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Mouse Models of Innate Immunity: Methods And Protocols (Methods In Molecular Biology Series #1031)
by Irving C. AllenThis second edition presents methods and protocols to aid readers in the design and execution of experiments used to define critical elements associated with innate immune system function. New and updated chapters detail protocols on in vitro and ex vivo studies in key cell types associated with innate immunity and with in vivo protocols used to study immune system function in the mouse. Additionally, chapters describe methods to evaluate innate immune function and new protocols associated with autism, cancer, microfluidics platforms, and CRISPR systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. <P><P> Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols, Second Edition will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune system.
Mouse Models of Innate Immunity: Methods and Protocols
by Irving C. AllenThe innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.
Mouse Models of Vascular Diseases
by Masataka SataThis book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders.
Mouse Retinal Phenotyping: Methods And Protocols (Methods In Molecular Biology #1753)
by Naoyuki TanimotoThe aim of this volume is to provide a wide range of techniques and aspects of mouse retinal phenotyping and characterization. Chapters guide readers through morphological and functional properties of the mouse retina and techniques for the analysis of outer to mid-retina and mid- to inner retina. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mouse Retinal Phenotyping: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Mouse as a Model Organism
by Cord Brakebusch Taina PihlajaniemiCell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gene mutations, the mouse has become the favourite mammalian model organism to study in vivo function of genes during development and in disease. This book combines review articles on selected subjects presented at the symposium "Mouse as a Model Organism - From Animals to Cells", held in Rovaniemi, Finland, 2009. Among other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer in mice are described. This book will give an excellent introduction to scientists interested in the use of mice as a model to understand complex biological questions in the post-genomic era. It will highlight the possibilities, but also discuss the current problems and shortcomings, to give a realistic view of the current state-of-art in this fascinating field of biomedical research.
Move!: The New Science of Body Over Mind
by Caroline WilliamsDid you know that walking can improve your cognitive skills? That strengthening your muscular core reduces anxiety? That light stretching can combat a whole host of mental and bodily ailments, from stress to inflammation? We all know that exercise changes the way you think and feel. But scientists are just starting to discover exactly how it works.In Move!, Caroline Williams explores the emerging science of how movement opens up a hotline to our minds. Interviewing researchers and practitioners around the world, she reveals how you can work your body to improve your mind. As lockdown throws us back on our own mental and physical resources, there is no better time to take control of how you think and feel.
Movement Disorder Emergencies
by Steven J. FruchtUpdated and expanded with nine additional chapters, Movement Disorder Emergencies: Diagnosis and Treatment, Second Edition is an indispensable resource for general neurologists, specialists, fellows, and residents eager to improve their approach toward the patient with a movement disorder emergency. In this comprehensive second edition, prominent neurologists from around the world logically and systematically review the major movement disorder emergencies, instructing the reader on how optimally to recognize and manage these problems. The authors cover a broad range of disorders, including acute dystonic reactions, neuroleptic malignant syndrome, startle syndromes, tic emergencies, and others; and they stress the importance of certain obvious diagnoses such as Wilson's disease, dopa-responsive dystonia, and Whipple's disease, in which delayed diagnosis in less emergent situations can lead to slowly evolving and often irreversible neurologic damage with tragic consequences. In addition, nine topics not covered in the first edition are provided, including genetic counseling and testing crises, suicide risk, psychogenic movement disorders, and others. Patient vignettes at the beginning of each chapter focus the reader's attention and highlight the urgency of the problem. Since astute clinical diagnosis of many movement disorders is still largely dependent on visual pattern recognition in the clinic, an accompanying online collection of physician-patient vignettes illustrates virtually all of the movement disorders described in the text. Importantly, the authors also discuss a range of new treatment paradigms that have emerged since publication of the first edition, especially deep brain stimulation. Authoritative and a leading text in the field, Movement Disorder Emergencies: Diagnosis and Treatment, Second Edition is an established, practical reference that continues to achieve excellence in the field of diagnosis and management of movement disorder emergencies.
