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Muscles as Molecular and Metabolic Machines (Routledge Revivals)
by Peter W. HochachkaFirst published in 1994, this book explores the paradigm of muscles as molecular and metabolic machines in which all structures and functions are exquisitely integrated and matched to each other. The analysis begins with a standard reductionist approach-reviewing the integrated machine parts. The key working components of the complete muscle machine are proteins (soluble, organelle, or membrane localized), and a conservative count indicates that today more than 100 such machine parts are known, essentially all occurring as cell specific isoforms. Random assortment of these machine parts or protein isoforms could generate an astronomical number of "muscle machines" and an equally enormous number of muscle fiber types. The question is, why aren't such large numbers ever seen?To attack this problem, the reductionist approach is complemented with an integrationist/adaptational one. Evidence is presented that the more highly specialized the muscle type, the further one moves from the above extreme; in the most highly specialized muscles, typically only one fiber type is found. It is argued that instead of random assortment of isoforms or machine parts, only specific and often unique combinations can work in appropriate fashion. A few established examples of this fundamental principle are reviewed, but emphasis is placed on the fact that we know dreadfully little about why this is so and what kinds of further studies are needed. The issue of why the very large numbers of fiber types theoretically possible are never even approximately realized has never before been addressed. Indeed, it is rarely recognized. Muscles as Molecular and Metabolic Machines is the first work of its kind on the subject.
Muscles of Chordates: Development, Homologies, and Evolution
by Rui Diogo Julia Molnar Janine M. Ziermann Natalia Siomava Virginia AbdalaChordates comprise lampreys, hagfishes, jawed fishes, and tetrapods, plus a variety of more unfamiliar and crucially important non-vertebrate animal lineages, such as lancelets and sea squirts. This will be the first book to synthesize, summarize, and provide high-quality illustrations to show what is known of the configuration, development, homology, and evolution of the muscles of all major extant chordate groups. Muscles as different as those used to open the siphons of sea squirts and for human facial communication will be compared, and their evolutionary links will be explained. Another unique feature of the book is that it covers, illustrates, and provides detailed evolutionary tables for each and every muscle of the head, neck and of all paired and median appendages of extant vertebrates. <P><P> Key Selling Features: <li>Has more than 200 high-quality anatomical illustrations, including evolutionary trees that summarize the origin and evolution of all major muscle groups of chordates <li>Includes data on the muscles of the head and neck and on the pectoral, pelvic, anal, dorsal, and caudal appendages of all extant vertebrate taxa <li>Examines experimental observations from evolutionary developmental biology studies of chordate muscle development, allowing to evolutionarily link the muscles of vertebrates with those of other chordates <li>Discusses broader developmental and evolutionary issues and their implications for macroevolution, such as the links between phylogeny and ontogeny, homology and serial homology, normal and abnormal development, the evolution, variations, and birth defects of humans, and medicine.
Muscles, Nerves and Movement: In Human Occupation
by June Grieve Barbara TyldesleyThis book has established itself as the leading textbook for the study of movement by occupational therapists. Two senior tutors in occupational therapy act as consultants on this new third edition. The early chapters provide a foundation for the study of movement with the complexity of detail increasing as the book progresses. The functional anatomy is related to the movements of daily living and is supported by activities for experiencing and observing the way we perform everyday tasks. The later chapters consider the integration of sensory and motor processes in the nervous system for the planning and execution of movement. Clinical note-pads link the basic knowledge to the clinical features of common orthopaedic and neurological problems.
Muscular Dystrophy
by Katherine M.D. Bushby Louise V.B. AndersonKatherine Bushby and Louise Anderson assemble an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular dystrophy. Each method is highly detailed to ensure success and is presented by a hands-on expert. The various DNA techniques focus on both the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. The protein methods include expression analysis, multiplex western blot analysis, immunocytochemical analysis, and reviews of immunological reagents and of amplification systems. Comprehensive and highly practical, Muscular Dystrophy: Methods and Protocols offers today's diagnostic laboratories, basic and medical researchers, and clinicians an authoritative collection of tools that will serve as exacting diagnostic tools as well as greatly empowering research on the novel therapeutics now beginning to emerge.
