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Macrophages: Methods And Protocols (Methods in Molecular Biology #1784)
by Germain RousseletThis volume discusses basic and advanced techniques to study macrophages and their unique properties. The chapters in this book cover numerous topics such as in vitro culture models for murine and human macrophages; isolation of resident macrophages from several tissues; functional analyses of macrophages; and transgenic models of macrophage depletion and macrophage targeting. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Macrophages: Methods and Protocols is a valuable resource for researchers who are interested in studying macrophages on an experimental level.The chapters A Simple Multi-Step Protocol for Differentiating Human Induced Pluripotent Stem Cells into Functional Macrophages and Isolation and Phenotyping of Adult Mouse Microglial Cells are open access under a CC BY 4.0 license via link.springer.com.
Macropinocytosis: Functions and Mechanisms (Subcellular Biochemistry #98)
by Cosimo CommissoThis book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process.Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen presentation. Macropinocytosis has recently been recognized as a critical pathway in disease pathology and treatment. Therefore, a broad overview of macropinocytosis will benefit clinicians, as well as translational and basic research scientists. Moreover, as one of the main clathrin-independent endocytic routes, compiling all the critical information about macropinocytosis in one collection, this book will also be helpful to educators and their students.
Macroporous Polymers: Production Properties and Biotechnological/Biomedical Applications
by Ashok Kumar Bo Mattiasson Igor Yu. GalaevMacroporous polymers are rapidly becoming the material of choice for many tissue engineering, bioseparation, and bioprocessing applications. However, while important information is scattered about in many different publications, none, to date, have drawn this information together in user-friendly format, until now. Meeting the need for an accessibl
Macular Degeneration: The Complete Guide to Saving and Maximizing Your Sight
by Lylas G. Mogk Marja MogkDr. Lylas Mogk has a unique personal and professional understanding of AMD. This book explains how to successfully manage and limit its effect on a person's life.
Macular Disease: Practical Strategies for Living with Vision Loss
by Peggy R. WolfeThis invaluable guide to living well with vision loss is the perfect blend of abundant factual material and real-life experience. The book's positive, take-charge approach offers reassurance, hope, and hundreds of proven techniques, strategies, and tips for both the newly diagnosed and those at later stages of their disease. "My Story" vignettes in each chapter describe the author's fears, foibles, and triumphs in challenging situations. Readers will identify with the author's experiences and be encouraged by knowing she successfully traveled the same path.
Macular Disorders (Retina Atlas)
by Ivana K. KimThis atlas presents chapters on common and rare macular diseases including variants of age-related macular degeneration (dry, neovascular, polypoidal choroidal vasculopathy), cystoid macular edema, macular telangiectasia, central serous retinopathy and pachychoroid disease, photic retinopathy, presumed ocular histoplasmosis syndrome, myopic degeneration, angioid streaks, and a recently described entity: perifoveal exudative vascular anomalous complex. It provides a wealth of representative images, using various modalities to help the reader recognize the respective conditions. Importantly, it also includes images acquired using techniques more recently adopted in clinical practice such as autofluoresence, optical coherence tomography (OCT), and OCT angiography. The concise text reviews the basic concepts of etiology, diagnosis, and management in a highly accessible format. In contributions prepared by internationally respected experts, the atlas provides a cutting-edge analysis of each condition, as well as excellent summaries of recent work in the field. Macular Disorders is one of nine volumes in the series Retina Atlas. The series offers a global perspective on vitreoretinal diseases, covering imaging basics, retinal vascular disease, ocular inflammatory disease, retinal degeneration, surgical retina, macular disorders, ocular oncology, pediatric retina and trauma. In nine volumes and over 100 chapters, Retina Atlas offers comprehensive and validated information on retinal disorders.
