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Mesothelioma: From Research to Clinical Practice
by Emilio Bombardieri Giovanni Luca Ceresoli Maurizio D’IncalciThis book offers an updated review of malignant mesothelioma, including the latest advances in our understanding of its genetic control and molecular biology, as well as pre-clinical and clinical research. It also presents state-of-the-art diagnostic approaches and therapeutic options, and an open discussion on the future prospects for patient management. Malignant mesothelioma is an enormous global health problem related to asbestos exposure. Despite the best efforts of scientists and oncologists, the prognosis for those affected remains poor. Due to anatomical characteristics and non-specific symptoms, the diagnosis of mesothelioma at an early stage is often difficult, while surgery and radiotherapy are only of limited use, even if some multimodality approaches seem promising. In turn, medical treatments are sometimes successful in tumor control, but have little impact on overall survival. However, advances in our understanding of the disease’s biology, together with the availability of new drugs and combinations, make mesothelioma an essential and highly topical field for pre-clinical and clinical studies. This book is subdivided into four parts: epidemiology and preclinical data, diagnosis, therapy, and extrathoracic mesothelioma. It highlights the progress made in a variety of areas – e.g. in vitro and in vivo experimental models, genetics, environment, biomarkers, targeting agents, immunotherapy, metabolic imaging and ongoing clinical trials – and describes the standard clinical management of mesothelioma patients, including those with extra-thoracic localizations. Given its scope, the book offers an invaluable tool for researchers, oncologists and clinicians alike.
Mesotheliomas of Animals: A Comprehensive, Tabular Compendium of the World's Literature
by Edward B. IlgrenMesotheliomas of Animals is the first book to provide a comprehensive compilation of the diverse and often disparate literature regarding animal mesotheliomas. The compendium presents evidence to support the existence of "background" and "threshold," both of which are concepts central to the controversy surrounding nonasbestos-related mesotheliomas. Examples of "background" tumors (those which are nonasbestos-related) are described in detail, and indications of "threshold" for the induction of mesotheliomas following exposure to asbestiform and nonasbestiform agents are evident from the "positive dose-response" studies that are discussed. This compendium also allows for easy comparison of tumor yields elicited in "inoculation" studies performed with the same fiber types at similar doses. These comparisons often demonstrate markedly different tumor yields and highlight the limitations of injection techniques for fiber safety assessment. Mesotheliomas of Animals will be an essential reference for industrial hygienists, environmental lawyers, cancer researchers, and pulmonary scientists. It will be particularly useful to anyone involved with the design of fiber safety tests or with developing experimental models and protocols to assess the manner in which mesotheliomagenesis occurs.
Mesotherapy and Its Medical Applications (Updates in Clinical Dermatology)
by Howard Maibach Esraa M. AlEdaniThis book is the first authoritative book volume dedicated to the application of Mesotherapy in dermatology. This book provides an up-to-date and comprehensive overview of the basic structural component of Mesotherapy and its constitution from the chemical side of view, then we will discuss its role in cosmetic dermatology, facial rejuvenation, its anti-aging properties, and its role with hyaluronic acid and mesoneedling therapy for facial youthfulness. This volume will describe interplay of mesotherapy and other dermatological diseases such as alopecia hair loss, melasma, acne, psoriasis, and eczema. Chapters will address key issues, such as mesotherapy complications and urticaria that are caused because of it. In addition, the book will discuss severe acute caffeine poisoning due to intradermal mesotherapy injections and the use of mesotherapy as a lucrative business in the cosmetic industry. This book will be a valuable resource to dermatologists, general practitioners, dermatology residents, and medical students.
