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Microscopy of the Heart
by Lars Kaestner Peter LippThis book provides in depths information on different microscopy approaches and supplies the reader with methods how to untangle highly complex processes involved in physiological and pathophysiological cardiac signaling. Microscopy approaches have established themselves as the quasi gold standard that enables us to appreciate the underlying mechanisms of physiological and pathophysiological cardiac signaling. This book presents the most important microscopy techniques from the level of individual molecule e.g. Förster-Resonance Energy Transfer (FRET), up to cellular and tissue imaging, e.g. electron microscopy (TEM) or light sheet microscopy. The book is intended for graduate students and postdocs in cardiovascular research, imaging and cell biology, pre-clinical and clinical researchers in cardiovascular sciences as well as decision makers of the pharmaceutical industry.
Microskin Grafting for Vitiligo
by Devendra K. GuptaThis book aims to provide information on the application of microskin grafting to repigmentation of vitiligo, effectively economising the procedure and offering a quick surgical practice. The procedure will be illustrated in an extensive selection of images to offer the physician a thorough education in the technique so they may carry out the process safely, efficiently and with confidence. This atlas will focus on the surgical procedure, but special attention will also be given to regional anesthesia techniques which will also work as postoperative analgesia for the donor site discomfort and burning.
Microsoft Dynamics 365 Business Central Cookbook: Effective recipes for developing and deploying applications with Dynamics 365 Business Central
by Michael GlueGain useful insights to help you efficiently build, test, and migrate customized solutions on Business Central cloud and on-premise platforms Key Features Explore enhanced functionalities and development best practices in Business Central Develop powerful Business Central projects using the AL language Master the new Business Central with easy-to-follow recipes Book Description Microsoft Dynamics 365 Business Central is a complete business management solution that can help you streamline business processes, connect individual departments in your company, and enhance customer interactions. Ok. That first part was really professional sounding, right? Now, let's get into what this cookbook is going to do for you: put simply, it's going to help you get things done. This book will help you get to grips with the latest development features and tools for building applications using Business Central. You'll find recipes that will guide you in developing and testing applications that can be deployed to the cloud or on-premises. For the old-schoolers out there, you'll also learn how to take your existing Dynamics NAV customizations and move them to the new AL language platform. Also, if you haven't figured it out already, we're going to be using very normal language throughout the book to keep things light. After all, developing applications is fun, so why not have fun learning as well! What you will learn Build and deploy Business Central applications Use the cloud or local sandbox for application development Customize and extend your base Business Central application Create external applications that connect to Business Central Create automated tests and debug your applications Connect to external web services from Business Central Who this book is for This book is for Dynamics developers and administrators who want to become efficient in developing and deploying applications in Business Central. Basic knowledge and understanding of Dynamics application development and administration is assumed.
Microsoft Dynamics AX 2012 R3 Financial Management
by Mohamed AamerThis book is intended for application consultants, controllers, CFOs, and other professionals who are engaged in a Microsoft Dynamics AX implementation project. Basic knowledge of financial terms, concepts, and Microsoft Dynamics AX terminologies is required.
Microsoft Dynamics CRM Customization Essentials
by Nicolae TarlaIf you are new to Dynamics CRM or a seasoned user looking to enhance your knowledge of the platform, then this book is for you. It is also for skilled developers who are looking to move to the Microsoft stack to build business solution software.
Microsoft Dynamics NAV Development Quick Start Guide: Get up and running with Microsoft Dynamics NAV
by Alexander DroginLearn development skills and improve productivity when programming in Microsoft Dynamics NAV 2018 - the popular Enterprise Resourse Planning management system used across a variety of industries for business process management Key Features Solve common business problems with the valuable features and flexibility of Dynamics NAV Understand the structure of NAV database - how documents and business entities are mapped to DB tables Design user interface and bind the presentation layer with the data storage Book Description Microsoft Dynamics NAV is an enterprise resource planning (ERP) software suite for organizations. The system offers specialized functionality for manufacturing, distribution, government, retail, and other industries. This book gets you started with its integrated development environment for solving problems by customizing business processes. This book introduces the NAV development environment – C/SIDE. It gives an overview of the internal system language and the most essential development tools. The book will enable the reader to customize and extend NAV functionality with C/AL code, design a user interface through pages, create role centers, and build advanced reports in Microsoft Visual Studio. By the end of the book, you will have learned how to extend the NAV data model, how to write and debug custom code, and how to exchange data with external applications. What you will learn Manage NAV Server configuration with Microsoft Management Console Manage NAV installation with the NAV Administration Shell Create integration events and extend functionality via the NAV event model Run XML Ports from C/AL code Design reports and write client code in RDLC expressions Who this book is for This book is for experienced NAV users who have an understanding of basic programming concepts. Familiarity with NAV development environment or its internal development language-C/AL is not expected.