Macular Dystrophies
by Giuseppe Querques Eric H. SouiedThis book provides the ophthalmologist with the most recently available data on the macular dystrophies, a group of many different inherited or sporadic eye conditions linked by a problem with photoreceptors or other structures of the central retina. Internationally recognized experts in the field present the latest evidence and discuss their own personal experiences with regard to each of the principal dystrophies as well as some very rare entities. Topics covered include molecular biology, state-of-the-art diagnostic techniques, and the newest treatment options, including still experimental therapies. Attention is also devoted to a range of issues that continue to be debated. The editors have taken care to ensure that chapters are of a uniformly high standard while not sacrificing the originality of the individual authors. Macular Dystrophies will fully acquaint the reader with both the latest research findings and the current and emerging approaches to diagnosis and treatment.
Macular Surgery: A Clinical Guide
by Fabio Patelli Stanislao Rizzo Carl AwhThis book provides a practical guide to techniques for recurrent macular hole and the application of new devices for macular surgery. Newer and more sophisticated optical coherence tomography (OCT) instruments are described in detail which allow the surgeon to better understand the anatomy of the retina before and after surgery. New forceps and intraoperative OCT that gives immediate visualisation during surgery and permits better surgical outcomes are also highlighted in the book. Macular Surgery: A Clinical Guide will be an essential resource for all ophthalmic surgeons seeking an informative and easy-to-follow clinical guide for routine and difficult cases.
Macular Surgery: Current Practice and Trends
by Andrew Chang Masahito Ohji William F. MielerRecent technological advances in the diagnosis of macular disorders have enhanced our understanding of these diseases. At the same time, advances in small-gauge vitrectomy instrumentation and techniques have improved the safety and efficiency of surgery, allowing macular conditions that would have otherwise resulted in blindness to be treated effectively, preserving patients’ sight. Macular surgery continues to evolve rapidly, thanks to exciting future technology trends. This book provides a detailed and up-to-date overview of the field. It begins with essential information on macular anatomy and pathophysiology, examination techniques, and surgical instrumentation. In turn, it discusses a broad range of disease processes, including macular holes, epiretinal membrane, vitreomacular traction and myopic maculopathy. The role and benefits of advanced vitrectomy techniques including submacular surgery, prosthetic vision, robotic surgery, and stem cell and gene therapy are addressed in detail. A review of perioperative care and potential complications rounds out the coverage.
Mad Cow Crisis: Health And The Public Good
by Scott C. RatzanThe announcement that BOSER might cause a fatal human disease "Creutzfeldt- Jacob disease CJD" triggered enormous media attention, public alarm and government wrangling that threatened the future of European integration.; As Scott Ratzan argues: "It is my belief that the [BOSER crisis] represents a quintessential case that will go down in history as the Exxon Valdez Union Carbide's Bhopal accident, and other such cases of interdisciplinary study".; This book offers lessons learned from the crisis, with contributions from experts with different viewpoints - veterinarians, Eurocrats, public relations experts, politicians, policy- makers, journalists and representatives of the beef industry.; It also offers a compilation of the key reports from governmental bodies. as a case-study in policy-making, scientific/health discovery and dissemination of information, as well as looking at the issues from the perspective of psychology and media studies.
Mad Dogs and Other New Yorkers: Rabies, Medicine, and Society in an American Metropolis, 1840–1920 (Animals, History, Culture)
by Jessica WangHow rabid dogs, the struggles to contain them, and their power over the public imagination intersected with New York City's rise to urban preeminence.Rabies enjoys a fearsome and lurid reputation. Throughout the decades of spiraling growth that defined New York City from the 1840s to the 1910s, the bone-chilling cry of "Mad dog!" possessed the power to upend the ordinary routines and rhythms of urban life. In Mad Dogs and Other New Yorkers, Jessica Wang examines the history of this rare but dreaded affliction during a time of rapid urbanization. Focusing on a transformative era in medicine, politics, and urban society, Wang uses rabies to survey urban social geography, the place of domesticated animals in the nineteenth-century city, and the world of American medicine. Rabies, she demonstrates, provides an ideal vehicle for exploring physicians' ideas about therapeutics, disease pathology, and the body as well as the global flows of knowledge and therapeutics. Beyond the medical realm, the disease also illuminates the cultural fears and political contestations that evolved in lockstep with New York City's burgeoning cityscape.Mad Dogs and Other New Yorkers offers lay readers and specialists alike the opportunity to contemplate a tumultuous domain of people, animals, and disease against a backdrop of urban growth, medical advancement, and social upheaval. The result is a probing history of medicine that details the social world of New York physicians, their ideas about a rare and perplexing disorder, and the struggles of an ever-changing, ever-challenging urban society.