Message in a Bottle: The Making of Fetal Alcohol Syndrome
by Janet GoldenA generation has passed since a physician first noticed that women who drank heavily while pregnant gave birth to underweight infants with disturbing tell-tale characteristics. Women whose own mothers enjoyed martinis while pregnant now lost sleep over a bowl of rum raisin ice cream. In Message in a Bottle, Janet Golden charts the course of Fetal Alcohol Syndrome (FAS) through the courts, media, medical establishment, and public imagination. Long considered harmless during pregnancy (doctors even administered it intravenously during labor), alcohol, when consumed by pregnant women, increasingly appeared to be a potent teratogen and a pressing public health concern. Some clinicians recommended that women simply moderate alcohol consumption; others, however, claimed that there was no demonstrably safe level for a developing fetus, and called for complete abstinence. Even as the diagnosis gained acceptance and labels appeared on alcoholic beverages warning pregnant women of the danger, FAS began to be de-medicalized in some settings. More and more, FAS emerged in court cases as a viable defense for people charged with serious, even capital, crimes and their claims were rejected. Golden argues that the reaction to FAS was shaped by the struggle over women's relatively new abortion rights and the escalating media frenzy over "crack" babies. It was increasingly used as evidence of the moral decay found within marginalized communities--from inner-city neighborhoods to Indian reservations. With each reframing, FAS became a currency traded by politicians and political commentators, lawyers, public health professionals, and advocates for underrepresented minorities, each pursuing separate aims.
Messenger RNA Therapeutics (RNA Technologies #13)
by Jan Barciszewski Stefan JurgaThis book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine. Thus, this handbook is an essential resource for researchers in academia and industry contributing to the development of this new area of therapeutics.
Messenger: The Legacy of Mattie J. T. Stepanek and Heartsongs
by Jeni Stepanek Larry LindnerIn Messenger, Jeni Stepanek shares the inspiring story of her son's life. Mattie was born with a rare disorder called Dysautonomic Mitochondrial Myopathy, and Jeni was advised to institutionalize him. Instead, she nurtured a child who transformed his hardships into a worldwide message of peace and hope.
Messung von Rückenmarksverletzungen: Ein praktischer Leitfaden für Outcome-Messungen
by Giovanni Galeoto Anna Berardi Marco Tofani Maria Auxiliadora MarquezDieses Buch beschreibt validierte Ergebnismessungen für die internationale Bevölkerung mit Rückenmarksverletzungen. Auf der Grundlage strenger systematischer Überprüfungen von ca. 80.000 wissenschaftlichen Artikeln stellen die Autoren Bewertungsinstrumente für verschiedene klinische Anwendungen in den Gesundheitswissenschaften vor und berücksichtigen dabei Parameter wie Validität, Zuverlässigkeit und Ansprechbarkeit.Für die Entwicklung der klinischen Praxis und der Forschung ist es wichtig, dass praktische und geeignete Messinstrumente allgemein akzeptiert werden; dies würde Vergleiche und Meta-Analysen von qualitativ hochwertigen randomisierten kontrollierten Studien mit Menschen mit dieser immer häufigeren Verletzung ermöglichen.Dieses Buch unterstreicht die Notwendigkeit eines Konsenses unter den Forschern darüber, welche Instrumente eingehend untersucht oder an andere nationale Kontexte angepasst werden müssen, oder welche Messinstrumente standardisiert werden sollten, um universelle Normen und Standards für die Leistung von Menschen mit Rückenmarksverletzungen zu entwickeln. Es bietet einen wertvollen praktischen Leitfaden für Kliniker, Rehabilitationsfachleute und Pflegepersonal, wird aber auch Forschern helfen, mehr Vertrauen in die Verwendung gültiger und zuverlässiger Bewertungsinstrumente für vergleichbare klinische Studien zu gewinnen.
Meta-Analysis for Psychologists
by Richard CookeThis textbook provides a comprehensive, user-friendly guide to meta-analysis and how to conduct it, using open source software and based on examples commonly found in the field of psychology. Meta-analysis is a key tool used in systematic literature reviews to synthesize research findings across studies, but despite being relatively straightforward to perform, it remains underused by psychologists. In the first section the reader is introduced to key ideas that underlie meta-analysis and how it might be best employed. Following this the reader is guided through how to run a meta-analysis of correlational studies and experimental studies using the free and open statistical software JAMOVI. In the concluding section Professor Cooke considers common issues, key debates and examines the relative merits of different analyses and different software packages.Covers theory, key issues and step-by-step demonstrationsIncludes examples worked examples familiar to psychologists and datasetsCompanion videos demonstrate the methods outlinedIt will provide a valuable new resource for postgraduate students and researchers in the behavioural and social sciences looking to enhance their methodological skills.
