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Mercury Toxicity Mitigation: Sustainable Nexus Approach (Earth and Environmental Sciences Library)
by Nitish KumarMercury is a naturally occurring element that is toxic in nature. According to the US Environmental Protection Agency, the safe limit of mercury ion in drinking water is 10 nM to avoid the serious health problems to humans. Mercury is a pollutant of global concern. Both anthropogenic activities and natural processes cause its release into different spheres of the environment resulting in severe adverse impacts. Increased anthropogenic discharge of mercury leads to disturbance in its natural biogeochemical cycle which results in to unenviable diseases and hazardous health effects.This book will provide state-of-the-art information to the graduate students training in toxicology, risk assessors, researchers and medical providers at large. Many monographs, book chapters, contemporary reviews, and peer reviewed articles about mercury health impact are also available worldwide. However, there is no complete understanding available on toxicological studies of mercury, which covers the broader spectrum of findings that range from sources of exposure to mercury toxicity as well as its remediation strategies. It is aimed to bring the readers updated information about the sources of mercury contamination, and its impact on human health and on prospective mitigation strategies through multi-disciplinary approaches. The book contains three sections. First section describes the different sources and distribution of mercury in the environment. Second section explains the health risks linked to mercury poisoning. Third section addresses sustainable mercury toxicity mitigation strategies through multi-disciplinary approaches. The key topic of this book will cover following: •Source and distribution of mercury in the environment•Effects and responses of mercury toxicity in plants• Health risk linked to mercury poisoning• Sustainable mercury toxicity mitigation strategiesThis book is a valuable resource to students, academics, researchers, and environmental professionals doing field work on mercury contamination throughout the world.
Mercury Toxicity: Challenges and Solutions (Environmental Science and Engineering)
by Nitish KumarThis book presents mercury toxicity with respect to remediation and health issues. It covers sources of mercury contamination, its impact on human health, and prospective remediation by both bioremediation and phytoremediation with the application of recent advanced techniques such as genetic engineering and nanotechnology.Both anthropogenic activities and natural processes cause the release of mercury into different spheres of the environment resulting in severe adverse impacts. Increased anthropogenic discharge of mercury leads to disturbance in its natural biogeochemical cycle, which results in unenviable diseases and hazardous health effects. Mercury pollution is responsible for causing neurobehavioral, kidney, heart, gastrointestinal, liver, and other diseases. Many published works about the impact of mercury on health are also available worldwide; however, there is no complete understanding available on toxicological studies of mercury that covers the broader spectrum of findings ranging from sources of exposure to mercury toxicity to its remediation strategies.This book brings together a diverse group of environmental science, sustainability, and health researchers to address the challenges posed by global mass poisoning caused by mercury contamination. The book also proposes solutions to contamination through multi-disciplinary approaches.The book contains three sections. The first part describes the different sources and distribution of mercury in soil and plant ecosystems. The second part explains the health risks linked to mercury toxicity. The third part addresses sustainable mercury toxicity mitigation strategies and the potential applications of recent technology in providing solutions. This book is a valuable resource to students, academics, researchers, and environmental professionals working in the field of mercury contamination.
Mercury, Mining, and Empire: The Human and Ecological Cost of Colonial Silver Mining in the Andes
by Nicholas A. RobinsOn the basis of an examination of the colonial mercury and silver production processes and related labor systems, Mercury, Mining, and Empire explores the effects of mercury pollution in colonial Huancavelica, Peru, and Potosí, in present-day Bolivia. The book presents a multifaceted and interwoven tale of what colonial exploitation of indigenous peoples and resources left in its wake. It is a socio-ecological history that explores the toxic interrelationships between mercury and silver production, urban environments, and the people who lived and worked in them. Nicholas A. Robins tells the story of how native peoples in the region were conscripted into the noxious ranks of foot soldiers of proto-globalism, and how their fate, and that of their communities, was—and still is—chained to it.
Mercy 6
by David BajoIn Mercy 6, David Bajo’s courageous new medical thriller, four people collapse dead in the same instant within a newly renovated Los Angeles hospital. Dr. Mendenhall, the woman who is head of the emergency room, isn't convinced the cause of death is a contagion. But it's in the interests of the hospital administrators - and of the world at large - for people to think that it is. If the world knew the truth there could only be widespread panic. The hospital is immediately locked down. Information is suddenly being strictly controlled. Government troops encircle the hospital to enforce the quarantine, and other bodies arrive in ER. Working with an ally in pathology and a colleague outside the hospital, Mendenhall develops her understanding that what has taken these lives has global implications . . . and whatever it is, it’s not a virus.
