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Murder by an Aristocrat (The\sarah Keate Mysteries Ser. #5)
by Mignon G EberhartAn aristocratic family hiding secrets - and murder.Classic crime from 'One of American's favourite writers' Mary Higgins Clark'Suspense to the very end' NEW YORK TIMESNurse Sarah Keate is no stranger to mystery - she has solved conspiracies and murders in places as varied as her once-sleepy hospital ward, a gothic mansion, and the Sand Hills of Nebraska. But the Thatchers are different. As close to aristocracy as an American family can get, one of their own requires Keate's care for a suspicious bullet wound to his right shoulder. A wound a relative insists was self-inflicted ...When the victim dies under even stranger circumstances, Keate knows that he was murdered. As the family closes ranks and struggles to keep its darkest secrets buried, Nurse Keate will stop at nothing to find the truth - but at what cost?
Murder in the Chilcotin (Inspector Coswell of the RCMP #3)
by Roy InnesThe third book in Roy Innes' mystery series sends RCMP Inspector Coswell and the newly promoted Sergeant Blakemore to the rugged district of West Cariboo in British Columbia, where a young Mountie constable has been found dead in his burnt-out cruiser at the bottom of a ravine. But what looks like an accident quickly reveals itself as a poorly disguised murder. With a young and ambitious Tribal Police intern as their unexpected ally, Coswell and Blakemore's investigation takes them from cattle ranches and native reserves to forests high in the hills where logging operations and marijuana grow-ops exist side by side. And all the while, the case threatens to ignite racial conflicts that have been simmering in the region for more than a century.
Murder on the Home Front: A True Story of Morgues, Murderers, and Mysteries during the London Blitz
by Molly LefebureIt is 1941. While the "war of chaos" rages in the skies above London, an unending fight against violence, murder and the criminal underworld continues on the streets below.One ordinary day, in an ordinary courtroom, forensic pathologist Dr. Keith Simpson asks a keen young journalist to be his secretary. Although the "horrors of secretarial work" don't appeal to Molly Lefebure, she's intrigued to know exactly what goes on behind a mortuary door.Capable and curious, "Miss Molly" quickly becomes indispensible to Dr. Simpson as he meticulously pursues the truth. Accompanying him from somber morgues to London's most gruesome crime scenes, Molly observes and assists as he uncovers the dark secrets that all murder victims keep.With a sharp sense of humor and a rebellious spirit, Molly tells her own remarkable true story here with warmth and wit, painting a vivid portrait of wartime London.
Murdering Animals: Writings On Theriocide, Homicide And Nonspeciesist Criminology (Palgrave Studies In Green Criminology Ser.)
by Piers BeirneMurdering Animals confronts the speciesism underlying the disparate social censures of homicide and “theriocide” (the killing of animals by humans), and as such, is a plea to take animal rights seriously. Its substantive topics include the criminal prosecution and execution of justiciable animals in early modern Europe; images of hunters put on trial by their prey in the upside-down world of the Dutch Golden Age; the artist William Hogarth’s patriotic depictions of animals in 18th Century London; and the playwright J.M. Synge’s representation of parricide in fin de siècle Ireland. Combining insights from intellectual history, the history of the fine and performing arts, and what is known about today’s invisibilised sites of animal killing, Murdering Animals inevitably asks: should theriocide be considered murder? With its strong multi- and interdisciplinary approach, this work of collaboration will appeal to scholars of social and species justice in animal studies, criminology, sociology and law.
Murderous Minds: Neurological Imaging and the Manifestation of Evil
by Dean A. HaycockIs there a biological basis for evil? From neurological imaging to behavioral studies, Dean Haycock's account of the groundbreaking research reveals what scientists are learning about the psychopaths living among us. How many times have you seen a murder on the news or on a TV show like CSI: Crime Scene Investigation, and said to yourself, "How could someone do something like that?" Today, neuroscientists are imaging, mapping, testing and dissecting the source of the worst behavior imaginable in the brains of the people who lack a conscience: psychopaths. Neuroscientist Dean Haycock examines the behavior of real life psychopaths and discusses how their actions can be explained in scientific terms, from research that literally looks inside their brains to understanding how psychopaths, without empathy but very goal-oriented, think and act the way they do. Some don’t commit crimes at all, but rather make use of their skills in the boardroom. But what does this mean for lawyers, judges, psychiatrists, victims and readers--for anyone who has ever wondered how some people can be so bad. Could your nine-year-old be a psychopath? What about your co-worker? The ability to recognize psychopaths using the scientific method has vast implications for society, and yet is still loaded with consequences. 8 page color insert
Murine Models, Energy Balance, and Cancer
by Nathan A. BergerThis volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.
