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An Omics Perspective on Cancer Research
by William C.S. ChoOmics is an emerging and exciting area in the field of science and medicine. Numerous promising developments have been elucidated using omics (including genomics, transcriptomics, epigenomics, proteomics, metabolomics, interactomics, cytomics and bioinformatics) in cancer research. The development of high-throughput technologies that permit the solution of deciphering cancer from higher dimensionality will provide a knowledge base which changes the face of cancer understanding and therapeutics. This is the first book to provide such a comprehensive coverage of a rapidly evolving area written by leading experts in the field of omics. It complies and details cutting-edge cancer research that covers the broad advances in the field and its application from cancer-associated gene discovery to drug target validation. It also highlights the potential of using integration approach for cancer research. This unique and timely book provides a thorough overview of developing omics, which will appeal to anyone involved in cancer research. It will be a useful reference book for graduate students of different subjects (medicine, biology, engineering, etc) and senior scientists interested in the fascinating area of advanced technologies in cancer research. Readership: This is a precious book for all types of readers - cancer researchers, oncologists, pathologists, biologists, clinical chemists, pharmacologists, pharmaceutical specialists, biostatisticians, and bioinformaticists who want to expand their knowledge in cancer research.
An Open Secret: The History of Unwanted Pregnancy and Abortion in Modern Bolivia
by Natalie L. KimballMany women throughout the world face the challenge of confronting an unexpected or an unwanted pregnancy, yet these experiences are often shrouded in silence. An Open Secret draws on personal interviews and medical records to uncover the history of women’s experiences with unwanted pregnancy and abortion in the South American country of Bolivia. This Andean nation is home to a diverse population of indigenous and mixed-race individuals who practice a range of medical traditions. Centering on the cities of La Paz and El Alto, the book explores how women decided whether to continue or terminate their pregnancies and the medical practices to which women recurred in their search for reproductive health care between the early 1950s and 2010. It demonstrates that, far from constituting private events with little impact on the public sphere, women’s intimate experiences with pregnancy contributed to changing policies and services in reproductive health in Bolivia.
An Oral History of the Special Olympics in China Volume 1: Overview (Economy and Social Inclusion)
by William P. Alford Mei Liao Fengming CuiThis open access book is unique in presenting the first oral history of individuals with an intellectual disability and their families in China. In this summary volume and the two accompanying volumes that follow, individuals with an intellectual disability tell their life stories, while their family members, teachers, classmates, and co-workers describe their professional, academic, and family relationships. Besides interview transcripts, each volume provides observations and records in real time the daily experiences of people with an intellectual disability. Drawing on the methodologies of sociology and oral history, the summary volume provides an unprecedented account of how people with intellectual disabilities in China understand themselves while also examining pertinent issues of public policy and civil society that have ramifications beyond the field of disability itself.
An Oral History of the Special Olympics in China Volume 2: The Movement (Economy and Social Inclusion)
by William P. Alford Mei Liao Fengming CuiThis open access book contains the oral histories that were inspired by the work of the Special Olympics in conjunction with the 50th anniversary of its founding. The foreword and prefatory materials provide an overview of the Special Olympics and its growth in the People’s Republic of China. The sections that follow record interview transcripts of individuals with intellectual disabilities living in Shanghai. In addition to chronicling the involvement of these individuals and their families in the Special Olympics movement, the interview transcripts also capture their daily lives and how they have navigated school and work.
An Oral History of the Special Olympics in China Volume 3: Finding and Keeping a Job (Economy and Social Inclusion)
by William P. Alford Mei Liao Fengming CuiThis open access book brings together oral histories that record the experiences of individuals with intellectual disabilities in Shanghai as they participate in their careers. Employees with intellectual disabilities describe their experiences seeking, attaining, and maintaining employment. Their managers, colleagues, and family members also provide keen insight into the challenges and opportunities these individuals have encountered in the process of securing employment. An appendix provides a compilation of employment policies related to people with intellectual disabilities, particularly with respect to Shanghai.