Movement Disorder Emergencies: Diagnosis and Treatment (Current Clinical Neurology)
by Steven J. FruchtThis book logically and systematically reviews the major movement disorder emergencies. It instructs the reader on how to recognize and manage these problems. This updated new edition of Movement Disorder Emergencies consists of five comprehensive sections. It begins with chapters that relay the various practical approaches one can administer when treating a patient with a movement disorder emergency. Section two then delves into specific hyperacute movement disorder emergencies such as acute parkinsonism, serotonin syndrome, and malignant catatonia. Following this, section three examines various acute movement disorder emergencies, including tic emergencies and Sydenham’s chorea. Sections four and five explore issues that can occur during treatment, such as pitfalls in diagnosis and risks in the clinic. Written by prominent neurologists from around the world, Movement Disorder Emergencies, 3rd edition is a practical reference that achieves excellence in diagnosis and management of movement disorder emergencies.
Movement Disorder Genetics
by Susanne A. Schneider José M. Tomás BrásThis book covers recent developments and possible pitfalls in the diagnosis of genetic movement disorders and related conditions. It is divided into three sections: technical and scientific aspects; clinical aspects with guidance towards work-up; and ethical and legal aspects of genetic testing in a clinical and research setting. The first section includes chapters on genetic analysis and counselling with critical discussion of potential problems when interpreting the results. Clinical chapters summarize genetic forms of movement disorders including parkinsonism, tics and dystonia with algorithms for hands-on daily practice. Related conditions such as RLS, ataxias and dementias are also covered. Finally, chapters on ethical and legal aspects of genetic testing are included. Movement Disorder Genetics is aimed at clinicians and scientists working in the field of movement disorders and related conditions.
Movement Disorders Curricula
by Joaquim Ferreira Cristian Falup-Pecurariu Pablo Martinez-Martin Kallol Ray ChaudhuriThis book offers a comprehensive approach to the wide range of movement disorders, an important specialty in the field of neurology, guiding readers from the phenomenology to diagnosis and management. Reflecting the latest developments in the field, it offers a unique summary of this dynamic area by pursuing a uniform approach to movement disorders curricula. Divided into three parts, Movement Disorders Curricula provides an authoritative overview of this growing branch of neurology. The first part presents the basic elements of movement disorders, including descriptions of the anatomy and physiology of the basal ganglia. It also features sections on clinical trials for movement disorders, practical skills, and rating scales. The second and third part examine in detail hypokinetic and hyperkinetic movement disorders, respectively. Equipping readers with the practical and research skills needed in the movement disorders field, the book offers a valuable tool to help them prepare for board examinations on general neurology, as well as for fellowships in movement disorders.
Movement Disorders Phenomenology: An Office-Based Approach
by Steven J. Frucht Pichet TermsarasabThis book presents a comprehensive, practical approach to the evaluation of movement disorders using phenomenological basic principles, new discoveries in phenomenological research, and core values of outpatient neurology.Movement Disorders Phenomenology begins with an overview of phenomenology and common approaches to movement disorder patients. Subsequent chapters then accurately and concisely relay information on major hypokinetic disorders such as atypical Parkinsonism, idiopathic Parkinson’s disease, cortical myoclonus, and complex motor tics. Expertly written text is further supplemented by patient vignettes at the beginning of select chapter that focus the reader's attention and highlight the urgency of the problem. These high quality videos aid in the astute clinical diagnosis of many movement disorders that are still largely dependent on visual pattern recognition in the clinic. The book closes with a timely discussion on the role of genetics in movement disorders.Written for the practicing physician, Movement Disorders Phenomenology is an indispensable reference for neurology residents, general neurologists, movement disorders fellows and clinicians, and to any clinician who encounters and evaluates patients in the outpatient arena.
Movement Disorders Phenomenology: Therapy and Management, Volume II
by Steven J. Frucht Pichet TermsarasabThis practical, case-based book offers an approach to diagnosis and treatment of movement disorders in the outpatient setting. The major hypokinetic and hyperkinetic disorders are considered in turn, with more than 1,000 videos illustrating the role of phenomenology in the diagnosis and treatment of these conditions. Discussion of the role of ancillary testing (imaging, genetic testing) and treatment options with medications, botulinum toxin injections, and surgical intervention are woven in to the discussion of cases throughout the book. Special attention is directed to pitfalls and perils of office-based practice. This volume will be of interest to movement disorders neurologists and trainees, general neurologists, neurology residents, and any healthcare professional with an interest in exploring the application of the many treatments that have transformed movement disorders into a therapeutic field. Rather than a textbook of movement disorders, thisvolume will help the practicing clinician in guiding the thought process for evaluation and management of patients in the clinic.