Mercy: A Novel
by Michael Palmer Daniel PalmerMercy: What's your definition? Dr. Julie Devereux is an outspoken advocate for the right to die--until a motorcycle accident leaves her fianc#65533;, Sam Talbot, a quadriplegic. Sam begs to end his life, but Julie sees hope in a life together. Then, just as Sam seems to be coming around to her point of view, he has an unexpected heart attack. An autopsy reveals that Sam died of an unusual heart defect, one seen only in those under extreme stress--in fact, it appears that Sam had literally been scared to death. As Julie investigates similar cases, she finds a frightening pattern. . . and finds herself the target of disturbing threats. The more cases Julie discovers, the more the threats escalate, until she is accused of a mercy killing of her own. Now, to clear her name and save her career, she must track down whoever is behind these mysterious deaths. . . but time is running out, as someone has decided that killing Julie is the only way to stop her. This edition of the book is the deluxe, tall rack mass market paperback.
Mercy: A Novel
by Michael Palmer Daniel PalmerA doctor uncovers a series of suspicious deaths that may be someone’s twisted idea of mercy in this “superior thriller” from the New York Times–bestselling author’s (Publishers Weekly, starred review).Dr. Julie Devereux is an outspoken advocate for the right to die—until a motorcycle accident leaves her fiancé, Sam, a quadriplegic. Sam begs to end his life, but Julie sees hope in a life together. When he suddenly dies from an unexpected heart attack, an autopsy reveals an unusual heart defect, one only seen in individuals under extreme stress. It appears that Sam was literally scared to death.As Julie investigates similar cases, she finds a frightening pattern . . . and finds herself the target of disturbing threats. She is determined to track down whoever is behind these mysterious deaths, but time is running out as someone has decided that killing Julie is the only way to stop her.
Mergers and Acquisitions: The Pharmaceutical and Biotechnology Industries (Routledge Studies in International Business and the World Economy)
by Mark Thomas Janna L. RoseCovid-19 has brought so much uncertainty, but one certainty is that the vaccine race will generate winners and losers in the pharmaceutical and biotechnology industries. This will have a major impact on merger and acquisition activity. While the plethora of merger and acquisition deals are abundantly reported by the news media, there is a clear lack of in-depth analysis on the multiple rationales and various challenges in the life sciences industry. By offering contributions from a variety of experts in the biotechnology and pharmaceutical industries, as well as experts on mergers and acquisitions, this edited collection will draw upon the knowledge of a variety of different actors within the fields of pharma and biotech. This book offers a timely exploration of the complexities of mergers and acquisitions in the pharmaceutical and biotechnology industries while seeking to bridge the gap between theory and practice. It presents a critical analysis of the rationale for acquisitions and studies the challenges of ensuring a successful deal. In the light of the Covid-19 pandemic, it will also explore the impact this may have on the industry, which may further stimulate merger and acquisition activity. It will be of interest to researchers, academics, policymakers, and students in the fields of strategy, management, governance, and the biotechnology and pharmaceutical industries.
Meridians and Acupoints
by Hongcai Wang Bing ZhuAn in-depth understanding of the meridians and acupoints lies at the heart of effective practice in traditional Chinese medicine. This book outlines everything that practitioners and students need to know. The book explains how meridians relate to the major organs, where they are located in the body, and how they are linked to the healthy flow of Qi and blood. A large section of the book is devoted to descriptions of specific acupoints - their names, how to locate them, an introduction to the symptoms they can be used to treat, and how. Also included is a thorough introduction to the basics of acupuncture practice, including how to prepare a patient prior to treatment, how to insert and manipulate acupuncture needles, how and when to use moxibustion and cupping techniques, and what to do if treatment goes wrong. This useful and authoritative textbook, compiled by the China Beijing International Acupuncture Training Centre (CBIATC), under the editorial direction of leading Chinese clinicians Zhu Bing and Wang Hongcai, is essential reading for students of traditional Chinese medicine, and an excellent reference for acupuncture practitioners at all levels.
Meridians: Maps of the Soul
by Mike MandlMeridians are the bridge between the psyche and soma, the system that allows our life force to flow through our body. Each of the twelve main meridians stand for a fundamental life principle and by examining them, we can begin a journey towards better health- as well as freedom and contentment.In this inspirational, easy-to-read deep dive, Mike Mandl uses his own wit and humour to explore the life principles of the meridians and offers a toolbox for self-diagnostic purposes, demonstrating how to strengthen these principles, correct imbalances, and keep in harmony with yourself through daily observation and maintenance.Translating the principles of Traditional Chinese Medicine into an engaging, accessible resource for practitioners and novices alike, this is the perfect first step in harnessing the meridians for your own self-actualisation.