Microspheres and Regional Cancer Therapy
by Neville Willmott John M. DalyMicrospheres and Regional Cancer Therapy takes an interdisciplinary approach to the subject of microspheres and regional cancer therapy. It synthesizes laboratory and clinical data to demonstrate the utility of microsphere-based strategies in the treatment of localized solid tumors (particularly in the liver) not amenable to surgery and as a component of strategies for treatment of disseminated disease. Using the same techniques that show the deficiencies of delivery strategies involving antibodies, liposomes, and synthetic polymers, clear evidence is presented describing how microspheres of appropriate size can be localized in solid tumor deposits in the liver with little exposure to other organs. To exploit this phenomenon, the extent and nature of the incorporation of active agents within microspheres is discussed in relation to release, pharmacokinetics, and tumor response achieved by intensification of therapy in the manner described. This book will benefit laboratory-based scientists and clinicians in pharmaceutics, pharmacology, physiology, surgical oncology, and nuclear medicine. In addition, cancer clinicians interested in the value of regional therapy will be able to evaluate the underlying theory and learn the necessary methodology.
Microspheres: Medical and Biological Applications (CRC Press Revivals)
by Alan Rembaum Zoltan A. TokesWe have previously described the syntheses of both magnetic and nonmagnetic polymeric microspheres, and we have reported their application in removal of neuroblastoma cells from normal cells in bone marrow, in the separation of red blood cells, and the separation of human B and T lymphocytes. In the present study, we describe a series of hydrophilic microspheres consisting of (1) poly-HEMA and (2) a copolymer sequence of HEMA-acrolein microspheres.
Microsporidia: Current Advances in Biology (Experientia Supplementum #114)
by Louis M. Weiss Aaron W. ReinkeThis book provides an up-to-date overview on the biology of microsporidia, focusing on areas where significant progress has been made in recent years. In particular, our understanding of the evolutionary position and the role of genome reduction in the biology of these enigmatic intracellular pathogens is discussed. This book also offers important updates on the mechanisms used by these organisms to modify the host cell biology of mammals, insects, nematodes, and aquatic animals, as well as the mechanisms controlling infection and host specificity. Readers gain a detailed overview of the structure and function of the polar tube, the unique invasion apparatus of microsporidia, as well as the physics and dynamics of spore firing. Particular attention is given to chronic infections in mammals caused by microsporidia, as well as common immune responses.Written by an international team of authors representing the main research groups working on microsporidian biology, this book is a valuable resource for health management professionals, experienced microbiologists, and early career scientist alike who want to learn more about these fascinating parasites. The ideas and latest finding covered in this book contribute to UN Sustainable Development Goal 3: Good Health and Well-Being. Chapter “Impact of Genome Reduction in Microsporidia“ is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Microstructural Parcellation of the Human Cerebral Cortex: From Brodmann's Post-Mortem Map to in Vivo Mapping with High-Field Magnetic Resonance Imaging
by Robert Turner Stefan GeyerUnraveling the functional properties of structural elements in the brain is one of the fundamental goals of neuroscientific research. In the cerebral cortex this is no mean feat, since cortical areas are defined microstructurally in post-mortem brains but functionally in living brains with electrophysiological or neuroimaging techniques - and cortical areas vary in their topographical properties across individual brains. Being able to map both microstructure and function in the same brains noninvasively in vivo would represent a huge leap forward. In recent years, high-field magnetic resonance imaging (MRI) technologies with spatial resolution below 0.5 mm have set the stage for this by detecting structural differences within the human cerebral cortex, beyond the Stria of Gennari. This provides the basis for an in vivo microanatomical brain map, with the enormous potential to make direct correlations between microstructure and function in living human brains. This book starts with Brodmann's post-mortem map published in the early 20th century, moves on to the almost forgotten microstructural maps of von Economo and Koskinas and the Vogt-Vogt school, sheds some light on more recent approaches that aim at mapping cortical areas noninvasively in living human brains, and culminates with the concept of "in vivo Brodmann mapping" using high-field MRI, which was introduced in the early 21st century.