Muscular Dystrophy
by Raymond A. HumlThis practical and concise guide offers an overview of muscular dystrophy's complicated features, treatment options and general resources. New treatments and a greater understanding of proteins and structures associated with MD are discussed along with long term patient care. Also included are clinical and developmental challenges within the current regulatory landscape and recent scientific and clinical advances. Muscular Dystrophy offers clinicians, researchers, pharmaceutical executives and patient advocacy groups an easy-to-read reference that provides the necessary perspectives of the care giver and patient.
Muscular Dystrophy Therapeutics: Methods and Protocols (Methods in Molecular Biology #2587)
by Toshifumi Yokota Rika MaruyamaThis detailed book presents a comprehensive collection of state-of-the-art protocols on muscular dystrophy therapeutics, covering therapeutics using antisense oligonucleotides, gene replacement, genome editing, small molecules, stem cells, and antibodies. Written by leaders in the field, the volume explores techniques that are currently in use and are starting an exciting therapeutic revolution in muscular dystrophy. As a part of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Muscular Dystrophy Therapeutics: Methods and Protocols serves as an ideal resource to inspire readers and provide tips, strategies, and advice to develop new therapeutic technologies for this group of diseases.
Muscular Dystrophy and Other Neuromuscular Diseases: Psychosocial Issues
by Austin H. Kutscher Leon I. Charash Robert E. Lovelace Claire F. Leach Rabbi Jacob Goldberg David Price RoyeHere is a thoughtful new book for professionals who assist persons afflicted with neuromuscular disorders to help them and their families adapt to lifestyle changes accompanying the onset of these disorders. Health care professionals provide strategies to maintain the psychosocial well-being of children and adults with neuromuscular disorders which, in addition to physical damage, also assault the sense of self and challenge the individual’s ability to move and communicate. Chapters describe the psychosocial aspects of a variety of neuromuscular diseases such as Duchenne and myotonic muscular dystrophy, multiple sclerosis, amyotrophic lateral sclerosis, Friedeich’s ataxia, and Charcot-Marie-Tooth disease. The distinctive characteristics of each disease are examined with special attention given to the natural history, treatment, management, and psychosocial issues of the specific disorder. Beyond the clinical and research importance of Muscular Dystrophy and Other Neuromuscular Diseases, it also addresses the anxiety, doubts, and questions felt by patients with chronic progressive disabilities and their families. This helpful guide is unique in the way it features the interaction of professionals in the social services, psychology, religion, and various medical specialties in the care and treatment of these patients. Professionals in all of these disciplines, as well as the patients and families afflicted by these disorders, will benefit from this valuable resource.
Muscular Injuries in the Posterior Leg
by J. Bryan DixonTaking a multidisciplinary approach to a common and often frustrating problem for athletes and those with an active lifestyle, this book is the first of its kind, addressing muscular injuries to the posterior leg using an in-depth and expansive style that is uniquely dedicated to ensuring all content is explicitly linked to the practical care of patients with calf pain. It is divided thematically into three sections. The first section covers underlying principles involved in these issues, including anatomy, physiology, pathophysiology of injury and neurophysiology of musculoskeletal pain. Clinical assessment techniques and imaging are covered in the second section. The third section on treatment is the most expansive, discussing acute, sub-acute and chronic posterior leg muscle injuries, as well as surgical management, rehabilitation techniques, complementary medicine and special populations. Overall, the book is designed to use muscular injuries of the posterior leg to as a means to understand the assessment and treatment of muscular injuries more broadly. Taken together, it is the consummate source for orthopedists, doctors in sports medicine, podiatrists, rehabilitation professionals and primary care physicians who treat muscular injuries in the posterior leg, though reader will gain a conceptual and practical framework for the assessment and treatment of muscular injuries in general.