An Order For Death: The Seventh Matthew Bartholomew Chronicle (Chronicles of Matthew Bartholomew #7)
by Susanna GregoryThe seventh chronicle in the Matthew Bartholomew series. It is a time of division and denomination at the great University. The Carmelites and the Dominicans are at theological loggerheads, so much so that the more fanatical members are willing to swap rational judgement for a deadlier form of debate. And no sooner is Carmelite friar Faricius found stabbed than a Junior Proctor is found hanging from the walls of the Dominican Friary.What was Faricius doing out when he had not been given permission to wander? How are the nuns at the nearby convent of St Radegund involved? And who is brokering trouble between Cambridge and its rival University at Oxford? The longer their enquiries go on, the more Bartholomew and Michael realise that the murders are less to do with high-minded academic principles, and more to do with far baser instincts.'A first-rate treat for mystery lovers' (Historical Novels Review)'Susanna Gregory has an extraordinary ability to conjure up a strong sense of time and place' (Choice)
An Order For Death: The Seventh Matthew Bartholomew Chronicle (Chronicles of Matthew Bartholomew #7)
by Susanna GregoryBelievers in the theory of nominalism have set some Cambridge colleges at the throats of those who believe them to be heretics and Michael, the Senior Proctor, has his work cut out to keep the peace. When a nominalist is murdered during a riot Michael is certain he will easily find the killer amongst the Dominicans, but before he can get any sense out of them his junior proctor, Walcote, is found hanged and he discovers that his trusted ally had arranged secret meetings at the St Ragelund Convent between men who would not normally be seen together - and the nuns of St Ragelund are renowned for behaviour entirely inappropriate to their calling. Meanwhile Matthew Bartholomew learns that Michael, his lifelong friend, is in all probability the thief who relieved one of the anti-nominalist colleges of some of their most precious papers. If that charge were proved it would put paid to Michael's long term plans to become Master of Michaelhouse - but would he kill to protect himself? Unable to believe his colleague would be capable of such acts, Bartholomew knows the only way he can quiet his own conscience is to solve the murders himself.
An Ordinary Future: Margaret Mead, the Problem of Disability, and a Child Born Different
by Thomas W PearsonThis vivid portrait of contemporary parenting blends memoir and cultural analysis to explore evolving ideas of disability and human difference. An Ordinary Future is a deeply moving work that weaves an account of Margaret Mead's path to disability rights activism with one anthropologist's experience as the parent of a child with Down syndrome. With this book, Thomas W. Pearson confronts the dominant ideas, disturbing contradictions, and dramatic transformations that have shaped our perspectives on disability over the last century. Pearson examines his family's story through the lens of Mead's evolving relationship to disability—a topic once so stigmatized that she advised Erik Erikson to institutionalize his son, born with Down syndrome in 1944. Over the course of her career, Mead would become an advocate for disability rights and call on anthropology to embrace a wider understanding of humanity that values diverse bodies and minds. Powerful and personal, An Ordinary Future reveals why this call is still relevant in the ongoing fight for disability justice and inclusion, while shedding light on the history of Down syndrome and how we raise children born different.
An Organ of Murder: Crime, Violence, and Phrenology in Nineteenth-Century America (Critical Issues in Health and Medicine)
by Courtney E. ThompsonAn Organ of Murder explores the origins of both popular and elite theories of criminality in the nineteenth-century United States, focusing in particular on the influence of phrenology. In the United States, phrenology shaped the production of medico-legal knowledge around crime, the treatment of the criminal within prisons and in public discourse, and sociocultural expectations about the causes of crime. The criminal was phrenology’s ideal research and demonstration subject, and the courtroom and the prison were essential spaces for the staging of scientific expertise. In particular, phrenology constructed ways of looking as well as a language for identifying, understanding, and analyzing criminals and their actions. This work traces the long-lasting influence of phrenological visual culture and language in American culture, law, and medicine, as well as the practical uses of phrenology in courts, prisons, and daily life.
