutische Expertise sollte deshalb als Bestandteil der Diagnostik und des symptomatischen, interdisziplinären Behandlungskonzept bedacht werden. In diesem essential werden Diagnosekriterien, Möglichkeiten zur psychiatrischen Differentialdiagnostik sowie Ansatzpunkte zur psychotherapeutischen Behandlung bei Long-/Post-Covid dargestellt.
Long-Lost Son: Brand-New Family
by Lilian DarcyA child who needs his father... Janey Stafford never expected to become a mum, but now she must raise her vulnerable little nephew, who has lost his mother. Janey's only wish is to ensure the boy's happiness--she'll even go in search of Luke, the boy's father. But en route they're involved in an accident--she is hospitalised, and her nephew goes missing... Luke Bresciano keeps a vigil at Janey's hospital bedside, determined to discover why she's in Crocodile Creek, and whether she can help him find his son. Luke and Janey go way back, but could her shocking news unite them--this time as a family...?
Long-Memory Processes: Probabilistic Properties and Statistical Methods
by Rafal Kulik Jan Beran Yuanhua Feng Sucharita GhoshLong-memory processes are known to play an important part in many areas of science and technology, including physics, geophysics, hydrology, telecommunications, economics, finance, climatology, and network engineering. In the last 20 years enormous progress has been made in understanding the probabilistic foundations and statistical principles of such processes. This book provides a timely and comprehensive review, including a thorough discussion of mathematical and probabilistic foundations and statistical methods, emphasizing their practical motivation and mathematical justification. Proofs of the main theorems are provided and data examples illustrate practical aspects. This book will be a valuable resource for researchers and graduate students in statistics, mathematics, econometrics and other quantitative areas, as well as for practitioners and applied researchers who need to analyze data in which long memory, power laws, self-similar scaling or fractal properties are relevant.
Long-Term Care Managing Across the Continuum
by John PrattThe profession of long-term care administration is one that provides many wonderful opportunities, some considerable challenges, and very significant responsibilities. It is absolutely critical to remain connected and current at all times to provide effective, relevant leadership. The author has updated his comprehensive text with this fourth edition dedicated to long-term care knowledge and practical insight. This provides an excellent read for both those new to the profession and those with experience looking to gain a new perspective to assist in improving their leadership and management skills.
Long-Term Care Medicine
by Pamela Ann Fenstemacher Peter WinnLong-Term Care Medicine: A Pocket Guide lessens the uncertainty involved in caring for patients in a long-term care facility. This practical pocket guide is divided into four sections: Introduction, Common Clinical Conditions, Psychosocial Aspects, and Special Issues in Long-Term Care. The chapters address all the varied components of the LTC system as well as how to take care of the patients and residents living within it. The contributors to this easy-to-read guide are passionate about LTC and many have worked within the American Medical Directors Association to create and disseminate a knowledge base for practitioners. Long-Term Care Medicine: A Pocket Guide is an invaluable resource for clinicians, practitioners, and educators who are seeking to optimize the care and living experience of residents in LTC by providing resident-centered care as well as resident choice, well-being, dignity, and an improved quality of life.
Long-Term Care and Older People in Western Europe: Lessons From the COVID-19 Pandemic (Transforming Care)
by Eloísa del Pino and Francisco Javier Moreno-FuentesBased on a comparative study covering 15 Western European countries, this edited volume examines the responses of long-term care homes for older people to the COVID-19 pandemic. It analyses the preparedness of governments and residences and the structural weaknesses revealed and exacerbated by the crisis, such as staff shortages, the precariousness of employment in the sector, and the deficient coordination between the health and caring sectors. By examining the governance structures of the care home sector and their performance before and during the crisis, the book highlights the institutional, organisational, and management challenges facing care homes, both in continuing to provide services to an increasingly ageing population and in the event of future public health crises.
Long-Term Care in Europe
by Kai Leichsenring Jenny Billings Henk NiesDrawing on research across a wide range of European countries, this book analyzes the key issues at stake in developing long-term care systems for older people in Europe with a focus on progression and improvement for policy and practice.
Long-Term Care in Europe: A Juridical Approach
by Ulrich Becker Hans-Joachim ReinhardThis book provides a comprehensive overview on the long-term care systems in 12 EU member states and Norway. Focusing on the legal background and its main principles, it includes a comparative analysis which highlights the principal dissimilarities between European long term care benefits, but at the same time also a variety of features in common. It also discusses the increasingly transnational dimension of long-term as a result of migrants returning to their country of origin in old age, and the still-unsolved legal problem of entitlement to long-term care benefits in another EU-member state.