Murmuration
by Tj KluneIn the small mountain town of Amorea, it's stretching toward autumn of 1954. The memories of a world at war are fading in the face of a prosperous future. Doors are left unlocked at night, and neighbors are always there to give each other a helping hand. The people here know certain things as fact: Amorea is the best little town there is. The only good Commie is a dead Commie. The Women's Club of Amorea runs the town with an immaculately gloved fist. And bookstore owner Mike Frazier loves that boy down at the diner, Sean Mellgard. Why they haven't gotten their acts together is anybody's guess. It may be the world's longest courtship, but no one can deny the way they look at each other. Slow and steady wins the race, or so they say. But something's wrong with Mike. He hears voices in his house late at night. There are shadows crawling along the walls and great clouds of birds overhead that only he can see. Something's happening in Amorea. And Mike will do whatever he can to keep the man he loves.
Muscarinic Receptor Subtypes in Smooth Muscle (Handbooks In Pharmacology And Toxicology Ser. #42)
by Richard M. EglenThis book explores several subtypes of muscarinic receptors that modulate smooth muscle activity. Main topics include a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, the role of muscarinic receptors in the function of gastrointestinal and genitourinary smooth muscle, and prejunctional muscarinic receptors in smooth muscle. Discussions cover the current state of research and are intended to generate further research into the design of novel therapeutics for disorders of smooth muscle function.
Muscarinic Receptor: From Structure to Animal Models
by Jaromir Myslivecek Jan JakubikThis volume provides methods for characterization of muscarinic receptor in crystallography studies that advanced our understanding of structural properties and activation mechanism of muscarinic receptors and are cornerstone in molecular modeling and computerbased approaches to study muscarinic receptors. Muscarinic Receptor: From Structure to Animal Models guides readers through binding techniques, protocols to investigate molecular properties of muscarinic receptors, protocols to study muscarinic receptors in the central nervous system using autoradiography and PET studies and protocols on animals with knock-out and knock-in muscarinic genes to study role of muscarinic receptors in physiology and behavior. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Concise and easy-to-use, Muscarinic Receptor: From Structure to Animal Models aims to ensure successful results in the further study of this vital field.
Muscarinic Receptors
by Neil M. Nathanson Arthur Christopoulos Allison D. FryerMuscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.
Muscle Aging, Inclusion-Body Myositis and Myopathies
by Valerie Askanas W. King EngelThe aging of society is leading to many challenges across all areas of medicine. The problems of muscle aging have led to a rise in the incidence of less common conditions, which though not terminal are debilitating and frequently progressive, and often underdiagnosed or misdiagnosed. Written by a team of international experts, this landmark book will look at the general clinical problems associated with muscle aging before examining inclusion-body myositis and myopathies, a group of the more important diseases of muscle aging. With case vignettes to aid diagnosis to ensure correct management of an illness, here is an essential reference for professionals and students.
Muscle Atrophy (Advances in Experimental Medicine and Biology #1088)
by Junjie XiaoThe book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.
Muscle Biophysics
by Rassier Dilson J.EThe field of muscle biophysics has changed dramatically over the past years and new studies are reshaping the way we think muscles contract. Rapidly evolving techniques and advances are allowing us to understand the mechanics of individual molecules and cells as we could never do so before. This book, a contributed volume of the work of several current opinion leaders and well-known scientists in the field, will be unique for its rich list of authors as well as its updated, comprehensive inclusion of techniques in both cell and molecular biophysiology.
Muscle Disease: Pathology and Genetics
by Roy O. Weller Caroline A. Sewry Hans H. GoebelWritten by more than 60 international experts in the field, Muscle Disease embodies the explosion of new concepts and information on the pathology and genetics of muscle disease that has occurred in recent years. In order to accommodate the new complex principles involved, the book is organized around the motor unit and the inherited disorders, in particular, are centered on the ultrastructure and organelles within the muscle fiber. In this way, the wide spectrum of muscle diseases, ranging from neurogenic and inflammatory disorders to those involving defects in a single gene, can be expressed in a logical sequence. For example, disorders that principally involve specific organelles or particular metabolic processes are grouped together, with sections on disorders of the sarcolemma, mitochondria, myofibrils, glycogen and lipid metabolism, etc. Firm reference to clinical aspects and classification of muscle diseases has been maintained throughout the book with an initial clinical overview and with specific clinical sections in each chapter. For ease of navigation through the complex variety of muscle diseases, each chapter has been organized in a standard pattern that allows the reader to easily locate information on individual disease entities in different chapters. This new edition of Muscle Disease: Pathology and Genetics will be a very valuable resource for clinicians, pathologists, geneticists and basic neuroscientists involved in diagnosis, research, treatment and management of patients with muscle disease.