An Orthopaedics Guide for Today's GP
by Maneesh Bhatia Tim JenningsThis practical handbook is an essential reference for GPs when dealing with musculoskeletal disorders, as well as a useful exam prep aid for the common MSK cases that occur in the CSA. Responding to increasing pressures on GPs to reduce the number of referrals and treat more patients in the community, the book covers a breadth of orthopaedic disorders, with clear colour photographs and diagrams to demonstrate techniques in practice. Chapters are authored by experts in each disorder with GP input, putting a strong focus on diagnosis and easy-to-follow processes for deciding courses of action and investigation. Each section explores the range of treatment options for that topic, including step-by-step injection techniques where relevant, and signposts need-to-know areas with ‘red flags’. This is an important reach-for guide to assist GPs with easy diagnosis and to provide clear direction on next recommended steps.It will also be useful for medical students taking orthopaedics modules.
An Osteopathic Approach to Diagnosis and Treatment
by Eileen DiGiovanna Christopher Amen Denise BurnsThe most comprehensive resource available on osteopathic manual medicine models, An Osteopathic Approach to Diagnosis and Treatment, Fourth Edition is both an ideal introduction for students and a valuable reference for practicing physicians. While many texts favor specific OMM models, this practical compendium reflects the most current and clinically relevant approaches across the full spectrum of osteopathic practice, organizing osteopathic concepts and step-by-step techniques into a single volume. The book’s integrated method for diagnosis and treatment embraces basic osteopathic history and philosophy, palpation and manipulation, and specific manipulative treatments and concepts to deliver a robust understanding, with cases and clinical examples that prepare students for the realities of practice. Now in full color, abundant photographs demonstrate step-by-step techniques, and meticulous illustrations clarify underlying anatomy in rich detail.
An Ounce of Hope: A powerful, addictive love story (A Pound of Flesh)
by Sophie JacksonAn Ounce of Hope is the third title in the A Pound of Flesh series from fan-fiction superstar Sophie Jackson.From the fanfic phenomenon whose sensational debut, A Pound of Flesh, had over 4.5 million reads. You fell for Wes Carter. Now there's a new bad boy in town. Just as sexy, just as edgy. Meet Carter's best friend, Max...Fans of Samantha Young, Jodi Ellen Malpas, Jamie McGuire, Katy Evans and Prison Break will find Sophie Jackson's powerful love stories utterly addictive and unforgettable. Can true love heal the deepest scars?Max O'Hare: Tortured by memories of the woman he loved, the child he lost and the drugs that numbed his pain, Max is haunted by his past.Grace Brooks: An eternal optimist, Grace appears to be the perfect girl, but she keeps the truth of her own difficult history closely guarded.Fresh out of rehab, the last thing on Max's mind is a relationship. Yet he's drawn to Grace, sensing that she too is looking for escape. Bound by their greatest fears and deepest secrets, Max and Grace must learn to trust again. And the key to opening their hearts lies in one another...Loyalty. Redemption. All-consuming love against the odds. Prepare to fall for the powerful storytelling of Sophie Jackson. Check out the whole A Pound of Flesh series: A Pound of Flesh, Love and Always, An Ounce of Hope, Fate and Forever and A Measure of Love.
An Ounce of Prevention-Is Worth a Pound of Cure: A Modern Guide To Healthful Living From The Originator Of The Blood-type Diet
by James L. DAdamoWritten in the infancy of America's modern natural-healing movement, his first book, One Man's Food . . . is someone else's poison, detailed his unique, individual treatment method that correlated a person's type of blood with diet, exercise, and spiritual practice. Just An Ounce of Prevention . . . Is Worth a Pound of Cure comes almost 30 years later, as people around the world have increasingly awakened to the efficacy of natural remedies . . . and at a time when the American health-care system is increasingly failing the public. In this fascinating book, Dr. D'Adamo exhorts us to take responsibility for our own health and prevent chronic degenerative diseases using his newest discoveries, which has given him the opportunity to treat more than 50,000 patients. He explains which foods and exercises are right for each of us, what assets and liabilities we're born with, and how our minds can work to better process information. This book contains Dr. D'Adamo's most up-to-date and comprehensive teachings; and includes recipes, exercise regimens, and a panoply of natural therapies he recommends to the patients at his institute. Just An Ounce of Prevention is the consummate statement on natural healing from this generation's most original naturopath. As Dr. D'Adamo writes: "We are all here for a purpose, and we can only aspire to our physical and spiritual fulfillment when the body is healthy and the mind clear. Blood types are a Truth of Nature and, if followed, will provide a person with the physical and spiritual health that Nature has intended for them."