Movement Disorders Rehabilitation
by Hsin Fen Chien Orlando Graziani Povoas BarsottiniThe aim of this book is to provide a comprehensive overview of the most important movement disorders and describe the rehabilitation tools available for each disease. The management of movement disorders is challenging since most of these diseases are not curable and hardly treatable. Many of the disorders are chronic or degenerative diseases, therefore patients develop motor complications that could improve with rehabilitation interventions. Movement Disorders Rehabilitation intends to serve as a practical guide on the field, attracting the interest of professionals and researchers on the fields of neurology, physical therapy, occupational therapy, speech therapy and other correlated therapies.
Movement Disorders in Dementias
by Marcelo Merello Sergio E. StarksteinThis book focuses on extrapyramidal signs and symptoms of all types of dementia, and addresses the issue of the artificial boundary between dementias and Parkinsonism, which represent the two most common symptoms found in degenerative central nervous system diseases. In Movement Disorders in Dementias, movement disorder specialists from around the world write on topics generally restricted to dementia experts. Important motor issues related to either medication in demented patients (drug-induced movement disorders) or manifestations common to all forms of dementia, regardless of underlying cause (gait disorders, falls, fear of falling), is followed by analysis of the relationship between motor and cognitive symptoms, from their common pathogenesis to specific medical treatments. Movement Disorders in Dementias is aimed at general neurologists, dementia specialists, movement disorders specialists, neuropsychologists and geriatricians.
Movement Disorders in Neurologic and Systemic Disease
by Werner Poewe Joseph JankovicMovement disorders - ranging from parkinsonism to a variety of hyperkinetic disorders, such as tremors, dystonic, chorea and myoclonus - can be the presenting or a prominent clinical feature in a broad spectrum of systemic conditions such as endocrine and metabolic disorders, autoimmune diseases, infections, intoxications, tumors and pareneoplastic syndromes, stroke and multiple sclerosis. The resulting clinical scenarios can be confusing and difficult to interpret by internists, generalists and neurologists. Movement Disorders in Neurologic and Systemic Disease provides comprehensive coverage of the most common movement disorders seen in systemic and general neurologic disease, as well as differential diagnostic and therapeutic algorithms. The chapters are written by internationally recognized experts and more than 50 illustrative videos highlight the phenomenology of some of the movement disorders and provide a useful 'bed-side' diagnostic tool. This book is a valuable resource for neurologists, physiatrists, psychiatrists, internists, primary care physicians and trainees in medicine and neurology.
Movement Disorders of the Upper Extremities in Children: Conservative and Operative Therapy
by Jörg BahmThis book discusses the diagnosis and therapy for movement disorders of the upper extremities in children caused by brachial plexus injuries, peripheral nerve lesions or spasticity. The diagnostic procedures are presented from the perspective of pediatricians and surgeons. In addition to detailed descriptions of primary reconstructive and secondary surgical procedures, it also presents essentials of non operative treatment, such as physiotherapy, occupational therapy and orthopedic technologies. The book is rounded out with information on the management of these patients and their parents.Written by experienced clinicians, it offers valuable reading for plastic surgeons, pediatricians and surgeons who are interested in this topic.