Mad Knowledges and User-Led Research (The Politics of Mental Health and Illness)
by Diana Susan RoseThis book presents a critical examination of the development of user involvement within research, and investigates the issues currently preventing a productive integration of Mad knowledges within research and practice. Drawing on social, linguistic and critical theories, it proposes the conditions needed to address the development of Mad epistemologies. The author’s unique approach deliberately highlights her own positionality and draws on decades of experience as a service recipient, survivor, activist and researcher to illustrate the structural and symbolic barriers faced. Employing concepts including epistemic injustice, individualization, normalization and structural violence, it suggests a radically new way of articulating ‘what’s the matter with us?’ In doing so, the book itself goes some way towards enacting the radical challenge to academic and epistemic hierarchies which, it is argued, will be required to further advance mad knowledges and user-led research. Crucially, it demonstrates how this approach can be both methodologically and conceptually rigorous. This novel work holds important insights for students and scholars across the humanities and social sciences; particularly those working in the areas of critical psychology, disability studies, Mad studies, feminist studies, critical race theory, and Queer theory.
Mad Science: Psychiatric Coercion, Diagnosis, and Drugs
by Stuart A. Kirk*Winner of an honorable mention from theSociety for Social Work and ResearchforOutstanding Social Work Book AwardMad Science argues that the fundamental claims of modern American psychiatry are based on misconceived, flawed, and distorted science. The authors address multiple paradoxes in American mental health research, including the remaking of coercion into scientific psychiatric treatment, the adoption of an unscientific diagnostic system that controls the distribution of services, and how drug treatments have failed to improve the mental health outcome.When it comes to understanding and treating mental illness, distortions of research are not rare, misinterpretation of data is not isolated, and bogus claims of success are not voiced by isolated researchers seeking aggrandizement. This book's detailed analysis of coercion and community treatment, diagnosis, and psychopharmacology reveals that these characteristics are endemic, institutional, and protected in psychiatry. They are not just bad science, but mad science.This book provides an engaging and readable scientific and social critique of current mental health practices. The authors are scholars, researchers, and clinicians who have written extensively about community care, diagnosis, and psychoactive drugs. This paperback edition makes Mad Science accessible to all specialists in the field as well as to the informed public.
Mad Studies Reader: Interdisciplinary Innovations in Mental Health
by Bradley Lewis, Alisha Ali and Jazmine RussellThe last few years have brought increased writings from activists, artists, scholars, and concerned clinicians that cast a critical and constructive eye on psychiatry, mental health care, and the cultural relations of mental difference. With particular focus on accounts of lived experience and readings that cover issues of epistemic and social injustice in mental health discourse, the Mad Studies Reader brings together voices that advance anti-sanist approaches to scholarship, practice, art, and activism in this realm.Beyond offering a theoretical and historical overview of mad studies, this Reader draws on the perspectives, voices, and experiences of artists, mad pride activists, humanities and social science scholars, and critical clinicians to explore the complexity of mental life and mental difference. Voices from these groups confront and challenge standard approaches to mental difference. They advance new structures of meaning and practice that are inclusive of those who have been systematically subjugated and promote anti-sanist approaches to counter inequalities, prejudices, and discrimination. Confronting modes of psychological oppression and the power of a few to interpret and define difference for so many, the Mad Studies Reader asks the critical question of how these approaches may be reconsidered, resisted, and reclaimed.This collection will be of interest to mental health clinicians; students and scholars of the arts, humanities and social sciences; and anyone who has been affected by mental difference, directly or indirectly, who is curious to explore new perspectives.