Meta-Analysis: Methods for Health and Experimental Studies (Statistics for Biology and Health)
by Shahjahan KhanThis book focuses on performing hands-on meta-analysis using MetaXL, a free add-on to MS Excel. The illustrative examples are taken mainly from medical and health sciences studies, but the generic methods can be used to perform meta-analysis on data from any other discipline. The book adopts a step-by-step approach to perform meta-analyses and interpret the results. Stata codes for meta-analyses are also provided. All popularly used meta-analytic methods and models – such as the fixed effect model, random effects model, inverse variance heterogeneity model, and quality effect model – are used to find the confidence interval for the effect size measure of independent primary studies and the pooled study. In addition to the commonly used meta-analytic methods for various effect size measures, the book includes special topics such as meta-regression, dose-response meta-analysis, and publication bias. The main attraction for readers is the book’s simplicity and straightforwardness in conducting actual meta-analysis using MetaXL. Researchers would easily find everything on meta-analysis of any particular effect size in one specific chapter once they could determine the underlying effect measure. Readers will be able to see the results under different models and also will be able to select the correct model to obtain accurate results.
Meta-Health: Understanding Metaverse for Healthcare
by Sunil Gupta Sonali Vyas Abhishek TyagiMetaverse is an emerging trend these days. It reflects in every field, like education, entertainment, business, and even healthcare. As we can experience, the Healthcare industry is constantly transforming due to emerge of new trends and technologies like moving from X-Rays to digital reports and from telehealth to Virtual Reality. It is a vast digital shift from regular practices to innovative techniques for efficient healthcare services. Metaverse plays a significant role in changing healthcare because it connects innovative technologies like Artificial Intelligence, Virtual Reality, Augmented Reality, IoT, Web 3.0, Quantum Computing, Robotics, etc. This book discusses the application area of utilizing Metaverse in Healthcare services. It focuses on various research trends and technologies related to implementing a metaverse in healthcare systems. It also covers challenges, emerging trends and techniques, and future directions for meta-healthcare systems.
Meta-analysis in Clinical Research: Principles and Procedures
by Anoop KumarThis book provides conceptual information on the various processes involved in meta-analysis. It examines the importance of meta-analysis for the analyses of clinical data to draw a valid conclusion using suitable software. The initial sections of the book introduce meta-analysis, how to perform a systematic literature review (SLR), quality assessment of studies, extraction, and analysis of data. The subsequent section of the book contains information on advanced topics including, meta-regression, network meta-analysis, issues, mistakes, and future perspectives. In summary, the book provides a statistical method for combining the results of different studies on the same topic and resolving conflicts among studies. This book is written with the intent to allow a wide range of readers including students, researchers, and health care professionals, including physicians, nurses, pharmacists, and paramedical, and is also helpful for a beginner who would like to do a meta-analysis.
Metabolic & Therapeutic Aspects of Amino Acids in Clinical Nutrition
by Luc A. CynoberThe first edition of this innovative book brought a new perspective to the metabolic and therapeutic aspects of amino acids in clinical nutrition. Since its publication, a number of very important advances have been made in the field and interesting new findings have emerged. Until now, no reference has fully explored the promising new developments
Metabolic Aspects of PCOS
by Mariagrazia Stracquadanio Lilliana CiottaThis book on the metabolic aspects of polycystic ovary syndrome (PCOS) reviews the scientific evidence for the key etiological role of insulin resistance in the pathogenesis of PCOS. It also presents a new clinical and diagnostic approach and clearly explains the value of insulin-sensitizing agents, or "insulin sensitizers," in reducing hyperandrogenism and improving fertility outcome. Detailed information is provided on the use of insulin sensitizers such as metformin and inositol and suitable therapeutic protocols are described. All too often, PCOS is treated by gynecologists only as an endocrine disorder, without recognition of the very important part that insulin plays in the syndrome. Practitioners will find this book to be a valuable source of information on PCOS as a metabolic syndrome and a comprehensive guide to achieving good treatment results.