An Outline of Psychiatry in Clinical Lectures: The Lectures of Carl Wernicke
by John Dennison Robert MillerThis work is a collection of Carl Wenicke's lectures on neuropsychiatry translated into English for the first time. Beginning with basic concepts about normal brain function, the book moves to clinical topics, dealing first with chronic mental disorders and 'paranoid states', and then to the more complex area of acute mental disorders. Many of the featured topics are still clinically relevant, and matters of contemporary debate. Carl Wernicke is one of the pioneers of neurology and psychiatry; clinicians, researchers and historians will find this of great interest.
An Unbreakable Cycle:Drug Dependency Treatment, Mandatory Confinement, and HIV/AIDS in China’s Guangxi Province
by Human Rights WatchIn China, illicit drug use is an administrative offense and Chinese law dictates that drug users "must be rehabilitated." In reality, police raids on drug users often drive them underground, away from methadone clinics, needle exchange sites, and other proven HIV prevention services. And every year Chinese police send tens of thousands of drug users to mandatory drug treatment centers, often for years, without trial or due process. This report finds that most mandatory treatment centers, while ostensibly meant to provide drug treatment, do not actually offer forms of drug dependence treatment internationally recognized as effective. Mostly, drug users are forced to work or to spend their days in crowded cells little different from prisons.
An Uncertain Inheritance: Writers on Caring for Ill Family Members
by Nell CaseyIn this eloquent collection of essays—from the editor of the national bestseller Unholy Ghost: Writers on Depression—contributors reveal their experiences in caring for family through illness and deathToday, thirty million people look after frail family members in their own homes. This number will increase drastically over the next decade—as baby boomers tiptoe toward old age; as soldiers return home from war wounded, mentally and physically; as a growing number of Americans find themselves caught between the needs of elderly parents and young children; as medical advances extend lives and health insurance fails to cover them. This compelling book offers both literary solace and guidance to the people who find themselves witness to—and participants in—the fading lives of their intimates.Some of the country's most accomplished writers offer frank insights and revelations about this complex relationship. Julia Glass describes the tension between giving care—to her two young sons—and needing care after being diagnosed with breast cancer; Ann Harleman explores her decision to place her husband in an institution; Sam Lipsyte alternates between dark humor and profound understanding in telling the story of his mother's battle with cancer; Ann Hood wishes she'd had more time as a caregiver, to prepare herself for the loss of her daughter; Andrew Solomon examines the humbling experience of returning as an adult to be cared for by his father; cartoonist Stan Mack offers an illustrated piece about the humor and hell of making his way through the medical bureaucracy alongside his partner, Janet; Julia Alvarez writes about the competition between her and her three sisters to be the best daughter as they tend to their ailing parents. An Uncertain Inheritance examines the caregiving relationship from every angle—children caring for parents; parents caring for children; sib-lings, spouses, and close friends, all looking after one another—to reveal the pain, intimacy, and grace that take place in this meaningful connection.
An Uncertain Safety: Integrative Health Care for the 21st Century Refugees
by Thomas Wenzel Boris DrožđekThis book addresses the psychosocial and medical issues of forced migration due to war, major disasters and political as well as climate changes. The topics are discussed in the context of public health and linked to organizational, legal and practical strategies that can offer guidance to professionals, as well as governmental and non-governmental organizations. Both internal and international displacement present substantial challenges that require new solutions and integrated approaches. Issues covered include an overview of current health challenges in the new refugee crises: medicine and mental health in disaster areas, long-term displacement and mental health, integration of legal, medical, social and health economic issues, children and unaccompanied minors, ethical challenges in service provision, short and long-term issues in host countries, models of crises intervention, critical issues, such as suicide prevention, new basic and “minimal” intervention models adapted to limited resources in psychosocial and mental health care, rebuilding of health care in post-disaster/conflict countries, training and burn-out prevention. The book was developed in collaboration with the World Psychiatric Association, and is endorsed by Fabio Grandi (UN High Commissioner for Refugees), Manfred Nowak (former UN Special Rapporteur for Torture), and Jorge Aroche (President of IRCT).
