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Moving Through Cancer: An Exercise and Strength-Training Program for the Fight of Your LifeEmpowers Patients and Caregivers in 5 Steps
by Dr. Kathryn SchmitzCancer diagnosis and treatment doesn't have to be a passive experience, and it shouldn't be. Dr. Kathryn Schmitz's Moving Through Cancer introduces a 21-day program of strength training and exercise for cancer prevention and recovery.Go from diagnosis to thriving with this empowering guide to using strength training and exercise to improve your mental and physical health before, during, and after cancer diagnosis and treatment.This groundbreaking program will show you how to use exercise and movement to:• Recover more quickly from surgery• Withstand chemotherapy (or other drug treatments) or radiation with fewer side effects• Bounce back to daily life following cancer treatments• Prevent loss of function or fitness due to treatment• Return to work more quickly or stay at work throughout treatment• Protect against late side effects of treatment that come years after diagnosisLeading exercise oncology researcher Dr. Kathryn Schmitz shows you how to prepare for cancer treatment and begin regularly exercising in just 21 days using five key steps: Move, Lift, Eat, Sleep, and Log. Both informative and practical, Moving Through Cancer explains the science of healing and prevention and delivers a paradigm-shifting message for patients, doctors, and caregivers about using exercise to live with and beyond cancer.FOR READERS OF: Anticancer Living and The Cancer-Fighting Kitchen.A PRACTITIONER AND CAREGIVER: Dr. Kathryn Schmitz is a pracademic (practitioner + academic) and a caregiver: In 2010, the publication of one of her trials in The New England Journal of Medicine and the Journal of the American Medical Association overturned years of entrenched dogma and conventional wisdom that told breast cancer survivors to avoid upper body exercise. In 2016, Dr. Schmitz's wife, Sara, was diagnosed with stage 3 squamous cell carcinoma—she is currently NED (no evidence of disease) and cancer free. Moving Through Cancer is inspired by Dr. Schmitz's professional and personal experience with cancer.HELPS PATIENTS AND CAREGIVERS TO COMBAT THE POWERLESSNESS OF THE CANCER JOURNEY: Dr. Schmitz's empowering message will not only resonate with anyone who has been diagnosed with cancer but with their family and loved ones as well. Dr. Schmitz is able to give life back to readers by providing results that include better sleep, better sex, less chemo brain, reduced nausea, and improved recovery.PARADIGM-SHIFTING PROTOCOL: Moving Through Cancer is the center of Dr. Schmitz's campaign to have doctors prescribing exercise to cancer patients as common practice by 2029.THE FIRST MAINSTREAM EXERCISE-FOR-CANCER BOOK: Until now, exercise-for-cancer books have been limited to academic approaches or one-cancer-specific (breast) or one-exercise specific (yoga, pilates) books. Moving Through Cancer is for all cancer patients and survivors and their caregivers.GREAT FOR THE CLASSROOM: Students and teachers will want to use these techniques in their classrooms to provide a better understanding of how to treat cancer patients.Perfect for: 18+, Health enthusiasts, rehab, exercise, academia, medical professionals
Moving and Handling Patients at a Glance
by Hamish MacgregorA clear, concise and comprehensive guide to moving and handling patients Superbly illustrated, with full colour photographs throughout Practice-oriented and based on the latest evidence to provide safe and effective patient care Ideal for nursing students, health care assistants, newly qualified nurses, as well as physiotherapists and occupational therapists
Moving and Interacting in Infancy and Early Childhood: An Embodied, Intersubjective, and Multimodal Approach to the Interpersonal World
by Silvia Español Mauricio Martínez Fernando G. RodríguezThis book introduces studies on infant and early childhood development that are in a permanent dialogue with the psychology of music, the philosophy of mind, and human movement studies. They are based on an innovative framework that combines embodied cognition, the multimodal approach to child development, and the second-person perspective in social cognition. This frame of reference allows authors to revisit relevant topics in developmental psychology, such as adult-infant interactions; early intersubjective experiences; the development of perceptual, verbal and gestural communication skills; as well as the complexity of play in infancy and early childhood.In the field of infancy and early childhood studies, the three viewpoints brought together in this volume had a clear innovative impact. Embodied psychology showed the body to be the primary agent in the interactions that shape the infant's psyche. The second-person perspective exhibited the direct, transparent, I-Thou contact involved in the first patterns of reciprocity between adult and infant, and the multimodal theory of perceptual development revealed an infant immersed in a multisensory environment conveying information to all perceptual systems as a unified experience. The studies presented in this volume combine these three viewpoints and link them through the use of analytical tools and concepts from the temporal arts (music and dance). This way of conducting empirical research on some central topics in early infancy led to an aesthetic conception of development that emphasizes bodily experience, temporal affects and their intertwining with symbolic capacitiesMoving and Interacting in Infancy and Early Childhood: An Embodied, Intersubjective, and Multimodal Approach to the Interpersonal World will provide innovative tools for developmental and cognitive psychologists studying the development of early socio-cognitive skills in infants and young children, and will also serve as a rich source of information for researchers and practitioners in other fields, such as education and nursing, who can benefit from cutting-edge knowledge in developmental sciences.
