- Table View
- List View
Neuropharmacotherapy in Critical Illness (Updates in Neurocritical Care)
by Gretchen Brophy Dr Teresa A Allison Dr Karen Berger Dr Kathleen A. Bledsoe Dr Jennifer Bushwitz Dr Amber Castle Dr Katleen Chester Dr Aaron M Cook Dr Emily Durr Dr Olabisi Falana Dr Jose Guzman Garcia Dr Haley Goodwin Gibbs Dr Kristy N Greene Dr Jimmi Hatton-Kolpek Dr Teresa Human Dr Lisa Kurczewski Dr John J Lewin III Dr Norah Liang Dr Kathryn A Morbitzer Dr Christopher Morrison Dr Ron Neyens Dr Viet Nguyen Dr Nicholas G Panos Dr Denise H Rhoney Dr A. Shaun Rowe Dr Ted Siindlinger Dr Eljim P TesoroThe field of research related to neurocritical care has grown significantly in recent years, and the clinical demands for current and dependable expertise has followed suit. It can be a challenge for the neurocritical practitioner to keep up with cutting-edge evidence-based research and best practices, especially regarding the role of pharmacotherapeutics. In the treatment of neurocritical disease states, pharmacotherapeutic strategies are increasingly relevant. Neuropharmacotherapy in Critical Illness is the first book that provides this information in a high-yield format for the busy healthcare provider. Edited and authored by leading experts in the field, this book provides practitioners with clinical pearls on neuropharmacology, dosing strategies, monitoring, adverse events, drug interactions, and evidence-based pharmacotherapy.
Neurophotonics and Brain Mapping
by Yu Chen Babak KatebUnderstanding how the brain works and developing effective therapeutics are important in advancing neuroscience and improving clinical patient care. Neurophotonics and Brain Mapping covers state-of-the-art research and development in optical technologies and applications for brain mapping and therapeutics. It provides a comprehensive overview of various methods developed using light, both microscopic and macroscopic techniques. Recent developments in minimally-invasive endoscopic imaging of deep brain structure and function, as well as light-based therapy are also reviewed.
Neurophysiologic Biomarkers in Neuropsychiatric Disorders: Etiologic and Treatment Considerations (Advances in Neurobiology #40)
by Daniel C. Javitt James C. McPartlandThis book reviews neurophysiological biomarkers in neuropsychiatric disorders from the viewpoint of the 21st Century Cures Act, which encourages the use of biomarkers for a variety of purposes during drug development. It covers both traditional etiologic uses of biomarkers and the more recent Biomarkers, EndpointS, and other Tools (BEST) classification scheme used by the FDA, which permits biomarkers for purposes of susceptibility, diagnosis, monitoring, prognosis, pharmacodynamics/response, and safety. The first section of the book describes potential uses of neurophysiologic biomarkers. Subsequent sections focus on a wide range of conditions, including schizophrenia, autism spectrum disorder, Parkinson’s disease, and depression, as well as cross-diagnostic and translational uses, including monkey and rodent analogs. The purpose of the book is to help clinicians understand how neurophysiological biomarkers may be used to understand and manage clinical conditions; to help researchers to understand how biomarkers may be used translationally to test specific theories; and to help pharma investigators to understand how biomarkers can be used to accelerate treatment development.
Neurophysiological Techniques, I: Applications to Neural Systems
by Alan A. Boulton Glen B. Baker Case H. VanderwolfThe latest information and methodologies for studying the activity of living nervous tissue, with special emphasis on electrophysiological techniques and their applications, ranging from ion channels to human behavior.
Neurophysiological Techniques, I: Basic Methods and Concepts
by Alan A. Boulton Glen B. Baker Case H. VanderwolfThe latest information and methodologies for studying the activity of living nervous tissue, with special emphasis on electrophysiological techniques and their applications, ranging from ion channels to human behavior.