Mad Studies: The Basics (The Basics)
by Merrick Daniel PillingMad Studies: The Basics provides an introductory account of a field that emerged from, and must remain grounded within, community knowledge, activism, and the perspectives of those who have experienced madness and mental health systems.It is a concise text that introduces the field through an exploration of some origins of Mad Studies, as well as two interrelated queries: what does Mad Studies help us understand, and what does Mad Studies help us do? This exploration reveals that Mad Studies is an interdisciplinary, intersectional, and multi-vocal field that demands different answers to the very meaning of the beliefs, behaviours, and bodymind experiences that are currently characterized as being indicative of mental illness. At the heart of Mad Studies is a liberationist desire to resist, transform, and abolish the systems that create marginalization, and implement responses to madness that are grounded in the collective knowledge of those deemed Mad. This book shows that the contributions of Indigenous, Black, racialized, queer, and trans people must be understood as central to, and already embedded within, Mad Studies and activism rather than as add-ons, expansions, or efforts to make Mad Studies more inclusive.It will be of interest to all scholars and students of disability studies, social work, gender studies, education, health sciences, sociology, and psychology, as well as practitioners in mental health care, and those with lived experience of madness and mental health systems.
Mad Tales from Bollywood: Portrayal of Mental Illness in Conventional Hindi Cinema (Maudsley Series #48)
by Dinesh BhugraThis is the first book to investigate how mental illness is portrayed in Hindi cinema. It examines attitudes towards mental illness in Indian culture, how they are reflected in Hindi films, and how culture has influenced the portrayal of the psychoses. Dinesh Bhugra guides the reader through the history of Indian cinema, covering developments from the idealism of the 1950s to the stalking, jealousy and psychopathy that characterises the films of the 1990s. Critiques of individual films demonstrate the culture’s approach towards mental illness and reflect the impact of culture on films and vice versa. Subjects covered include: Cinema and emotion Attitudes towards mental illness Socio-economic factors and cinema in India Indian personality, villainy and history Psychoanalysis in the films of the 60s. Mad Tales from Bollywood will be of interest to psychiatrists, mental health professionals, students of media and cultural studies and anyone with an interest in Indian culture.
Mad Tuscans and Their Families
by Elizabeth W. MellynBased on three hundred civil and criminal cases over four centuries, Elizabeth W. Mellyn reconstructs the myriad ways families, communities, and civic and medical authorities met in the dynamic arena of Tuscan law courts to forge pragmatic solutions to the problems that madness brought to their households and streets. In some of these cases, solutions were protective and palliative; in others, they were predatory or abusive. The goals of families were sometimes at odds with those of the courts, but for the most part families and judges worked together to order households and communities in ways that served public and private interests.For most of the period Mellyn examines, Tuscan communities had no institutions devoted solely to the treatment and protection of the mentally disturbed; responsibility for their long-term care fell to the family. By the end of the seventeenth century, Tuscans, like other Europeans, had come to explain madness in medical terms and the mentally disordered were beginning to move from households to hospitals. In Mad Tuscans and Their Families, Mellyn argues against the commonly held belief that these changes chart the rise of mechanisms of social control by emerging absolutist states. Rather, the story of mental illness is one of false starts, expedients, compromise, and consensus created by a wide range of historical actors.
Mad by the Millions: Mental Disorders and the Early Years of the World Health Organization (Culture and Psychiatry)
by Harry Yi-Jui WuThe World Health Organization's post-World War II work on the epidemiology and classification of mental disorders and its vision of a "world psyche."In 1946, the World Health Organization undertook a project in social psychiatry that aimed to discover the epidemiology and classification of mental disorders. In Mad by the Millions, Harry Y-Jui Wu examines the WHO's ambitious project, arguing that it was shaped by the postwar faith in technology and expertise and the universalizing vision of a "world psyche." Wu shows that the WHO's idealized scientific internationalism laid the foundations of today's highly highly metricalized global mental health system.