Moving from the Inside Out: 7 Principles for Ease and Mastery in Movement--A Feldenkrais Approach
by Lesley McLennan Julie PeckSeven powerful principles for better, more easeful movement--a Feldenkrais approach.More often than not, we move through life focused on results or where we're going, rarely paying attention to how we move until we experience pain or need to learn a new skill or perform at an elite level. But movement isn't just about getting things done or getting from here to there: at its essence, it's an integration of thinking, sensing, and feeling with action such that to change one part changes the whole.This book is written for those times when we don't need quick fixes, bandaids, or shortcuts to solve an immediate problem, but can instead dedicate time and attention to explore, laying the foundation to become experts in our own body and movement patterns for long-lasting positive growth. Moving from the Inside Out shows us how to resolve complex movement issues, balance stability and instability, increase power and precision, and explore our own movement using innate learning strategies.Written for practitioners, movement therapists, and somatic teachers and students, the curious athlete or casual learner will also find much to gain in learning the practical and accessible fundamentals of movement. Authors Lesley McLennan and Julie Peck introduce seven core principles that address: • The dynamic balance between instability and stability • How to move with ease and grace • The secrets of flexibility and support embedded in every musculo-skeletal system • How anxiety and curiosity shape our individual developmental sequence • How qualities of movement are clues for your investigation • The special role of intra-abdominal pressure in our physical and emotional worlds • How moving and learning are entwined<
Moyamoya Disease Explored Through RNF213
by Teiji Tominaga Kiyohiro Houkin Akio Koizumi Kazuhiro Nagata Susumu Miyamoto Shigeo Kure Elizabeth Tournier-LasserveThis book presents the latest findings on biological, epidemiological, and clinical investigations of RNF213, which is thought to be involved in many biological processes and plays a key role in cerebro- and cardio- vascular disease . By discussing the epidemiology and genetic epidemiology of the disease with a particular focus on the molecular function of RNF213, research using animal models, diagnosis, therapy and clinical management around the world, this work makes a valuable contribution to the study of the disease. Moyamoya Disease Explored Through RNF213 is an indispensable resource for both beginning and experienced researchers, pediatricians, neurologists, and neurosurgeons who are seeking comprehensive information on adult and childhood stroke.
Moyamoya Disease Update
by Byung-Kyu Cho Teiji TominagaMoyamoya disease (MMD) was first reported as a new entity among vascular disorders in 1957. Named for the abnormal vascular networks found around the occluded distal internal carotid artery, it is the most common pediatric cerebrovascular disease in East Asia. In recent years large amounts of data on MMD have been collected and important investigations have been carried out in Japan and Korea, even as the pathophysiology of the disease remains to be discovered. This monograph covers a diversity of topics and presents a systematic compilation of the data and current status of MMD in clinical practice and basic research. With contributions by more than 70 authors, the book includes sections on genetics, computational analysis of hemodynamic shear stress, new imaging techniques, and endovascular treatment of MMD, along with practical applications and future directions for gene and stem cell therapies. For neurosurgeons as well as neurologists and pediatricians, this volume will help lead to more efficient and informed management of MMD.
Moyamoya Disease: Current Knowledge and Future Perspectives
by Satoshi KurodaThis book brings together the latest knowledge on moyamoya disease, covering diagnostic criteria, status as a disease entity, genetic aspects, pathophysiology, novel neuroradiological findings, and surgical therapy. Information is also provided on recent basic and clinical research with the aim of identifying future perspectives on the disease. Since moyamoya disease was first reported in an English language article more than 50 years ago, our understanding of it has advanced considerably. Genetic and radiological analysis has delivered novel insights, and the latest multicenter studies are changing routine diagnosis and surgical therapy. The gene encoding the ring finger protein 213 (RNF213) has been identified as a susceptibility gene for moyamoya disease. Indications and procedures for surgical revascularization have been revised, with resultant improvements in outcomes, and studies performed over the past decade have provided new knowledge on the neuroradiological findings before and after surgery. In describing these advances, this book will be an invaluable asset for all general physicians, pediatricians, neurologists, radiologists, and neurosurgeons who care for patients with moyamoya disease across the world.
