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Neurocritical Care Informatics: Translating Raw Data into Bedside Action
by Michael De Georgia Kenneth LoparoHealth care in the twenty-first century requires intensive use of technology in order to acquire and analyze data and manage and disseminate information. No area is more data intensive than the neurointensive care unit. Despite the massive amount of data, however, providers often lack interpretable and actionable information. This book reviews the concepts underlying the emerging field of neurocritical care informatics, with a focus on integrated data acquisition, linear and nonlinear processing, and innovative visualization in the ICU. Subjects addressed in individual chapters are thus wide ranging and encompassing, for example, multimodal and continuous EEG monitoring and data integration, display of data in the ICU, patient-centered clinical decision support, optimization of collaboration and workflow, and progress towards an “integrated medical environment”. All of the nine chapters have been written by international thought leaders in the field.
Neurocritical Care for Neurosurgeons: Principles and Applications
by Eberval Gadelha Figueiredo Leonardo C. Welling Nícollas Nunes RabeloThis unique book discusses the management of neurocritical care patients, including basic concepts, pathophysiologic principles, monitoring, treatment indications, and factors that affect outcomes in patients requiring neurocritical care assistance. It addresses the need to improve continuing education in this area, highlighting patient care in the perioperative period. This is the first book to provide a simplified overview for neurosurgeons and neurologists to understand the neurocritical patient journey. It is divided into three parts: the first covers the basics concepts, from monitoring to the interpretation of exams; the second explores general management of specific situations encountered in intensive care and the last part includes prognostic and rehabilitation models, as well as new perspectives. Thanks to the accessible, neurosurgical specific language, the book is well suited for all professionals involved in neurocritical care, including students, but is also a valuable resource for residents and researches, as well as experienced neurosurgeons or neurologists looking for updated information and guidelines.
Neurocritical Care for the Advanced Practice Clinician
by Jessica L. White Kevin N. ShethBy utilizing a review of case-based studies and providing concise management recommendations from leaders in the field, this book provides essential knowledge for those practicing in a dynamic specialty. In the rapidly developing field of Neurocritical Care, Advanced Practice Clinicians have become an integral component of the multi-disciplinary team. This essential volume provides a frame of reference for advanced practice nurses, physician assistants, physicians, and students on a wide range of common Neuro ICU diagnoses and management strategies.
Neurocutaneous Disorders: A Clinical, Diagnostic and Therapeutic Approach
by Christos P. Panteliadis Ramsis Benjamin Christian HagelThis book provides extensive data on the more common and many of the more rare congenital and hereditary syndromes that manifest in the nervous system and skin. Though often complex and multi-systemic, these disorders can frequently be diagnosed using a combination of simple visual inspection and sound clinical expertise. Drawing on fully referenced information from thousands of articles, the international editorial team has prepared a comprehensive overview that includes historical perspectives, clinical features, the pathogenesis, and diagnostic and therapeutic strategies. In addition, it addresses the biochemical, molecular, and genetic basis of the disorders. The book is divided into four main sections. Starting with general aspects of aetiology, diagnostics and therapy, the first part then covers the genetics, neuro-imaging, neuropathology, ocular manifestations and surgical management. The second part discusses developmental malformations, such as Sturge-Weber syndrome, Ataxia-Telangiectasia, Hypomelanosis of Ito and other rare syndromes, including haemangiomas. The focus of the third part is on tumour suppressor/DNA repair disorders, the most common of which is Neurofibromatosis 1. It also describes Neurofibromatosis 2, Schwannomatosis, Tuberous sclerosis, von Hippel-Lindau disease, Naevoid basal cell carcinoma and others. The book’s fourth and final section covers defects in enzymes and structural proteins, which manifest as Cerebrotendinous xanthromatosis, Ehlers-Danlos syndrome, Menkes syndrome, Refsum disease.