Movement Disorders: 100 Instructive Cases
by Stephen G ReichWritten in an easy-to-follow, quick reference format, Movement Disorders: 100 Instructive Cases provides a series of 100 case studies of patients with movement disorders. Radiology images, histopathology, and patient photographs are presented in full color. The book‘s uniform structure of listing each disorder followed by examination, discussion, a
Movement Disorders: A Video Atlas (Current Clinical Neurology)
by Daniel Tarsy Roongroj BhidayasiriMovement Disorders: A Video Atlas is a practical and concise title offering an introduction to the field of movement disorders, which is expanding rapidly with the involvement of various disciplines and specialties. The unique feature of the book is the accompanying video content, comprising common cases in each category of movement disorders. The video clips come from Dr. Tarsy's personal video collection at Beth Israel Deaconess Medical Center and Dr. Bhidayasiri's personal collection at Chulalongkorn University and UCLA. The video is on an accompanying DVD and can also be found at www.springerimages.com/Tarsy. Each case includes expert narration from Dr. Tarsy. Rather than focusing on rare cases, the authors emphasize typical cases, with good history and physical signs. Unique, easy to read, with highly instructive supporting video content, Movement Disorders: A Video Atlas is an indispensable reference for all clinicians interested in the fascinating field of movement disorders.
Movement Integration: The Systemic Approach to Human Movement
by Martin Lundgren Linus JohanssonA paradigm-shifting, integrative approach to understanding body movement.The ability to move with efficiency and agility has been an essential component to our evolution and survival as a species. It has enabled us to find food, fight threats, flee danger, and flourish both individually and collectively. Our body's intricate network of bones, muscles, tissues, and organs moves with great complexity. While traditional anatomy has relied on a reductionist frame for understanding these mechanisms in isolation, the contributors to Movement Integration take a more systemic, integrative approach. Ensomatosy is a new paradigm for comprehending movement from the perspective of the body's entirety. The body's many systems are understood as synchronized both internally and externally. Drawing on expertise in physiotherapy, somatics, sports science, Rolfing, myofascial therapy, craniosacral therapy, Pilates, and yoga, the authors assert that a more comprehensive understanding of movement is key to restoring the body's natural ability to move fluidly and painlessly. With over 150 images, the Color Illustration Model of Relative Movement provides a visual tool for understanding how joints interact with surrounding structures (rather than in isolation). This is an ideal book for physiotherapists, massage therapists, structural integrators, coaches, as well as yoga and Pilates instructors.
Movement Sciences: Transfer of Knowledge into Pediatric Therapy Practice
by Robert J PalisanoDiscover new perspectives and recent research findings to apply to the children and families on your caseload With Movement Sciences: Transfer of Knowledge into Pediatric Therapy Practice, you will explore the motor control, learning, and development of children with movement disorders, allowing you to increase the effectiveness of intervention. This book provides cutting-edge information on motor disabilities in children-such as cerebral palsy, Down syndrome, or Erb's palsy-and how prehension, balance, and mobility are affected. Expert researchers and practitioners offer their findings and techniques for improving motor processes, using figures, tables, and extensive resources to help you create more effective pediatric rehabilitation programs. With this book, you will gain a better understanding of: motor control for posture and prehension the motor learning challenges of children with movement dysfunction predictors of standing balance in children with cerebral palsy the effect of environment setting on mobility methods of children with cerebral palsy the reliability of a clinical measure of muscle extensibility in preterm and full-term newborn infants Movement Sciences: Transfer of Knowledge into Pediatric Therapy Practice will help physical therapists, occupational therapists, and other health care professionals implement motor learning concepts safely and effectively. This book also delivers practical advice for achieving the best results with a younger population by utilizing interventions that address the needs of their clients. With this guide, you will be able to determine which approaches are acceptable to the children and families in your practice, and ensure the therapy is meaningful to their daily lives.
Movement Skill Assessment
by Allen W. Burton Daryl E. MillerThis unique text focuses exclusively on the assessment of movement skills, offering background information, discussions of six levels of movement skill assessment, and strategies for implementation. Practical and user-friendly, Movement Skill Assessment helps readers acquire the skills they need to successfully carry out their assessment responsibilities. Filled with information on more than 150 tests and including more than 650 references, the book emphasizes a top-down, functional approach to the assessment of movement skills.