Meridians: Maps of the Soul
by Mike MandlAn accessible explanation of the essence of TCM and Meridians.Meridians are the bridge between the psyche and soma, the system that allows our life force to flow through our body. Each of the twelve main meridians stand for a fundamental life principle and by examining them, we can begin a journey towards better health- as well as freedom and contentment.In this inspirational, easy-to-read deep dive, Mike Mandl uses his own wit and humour to explore the life principles of the meridians and offers a toolbox for self-diagnostic purposes, demonstrating how to strengthen these principles, correct imbalances, and keep in harmony with yourself through daily observation and maintenance.Translating the principles of Traditional Chinese Medicine into an engaging, accessible resource for practitioners and novices alike, this is the perfect first step in harnessing the meridians for your own self-actualisation.(P)2023 Hodder & Stoughton Limited
Merkel Cell Carcinoma
by Murad Alam Siegrid S. Yu Jeremy S. BordeauxMerkel Cell Carcinoma is one of the first comprehensive, single-source clinical texts on the subject. Although not as common as melanoma, Merkel cell carcinoma is not rare - and it is both more deadly than melanoma and increasing at an epidemic rate. The book is clinical in focus and emphasizes treatment of this poorly understood cancer. Contributing authors include dermatologists, surgical oncologists, radiation oncologists, and medical oncologists from the US and around the world. Features: · Comprehensive single-source clinical reference · Treatment focus · Written for practitioners, with emphasis on clinical relevance and quick retrieval of information · Contributing authors represent all disciplines involved in treatment of Merkel cell carcinoma: dermatology, surgical oncology, radiation oncology, and medical oncology · International in perspective, with contributors from US and abroad · Members of active Merkel Cell Carcinoma Multicenter Interest Group have authored some of the chapters
Merritt’s Neurology
by Elan D Louis Stephan A MayerFor more than 60 years, Merritt’s Neurology has remained a trusted landmark text in clinical neurology, providing unparalleled guidance on neurologic protocols, treatment guidelines, clinical pathways, therapeutic recommendations, and imaging. The fourteenth edition reflects the state of today’s practice, with fully updated content and timely new sections and chapters. With this edition, Dr. James Noble joins Drs. Elan Louis and Stephan A. Mayer as co-editor, all of whom trained at Columbia University where Dr. H. Houston Merritt wrote the initial editions of this book. Lauded for its comprehensive coverage, colorful and dynamic visual style, readability, and ease of use, this up-to-date reference is ideal for neurologists, primary care physicians, and residents alike.
Mesenchymal Stem Cell in Veterinary Sciences
by Mudasir Bashir Gugjoo Amar PalThis book focuses on mesenchymal stem cells (MSCs) of animal origin, including their isolation, characterization, and clinical applications. After briefly discussing the historical development of the field of stem cell research, it describes the basic properties and nature of stem cells particularly in relation to MSCs. In turn, it reviews materials and methods used to isolate MSCs from various sources, culture expansion, characterization and long-term storage. It also explores the therapeutic efficacy, immunomodulation and anti-inflammatory, and differentiation properties of MSCs. Importantly, the book discusses the applications of genetic engineering to enhance the efficacy and potential of MSCs in regenerative medicine. The book largely addresses the potential applications of mesenchymal stem cells in therapies for important species of domesticated animals including sheep, goats, cattle, buffalo, cats, dogs and horses. Finally, the book presents an abridgement of challenges and future prospects of stem cell research and application in medicine, in general and veterinary sciences, in particular.
Mesenchymal Stem Cells
by Darwin J. Prockop Bruce A. Bunnell Donald G. PhinneyFor over forty years, mesenchymal stem cells (MSCs) have been scrutinized and studied, garnering much attention due to their broad therapeutic efficacy. In this essential book, leaders in the field were assembled to contribute detailed methodologies for the isolation and characterization of human and rodent MSCs. Cutting edge and easy to use, this book is the perfect resource for scientists attempting to pursue this important and ever-developing field of research.
Mesenchymal Stem Cells
by Massimiliano GnecchiThis volume aims to outline the current status of the Mesenchymal Stem Cells(MSC) field in regenerative medicine and to propose clear and reproducible protocols to better define the identity, function and use of these cells that are today, more than ever, "under the spotlight". Mesenchymal Stem Cells: Methods and Protocols, Second Edition is organized into four sections. The first guides the reader through a series of state-of-the-art reviews summarizing the use of MSC for the treatment of various diseases. The other three sections are a collection of methodological chapters covering several aspects: isolation and characterization of MSC; expansion of MSC for clinical use; production and characterization of the MSC secretome. Written in the highly successful Methods in Molecular Biology series format, the method chapters include introductions to their respective topics, complete lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting which will help the researcher to avoid known pitfalls. Authoritative and cutting-edge, Mesenchymal Stem Cells: Methods and Protocols, Second Edition, aims to ensure successful results in the further study of this vital field.