Metabolic Basis of Obesity
by Rexford S. AhimaThe obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.
Metabolic Bone Diseases: A Case-Based Approach
by Pauline M. CamachoThis concise, case-based text discusses the current state of the art for the diagnosis and management of metabolic bones diseases. Each chapter opens with a unique case presentation and utilizes a consistent format that includes relevant anatomy, physiology, and pathophysiology as well as examination, treatment approaches and clinical outcomes. Topics covered include osteoporosis, rickets and osteomalacia, hypoparathyroidism and pseudohypoparathyroidism, osteogenesis imperfecta, Paget's disease of bone, calcium and phosphorous disorders, hypophosphatasia, sclerotic bone disorders, fibrous and osteochondroplasia, and other malignancies of bone. Written and edited by experts in the field, Metabolic Bone Diseases is a valuable resource for practicing endocrinologists, rheumatologists and orthopedic surgeons, residents and fellows.
Metabolic Control
by Stephan HerzigThe HEP issue on Metabolic Control provides a state-of the art overview over both classical concepts and emerging areas in metabolism and associated disorders. In this context, metabolic control is highlighted at various levels of complexity ranging from transcriptional mechanisms in metabolic pathway control over metabolic communication routes in physiology and pathophysiology to current treatment modalities and options in metabolic disorders, including type 2 diabetes and obesity. Dedicated chapters by leading experts in their fields provide a concise overview over important areas in metabolic research at a molecular level, including the role of the central nervous system in metabolism, inflammation and metabolism, pancreatic hormone signaling, brown adipose tissue, and therapeutic concepts.
Metabolic Disorders and Critically Ill Patients
by Carole Ichai Hervé Quintard Jean-Christophe OrbanThe purpose of this book is to bring together the latest findings on metabolic disorders that are strongly implicated in various critically ill patients. Since the beginning of the 20th century, maintaining the "milieu int#65533;rieur" has been a major challenge for intensivists. In addition to considerable technological developments in intensive care units, important advances in our understanding of metabolic disorders observed in critically ill patients have been made during the 10 last years. Today, the intensivit can't ignore these disorders when selecting the most appropriate treatment for an illness. Cellular metabolic abnormalities are responsible for systems and organ failures, so the modern approach of organ dysfunctions now includes prevention or treatment of such disorders. This book is a comprehensive tool, allowing the physician to understand, diagnose and treat these metabolic disorders. Water, electrolyte, acid-base, glycemic and endocrinologic problems, as well as metabolic abnormalities observed in renal, cerebral and hepatic failure are presented in different chapters. The last part of the book is devoted to modern nutritional concepts, the consequences of energy modifications, mitochondrial dysfunction, hypothermia, oxidative stress and ischemia reperfusion, which open the way for new therapies.
Metabolic Dysfunction-Associated Steatotic Liver Disease: Prevalence, research insights and the future directions
by Xingshun Qi Nahum Méndez-SánchezThis book provides crucial insights into the most recent advancements in understanding pathophysiology of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), and presents innovative treatment approaches. The emerging areas of study and potential avenues for further investigation are discussed in chapters. Additionally, the latest information on diagnostic tools, lifestyle interventions, and pharmacological treatments is also presented. With the worldwide prevalence of MASLD on the rise, it helps to equip medical professionals (hepatologists, gastroenterologists, endocrinologists, cardiologists, nephrologists, internists, and surgeons), researchers, and patients with up-to-date knowledge to effectively combat this multifaceted condition.