An Undisciplined Economist: Robert G. Evans on Health Economics, Health Care Policy, and Population Health
by Kimberlyn M. Mcgrail Greg L. Stoddart Chris B. Mcleod Morris L. BarerFor four decades Robert Evans has been Canada's foremost health policy analyst and commentator, playing a leadership role in the development of both health economics and population health at home and internationally. An Undisciplined Economist collects sixteen of Evans's most important contributions, including two new articles. The topics addressed range widely, from the peculiar structure of the health care industry to the social determinants of the health of entire populations to the misleading role that economists have sometimes played in health policy debates. Written with Evans's characteristic clarity, candour, and wit, these essays unabashedly expose health policy myths and the special interests that lie behind them. He refutes claims that public health insurance is unsustainable, that the health care costs of an aging population will bankrupt Canada, that user charges will make the health care system more efficient, and that health care is the most important determinant of a population's health. An Undisciplined Economist is a valuable collection for those familiar with Evans's work, a lucid introduction for those new to the fields of health economics, health policy, and population health, and a fitting tribute to an outstanding scholar.
An Undisciplined Economist: Robert G. Evans on Health Economics, Health Care Policy, and Population Health (Carleton Library Series)
by Greg L. Stoddart Morris L. Barer Kimberlyn M. McGrail Chris B. McLeodFor four decades Robert Evans has been Canada’s foremost health policy analyst and commentator, playing a leadership role in the development of both health economics and population health at home and internationally. An Undisciplined Economist collects Evans’ most important contributions and includes two new articles. The topics addressed range widely, from the peculiar structure of the health care industry to the social determinants of the health of entire populations to the misleading role that economists have sometimes played in health policy debates. Written with Evans' characteristic clarity, candour, and wit, these essays unabashedly expose health policy myths and the special interests that lie behind them. He refutes claims that public health insurance is unsustainable, that the health care costs of an aging population will bankrupt Canada, that user charges will make the health care system more efficient, and that health care is the most important determinant of a population’s health. An Undisciplined Economist is a valuable collection for those familiar with Evans’ work, a lucid introduction for those new to the fields of health economics, health policy, and population health, and a fitting tribute to an outstanding scholar.
An Unexpected Miracle
by Jennifer De PippoThree days before her eighth birthday, Jennifer De Pippo was nearly killed in a car accident which claimed the life of her mother and left her with brain injuries so severe that the doctors said she would never walk or talk again. Join Jennifer as she describes the highs and lows of her life-long struggle to prove the doctors wrong, and to rebuild herself into a functioning, fun-loving and fast-thinking adult.Through sheer determination, Jennifer has succeeded in achieving what was considered impossible, turning every day of her life into an unexpected miracle.
An Ungovernable Foe: Science and Policy Innovation in the U.S. National Cancer Institute
by Natalie B. AvilesIn American politics, medical innovation is often considered the domain of the private sector. Yet some of the most significant scientific and health breakthroughs of the past century have emerged from government research institutes. The U.S. National Cancer Institute (NCI) is tasked with both understanding and eradicating cancer—and its researchers have developed a surprising expertise in virus research and vaccine development.An Ungovernable Foe examines seventy years of federally funded scientific breakthroughs in the laboratories of the NCI to shed new light on how bureaucratic organizations nurture innovation. Natalie B. Aviles analyzes research and policy efforts around the search for a viral cause of leukemia in the 1960s, the discovery of HIV and the development of AIDS drugs in the 1980s, and the invention of the HPV vaccine in the 1990s. She argues that the NCI transformed generations of researchers into innovative public servants who have learned to balance their scientific and bureaucratic missions. These “scientist-bureaucrats” are simultaneously committed to conducting cutting-edge research and stewarding the nation’s investment in cancer research, and as a result they have developed an unparalleled expertise. Aviles demonstrates how the interplay of science, politics, and administration shaped the NCI into a mission-oriented agency that enabled significant breakthroughs in cancer research—and in the process, she shows how organizational cultures indelibly stamp scientific work.