Mozart and the Whale: An Asperger's Love Story
by Jerry Newport Mary Newport Johnny DoddA riveting and inspiring memoir about a couple who fell in love, fell apart, and finally overcame the pressures of fame, family, and Asperger's syndrome to build a life together. When Jerry and Mary Newport met, the connection was instant; neither had ever felt more comfortable. A musical genius and a mathematical wonder, the two shared astronomical IQs, but they also shared something else -- they both were diagnosed with Asperger's syndrome, a form of autism that affects millions of Americans and makes social contact painfully unbearable. Finding each other after a lifetime of loneliness was a miracle. When Jerry and Mary married, they were catapulted into the limelight. They appeared on 60 Minutes and soon were known as "superstars in the world of autism," shining examples of two people who refused to give up in the face of their mutual challenges. But just when it appeared that their lives would enjoy a fairy-tale ending, their marriage fell apart. The Hollywood feeding frenzy was too much to handle, and they divorced. After years of heartache, soul searching, and personal growth, Jerry and Mary remarried. Today, with their union stronger than ever, they have dedicated themselves to helping countless other people with Asperger's and autism lead lives of dignity. Mozart and the Whale is an unforgettable love story, the incredible chronicle of their journey together -- and apart.
Mr. Food Test Kitchen's Hello Taste, Goodbye Guilt!: Over 150 Healthy and Diabetes Friendly Recipes
by Food Test KitchenMr. Food has been delivering recipes, cooking tips, and kitchen techniques to television audiences for more than 30 years. Now, he and the Mr. Food Test Kitchen have again teamed up with the American Diabetes Association for their fifth project; a brand new cookbook filled with recipes that are nearly too good to be true! Perfect for people with diabetes and pre-diabetes, 'Hello Taste, Goodbye Guilt' is a collection of unbelievable meals and dishes crafted by the culinary professionals viewers nationwide have grown to trust. Specifically designed to meet the nutrition needs of those with diabetes, pre-diabetes, or those just looking to improve their health, these recipes prove that you can eat healthy without sacrificing an ounce of flavor. Drawing on their decades of experience, the Mr. Food Test Kitchen Team has taken well-known favorites and mixed in some new surprises to create meals that are long on taste and short on guilt. Whether it's Sweet Potato Crowns, Carolina Brisket Sliders, or Caramel Walnut Brownies, the recipes in 'Hello Taste, Goodbye Guilt'will leave people looking to control their blood glucose or shave off a few extra pounds amazed at what they can fit into their meal plans. With over 150 recipes designed for every meal and every occasion, including breakfast dishes, desserts, sides, salads, and more, and paired with original photography and an attractive four-color design, this collection covers it all. Plus, each recipe is designed to meet the nutrition guidelines of the American Diabetes Association, which use evidence-based research to craft recommendations shown to help control glucose levels and promote weight loss. With the help of the Mr. Food Test Kitchen and the American Diabetes Association, eating well and controlling diabetes has never tasted so good.
Mr. Humble and Dr. Butcher: A Monkey's Head, the Pope's Neuroscientist, and the Quest to Transplant the Soul
by Brandy SchillaceThe &“delightfully macabre&” (The New York Times) true tale of a brilliant and eccentric surgeon…and his quest to transplant the human soul.In the early days of the Cold War, a spirit of desperate scientific rivalry birthed a different kind of space race: not the race to outer space that we all know, but a race to master the inner space of the human body. While surgeons on either side of the Iron Curtain competed to become the first to transplant organs like the kidney and heart, a young American neurosurgeon had an even more ambitious thought: Why not transplant the brain? Dr. Robert White was a friend to two popes and a founder of the Vatican&’s Commission on Bioethics. He developed lifesaving neurosurgical techniques still used in hospitals today and was nominated for the Nobel Prize. But like Dr. Jekyll before him, Dr. White had another identity. In his lab, he was waging a battle against the limits of science and against mortality itself—working to perfect a surgery that would allow the soul to live on after the human body had died. This &“fascinating&” (The Wall Street Journal), &“provocative&” (The Washington Post) tale follows his decades-long quest into tangled matters of science, Cold War politics, and faith, revealing the complex (and often murky) ethics of experimentation and remarkable innovations that today save patients from certain death. It&’s a &“masterful&” (Science) look at our greatest fears and our greatest hopes—and the long, strange journey from science fiction to science fact.