Microstructural Parcellation of the Human Cerebral Cortex: From Brodmann's Post-Mortem Map to in Vivo Mapping with High-Field Magnetic Resonance Imaging
by Stefan Geyer and Robert TurnerUnraveling the functional properties of structural elements in the brain is one of the fundamental goals of neuroscientific research. In the cerebral cortex this is no mean feat, since cortical areas are defined microstructurally in post-mortem brains but functionally in living brains with electrophysiological or neuroimaging techniques – and cortical areas vary in their topographical properties across individual brains. Being able to map both microstructure and function in the same brains noninvasively in vivo would represent a huge leap forward. In recent years, high-field magnetic resonance imaging (MRI) technologies with spatial resolution below 0.5 mm have set the stage for this by detecting structural differences within the human cerebral cortex, beyond the Stria of Gennari. This provides the basis for an in vivo microanatomical brain map, with the enormous potential to make direct correlations between microstructure and function in living human brains.This book starts with Brodmann’s post-mortem map published in the early 20th century, moves on to the almost forgotten microstructural maps of von Economo and Koskinas and the Vogt-Vogt school, sheds some light on more recent approaches that aim at mapping cortical areas noninvasively in living human brains, and culminates with the concept of “in vivo Brodmann mapping” using high-field MRI, which was introduced in the early 21st century.
Microsurgery 101: Tips and Tricks for Microvascular and Peripheral Nerve Repair Techniques
by Yelena Akelina Alberto BallestínThis book is a detailed teaching manual for training in microvascular and peripheral nerve surgery with step-by-step instructions using high-quality pictures and videos. It consists of valuable practical tips and tricks that are explained in detail to the readers, making it a useful tool for both inexperienced and experienced practitioners looking to improve their skills. Microsurgery has diverse clinical applications across multiple medical specialties. It is commonly employed in reconstructive surgery to address tissue defects following trauma, oncological resections, or congenital anomalies, utilizing precise procedures to reattach small blood vessels and nerves. This includes the replantation of amputated body parts such as fingers or hands, as well as the reconstruction of complex defects in the head and neck region, upper and lower extremities and breast among others. Microsurgical techniques are also crucial in nerve repair surgeries to restore function and sensation after trauma but as well in facial reanimation procedures to address paralysis; meanwhile lymphaticovenous anastomosis and vascularized lymph node transfers are useful procedures to treat or prevent lymphedema. Overall, microsurgery represents a cornerstone in modern medicine, offering innovative solutions for a wide range of clinical challenges. Microsurgery 101 - Tips and Tricks for Microvascular and Peripheral Nerve Repair Techniques is a unique guidebook for medical students, residents, fellows, and practicing surgeons from multiple specialties: plastic, hand and orthopedic, maxillofacial, head and neck, neurosurgery, transplant, ophthalmology, pediatric, cardiovascular, urology, gynecology, vascular, general surgery and veterinary surgery.
Microsurgery Manual for Medical Students and Residents: A Step-by-Step Approach
by Arbak Khachatryan Artur Tevosyan David Novoselskiy Gevorg Arakelyan Alexey Yushkevich David Nazaretovich NazarianThis book provides a practically applicable guide on how to develop essential microsurgery skills and successfully perform a range of procedures. Emphasis is placed within each chapter on equipping the reader with the necessary information to enable them to develop a strong foundational knowledge of every technique covered with clear step-by-step guides on how to perform a range of methodologies. Helpful tips are provided on how to avoid common pitfalls and enhance skill acquisition. Accompanying video material also reinforces the key points detailed. Topics covered include how to develop skills utilizing the porcine model of flap harvesting along with the use of animal models for techniques such as vascular anastomoses, anesthesia, and exposure of relevant recipient vessels. Microsurgery Manual for Medical Students and Residents is a detailed resource on how to acquire core microsurgery skills, making it an ideal resource for medical students and trainees seeking a resource on how to further develop their skills.