An Unholy Alliance: The Second Chronicle of Matthew Bartholomew (Chronicles Of Matthew Bartholomew Ser. #2)
by Susanna GregoryFor the twentieth anniversary of the Matthew Bartholomew series, Sphere reissued the books with beautiful new illustrated covers.-----------------------------In 1350, the people of Cambridge are struggling to overcome the effects of the Black Death - and with a high mortality rate among priests and monks, the townsfolk are vulnerable to sinister cults that have sprung up. At Michaelhouse, Matthew Bartholomew is training new physicians when the body of a friar is found in the massive chest that the University uses to store precious documents. While investigating, Bartholomew stumbles across a derelict church being used as a meeting place for the mysterious sect he believes is at the heart of a web of blackmail and deceit - with intention to overthrow the established religion.
An Unholy Alliance: The Second Chronicle of Matthew Bartholomew (Chronicles of Matthew Bartholomew #2)
by Susanna GregoryFor the twentieth anniversary of the Matthew Bartholomew series, Sphere reissued the books with beautiful new illustrated covers.-----------------------------In 1350, the people of Cambridge are struggling to overcome the effects of the Black Death - and with a high mortality rate among priests and monks, the townsfolk are vulnerable to sinister cults that have sprung up. At Michaelhouse, Matthew Bartholomew is training new physicians when the body of a friar is found in the massive chest that the University uses to store precious documents. While investigating, Bartholomew stumbles across a derelict church being used as a meeting place for the mysterious sect he believes is at the heart of a web of blackmail and deceit - with intention to overthrow the established religion.
An Unholy Alliance: The Second Chronicle of Matthew Bartholomew (Chronicles of Matthew Bartholomew #2)
by Susanna GregoryFor the twentieth anniversary of the Matthew Bartholomew series, Sphere reissued the books with beautiful new illustrated covers.-----------------------------In 1350, the people of Cambridge are struggling to overcome the effects of the Black Death - and with a high mortality rate among priests and monks, the townsfolk are vulnerable to sinister cults that have sprung up. At Michaelhouse, Matthew Bartholomew is training new physicians when the body of a friar is found in the massive chest that the University uses to store precious documents. While investigating, Bartholomew stumbles across a derelict church being used as a meeting place for the mysterious sect he believes is at the heart of a web of blackmail and deceit - with intention to overthrow the established religion.
An Unintended Journey
by Janet Yagoda ShagamAccording to the 2009 census, more than five million people living in the United States have Alzheimer's disease or some other form of dementia. Not reported in these statistics are the fifteen million family caregivers who, in total, contribute seventeen billion hours of unpaid care each year. This book addresses the needs and challenges faced by adult children and other family members who are scrambling to make sense of what is happening to themselves and the loved ones in their care. The author, an experienced medical and science writer known for her ability to clearly explain complex and emotionally sensitive topics, is also a former family caregiver herself. Using both personal narrative and well-researched, expert-verified content, she guides readers through the often-confusing and challenging world of dementia care. She carefully escorts caregivers through the basics of dementia as a brain disorder, its accompanying behaviors, the procedures used to diagnose and stage the disease, and the legal aspects of providing care for an adult who is no longer competent. She also covers topics not usually included in other books on dementia: family dynamics, caregiver burnout, elder abuse, incontinence, finances and paying for care, the challenges same-sex families face, and coping with the eventuality of death and estate management. Each chapter begins with a real-life vignette taken from the author's personal experience and concludes with "Frequently Asked Questions" and "Worksheets" sections. The FAQs tackle specific issues and situations that often make caregiving such a challenge. The worksheets are a tool to help readers organize, evaluate, and self-reflect. A glossary of terms, an appendix, and references for further reading give readers a command of the vocabulary clinicians use and access to valuable resources.