Neurodegeneration
by Anthony Schapira Nicholas Wood Ted M. Dawson Zbigniew K. WszolekThis book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson's Disease, Alzheimer's Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors
Neurodegeneration
by Institute of Medicine Clare Stroud Board on Health Sciences Policy Forum on Neuroscience and Nervous System Disorders Miriam DavisNeurodegeneration: Exploring Commonalities Across Diseases is the summary of a workshop hosted by the Institute of Medicine\'s (IOM\'s) Forum on Neuroscience and Nervous System Disorders in Spring 2012 to explore commonalities across neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Participants from academia; pharmaceutical and biotechnology industries; government agencies such as the National Institutes of Health and the U.S. Department of Veterans Affairs (VA); patient advocacy groups; and private foundations presented and identified potential opportunities for collaboration across the respective research and development communities. This report identifies and discusses commonalities related to genetic and cellular mechanisms, identifies areas of fundamental science needed to facilitate therapeutics development, and explores areas of potential collaboration among the respective research communities. Neurodegenerative diseases, such as Alzheimer\'s disease, Parkinson\'s disease, ALS, and FTD, are becoming increasingly prevalent in the United States due to an aging population. Implications are grave for quality of life and health care costs. Research on neurodegenerative diseases has expanded greatly over the past four decades. Nevertheless, fundamental questions remain about the biology of these diseases, and further insights into the mechanisms of these diseases would help to inform the development of effective means to prevent and to efficiently treat them. Recent findings have revealed certain commonalities in genetic and cellular mechanisms across neurodegenerative diseases. These findings suggest that it might be valuable - at least in some cases - to change the traditional way of studying these diseases by no longer seeing each as an independent entity, but rather as clinical variants of common cellular and molecular biological defects. This approach could help enhance basic scientific understanding of neurodegenerative disease, and could help with the development of biomarkers and new therapeutics.
Neurodegeneration
by Giovanni Manfredi Hibiki KawamataNeurodegenerative disorders, such as Alzheimer's and Parkinson's disease are a growing burden on our society. Understanding and treating these common diseases is one of the major current challenges for the biomedical field. In Neurodegeneration: Methods and Protocols, experts in the field tackle this challenge and present cutting-edge analytical and technological approaches to study the mechanisms underlying neurodegenerative processes. Organizes into five sections, chapters detail protocols for isolating and culturing cells from the nervous system, production and use of animal models, characterization of cell death, analytical tools to study disease mechanisms, and therapeutic approaches for neurodegeneration. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Neurodegeneration: Methods and Protocols serves as an ideal guide to both novice and professional researchers in the field of neurodegeneration.
Neurodegeneration Methods and Protocols
by Hugh A. Tilson Jean HarryAn outstanding collection of detailed, state-of-the-art techniques for studying many aspects of nervous system cell biology. The methods span a multidisciplinary range of cellular and molecular approaches to both normal and injured nervous system function, and particularly to neurodegenerative processes. Included are basic RT-PCR techniques, cell culture systems, second-messenger signaling methods, and patch-clamp techniques. These powerful techniques will illuminate nervous system function, injury, degeneration, and the repair/regenerative process.
Neurodegeneration – 35 Fallbeispiele aus der Praxis
by Anne-Sophie Biesalski Lars TöngesDieses Buch bietet 35 klinische Kasuistiken, die unterschiedliche Symptomatiken, Patientengruppen und Verläufe bei neurodegenerativen Erkrankungen darstellen. Eine Erkrankungsgruppe, die sich sehr heterogen präsentiert und in Diagnose und Therapie gerade für den Anfänger in der neurologischen Weiterbildung komplexe Fallstricke bereithalten kann. Die Fälle sind klar und einheitlich gegliedert. Relevante Informationen zu einer Erkrankung wurden komprimiert zusammengefasst, ergänzt durch Hinweise auf hilfreiche Zusatzthemen wie den Umgang mit Erkrankten oder Tipps zur Diagnose- und Prognosevermittlung. Die Fallgeschichten werden leitliniengerecht besprochen und orientieren sich an etablierten SOPs (Standard Operating Procedures) der Neurologie. Vertiefende Multiple-Choice-Fragen zum Selbstlernen sind über die Springer Flashcards-App zugänglich und regen zum klinischen Nach- und Mitdenken an.
Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders (Second Edition)
by Roy O. Weller Dennis DicksonMost textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.