Muscular Retraining for Pain-Free Living
by Craig WilliamsonHere's an innovative and practical approach to eliminating chronic muscle pain, written by a popular occupational therapist with thirty years of experience freeing people from the discomfort of tendonitis, lower back pain, and neck and shoulder tension. These types of chronic pain can be caused by a number of factors, including old injuries, habitual movement patterns, problems with body alignment, psychological causes, and inability to sense your own body movements accurately. Muscular Retraining for Pain-Free Living clearly and concisely explains the causes of persistent muscle pain and offers a therapeutic exercise program to address these problems and end pain. This book explains the basic principles behind Williamson Muscular Retraining, which helps people to use their bodies more efficiently and gracefully, in a way that is practical and easy to understand. The problems of poor posture, muscle tension, and stress-caused pain are corrected by seeing them through the lens of kinesthetic awareness. The importance of kinesthetic awareness is typically overlooked precisely because it is lacking in so much of our population, including health care practitioners. Retraining for Pain-Free Living presents case examples of how people have used body awareness to improve how they sit, stand, and move - to rid themselves of ongoing muscular pain.
Musculoskeletal Anatomy
by Gene L. Colborn D.B. LauseThis book is a guide for the dissection of the back and limbs - regions which are specifically relevant in the education of students in occupation and physical therapy. It contains data pertinent to many of the structures which are to be examined in the gross anatomy laboratory.
Musculoskeletal Assessment: Joint Motion and Muscle Testing (Third Edition)
by Hazel M. ClarksonA comprehensive textbook that contains the principles and methodology of joint Range of Motion (ROM) and manual muscle strength evaluation in one volume.
Musculoskeletal Assessment: Joint Range of Motion, Muscle Testing, and Function
by Hazel ClarksonDevelop the skills needed to proficiently evaluate a patient’s present functional status and create effective range of motion and muscle strength goals. <p><p> This updated fourth edition of Hazel Clarkson’s Musculoskeletal Assessment: Joint Range of Motion, Muscle Testing, and Function: A Research-Based Practical Guide offers a straight forward student-friendly approach to learning the clinical evaluation of Joint Range of Motion (ROM), Muscle Length, and Manual Muscle Testing (MMT). Now in striking full color, the fourth edition provides the right amount of detail students need to prepare for effective practice. <p><p> Each chapter is devoted to a separate anatomical region to help Physical Therapists and Occupational Therapists-in-training hone their understanding of pertinent surface and deep anatomy. The clear narrative outlines the steps taken in the assessment techniques and interpreting the results and is enhanced by a strong art program with meticulously created color illustrations and photographs that demonstrate patient and therapist positions and instrument placement.
Musculoskeletal Disease Associated with Diabetes Mellitus
by Masaaki InabaThe aim of this book is to review the latest findings on musculoskeletal disease associated with diabetes. It has been increasingly recognized that maintaining skeletal health is an important factor in achieving longevity in healthy subjects. Diabetes has been established as a disease independently associated with sarcopenia and increased risk of bone fracture resulting from osteoporosis; therefore, it is reasonable to maintain that musculoskeletal health is important in preserving good health. As either bone or muscle is intimately involved in the regulation of metabolic status, keeping the musculoskeletal system healthy is important for improving abnormal glucose metabolism toward normal levels and is vital, as well, for maintaining normal activities of daily living. Muscle is a target of insulin for enhancing the entry of glucose; thus it is conceivable that sarcopenia and muscle containing fat streaks causes insulin resistance in diabetic patients. Furthermore, bone is an organ that regulates Ca and Pi levels in serum by releasing or resorbing Ca and Pi to and from bone tissue. It is now known that bone is a definitive endocrine organ for regulating glucose metabolism and Pi metabolism by secreting osteocalcin and FGF-23 from osteocytes/osteoblasts. Readers will learn of the recent findings in this area, and this book will benefit physicians who deal with diabetes, particularly orthopedists and bone specialists, as well as all physical therapists.
Musculoskeletal Disease and Obesity: Multi-disciplinary Interventions
by John M. O´Byrne Fiachra Rowan Alan MolloyThis book provides short chapters with key learning points from experts within the area, about musculoskeletal conditions in patients with obesity. Each chapter will be structured in two parts: (a) the increasing musculoskeletal conditions caused by the obesity and (b) the difficulty of treating the musculoskeletal conditions in the presence of obesity. It is aimed at a multidisciplinary readership including clinicians, physiotherapists, rehabilitation specialists, general practitioners and sports physicians, and other allied health professionals involved in the treatment of musculoskeletal disorders.