Metabolic Effects Of Dietary Fructose
by Sheldon ReiserIt is hoped that the material presented in this book will provide the reader with a detailed description of the published research pertaining to the metabolic effects of dietary fructose, will define future research needs, and will stimulate interest in further research aimed at evaluating the advisability of the intake of fructose by humans.
Metabolic Encephalopathy
by David W. MccandlessMetabolic Encephalopathy is meant to combine and correlate animal and human studies. It is hoped that increased awareness of the importance of early diagnosis and treatment of these disorders may result in a lowering of the incidence of structural changes and morbidity. These disorders hold a special fascination for both basic scientists and clinical investigators because they are accessible, treatable and there exists good animal models for study. Therefore, this book will pull together basic and clinical neuroscience issue in the treatment of specific metabolic encephalopathies.
Metabolic Flux Analysis
by Jens O. Krömer Lars K. Nielsen Lars M. BlankMetabolic Flux Analysis: Methods and Protocols opens up the field of metabolic flux analysis to those who want to start a new flux analysis project but are overwhelmed by the complexity of the approach. Metabolic flux analysis emerged from the current limitation for the prediction of metabolic fluxes from a measured inventory of the cell. Divided into convenient thematic parts, topics in this essential volume include the fundamental characteristics of the underlying networks, the application of quantitative metabolite data and thermodynamic principles to constrain the solution space for flux balance analysis (FBA), the experimental toolbox to conduct different types of flux analysis experiments, the processing of data from 13C experiments and three chapters that summarize some recent key findings. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Metabolic Flux Analysis: Methods and Protocols presents protocols that cover a range of relevant organisms currently used in the field, providing a solid basis to anybody interested in the field of metabolic flux analysis.
Metabolic Influences on Risk for Tendon Disorders
by Paul W. Ackermann David A. HartThis book will be of considerable interest to students, practitioners (Doctors, Physiotherapists) and researchers who deal with the complex structures of tendons and tendon disorders. The book is divided into three sections: (1) Basic Biology; (2) Metabolic Disorders; and (3) Biochemical Markers and Tendon disorders. The first section, devoted to the basic biology of tendons, is aimed at those people who want to learn and gain basic information on tendons. The section on metabolic disorders will mainly be aimed at practitioners who need to know how to treat their patients. Finally, the section on biochemical markers is chiefly aimed at the researchers who are planning new studies within this field.
Metabolic Interaction in Infection (Experientia Supplementum #109)
by Ricardo Silvestre Egídio TorradoThis book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.
Metabolic Living: Food, Fat, and the Absorption of Illness in India
by Harris SolomonThe popular narrative of "globesity" posits that the adoption of Western diets is intensifying obesity and diabetes in the Global South and that disordered metabolisms are the embodied consequence of globalization and excess. In Metabolic Living Harris Solomon recasts these narratives by examining how people in Mumbai, India, experience the porosity between food, fat, the body, and the city. Solomon contends that obesity and diabetes pose a problem of absorption between body and environment. Drawing on ethnographic fieldwork carried out in Mumbai's home kitchens, metabolic disorder clinics, food companies, markets, and social services, he details the absorption of everything from snack foods and mangoes to insulin, stress, and pollutants. As these substances pass between the city and the body and blur the two domains, the onset and treatment of metabolic illness raise questions about who has the power to decide what goes into bodies and when food means life. Evoking metabolism as a condition of contemporary urban life and a vital political analytic, Solomon illuminates the lived predicaments of obesity and diabetes, and reorients our understanding of chronic illness in India and beyond.
Metabolic Medicine and Surgery
by Michael M. Rothkopf Michael J. Nusbaum Lisa P HaverstickThe first comprehensive overview of an emerging field, Metabolic Medicine and Surgery introduces a new paradigm in patient management that crosses existing subspecialty boundaries. This approach is necessitated by the challenges of treating patients with obesity, metabolic syndrome, cardiovascular disease and prediabetes, as well as those with mald