Mesenchymal Stem Cells - Basics and Clinical Application I
by Birgit Weyand Ralf Hass Roland Jacobs Massimo Dominici Cornelia KasperProspective Isolation and Characterization of Human Bone Marrow-Derived MSCs, by A. Harichandan, K. Sivasubramaniyan, H.-J. Bühring Urine as a Source of Stem Cells, by Christina Benda, Ting Zhou, Xianming Wang, Weihua Tian, Johannes Grillari, Hung-Fat Tse, Regina Grillari-Voglauer, Duanqing Pei, Miguel A. Esteban Expansion of Mesenchymal Stem/Stromal Cells under Xenogenic-Free Culture Conditions, by Sven Kinzebach, Karen Bieback Adipose-Derived Mesenchymal Stem Cells: Biology and Potential Applications, by Danielle Minteer, Kacey G Marra, J Peter Rubin Potential for Osteogenic and Chondrogenic Differentiation of MSC, by Antonina Lavrentieva, Tim Hatlapatka, Anne Neumann, Birgit Weyand, Cornelia Kasper Potential for Neural Differentiation of Mesenchymal Stem Cells, by Letizia Ferroni, Chiara Gardin, Ilaria Tocco, Roberta Epis, Alessandro Casadei, Vincenzo Vindigni, Giuseppe Mucci, Barbara Zavan Migratory Properties of Mesenchymal Stem Cells, by Thomas Dittmar, Frank Entschladen Dissecting Paracrine Effectors for Mesenchymal Stem Cells, by Stefania Bruno, Federica Collino, Ciro Tetta, Giovanni Camussi Proteomics Approaches in the Identification of Molecular Signatures of Mesenchymal Stem Cells, by Yin Xiao, Jiezhong Chen Does the Adult Stroma Contain Stem Cells?, by Richard Schäfer
Mesenchymal Stem Cells and Immunomodulation
by Charles J. Malemud Eben AlsbergThis essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response. It also further defines the methodologies required to develop research on MSCs in vitro into established preclinical animal models including those which are proven replicas of autoimmunity and pre-term labor, to name but two. Mesenchymal Stem Cells and Immunomodulation, part of Springer's Stem Cell Biology and Regenerative Medicine, is an invaluable resource for researchers and clinicians working with stem cells, autoimmune disease, oncology, and reproductive medicine.
Mesenchymal Tumors of the Breast and Their Mimics: A Diagnostic Approach
by J. Jordi Rowe Erinn Downs-KellyThis book utilizes a uniform approach to provide a framework for the diagnosis of mesenchymal tumors of the breast while highlighting their mimics. Emphasis is placed on a practical approach to the morphologic interpretation and useful ancillary tests while exploring the differential diagnoses in depth. Given the overall low incidence of mesenchymal lesions of the breast along with their mimics, surgical pathologists are not consistently exposed to these spindle cell lesions. Compounding this problem is the broad differential that these lesions engender, with entities ranging from reactive/reparative lesions to poorly differentiated spindle cell malignancies. Furthering the challenge, the diagnoses may be complicated by fixation issues, sampling method, small sample size, lack of clinical history and prior treatment effects. The goal of this book is to introduce readers to the spectrum of these lesions while providing a systematic approach that helps establish accurate diagnoses that in turn drive appropriate clinical follow up and treatment. Chapters cover the spectrum of benign and malignant mesenchymal tumors and their mimics that are found in the breast in an easy to read format with richly detailed images to aid in diagnoses. The text also discusses practical components to aid in establishing and evaluating the differential diagnosis. Given how morphologically and clinically diverse these lesions are, Mesenchymal Tumors of the Breast and Their Mimics provides a construct for integrating the varied components that go into establishing a diagnosis for this challenging aspect of breast pathology.
Mesenteric Principles of Gastrointestinal Surgery: Basic and Applied Science
by John Calvin Coffey Rishabh Sehgal Dara WalshMesenteric-based gastrointestinal and colorectal surgery has been practiced internationally for over a century. However, it is not yet universally adopted, and considerable variations exist. Such variations are explained by the historical disparity that has persisted between anatomic and surgical approaches to the intestinal mesentery. While mesenteric-based surgery is far from new, it is remarkable that its anatomic basis has only recently been formally described. This means that key mesenteric principles of intestinal and colorectal surgery can now be taught, conducted and developed, in an entirely standardised manner. This book is composed of two parts. In this new book surgical anatomy, activities and operations are carefully defined, and beautifully illustrated, to enable all surgeons to conduct mesenteric-based intestinal and colorectal surgery, appropriately and with confidence.