Mrs Winterbottom Takes a Gap Year: The brand new feel-good read from the author of THE SINGLE LADIES OF JACARANDA RETIREMENT VILLAGE
by Joanna NellA witty and touching tale about mismatched expectations and living life in the moment, from the author of cherished ebook bestseller, The Single Ladies of Jacaranda Retirement VillageIt's never too late for the adventure of a lifetime . . .Heather Winterbottom has worked side by side with her husband as GPs in their idyllic rural practice for over forty years. But as the time comes to hang up their stethoscopes, the Winterbottoms discover that they have rather different visions of retirement . . . Heather dreams of exploring the Greek Islands, of escaping the shackles of her routine life and embracing an exciting new adventure. Alan dreams of growing his own vegetables.When things come to a head at a family lunch, Heather announces that she has decided to take a year off. From her old life, from her marriage - from Alan. Alone in beautiful Greece, Heather embarks on her very own odyssey - complete with peak experiences, pitfalls and temptations. But what if coming home is the biggest adventure yet? ***Praise for Joanna Nell's uplifting and heartwarming novels:'Takes readers on a sweet journey. A warm-hearted read from Nell, who tells engaging stories with older protagonists' The Australian'Tender and funny' Woman's Weekly'Whip-smart dialogue, humour and sarcasm . . . highly addictive' Sun Herald'The Tea Ladies is a delight. Warm characters and observations and great pace' AMANDA HAMPSON'Another funny, warm-hearted read' Herald Sun'Lively and whimsical' Sydney Morning Herald(P)2023 Hodder & Stoughton Limited
Mrs Winterbottom Takes a Gap Year: The brand new feel-good read from the author of THE SINGLE LADIES OF JACARANDA RETIREMENT VILLAGE
by Joanna NellIt's never too late for the adventure of a lifetime . . .Heather Winterbottom has worked side by side with her husband as GPs in their idyllic rural practice for over forty years. But as the time comes to hang up their stethoscopes, the Winterbottoms discover that they have rather different visions of retirement . . . Heather dreams of exploring the Greek Islands, of escaping the shackles of her routine life and embracing an exciting new adventure. Alan dreams of growing his own vegetables.When things come to a head at a family lunch, Heather announces that she has decided to take a year off. From her old life, from her marriage - from Alan. Alone in beautiful Greece, Heather embarks on her very own odyssey - complete with peak experiences, pitfalls and temptations. But what if coming home is the biggest adventure yet? ***Praise for Joanna Nell's uplifting and heartwarming novels:'Takes readers on a sweet journey. A warm-hearted read from Nell, who tells engaging stories with older protagonists' The Australian'Tender and funny' Woman's Weekly'Whip-smart dialogue, humour and sarcasm . . . highly addictive' Sun Herald'The Tea Ladies is a delight. Warm characters and observations and great pace' AMANDA HAMPSON'Another funny, warm-hearted read' Herald Sun'Lively and whimsical' Sydney Morning Herald
Muchas vidas, muchos maestros
by Brian L. WeissEl doctor Brian Weiss, jefe de psiquiatría del hospital Mount Sinai de Miami, relata en este libro una asombrosa experiencia que cambió su vida por completo. Una de sus pacientes, Catherine, recordó bajo hipnosis varias de sus vidas pasadas y pudo encontrar en ellas el origen de muchos de sus traumas actuales. Catherine se curó, pero ocurrió algo todavía más importante: logró ponerse en contacto con los Maestros, los espíritus superiores que habitan los estados entre dos vidas. Ellos le comunicaron importantes mensajes de sabiduría y de conocimiento. Este relato, profundamente conmovedor, punto de encuentro entre ciencia y metafísica, es de obligada lectura en un mundo devastado por grandes sufrimientos y en continua búsqueda de un nuevo sentido espiritual.