Muscle Diseases: A Guide to Differential Diagnosis, Investigation and Management
by Andria Merrison and Stefen BradyThis volume is a how-to guide on the clinical assessment and investigation of patients presenting with muscle-related symptoms. Featuring a case-based approach, this accessible text is suitable for a wide range of clinical specialists who see patients presenting with both common and rare muscle diseases.Muscle diseases are often initially missed or misdiagnosed, as they are uncommon disorders and can present in a variety of ways, often mimicking other more common disorders. Careful assessment of the history, physical examination and appropriate choice of investigations is therefore essential to reaching a diagnosis and providing short- and long-term effective management plans. Key features of this resource include: A case-based approach using real cases seen in clinical practice and highlighting different clinical presentations Case vignettes that cover patient history, examination, investigations, diagnosis and discussion points to assist the reader in developing a mental framework for thinking about muscle disease and approaching diagnosis The relevant investigations (including muscle biopsy, neurophysiology and muscle imaging) required for each clinical scenario, aiding the clinician in clinicopathological correlation Being concise, practical and complemented by a wide range of figures to enhance understanding Patients with muscle diseases may be referred to one of several medical or surgical specialties, including neurology, rheumatology, neuropathology, neurophysiology, cardiology, respiratory medicine, intensive care medicine, gastroenterology, ophthalmology, orthopaedic and spinal surgery, before the correct diagnosis is considered. This accessible text is an ideal resource for clinicians.
Muscle Energy Techniques, Second Edition: A Practical Guide for Physical Therapists
by John GibbonsRevised and updated: a fresh new look to an established best-seller--an essential tool for physical therapists that offers unique insights into the versatile and highly effective technique of muscle energy techniques.Muscle Energy Techniques is a must-have for any student or practitioner of physical therapy, osteopathy, physiotherapy, chiropractic, or massage therapy. This practical guide--packed with full-color photographs and illustrations--fully explains the theory and practice of a range of muscle energy techniques.The book is broken in 5 parts. In part I, John Gibbons examines the theory and principles behind muscle energy techniques, with chapters that explain the technique, muscle imbalances, myofascial slings, and core muscle relationships. Parts II to IV break down the technique by body area--upper body, lower body, trunk, and pelvis--with clear descriptive explanations of the techniques. Accompanied by color photographs with directional arrows, each shows the practitioner how to maximize treatment benefits. Clear drawings allow the reader to understand the basic anatomy of each muscle. A concluding part V shows two applications of muscle energy techniques: self-lengthening techniques for the shoulder complex and muscle weakness testing of the gluteals.
Muscle Gene Therapy
by Dongsheng DuanMuscle disease represents an important health threat to the general population. There is essentially no cure. Gene therapy holds great promise to correct the genetic defects and eventually achieve full recovery in these diseases. Significant progresses have been made in the field of muscle gene therapy over the last few years. The development of novel gene delivery vectors has substantially enhanced specificity and efficiency of muscle gene delivery. The new knowledge on the immune response to viral vectors has added new insight in overcoming the immune obstacles. Most importantly, the field has finally moved from small experimental animal models to human patients. This book will bring together the leaders in the field of muscle gene transfer to provide an updated overview on the progress of muscle gene therapy. It will also highlight important clinical applications of muscle gene therapy.
Muscle Gene Therapy: Methods And Protocols (Methods In Molecular Biology #709)
by Dongsheng Duan Jerry R. MendellAbout 7 million people worldwide are suffering from various inherited neuromuscular diseases. Gene therapy brings the hope of treating these diseases at their genetic roots. Muscle Gene Therapy is the only book dedicated to this topic. The first edition was published in 2010 when the field was just about to enter its prime time. The progress made since then has been unprecedented. The number of diseases that have been targeted by gene therapy has increased tremendously. The gene therapy toolbox is expanded greatly with many creative novel strategies (such as genome editing and therapy with disease-modifying genes). Most importantly, clinical benefits have begun to emerge in human patients. To reflect rapid advances in the field, we have compiled the second edition of Muscle Gene Therapy with contributions from experts that have conducted gene therapy studies either in animal models and/or in human patients. The new edition offers a much needed, up-to-date overview and perspective on the foundation and current status of neuromuscular disease gene therapy. It provides a framework to the development and regulatory approval of muscle gene therapy drugs in the upcoming years. This book is a must-have for anyone who is interested in neuromuscular disease gene therapy including those in the research arena (established investigators and trainees in the fields of clinical practice, veterinary medicine and basic biomedical sciences), funding and regulatory agencies, and patient community.