Musculoskeletal Diseases 2013–2016
by J. Hodler G. K. Schulthess Ch. L. ZollikoferWritten by internationally renowned experts, this updated volume is a collection of chapters dealing with imaging diagnosis and interventional therapies in musculoskeletal diseases. The different topics are disease-oriented and encompass all the relevant imaging modalities including X-ray technology, nuclear medicine, ultrasound and magnetic resonance, as well as image-guided interventional techniques. This publication, including excellent radiologic images and color illustrations, will appeal not only to radiologists, rheumatologists, orthopaedics surgeons, but also to clinicians in other specialties wishing to update their knowledge in this field.
Musculoskeletal Diseases 2017-2020
by Rahel A. Kubik-Huch Gustav K. von Schulthess Juerg HodlerThis book focuses on with musculoskeletal imaging: during the last few years, there have been considerable advances in this area, driven by clinical as well as technological developments. The authors, internationally renowned experts in their field, have contributed chapters that are disease-oriented and cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As a result, this book offers a comprehensive review of the state of the art in musculoskeletal imaging. It is a valuable resource for general radiologists, radiology residents, rheumatologists, orthopaedic surgeons, and clinicians from other specialities wishing to update their knowledge in this discipline.
Musculoskeletal Diseases 2021-2024: Diagnostic Imaging (IDKD Springer Series)
by Rahel A. Kubik-Huch Gustav K. von Schulthess Juerg HodlerThis open access book focuses on imaging of the musculoskeletal diseases. Over the last few years, there have been considerable advances in this area, driven by clinical as well as technological developments. The authors are all internationally renowned experts in their field. They are also excellent teachers, and provide didactically outstanding chapters. The book is disease-oriented and covers all relevant imaging modalities, with particular emphasis on magnetic resonance imaging. Important aspects of pediatric imaging are also included. IDKD books are completely re-written every four years. As a result, they offer a comprehensive review of the state of the art in imaging. The book is clearly structured with learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers easily navigate through the text. As an IDKD book, it is particularly valuable for general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic knowledge, and for clinicians interested in imaging as it relates to their specialty.
Musculoskeletal Examination
by Elaine Rosen Joseph Fetto Jeffrey M. GrossMusculoskeletal Examination is a user-friendly textbook on the techniques of physical examination. Written by a physiatrist, orthopedic surgeon, and physical therapist, it has a uniquely multidisciplinary approach. Musculoskeletal Examination covers the complete basic examination and basic principles of normal and abnormal musculoskeletal function are fully explained, leading you to the correct differential diagnosis. The new fourth edition is now in full colour throughout and includes over 750 detailed illustrations, X-rays and MRIs, and more than 100 photographs showing examination techniques. It also includes a companion website at www.wiley.com/go/musculoskeletalexam featuring 107 MCQs and links to videos demonstrating key examination methods.Musculoskeletal Examination is perfect as a quick reference guide, while the detailed descriptions and clinically relevant examples of frequently encountered conditions will help even the most novice practitioner gain the understanding necessary to make a correct diagnosis and determine a successful treatment plan. It is ideal for physical therapists, physiatrists, orthopedists, medical students, practitioners, and all those involved in sports medicine and clinical massage.
Musculoskeletal Examination
by Jeffrey Gross Elaine Rosen Joseph FettoMusculoskeletal Examination is a user-friendly textbook designed for students, physical therapists and physicians. It is uniquely multidisciplinary in its approach, being written by a physiatrist, physical therapist and orthopedist. With tables and boxed features to emphasize and summarize key concepts, and 'sample examination' boxes to highlight and test difficult areas, it is ideal for teaching introductory courses yet detailed enough for professional reference within clinical practice. It includes an easy-to-follow examination process for all the joints and spine, as well as combining biomechanics with physical examination to enhance understanding of function. This third edition includes more and better anatomy illustrations; over 850 illustrations, x-rays and MRIs are perfect as a quick reference guide, while the detailed descriptions and clinically relevant examples of frequently encountered conditions will help out even the most novice practitioner. The chapter on basic science, the brief overview of anatomy, and the introductory remarks at the start of each chapter that provide a biomechanical overview of the region featured, all ensure Musculoskeletal Examination will help you gain the understanding necessary to make a correct diagnosis and determine a successful treatment plan for your patients. Musculoskeletal Examination is ideal for physiotherapists, physiatrists, orthopedists, medical students, practitioners and all those involved in sports medicine and clinical massage.