Microsurgery for Fertility Specialists
by Jay I. SandlowMicrosurgery for Fertility Specialists is an invaluable resource for physicians who specialize in the surgical treatment of male and female infertility. This practical text explains the basics of microsurgery and provides detailed operative descriptions of surgical procedures such as vasectomy reversal, sperm retrieval, tubal reanastomosis, and penile surgery. An exceptional cadre of reproductive specialists shares valuable knowledge of the current state of microsurgery, its role in infertility procedures, and the latest advances in the field --including some non-infertility microsurgical techniques. The book is an essential educational guide for those with a more advanced knowledge of microsurgical practice as it includes chapters that will help them mentor residents and fellows, and inspire future generations of reproductive surgeons.
Microsurgery in Endodontics
by Bekir Karabucak Meetu Kohli Frank SetzerMicrosurgery in Endodontics provides the definitive reference to endodontic microsurgery, with instructive photographs and illustrations. Provides a definitive reference work on endodontic microsurgery Includes contributions from pioneers and innovators in the field of microsurgical endodontics Describes techniques for a wide range of microsurgical procedures Includes more than 600 instructive illustrations and photographs
Microsurgery in Periodontal and Implant Dentistry: Concepts and Applications
by Hsun-Liang Albert Chan Diego Velasquez-PlataThis book compiles all relevant information regarding fundamental concepts and advanced techniques related to the applications of minimally invasive procedures in periodontal and implant therapy facilitated with the operating microscope. Microsurgical therapy, wound healing principles as well as biomechanical and design aspects of micro-instruments and suturing armamentarium are discussed. The book offers information that is usually scattered in the dental and medical literature and not only hard to compile but also to frame in the appropriate clinical categories. Its unique emphasis on ergonomics (patient, operator and assistant positioning) and collaboration techniques like four to six hand assisting make this work unique. Each topic is discussed by world renowned experts in the field. The book is a valuable resource for the dental society including general dentists, periodontists, oral surgeons and implantologists.
Microsurgical Anatomy and Surgery of the Posterior Cranial Fossa
by Toshio MatsushimaThis book describes the anatomy of the posterior fossa, together with the main associated surgical techniques, which are detailed in numerous photographs and step-by-step color illustrations. The book presents approaches and surgical techniques such as the trans-cerebellomedullary fissure approach and its variation to the fourth ventricle, as well as the cerebellomedullary cistern, infratentorial lateral supracerebellar approach to the fifth cranial nerve in the upper cerebellopontine angle, infrafloccular approach to the root exit zone of the seventh cranial nerve, transcondylar fossa approach through the lateral part of the foramen magnum, and the stitched sling retraction technique utilized during microvascular decompression procedures for trigeminal neuralgia and hemifacial spasm. It also describes in detail the bridging veins of the posterior fossa, especially the petrosal vein, and bridging veins to the tentorial sinuses, which can block approaches to the affected area. Each chapter begins with an anatomical description of the posterior fossa, after which the respective surgical approaches are explained in an easy-to-follow manner. The original Japanese version of this work was published 8 years ago, and has established itself as a trusted guide, especially among young neurosurgeons who need to study various surgical approaches and techniques. In the course of being translated into English, some sections have been revised and new information has been added. The author hopes that the book will help neurosurgeons around the world perform safer operations with confidence.
Microsurgical Brain Aneurysms
by Hans-Jakob Steiger Nima Etminan Daniel HänggiThis compact book provides step-by-step guidance in the approaches and techniques developed and currently used at the authors' center in Düsseldorf for the treatment of a variety of aneurysms. All of the described procedures are minimally invasive and of proven efficacy. In order to assist the reader in fully comprehending all aspects of the techniques, they are illustrated through clear graphics instead of complex photos and radiologic imaging. While the rapid development of endovascular treatment means that it is no longer necessary to employ microsurgery for difficult and hidden aneurysms, proficiency in microsurgery remains essential. For example, full mastery of microsurgical techniques is vital in order to treat middle cerebral and peripheral aneurysms efficiently and with minimal trauma. Minimal invasiveness and optimal cosmetic results have become critically important in enabling the microsurgical method to compete with the endovascular method. In documenting "tried and tested" procedures, this book will be invaluable for both established neurosurgeons and residents in neurosurgery.