Muscle Injuries in Sport Athletes
by Ali Guermazi Bernard Roger Abdalla SkafThis book attempts to provide a comprehensive look at all of the pathologies of muscles that are likely to be encountered in treating sports-related injuries. Its purpose is to give the practitioner a guide for identifying injuries and choosing the best therapeutic strategy. The first part presents the consensus view of current knowledge: the physiology of lesions and their prognosis as well as their anatomy, clinical imaging, and treatment. Then each of the muscles is described in turn, with a review of anatomy, clinical examination, the results of imaging, and therapeutic choices for acute and chronic injuries. A major section is dedicated to imaging, with the emphasis on which diagnostic methods are best for specific injuries and how to use diagnostic imaging to determine the most suitable therapeutic strategies. Special care has been taken to provide high-quality illustrations that clearly show how to identify the lesion of the damaged muscle. A wealth of illustrations, many in color, are included. Finally, the book concludes with some clinical cases and technical notes relevant to treatment of sports-related muscle injuries.
Muscle Injury in the Athlete: The Italian Consensus Conference Guidelines
by Piero Volpi Gian Nicola BisciottiThis volume provides a cutting-edge analysis concerning the biology and aetiology, classification, clinical assessment and conservative treatment of lower limb muscle injuries in athletes. Muscle injuries are the most common trauma both in team and individual sports and are responsible for most of the time lost both in training and in competition: in professional football (soccer), they account for 30% and in track and field for 48% of all injuries recorded. Despite the considerable interest in this topic among clinicians and researchers, there is still no consensus regarding the etiopathogenesis, classification, clinical examination and treatment of muscle lesions. Based on the first Italian Consensus Conference on guidelines for the conservative treatment of lower limb muscle injuries in athletes, which was held in April 2017 at Humanitas Clinic Institute in Milan, Italy under the auspices of the Italian Society of Arthroscopy, this comprehensive book addresses the main issues concerning muscle injuries, from biology and pathobiology to clinical evaluation and different treatment option, including the most frequently used physio-kinesitherapy therapies. It also presents a consensus classification of muscle injuries closely linked to prognostic factors. Written by international experts with diverse medical backgrounds, this book offers comprehensive practical guidance for orthopedic surgeons, sports physicians, athletic trainers, physiotherapists, sports science students, and physiatrists.
Muscle Metabolism
by Juleen R. Zierath Harriet Wallberg-HenrikssonDiabetes research on models comprising intact animal tissues, cell cultures and isolated pancreatic islets is essential for understanding the pathogenesis of the disease as well as the mechanisms responsible for the chronic complications associated with it. Enormous advances in the understanding of the development of diabetes and its prevention hav
Muscle Pain: Diagnosis and Treatment
by Robert D. Gerwin Siegfried MenseThe companion volume to Muscle Pain: Understanding the Mechanisms, this text shifts the emphasis from concepts to practical advice. It facilitates the diagnosis and management of the often enigmatic symptoms of chronic muscle pain.
Muscle Pain: Understanding the Mechanisms
by Robert D. Gerwin Siegfried MenseThe two books Muscle Pain: Understanding the Mechanisms and Muscle Pain: Diagnosis and Treatment will help the practitioner to understand why the patients feel pain, what to do about it and why the treatment works. In contrast to proceedings of scientific meetings on muscle pain, they center on practical aspects and can be used by the practitioner in his or her daily work. The two books together provide a unique combination of broad basic knowledge with comprehensive clinical information on the management of patients.
Muscle Revolution: Concepts and Recipes for Building Muscle Mass and Force
by Marco ToigoHow to Effectively and Efficiently Build Muscle Mass and Muscle ForceIn this informative as well as practical book based on the latest integrative muscle research, Marco Toigo, PhD, describes which factors are crucial to successfully build muscle mass and muscle force through resistance training. In addition, he presents the practical and science-based consequences for your training and nutritional behavior with a focus on protein intake. This work thus offers both a practical guide and a scientific explanation of the "why" and "how" of effective and efficient resistance training.This book is the English version of the very successful 2nd German edition of “MuskelRevolution“ (ISBN: 978-3-662-54764-9). The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content.
Muscle Testing: A Concise Manual
by Earle Abrahamson Jane LangstonMuscle testing - A Concise Manual, provides a reference for understanding how structure relates to function, and how by knowing function we can learn structural configurations.The book summarises the key anatomical facts and figures, give methods for muscle testing by several techniques, and provides clinically useful information to supplement the tests.