Musculoskeletal Examination of the Elbow, Wrist, and Hand: Making the Complex Simple
by Randall Culp Sidney JacobyThe physical examination of the elbow, wrist, and hand can be a complex topic for professionals with all levels of clinical experience. How can advance concepts be taught in a user friendly, clear format, while still providing necessary information for effective diagnosis and treatment of the elbow, wrist, and hand?Musculoskeletal Examination of the Elbow, Wrist and Hand: Making the Complex Simple by Dr. Randall Culp answers these questions. Written by experts, this easy-to-carry book provides a thorough review of the most common pathologic elbow, wrist, and hand conditions, techniques for diagnosis, as well as the appropriate treatment for each condition.Musculoskeletal Examination of the Elbow, Wrist and Hand: Making the Complex Simple contains clear photographic demonstrations, tables, sidebars, and charts throughout its pages, allowing a thorough and concise examination of the elbow, wrist, and hand.A glance at what is covered inside: Physical Examination Basics and specific tests of the elbow, wrist, and hand General Imaging Basics of general imaging of the elbow, wrist, and hand Common Conditions Tendinopathy, arthritis, wounds, soft tissue injuries, and more Musculoskeletal Examination of the Elbow, Wrist and Hand: Making the Complex Simple contains essential information to successfully take a complex subject, and bring it to a level that will be welcomed by all orthopedic residents, attendings, physical therapists, athletic trainers, medical students in training, and other health care providers.
Musculoskeletal Examination of the Foot and Ankle: Making the Complex Simple
by Shepard Hurwitz Selene ParekhThe physical examination of the foot and ankle can be a complex topic for professionals with all levels of clinical experience. How can advance concepts be taught in a user-friendly, clear format, while still providing necessary information for effective diagnosis and treatment of the foot and ankle?Musculoskeletal Examination of the Foot and Ankle: Making the Complex Simple by Drs. Shepard Hurwitz and Selene Parekh answers these questions. Written by experts, this easy-to-carry book provides a quick and thorough review of the most common pathologic foot and ankle conditions, techniques for diagnosis, as well as the appropriate treatment for each condition.Musculoskeletal Examination of the Foot and Ankle: Making the Complex Simple contains clear photographic demonstrations, tables, sidebars, and charts throughout its pages, allowing a thorough and concise examination of the foot and ankle.A glance at some of what is covered inside:• Physical Examinationo Basics and specific tests of the foot and ankle• General Imagingo Basic interpretation of common imaging modalities of the foot and ankle• Common Conditionso Bunions, toe deformities, Achilles pathology and posterior calcaneal pain, fractures, plantar fasciitis and plantar heel pain, and moreMusculoskeletal Examination of the Foot and Ankle: Making the Complex Simple contains essential information to successfully take a complex subject, and bring it to a level that will be welcomed by orthopedic residents, faculty, physical therapists, athletic trainers, medical students interested in musculoskeletal health careers, and other health care providers.
Musculoskeletal Examination of the Hip and Knee: Making the Complex Simple
by Bryan Kelly Anil RanawatThe physical examination of the hip and knee can be a complex topic for professionals with all levels of clinical experience. How can advance concepts be taught in a user-friendly, clear format, while still providing necessary information for effective diagnosis and treatment of the hip and knee?Musculoskeletal Examination of the Hip and Knee: Making the Complex Simple by Drs. Anil Ranawat and Bryan T. Kelly answers these questions. Written by experts, this easy-to-carry book provides a thorough review of the most common pathologic hip and knee conditions, techniques for diagnosis, as well as the appropriate treatment for each condition.Musculoskeletal Examination of the Hip and Knee: Making the Complex Simple contains clear photographic demonstrations, tables, and charts throughout its pages, allowing a thorough and concise examination of the hip and knee.A glance at some of what is covered inside: Physical Examination Basics and specific tests of the physical examination of the hip and knee General Imaging Basics of general imaging of the hip and knee Common Conditions Arthroscopic management of labral tears, snapping hip syndromes, meniscal tears, and more Musculoskeletal Examination of the Hip and Knee: Making the Complex Simple contains essential information to successfully take a complex subject and bring it to a level that will be welcomed by orthopedic residents, attendings, physical therapists, athletic trainers, medical students in training, and other health care providers.