Mesenteric Vascular Disease
by Gustavo S. OderichThis book represents the first comprehensive textbook devoted to the standard of care, current guidelines and innovations in the field of mesenteric vascular disease. The book reviews imaging modalities, diagnostic work up, physiologic tests, traditional open surgical techniques and novel endovascular approaches. Technical aspects of both open surgical and endovascular techniques are provided by experts in the field, with illustrations and photographs of key steps for each type of procedure. Results of epidemiologic studies and national databases are summarized, as well as large institutional experiences. An evidence-based approach is used for recommendations regarding best therapies. Diagnostic approaches including imaging and novel physiologic tests, including gastric tonometry and oxygen light spectroscopy are covered. Mesenteric Vascular Disease: Current Therapy will serve as a very useful resource for clinicians, surgeons, interventionalists, gastroenterologists and researchers dealing with and interested in mesenteric vascular diseases.
Meshless Methods in Biomechanics
by Jorge BelinhaThis book presents the complete formulation of a new advanced discretization meshless technique: the Natural Neighbour Radial Point Interpolation Method (NNRPIM). In addition, two of the most popular meshless methods, the EFGM and the RPIM, are fully presented. Being a truly meshless method, the major advantages of the NNRPIM over the FEM and other meshless methods, are the remeshing flexibility and the higher accuracy of the obtained variable field. Using the natural neighbour concept, the NNRPIM permits to determine organically the influence-domain, resembling the cellulae natural behaviour. This innovation permits the analysis of convex boundaries and extremely irregular meshes, which is an advantage in the biomechanical analysis, with no extra computational effort associated. This volume shows how to extend the NNRPIM to the bone tissue remodelling analysis, expecting to contribute with new numerical tools and strategies in order to permit a more efficient numerical biomechanical analysis.
Mesmerized
by Alissa WalserMozart's Vienna. A crucible for scientific experimentation and courtly intrigue, as Europe's finest minds vie for imperial favour. In a colourful, chaotic private hospital that echoes with the shrieks of hysterical patients, Franz Anton Mesmer is developing a series of controversial cure-alls for body and mind. When he is asked to help restore the sight of a blind musical prodigy favoured by the Empress herself, he senses that fame, and even immortality, is within his grasp. Mesmer knows that he will have to gain her trust if he is to open her eyes. But at what cost to her fragile talent? And will their intimacy result in scandal?
Mesmerized
by Alissa WalserMozart's Vienna. A crucible for scientific experimentation and courtly intrigue, as Europe's finest minds vie for imperial favour. In a colourful, chaotic private hospital that echoes with the shrieks of hysterical patients, Franz Anton Mesmer is developing a series of controversial cure-alls for body and mind. When he is asked to help restore the sight of a blind musical prodigy favoured by the Empress herself, he senses that fame, and even immortality, is within his grasp. Mesmer knows that he will have to gain her trust if he is to open her eyes. But at what cost to her fragile talent? And will their intimacy result in scandal?
Mesoamerican Healers
by Brad R. Huber Alan R. SandstromHealing practices in Mesoamerica span a wide range, from traditional folk medicine with roots reaching back into the prehispanic era to westernized biomedicine. These sometimes cooperating, sometimes competing practices have attracted attention from researchers and the public alike, as interest in alternative medicine and holistic healing continues to grow.<P><P>Responding to this interest, the essays in this book offer a comprehensive, state-of-the-art survey of Mesoamerican healers and medical practices in Mexico and Guatemala. The first two essays describe the work of prehispanic and colonial healers and show how their roles changed over time. The remaining essays look at contemporary healers, including bonesetters, curers, midwives, nurses, physicians, social workers, and spiritualists. Using a variety of theoretical approaches, the authors examine such topics as the intersection of gender and curing, the recruitment of healers and their training, healers' compensation and workload, types of illnesses treated and recommended treatments, conceptual models used in diagnosis and treatment, and the relationships among healers and between indigenous healers and medical and political authorities.
Mesothelioma
by Bruce W.S. Robinson A. Philippe ChahinianMesothelioma used to be a rare disease, but because of the widespread use of asbestos it has now been described as an epidemic around the world. The disease has proven exceptionally resistant to common forms of treatment (chemotherapy, radiotherapy and surgery). Mesothelioma has a very aggressive natural history with a median survival of around 9 m