Neurophysiologische Behandlung bei Erwachsenen und Kindern: Zentralneurologische Störungen verstehen und behandeln
by Sabine George Anke Hengelmolen-Greb Angela Harth Michael Ertl Reinhard Ott-Schindele Birgit RauchfußFunktionelles Alltagstraining ist bei zentralnervösen Schädigungen das A und O. Ergotherapeuten und Physiotherapeuten unterstützen hierbei den Patienten durch regelmäßiges Training und gezielte Behandlungseinheiten. In diesem Praxisbuch finden Sie die wesentlichen neurophysiologischen Grundlagen sowie die zugehörigen neuromuskulären, funktionellen Zusammenhänge, um Symptome bestmöglich behandeln zu können. In idealer Weise verknüpfen die erfahrenen Autoren und Therapeuten Praxis und Hintergrundwissen und zeigen bewährte Verfahren aus bekannten Therapiekonzepten wie Bobath, Affolter und Perfetti. Alltagsorientiert, aktuell und anregend: Das perfekte Nachschlagewerk für jeden Wissens- und Erfahrungsstand.Neu in der 4. Auflage: Videos veranschaulichen Fallbeispiele, sämtliche Kapitel komplett aktualisiert und erweitert.
Neurophysiology in Clinical Practice
by Abdul Qayyum Rana Ali T. Ghouse Raghav GovindarajanThis handbook provides a concise up to date review in interpreting electroencephalography and electromyography using simple illustrations. The book has been divided into two sections. Section 1 describes electroencephalography and Section 2 discusses electromyography and nerve conduction studies. Each chapter has been carefully drafted to provide the most up to date accurate information in an easy to understand format interspersed with diagrams and tables where needed. This book is aimed at trainees doing their neurophysiology rotation, general neurologists, general practitioners, advanced practice providers and neurophysiology technicians.
Neurophysiology of Neuroendocrine Neurons
by Jeffrey G. Tasker William E. ArmstrongNeurophysiology of Neuroendocrine Neurons provides researchers and students with not only an understanding of neuroendocrine cell electrophysiology, but also an appreciation of how this model system affords access to virtually all parts of the neuron for detailed study - something unique compared to most types of neuron in the brain. Chapters range from those describing the rich history and current state of in vivo recordings, highlighting the precise relationship between the patterns of action potential discharge in these neurons and hormone release, to in vitro approaches where neuroendocrine neurons can be precisely identified and their membrane properties, morphology, and synaptic responses, directly examined. * Written by a team of internationally renowned researchers, each chapter presents a succinct summary of the very latest developments in the field* Includes an evaluation of different experimental approaches, both in vivo and in vitro, and how the resulting data are interpreted* Both print and enhanced e-book versions are available* Illustrated in full colour throughoutThis is the first volume in a new Series 'Masterclass in Neuroendocrinology' , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.
Neurophysiology of the Migraine Brain (Headache)
by Gianluca Coppola Wei-Ta ChenRoughly one in every five patients referred to a neurologist suffers from headaches; the majority have migraines. Although headache specialists understand migraine on a clinical basis, the pathophysiological changes that provoke and accompany the development of a migraine attack continue to elude us. Several decades have passed since the pioneering electroencephalographic study by Golla and Winter (1959), which underscored the role of abnormal rhythmic activities in migraine. Since then, there have been substantial advances in the field; a wealth of neurophysiological studies has enriched our understanding of the pathophysiological facets of the migraine pathology. Virtually every known technique of clinical electrophysiology has since been used to study the migraine brain and, more recently, new neurophysiological tools have been added to the arsenal. Nevertheless, applying the principles of peripheral and central neuromodulation offers a promising way to transfer the principles of synaptic plasticity to the patient’s bedside. This book belongs to the Headache Series endorsed by the European Headache Federation. Written by internationally recognized experts in their respective fields, it covers all aspects of clinical neurophysiological methods that represent significant advances in our understanding of the pathophysiology of migraine. It will offer a valuable toolkit for beginners, and a reference guide for experts.
Neuroplasticity and Rehabilitation
by Sarah RaskinBrain plasticity is the focus of a growing body of research with significant implications for neurorehabilitation. This state-of-the-art volume explores ways in which brain-injured individuals may be helped not only to compensate for their loss of cognitive abilities, but also possibly to restore those abilities. Expert contributors examine the extent to which damaged cortical regions can actually recover and resume previous functions, as well as how intact regions are recruited to take on tasks once mediated by the damaged region. Evidence-based rehabilitation approaches are reviewed for a range of impairments and clinical populations, including both children and adults.