Muchísimo más: Las conmovedoras memorias de mi encuentro con el amor, la lucha contra la adversidad y la definición de la vida en mis propios términos (Atria Espanol)
by Zulema Arroyo FarleyMuchísimo más combina lo mejor de La última lección y Un momento extraordinario en este relato conmovedor de cómo Zulema Arroyo Farley, La Médium Latina, vive su vida al máximo, rehusando permitir que una forma rara de cáncer o cualquier otra enfermedad crónica determine su destino.En la cuarta cita de Zulema con su ahora esposo, la nueva pareja creó una “Lista de vida” llena de aventuras que compartirían juntos, incluyendo aventuras de paracaidismo, viajes lujosos alrededor del mundo y como recolectores de vino, viajando a las regiones vitivinícolas para conocer a sus productores de vino favoritos. Sumamente exitosa y enamorada, Zulema estaba viviendo un cuento de hadas. Pero, a dos años de casarse, la Lista de vida tomó una urgencia sorprendente cuando le diagnosticaron sarcoma, una forma de cáncer extremadamente rara e incurable, junto a una serie de otras condiciones médicas complejas y misteriosas. Zulema, impávida ante los desafíos de su salud, confió en sí misma y en quienes la rodeaban para reunir el coraje necesario para enfrentar sus enfermedades de frente, sin olvidar nunca acoger el espíritu de la Lista de vida con cada día que pasa. A pesar del dolor físico y mental insoportable, los reveses y las luchas personales, Zulema está decidida a experimentar cada segundo de la vida. En este nuevo capítulo, ha revelado un secreto que había conservado toda la vida: Ella es una médium psíquico. Después de años viendo, oyendo y sintiendo presencias que otros no podían ver, ella ha aprendido a confiar en ellos en sus momentos más difíciles y utiliza su don en servicio de todo a quien le concierne. Sus guías espirituales y sabiduría de la vida ayudarán a sus lectores a acoger su visión más importante: Siempre hay mucho más que vivir, que amar, que aprender y que crear.
Mucins: Methods and Protocols (Methods in Molecular Biology #2763)
by Akihiko KameyamaThis volume explores the latest advancements in mucin research. The chapters in this book are organized into 8 parts and cover a wide range of topics such as mucin extraction, isolation, physicochemical property analysis, and experimental methods. The chapters also discuss the origins of mucins in jellyfish, feces, saliva and salivary glands, bronchi, stomach, and cervical tract; organic synthesis of peptides glycosylated at specific sites; analysis of mucin gene expression and methylation-specific electrophoresis of genes; imaging of mucin networks by AFM; and experimental methods using supported molecular matrix electrophoresis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Mucins: Methods and Protocols is a valuable resource for researchers who want to obtain in-depth insight on how to more thoroughly conduct mucin research in their laboratories.
Mucocutaneous Manifestations of HIV/AIDS: Early Diagnostic Clues
by Li He Yu-Ye Li Kun-Hua WangThis book introduces a number of HIV/AIDS cases with mucocutaneous lesions. HIV/AIDS can manifest a variety of skin lesions due to immunological disorder, opportunistic infections and tumors always occur primarily with skin lesions. The cases included in this book reflect the diseases spectrum and evolution of mucocutaneous lesions at different stages before and after AIDS antiretroviral therapy (ART) as well. This book consists of nine chapters, including fungal, viral, bacterial, parasitic, neoplastic, inflammatory diseases, syphilis and ART-induced diseases, etc. More than 300 cases and 600 photos of representative and important clinical significances are selected, showing the different clinical characteristics of the same disease under different immune status. Clinical photos are combined with clear and concise medical history along with the discussion on it, by which the readers can understand why skin lesions can be used as the early diagnostic clues to HIV/AIDS infection. Moreover, every chapter summarizes the similarity and characteristics of each type of skin diseases, which outlines and explains why they are AIDS-related mucocutaneous lesions.