Neurodegenerative Disease and Micronutrients: Prevention and Treatment
by Kedar N. PrasadThe book proposes that a preparation of antioxidants and micronutrients, in combination with standard therapy, may reduce progression and improve management better than standard therapy alone for Alzheimer's, Parkinson's, and Huntington's disease, as well as PTSD, traumatic brain injury, concussions, and cerebral vascular insufficiency. The book pr
Neurodegenerative Diseases
by Celia DominguezThe Role of Histone Deacetylases in Neurodegenerative Diseases and Small-Molecule Inhibitors as a Potential Therapeutic Approach.- Phosphodiesterase Inhibition to Target the Synaptic Dysfunction in Alzheimer's Disease.- Glutamate and Neurodegenerative Disease.- Modulation of the Kynurenine Pathway for the Potential Treatment of Neurodegenerative Diseases.- Spinal Muscular Atrophy: Current Therapeutic Strategies
Neurodegenerative Diseases
by Daniela Galimberti Elio ScarpiniThis book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
Neurodegenerative Diseases
by Michael Robinson Philip Beart Marcus Rattray Nicholas J. MaragakisProvides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.
Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice (Neuromethods #173)
by Philip V. Peplow Bridget Martinez Thomas A. GennarelliThis volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.
Neurodegenerative Diseases: Clinical Aspects, Molecular Genetics And Biomarkers
by Daniela Galimberti Elio ScarpiniThis book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis.Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future
by Silvia MandelThis book will compile a collection of chapters dedicated to varied aspects of PPPM in neuropsychiatric and neurodegenerative diseases. Among the topics to be covered are: Recent advances in ALS research News about Clinical aspects and advanced therapy approaches in personalized treatment of ALS Schizophrenia: New treatments and clinical aspects Predictive, Preventive and Personalised Medicine in aging macular degeneration Advances in Multiple Sclerosis Pharmacogenetics, Tailoring Treatment Efficacy, Safety and Regimen Selection Multiple sclerosis related biomarkers: perspectives for clinical application Preventive clinical trials in brain aging: new trends & the need of guidelines MCI_ clinical guidelines in early diagnosis of dementia Alzheimer's disease: diagnostics, prognostics and the road to prevention Biomarkers for early diagnosis of Parkinson's and Alzheimer's diseases Synucleinopathies, tauopathies, TDP-43 proteinopathies and amyloidosis PSP, MSA and other parkinsonisms
Neurodegenerative Diseases: Translational Models, Mechanisms, and Therapeutics
by Sandeep Singh Santosh Kumar Singh Sachchida Nand RaiThis reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches.Key Features: Provides a comprehensive overview of neurodegenerative diseases and their models Examines the limitations associated with modeling neurodegenerative diseases Presents novel treatment strategies for Alzheimer's disease using cellular models Reviews importance of 3D organoid models for therapeutic approaches in Parkinson's disease Covers modeling techniques in understanding prion diseases Explores the role of genetic models in understanding Huntington's disease
Neurodegenerative Disorders
by Colin P. Doherty Orla HardimanNeurodegenerative Disorders provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice. Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions including Alzheimer Disease; Dementia and Cerebrovascular Disease; Parkinson's Disease; Fronto-Temporal Dementia; Amyotrophic Lateral Sclerosis; Huntington's Disease; Parkinsonism Plus syndromes and Prion Diseases. Final chapters cover important management issues including the use of palliative care strategies, advance directives and competence. Written by experts in the field internationally Neurodegenerative Disorders is a practical guide for clinicians that will be indispensable for the management of these conditions.
Neurodegenerative Disorders
by Colin P. Doherty Orla Hardiman Marwa Elamin Peter BedeThis new edition provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice. Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions and, new for the second edition, also HIV dementia and multiple sclerosis. Final chapters cover important management issues including the use of palliative care strategies, biomarkers and neuropsychology. Written by experts in the field internationally Neurodegenerative Disorders, Second Edition is a practical guide for clinicians that will be indispensable for the management of these conditions.
Neurodegenerative Disorders as Systemic Diseases
by Keiji WadaThis book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.