Neuroplasticity, Development, and Steroid Hormone Action
by Robert J. Handa Shinji Hayashi Ei Terasawa Mitsuhiro KawataA compilation of cutting-edge research, Neuroplasticity, Development, and Steroid Hormone Action explores the effects of steroid hormones on brain development, function, and aging. The experimental approaches used by the authors ranges from molecular to behavioral and endocrine to neurobiological. It contains scientific photographs, line drawings, tables, color illustrations, and graphs, this interesting and timely text covers the neuroplastic effects of steroid hormones throughout the lifetime of various animal models, such as bees, fish, lizards, turtles, birds, mice, rats, and primates.
Neuroprognostication in Critical Care
by David M. Greer Neha S. DangayachNeuroprognostication in patients with primary neurological diagnoses as well as in critically ill patients with concomitant neurological diagnoses is increasingly complex. With advances in critical care, the focus of the field is progressively moving from survivorship to improving patients' quality of life. This evidence-based resource provides an in-depth analysis of different aspects of prognostication in neurologically critically ill patients, covering how to gather the correct data and synthesize this information at the bedside. Delving into disease specific prognostication such as traumatic brain injury, acute ischemic stroke and delirium, guidance is provided for choosing management strategies based on overall perception of prognostication and shared decision making. Other topics covered include religious and legal issues, palliative care, chronic critical illness and new frontiers including machine learning and biomarkers usage. An online version of the book with expandable figures can be accessed on Cambridge Core, via the code printed inside the cover.
Neuroprosthetics and Brain-Computer Interfaces in Spinal Cord Injury: A Guide for Clinicians and End Users
by Gernot Müller-Putz Rüdiger RuppThis book provides a comprehensive overview of the current state of the art of practical applications of neuroprosthesis based on functional electrical stimulation for restoration of motor functions lost by spinal cord injury and discusses the use of brain-computer interfaces for their control.The book covers numerous topics starting with basics about spinal cord injury, electrical stimulation, electrical brain signals and brain-computer interfaces. It continues with an overview of neuroprosthetic solutions for different purposes and non-invasive and invasive brain-computer interface implementations and presents clinical use cases and practical applications of BCIs. Finally, the authors give an outlook on cutting edge research with a high potential for clinical translation in the near future.All authors committed themselves to use easy-to-understand language and to avoid very specific information, focusing instead on the essential aspects. This makes this book an ideal choice not only for researchers and clinicians at all stages of their education interested in the topic of brain-computer interface-controlled neuroprostheses, but also for end users and their caregivers who want to inform themselves about the current technological possibilities to improve paralyzed motor functions.
Neuroprosthetics: Principles and Applications (Rehabilitation Science in Practice Series)
by Justin C. SanchezMaster the tools of design thinking using Neuroprosthetics: Principles and Applications. Developed from successfully tested material used in an undergraduate and graduate level course taught to biomedical engineering and neuroscience students, this book focuses on the use of direct neural sensing and stimulation as a therapeutic intervention for complex disorders of the brain. It covers the theory and applications behind neuroprosthetics and explores how neuroprosthetic design thinking can enhance value for users of a direct neural interface. The book explains the fundamentals of design thinking, introduces essential concepts from neuroscience and engineering illustrating the major components of neuroprosthetics, and presents practical applications. In addition to describing the approach of design thinking (based on facts about the user’s needs, desires, habits, attitudes, and experiences with neuroprosthetics), it also examines how effectively "human centered" neuroprosthetics can address people’s needs and interactions in their daily lives. Identifying concepts and features of devices that work well with users of a direct neural interface, this book: Outlines the signal sensing capabilities and trade-offs for common electrode designs, and determines the most appropriate electrode for any neuroprosthetic application Specifies neurosurgical techniques and how electronics should be tailored to capture neural signals Provides an understanding of the mechanisms of neural–electrode performance and information contained in neural signals Provides understanding of neural decoding in neuroprosthetic applications Describes the strategies that can be used to promote long-term therapeutic interventions for humans through the use of neuroprosthetics The first true primary text for undergraduate and graduate students in departments of neuroscience and bioengineering that covers the theory and applications behind this science, Neuroprosthetics: Principles and Applications provides the fundamental knowledge needed to understand how electrodes translate neural activity into signals that are useable by machines and enables readers to master the tools of design thinking and apply them to any neuroprosthetic application.
Neuroprotection Methods and Protocols
by Tiziana BorselloThis book examines current research into the role of neuronal death in cell signaling pathways, and its role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. After introducing neurodegenerative, traumatic, and ishemic disorders, the authors cover in vitro and animal systems, and cellular and molecular mechanisms.