Mucocutaneous Manifestations of Viral Diseases: An Illustrated Guide to Diagnosis and Management
by Omar Lupi Angela Yen Moore Stephen K TyringExpertly distinguish viral diseases from other infectious or noninfectious diseases and choose the most effective treatment with this definitive Second Edition.The only existing text to address issues of skin manifestations of viral disease, Mucocutaneous Manifestations of Viral Diseases explores the diagnosis, treatment, and pathogenesis of viral
Mucosal Delivery of Biopharmaceuticals
by Bruno Sarmento José Das NevesBiopharmaceutical medicines, the newest class of therapeutics, are quite heterogeneous and include a range of molecules such as proteins, peptides, vaccines and nucleic acids, with use in virtually all therapeutic fields (e. g. cancer and infectious diseases, vaccination, metabolic dysfunctions) and diagnostics. This edited book gives a concise and up-to-date overview of the biological features justifying the use of different human mucosa as delivery routes for biopharmaceuticals, the technological strategies that have been followed so far regarding the optimization of mucosal potentialities as well as the challenges that arise with the advent of new biopharmaceutical drugs and alternative means of administration. Following a brief introduction, the first section addresses general aspects of the biology of mucosal tissues and their unique aspects toward beneficial or deleterious interaction with biopharmaceuticals and their delivery systems. The second part reviews the different delivery strategies that have recently been investigated for different mucosal sites. The third section describes the development and clinical applications of drug delivery systems and products enclosing biopharmaceuticals for mucosal delivery, with a focus on the most successful case studies of recent years. The last section briefly centers on relevant aspects of the regulatory, toxicological and market issues of mucosal delivery of biopharmaceuticals. Scientists and researchers in the fields of drug delivery, material science, biomedical science and bioengineering as well as professionals, regulators and policy makers in the pharmaceutical, biotechnology and healthcare industries will find in this book an important compendium of fundamental concepts and practical tools for their daily research and activities.
Mucosal Delivery of Drugs and Biologics in Nanoparticles (AAPS Advances in the Pharmaceutical Sciences Series #41)
by Pavan Muttil Nitesh K. KundaNanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.
Mucosal Immunology of Acute Bacterial Pneumonia
by Alice PrinceIn contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens. The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections. It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae. By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic.
Mucosal Vaccines
by Pamela A. KozlowskiThis volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.
Mueller-Matrix Tomography of Biological Tissues and Fluids: Digital Image Processing and Analysis Techniques (SpringerBriefs in Applied Sciences and Technology)
by Zhengbing Hu Iryna V. Soltys Yuriy A. Ushenko Oleksandr V. Dubolazov M. P. Gorsky Oleksandr V. Olar Liliya Yu. TrifonyukThis book presents experimental investigations and digital image processing, highlighting the interaction of polarized radiation with phase-inhomogeneous and optically anisotropic biological layers. The promising and efficient use of vector-parametric description of the formation of polarization-inhomogeneous object fields is noted. Applications of a set of Mueller-matrix polarimetry methods are highlighted. The book includes- structural and logical scheme of multi-parameter (singular, interference and layer-by-layer Stokes-polarimetric), polarization-correlation study of the structure of distributions of the number of singularities, maps of local contrast of interference distributions and layer-by-layer maps of microscopic polarization azimuth and ellipticity; determination of relationships between changes in the magnitude of statistical parameters characterizing polarization-correlation distributions and pathology of prostate tumors.
Muir's Textbook of Pathology: Sixteenth Edition
by C. Simon HerringtonThis classic text sets a standard in this subject by outlining the scientific aspects that underlie pathological processes, relating these to specific organ systems and placing all in a context that the student of medicine or pathology can appreciate, understand and enjoy. The clearly defined and easy-to-follow structure, enhanced by numerous photographs and explanatory line diagrams, focuses on core material without neglecting novel concepts and up-to-the minute detail. A one-stop-shop in pathology, it reflects fully the integration of pathology into clinical teaching whether system or problem-based, and will take the student right through medical school and beyond to postgraduate training.
Mulholland's The Nurse, The Math, The Meds: Drug Calculations Using Dimensional Analysis
by Susan TurnerMulholland’s The Nurse, The Math, The Meds, 4th Edition helps you overcome any math anxiety you may have by clearly explaining how to use dimensional analysis to minimize drug calculation errors. It shows how to analyze and set up problems, estimate a reasonable answer, and then evaluate the answer for accuracy. But first, a review of basic math ensures that you remember essential math skills. Updated by nursing educator Susan Turner, this edition includes plenty of practice exercises to help you understand and master each aspect of dimensional analysis.
Multi Modality State-of-the-Art Medical Image Segmentation and Registration Methodologies. Volume 1
by Jasjit S. Suri Majid Mirmehdi Ayman S. El-Baz Rajendra Acharya UWith the advances in image guided surgery for cancer treatment, the role of image segmentation and registration has become very critical. The central engine of any image guided surgery product is its ability to quantify the organ or segment the organ whether it is a magnetic resonance imaging (MRI) and computed tomography (CT), X-ray, PET, SPECT, Ultrasound, and Molecular imaging modality. Sophisticated segmentation algorithms can help the physicians delineate better the anatomical structures present in the input images, enhance the accuracy of medical diagnosis and facilitate the best treatment planning system designs. The focus of this book in towards the state of the art techniques in the area of image segmentation and registration.