Musculoskeletal Examination of the Shoulder: Making the Complex Simple
by Steven CohenThe physical examination of the shoulder can be a complex topic for professionals with all levels of clinical experience. How can advance concepts be taught in a user-friendly, clear format, while still providing necessary information for effective diagnosis and treatment of the shoulder?Musculoskeletal Examination of the Shoulder: Making the Complex Simple by Dr. Steven B. Cohen answers these questions. Written by experts, this easy-to-carry book provides a thorough review of the most common pathologic shoulder conditions, techniques for diagnosis, as well as the appropriate treatment for each condition.Musculoskeletal Examination of the Shoulder: Making the Complex Simple contains clear photographic demonstrations, tables, and charts throughout its pages, allowing a thorough and concise examination of the shoulder.A glance at some of what is covered inside:• Physical Examinationo Basics and specific tests of the physical examination of the shoulder• General Imagingo Basics of general imaging of the shoulder• Common Conditions o Superior labrar tears, Biceps tendon, Glenohumeral arthritis, and moreMusculoskeletal Examination of the Shoulder: Making the Complex Simple contains essential information to successfully take a complex subject and bring it to a level that will be welcomed by orthopedic residents, attendings, physical therapists, athletic trainers, medical students in training, and other health care providers.
Musculoskeletal Examination of the Spine: Making the Complex Simple
by Eric Harris Jeffrey RihnThe physical examination of the spine can be a complex topic for professionals with all levels of clinical experience. How can advance concepts be taught in a user-friendly, clear format, while still providing necessary information for effective diagnosis and treatment of the spine?Musculoskeletal Examination of the Spine: Making the Complex Simple by Drs. Jeffrey A. Rihn and Eric B. Harris answers these questions. Written by experts, this easy-to-carry book provides a thorough review of the most common pathologic spine conditions, techniques for diagnosis, as well as the appropriate treatment for each condition.Musculoskeletal Examination of the Spine: Making the Complex Simple contains clear photographic demonstrations, tables, and charts throughout its pages, allowing a thorough and concise examination of the spine.A Glance at some of what is covered inside:• Physical Examinationo Basics and specific tests of the examination of the cervical and thoracolumbar spine• General Imagingo Basics of general imaging of the degenerative and traumatic injuries of the spine• Common Conditionso Cervical spondylosis, Lumbar disk herniation, Diskitis and vertebral osteomyelitis of the spine, and moreMusculoskeletal Examination of the Spine: Making the Complex Simple contains essential information to successfully take a complex subject, and bring it to a level that will be welcomed by all orthopedic residents, attendings, physical therapists, athletic trainers, medical students in training, and other healthcare providers.
Musculoskeletal Health in Pregnancy and Postpartum
by Colleen M. Fitzgerald Neil A. SegalProviding clinicians with a comprehensive, evidence-based summary of musculoskeletal health in pregnancy and postpartum, this is the first book of its kind to describe the physiologic changes, prevalence, etiology, diagnostic strategies, and effective treatments for the most common musculoskeletal clinical conditions encountered during this phase of life. Lumbopelvic pain, upper and lower extremity diagnoses, labor and delivery considerations, including the impact on the pelvic floor, and medical therapeutics will be discussed. Additionally, the importance and influence of exercise in pregnancy, the long-term implications of musculoskeletal health in pregnancy and current and future directions for research will be addressed. The childbearing period is a time of remarkable reproductive and musculoskeletal change, predisposing women to potential injury, pain, and resultant disability. Musculoskeletal Health in Pregnancy and Postpartum offers musculoskeletal medicine specialists, obstetricians and any clinicians involved in the care of pregnant or postpartum women the tools necessary to prepare for, treat and prevent these concurrent injuries during an already challenging time.