Mad in America: Bad Science, Bad Medicine, and the Enduring Mistreatment of the Mentally Ill
by Robert WhitakerAn updated edition of the classic history of schizophrenia in America, which gives voice to generations of patients who suffered through "cures" that only deepened their suffering and impaired their hope of recoverySchizophrenics in the United States currently fare worse than patients in the world's poorest countries. In Mad in America, medical journalist Robert Whitaker argues that modern treatments for the severely mentally ill are just old medicine in new bottles, and that we as a society are deeply deluded about their efficacy. The widespread use of lobotomies in the 1920s and 1930s gave way in the 1950s to electroshock and a wave of new drugs. In what is perhaps Whitaker's most damning revelation, Mad in America examines how drug companies in the 1980s and 1990s skewed their studies to prove that new antipsychotic drugs were more effective than the old, while keeping patients in the dark about dangerous side effects. A haunting, deeply compassionate book-updated with a new introduction and prologue bringing in the latest medical treatments and trends-Mad in America raises important questions about our obligations to the mad, the meaning of "insanity," and what we value most about the human mind.
Mad with Freedom: The Political Economy of Blackness, Insanity, and Civil Rights in the U.S. South, 1840–1940
by Élodie Edwards-GrossiThe use of race in studies of insanity in the 1840s and 1850s gave rise to politically charged theories on the differential biology and pathologies of brains in whites and Blacks. In Mad with Freedom, Élodie Edwards-Grossi explores the largely unknown social history of these racialized theories on insanity in the segregated South. She unites an institutional history of psychiatric spaces in the South that housed Black patients with an intellectual history of early psychiatric theories that defined the Black body as a locus for specific pathologies. Edwards-Grossi also reveals the subtle, localized techniques of resistance later employed by Black patients to confront medical power. Her work shows the continuous politicization of science and theories on insanity in the context of Reconstruction and the Jim Crow South.
Mad, Bad and Sad: A History of Women and the Mind Doctors
by Lisa AppignanesiThis fascinating history of mind doctors and their patients probes the ways in which madness, badness, and sadness have been understood over the last two centuries. Lisa Appignanesi charts a story from the days when the mad were considered possessed to our own century when the official psychiatric manual lists some 350 mental disorders. Women play a key role here, both as patients "among them Virginia Woolf, Sylvia Plath, and Marilyn Monroe" and as therapists. Controversially, Appignanesi argues that women have significantly changed the nature of mind-doctoring, but in the process they have also inadvertently highlighted new patterns of illness.
Mad-Doctors in the Dock: Defending the Diagnosis, 1760–1913
by Joel Peter EigenA captivating history of the defense of the insanity plea in England.Shortly before she pushed her infant daughter headfirst into a bucket of water and fastened the lid, Annie Cherry warmed the pail because, as she later explained to a police officer, "It would have been cruel to put her in cold water." Afterwards, this mother sat down and poured herself a cup of tea. At Cherry’s trial at the Old Bailey in 1877, Henry Charlton Bastian, physician to the National Hospital for the Paralyzed and Epileptic, focused his testimony on her preternatural calm following the drowning. Like many other late Victorian medical men, Bastian believed that the mother’s act and her subsequent behavior indicated homicidal mania, a novel species of madness that challenged the law’s criterion for assigning criminal culpability.How did Dr. Bastian and his cohort of London’s physicians, surgeons, and apothecaries—originally known as "mad-doctors"—arrive at such an innovative diagnosis, and how did they defend it in court? Mad-Doctors in the Dock is a sophisticated exploration of the history of the insanity defense in the English courtroom from the middle of the eighteenth century to the early twentieth century. Joel Peter Eigen examines courtroom testimony offered in nearly 1,000 insanity trials, transporting us into the world of psychiatric diagnosis and criminal justice. The first comprehensive account of how medical insight and folk psychology met in the courtroom, this book makes clear the tragedy of the crimes, the spectacle of the trials, and the consequences of the diagnosis for the emerging field of forensic psychiatry.