Movement: Functional Movement Systems: Screening, Assessment, Corrective Strategies
by Greg Rose Gray Cook Lee Burton Kyle Kiesel Milo F. BryantMovement is a vivid discovery, a fundamental and explicit teaching in which the return to basics takes on a whole new meaning. In it, author Gray Cook crosses the lines between rehabilitation, conditioning and fitness, providing a clear model and a common language under which fitness and rehabilitation professionals can work together. By using systematic logic and revisiting the natural developmental principals all infants employ as they learn to walk, run and climb, Gray forces a new look at motor learning, corrective exercise and modern conditioning practices. The discoveries, lessons and approaches you'll learn * How to view and measure movement quality alongside quantity * How to ascertain dysfunctional patterns with the Functional Movement Screen * What clinicians need to know about the Selective Functional Movement Assessments * When to apply corrective strategies and how to determine which strategies to use * How to map movement patterns and understand movement as a behavior and not just as a mechanical idea This book is not simply about the anatomy of moving structures. Rather, it serves a broader purpose to help the reader understand authentic human movement, and how the brain and body create and learn movement patterns. Our modern dysfunctions are a product of our isolated and incomplete approaches to exercise imposed on our sedentary lifestyles. A return to movement principles can create a more comprehensive exercise and rehabilitation model, a model that starts with movement.
Moving Beyond Prozac, DSM, and the New Psychiatry: The Birth of Postpsychiatry
by Bradley LewisMoving Beyond Prozac, DSM, and the New Psychiatry looks at contemporary psychiatric practice from a variety of critical perspectives ranging from Michel Foucault to Donna Haraway. This contribution to the burgeoning field of medical humanities contends that psychiatry's move away from a theory-based model (one favoring psychoanalysis and other talk therapies) to a more scientific model (based on new breakthroughs in neuroscience and pharmacology) has been detrimental to both the profession and its clients. This shift toward a science-based model includes the codification of the Diagnostic and Statistical Manual of Mental Disorders to the status of standard scientific reference, enabling mental-health practitioners to assign a tidy classification for any mental disturbance or deviation. Psychiatrist and cultural studies scholar Bradley Lewis argues for "postpsychiatry," a new psychiatric practice informed by the insights of poststructuralist theory.
Moving Boundary PDE Analysis: Biomedical Applications in R
by William SchiesserMathematical models stated as systems of partial differential equations (PDEs) are broadly used in biology, chemistry, physics and medicine (physiology). These models describe the spatial and temporial variations of the problem system dependent variables, such as temperature, chemical and biochemical concentrations and cell densities, as a function of space and time (spatiotemporal distributions). For a complete PDE model, initial conditions (ICs) specifying how the problem system starts and boundary conditions (BCs) specifying how the system is defined at its spatial boundaries, must also be included for a well-posed PDE model. In this book, PDE models are considered for which the physical boundaries move with time. For example, as a tumor grows, its boundary moves outward. In atherosclerosis, the plaque formation on the arterial wall moves inward, thereby restricting blood flow with serious consequences such as stroke and myocardial infarction (heart attack). These two examples are considered as applications of the reported moving boundary PDE (MBPDE) numerical method (algorithm). The method is programmed in a set of documented routines coded in R, a quality, open-source scientific programming system. The routines are provided as a download so that the reader/analyst/researcher can use MFPDE models without having to first study numerical methods and computer programming.
Moving Health Sovereignty in Africa: Disease, Governance, Climate Change (Global Environmental Governance)
by Hany Besada Andrew F. CooperToday’s era of intense globalization has unleashed dynamic movements of people, pathogens, and pests that overwhelm the static territorial jurisdictions on which the governance provided by sovereign states and their formal intergovernmental institutions is based. This world of movement calls for new ideas and institutions to govern people’s health, above all in Africa, where the movements and health challenges are the most acute. This book insightfully explores these challenges in ways that put the perspectives of Africans themselves at centre stage. It begins with the long central and still compelling African health challenge of combating the pandemic of HIV/AIDS. It then examines the global governance responses by the major multilateral organizations of the World Bank and the World Trade Organization and the newer informal flexible democratically oriented ones of the Group of Eight. It also addresses the compounding health challenge created by climate change to assess both its intensifying impact on Africa and how all international institutions have largely failed to link climate and health in their governance response. It concludes with several recommendations about the innovative ideas and institutions that offer a way to closing the great global governance gaps and thus improving Africans’ health and that of citizens beyond.