Neurodevelopmental Disabilities: Clinical Care for Children and Young Adults
by Donald E. Greydanus Dilip R. Patel Hatim A. Omar Joav MerrickIncreasingly more and more children with developmental disabilities survive into adulthood. Pediatricians and other clinicians are called upon to care for an increasing number of children with developmental disabilities in their practice and thus there is a need for a practical guide specifically written for paediatricians and primary care clinicians that addresses major concepts of neurodevelopmental pediatrics. In the United States, the specialty training leading to a conjoint board certification by the American Board of Pediatrics and American Board of Psychiatry and Neurology, requires a total of 6 years of training (2 years of pediatrics, 1 year of neurology, 18 months of child neurology, 18 months of neurodevelopmental disabilities). As of December 2006, in the US, there were 241 pediatricians and 55 child neurologists certified in the subspecialty of Neurodevelopmental Disabilities. Thus most of the children with developmental disabilities are seen by pediatricians and therefore it is important for these pediatricians to be well informed of common issues in the field. The 60,000 or so pediatricians in the United States (and hundreds more in other countries) are the main target audience for a practical book on neurodevelopmental pediatrics.
Neurodevelopmental Disorders in Adult Women: Special Considerations in the Perinatal Period
by Anupriya GogneThis book elaborates on Neurodevelopmental Disorders (NDD) and their treatment in adult women with a special focus on the unique clinical presentation of these problems during the Perinatal period. Problems related to chronic, untreated NDD during adulthood are viewed through the lens of pregnant and postpartum mothers to highlight unique struggles as their family unit expands after having children. The content is based on the author&’s clinical experience with mothers under her psychiatric care between 2017-2024 at an outpatient practice, affiliated with Brown University. Comorbid psychiatric problems such as anxiety, mood disorders, trauma and substance use disorders are also reviewed. In addition to sharing clinical anecdotes, the author presents a consolidated review of scientific literature on the subject. I believe that this book can be an important addition to scientific literature at this time, when Neurodiversity is being explored and accepted more in society and we are more receptive to improving women&’s mental health. Afflicted mothers as well as their treatment providers have conveyed to me the profound relief on finally getting accurate diagnosis and treatment for NDDs. Several books have been published documenting the unique presentation and treatment interventions for ADHD and Autism in women, however, this will be the only book addressing symptomology and treatment interventions for NDD specifically during the perinatal period. I have seen how successful long-term treatment with a specialized team of mental health professionals can significantly improve the quality of life not just for the mother but also, for the entire family unit. The book will be divided into two parts: Part 1- Clinical Manifestations and Symptomology in Adult Women with NDD In the first part of the book, I plan to discuss the approach to diagnosis of Neurodevelopmental Disorders in General Adult Psychiatry and understand reasons for missed diagnosis, especially in females. I will outline my diagnostic and therapeutic approach, conceptualizing NDDsymptomology as variations of higher brain functioning rather than categorization of these symptoms as a &“disorder,&” and contemplating potential evolutionary advantages to neurodiversity. Based on my clinical practice, I will discuss tools for clinical assessment, including referral for neuropsychological testing and its utility in adults. In addition to the DSM-5 diagnoses, I will also propose conceptualizing difficulties in functioning and subjective distress in terms of symptom domains (executive dysfunction, hyperactivity/impulsivity, sensory overload and emotional regulation) as reflected in day-to-day functioning and social interactions in the adult life of women. Also, differential diagnoses including Obsessive Compulsive Disorder, Bipolar disorder, Post Traumatic Stress Disorder (PTSD), and personality disorders will be discussed, addressing the puzzling symptom overlap as well as genetic predisposition between these psychiatric illnesses and neurodevelopmental disorders. I will describe this association using clinical case examples and, later in the book, propose the inclusion of trauma-based interventions in treatment of Neurodevelopmental Illnesses in adult women. Lastly, comorbid substance use will be addressed. I will highlight struggles related to complex psychopathology and dual diagnosis. Given my training in Addiction Psychiatry, one of my goals is also to reduce stigma and apprehension about prescribing controlled medications in patients with history of substance use disorders. Part 2- Perinatal perspective on NDD Part 2 will have a specific perinatal focus starting with a detailed description of predisposing factors (Behavioral/Social, Psychological and Biological factors) for distress in Mothers with
Neurodevelopmental Disorders: Employing iPSC Technologies to Define and Treat Childhood Brain Diseases (Advances in Neurobiology #25)
by Emanuel DiCicco-Bloom James H. MillonigThis book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes.
Neurodevelopmental Pediatrics: Genetic and Environmental Influences
by Jerome Y. Yager Tim F. Oberlander David D. Eisenstat Dan GoldowitzThis book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.