Madame Restell: The Life, Death, and Resurrection of Old New York's Most Fabulous, Fearless, and Infamous Abortionist
by Jennifer Wright**Longlisted for the Brooklyn Public Library Book Prize in Nonfiction (2023)** **An Amazon EDITOR'S PICK for BEST BOOKS OF 2023 SO FAR in BIOGRAPHY/MEMOIR and HISTORY** **An Amazon EDITOR'S PICK for BEST BOOKS OF THE MONTH (March 2023)** **A Bookshop.Org EDITOR'S PICK (March 2023)** &“This is the story of one of the boldest women in American history: self-made millionaire, a celebrity in her era, a woman beloved by her patients and despised by the men who wanted to control them.&” An industrious immigrant who built her business from the ground up, Madame Restell was a self-taught surgeon on the cutting edge of healthcare in pre-Gilded Age New York, and her bustling &“boarding house&” provided birth control, abortions, and medical assistance to thousands of women—rich and poor alike. As her practice expanded, her notoriety swelled, and Restell established her-self as a prime target for tabloids, threats, and lawsuits galore. But far from fading into the background, she defiantly flaunted her wealth, parading across the city in designer clothes, expensive jewelry, and bejeweled carriages, rubbing her success in the faces of the many politicians, publishers, fellow physicians, and religious figures determined to bring her down. Unfortunately for Madame Restell, her rise to the top of her field coincided with &“the greatest scam you&’ve never heard about&”—the campaign to curtail women&’s power by restricting their access to both healthcare and careers of their own. Powerful, secular men—threatened by women&’s burgeoning independence—were eager to declare abortion sinful, a position endorsed by newly-minted male MDs who longed to edge out their feminine competition and turn medicine into a standardized, male-only practice. By unraveling the misogynistic and misleading lies that put women&’s lives in jeopardy, Wright simultaneously restores Restell to her rightful place in history and obliterates the faulty reasoning underlying the very foundation of what has since been dubbed the &“pro-life&” movement. Thought-provoking, character-driven, boldly written, and feminist as hell, Madame Restell is required reading for anyone and everyone who believes that when it comes to women&’s rights, women&’s bodies, and women&’s history, women should have the last word.
Made to Hear: Cochlear Implants and Raising Deaf Children (A Quadrant Book)
by Laura MauldinA mother whose child has had a cochlear implant tells Laura Mauldin why enrollment in the sign language program at her daughter&’s school is plummeting: &“The majority of parents want their kids to talk.&” Some parents, however, feel very differently, because &“curing&” deafness with cochlear implants is uncertain, difficult, and freighted with judgment about what is normal, acceptable, and right. Made to Hear sensitively and thoroughly considers the structure and culture of the systems we have built to make deaf children hear.Based on accounts of and interviews with families who adopt the cochlear implant for their deaf children, this book describes the experiences of mothers as they navigate the health care system, their interactions with the professionals who work with them, and the influence of neuroscience on the process. Though Mauldin explains the politics surrounding the issue, her focus is not on the controversy of whether to have a cochlear implant but on the long-term, multiyear undertaking of implantation. Her study provides a nuanced view of a social context in which science, technology, and medicine are trusted to vanquish disability—and in which mothers are expected to use these tools. Made to Hear reveals that implantation has the central goal of controlling the development of the deaf child&’s brain by boosting synapses for spoken language and inhibiting those for sign language, placing the politics of neuroscience front and center.Examining the consequences of cochlear implant technology for professionals and parents of deaf children, Made to Hear shows how certain neuroscientific claims about neuroplasticity, deafness, and language are deployed to encourage compliance with medical technology.
Made to Order: The Designing of Animals
by Margaret E. DerryAnimal breeding has been complicated by persisting factors across species, cultures, geography, and time. In Made to Order, Margaret E. Derry explains these factors and other breeding concerns in relation to both animals and society in North America and Europe over the past three centuries. Made to Order addresses how breeding methodology evolved, what characterized the aims of breeding, and the way structures were put in place to regulate the occupation. Illustrated by case studies on important farm animals and companion species, the book presents a synthetic overview of livestock breeding as a whole. It gives considerable emphasis to genetics and animal breeding in the post-1960 period, the relationship between environmental and improvement breeding, and regulation of breeding as seen through pedigrees. In doing so, Made to Order shows how studying the ancient human practice of animal breeding can illuminate the ways in which human thinking, theorizing, and evolving characterize our interactions with all-natural processes.