Microsurgical Orthopedics
by Guoxian PeiMicrosurgical techniques are widely used in the field of orthopaedics. This book addresses all aspects of orthopaedic microsurgery, from development of the principles to their applications. Replantation of fingers, hands and extremity parts are well summarized by highly experienced microsurgical surgeons. The methods for tissue transplantation and microsurgical reconstruction of tissue defects, which have been proved to be successful tools for saving severely injured extremities, were developed by experienced orthopaedic surgeons in cooperation with plastic surgeons. Injuries to peripheral nerves and the brachial plexus are also discussed extensively in this monograph. All illustrations and tables were meticulously selected and are easy to understand. The book was written for all microsurgeons who work in the fields of orthopaedics, plastic and hand surgery. Guoxian Pei is a professor at the Department of Orthopaedics, Xijing Hospital, the Fourth Military Medical University, Xi An, China.
Microsystems for Enhanced Control of Cell Behavior
by Andrés Díaz LantadaThis handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and biomimetic microsystems (including organs-on-chips), among others. Challenges relating to the development of reliable in vitro biomimetic microsystems, the design and manufacture of complex geometries, and biofabrication are also discussed.
Microsystems for Pharmatechnology
by Andreas DietzelThis book provides a comprehensive, state-of-the-art review of microfluidic approaches and applications in pharmatechnology. It is appropriate for students with an interdisciplinary interest in both the pharmaceutical and engineering fields, as well as process developers and scientists in the pharmaceutical industry. The authors cover new and advanced technologies for screening, production by micro reaction technology and micro bioreactors, small-scale processing of drug formulations, and drug delivery that will meet the need for fast and effective screening methods for drugs in different formulations, as well as the production of drugs in very small volumes. Readers will find detailed chapters on the materials and techniques for fabrication of microfluidic devices, microbioreactors, microsystems for emulsification, on-chip fabrication of drug delivery systems, respiratory drug delivery and delivery through microneedles, organs-on-chip, and more.
Microtechnology for Cell Manipulation and Sorting
by Wonhee Lee Peter Tseng Dino Di CarloThis book delves into the recent developments in the microscale and microfluidic technologies that allow manipulation at the single and cell aggregate level. Expert authors review the dominant mechanisms that manipulate and sort biological structures, making this a state-of-the-art overview of conventional cell sorting techniques, the principles of microfluidics, and of microfluidic devices. All chapters highlight the benefits and drawbacks of each technique they discuss, which include magnetic, electrical, optical, acoustic, gravity/sedimentation, inertial, deformability, and aqueous two-phase systems as the dominant mechanisms utilized by microfluidic devices to handle biological samples. Each chapter explains the physics of the mechanism at work, and reviews common geometries and devices to help readers decide the type of style of device required for various applications. This book is appropriate for graduate-level biomedical engineering and analytical chemistry students, as well as engineers and scientists working in the biotechnology industry.
Microtubule Proteins
by Jesus AvilaThis work focuses on the structural and functional description of the microtubule proteins. The objective of the authors is to establish a relationship between the structure of microtubule proteins and the functions in which these polymers are involved. This book covers topics which have been treated only in a preliminary manner in previous works, such as microtubule dynamics and microtubule poisons. Microtubules display a variety of cellular roles and are vital for the separation and correct distribution of chromosomes during cell division. They also play an important role in morphogenesis, intracellular transport, secretion, and motility. Microtubule Proteins is a concise, easy-to-read text which is particularly of interest to cell biologists, chemists, neurochemists, and graduate students interested in cell biology.
Microtubule Protocols
by Jun ZhouThis book presents a comprehensive collection of essential and up-to-date methods for studying both the biology of microtubules and the mechanisms of action of microtubule-interacting drugs. The book contains a straightforward presentation of readily reproducible protocols, tips for troubleshooting, and advice on avoiding common mistakes. Basic scientists and clinical researchers will benefit from this collection.
Microtubules: Methods and Protocols (Methods in Molecular Biology #2430)
by Hiroshi InabaThis volume provides state-of-the-art methodology to functionalize microtubules and construct microtubule-based materials. Chapters consists of six sections detailing modification of microtubule structures, observation and control of microtubule movement, material applications of microtubules in vitro, development of microtubule-binding molecules, comprehensive approaches to analyze properties of microtubules, and functionalization of microtubules in living cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Microtubules: Methods and Protocols aims to provide useful information for construction of microtubule-based materials and help to create new ideas for the next-generation of materials and applications through detailed protocols.