Neuroprotection and Neuroregeneration for Retinal Diseases
by Toru Nakazawa Yasushi Kitaoka Takayuki HaradaThis book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa. Glaucoma is one of the main causes of blindness throughout the world, and other diseases such as AMD and retinitis pigmentosa also lead to loss of vision. All these conditions are characterized by degeneration of specific retinal cell types, making it essential to establish treatments to protect retinal neurons and the optic nerve. With that aim in mind, this book explains the mechanisms underlying aforementioned diseases and their experimental models. The novel strategy proposals for the treatment of retinal diseases based on the concept of neuroprotection are also discussed in the main body of the text, while the section on regenerative research discusses optic nerve regeneration, endothelial progenitor cells, and iPS cells. This book is recommended as a professional reference work for all doctors and trainees in the field of ophthalmology who are interested in neuroprotective and neuroregenerative treatments.
Neuroprotection and Regeneration of the Spinal Cord
by Kenzo Uchida Masaya Nakamura Hiroshi Ozawa Shinsuke Katoh Yoshiaki ToyamaNeuroprotection and Regeneration of the Spinal Cord comprehensively covers the most recent research in the field of spinal cord injury. The first part of this book focuses on the latest animal models and clinically oriented work, providing extensive information on morphological factors and, biomechanical analysis, in addition to the mechanism of functional recovery. The book goes on to provide information on clinical relevance introducing analysis of spinal cord injuries using MRI and PET. Edited by renowned experts in the field, this book will provide clinical physicians, basic researchers and postgraduate students with valuable insight into the cutting-edge research and progress in the field of spinal cord injury, treatment and repair.
Neuroprotective Effects of Phytochemicals in Brain Ageing
by Surajit Pathak Antara BanerjeeThis book discusses the mechanism and therapeutic strategies of phytochemicals against brain ageing. It discusses the underlying anti-oxidative and anti-inflammatory mechanisms of the phytochemicals and the implications of these compounds in the prevention and treatment of geriatric diseases. It discusses the potential role of the highly complex interactive network between the gut and the brain in neurodegenerative diseases such as Parkinson’s disease (PD), and Alzheimer’s disease. The chapters provide insight into the mechanisms involved in brain ageing and the mechanism of actions of the phytochemicals that might be crucial in developing effective new therapies against brain ageing. The chapter also presents the mechanisms of action of phytoconstituents, bioavailabilities, and their effects on neuroinflammation. The chapters also examine the phytochemicals protection of neurons via targeting oxidative stress, mitochondrial dysfunction, neurotrophic factor deficit, apoptosis, and abnormal protein accumulation. This book aims to provide comprehensive and cutting-edge information on the potential neuroprotective role of phytochemicals on the brain and neurological disorders to researchers, neuroscientists, clinical nutritionists, and physicians.
Neuroprotective Effects of Phytochemicals in Neurological Disorders
by Akhlaq A. Farooqui Tahira FarooquiPhytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.
Neuroprotective Natural Products: Clinical Aspects and Mode of Action
by Goutam BrahmachariFocusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.
Neuroprotective Therapy for Stroke and Ischemic Disease
by Paul A. Lapchak John H. ZhangA critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.
Neuroproteomics
by Andrew K. Ottens Kevin K.W. WangWith the development of polypeptide ionization processes for mass spectrometry and the rapid processing of large-scale datasets with bioinformatics, researchers now have the tools necessary to propel neuroproteomics research to new levels. In Neuroproteomics: Methods and Protocols, experts in the neurological and analytical sciences present experimental details for applying proteomics to the study of the central nervous system (CNS) and its dysfunction through trauma and disease. Divided into four convenient sections, this collection covers CNS animal models used for neuroproteomics research, methods for separating and analyzing discrete subcomponents of the neuroproteome, large-scale approaches for CNS proteome characterization and quantification, as well as methods that evaluate biofluids and translate neuroproteomic results into clinical platforms. As a volume in the highly successful Methods in Molecular BiologyTM series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Neuroproteomics: Methods and Protocols includes the clear "how-to" information needed to critically assess what can be accomplished in the field and how to best perform and evaluate neuroproteomic experiments in one's own research.
Neuroproteomics
by Jr. Firas H. Kobeissy Stanley M. StevensThis new edition provides updated and novel protocols of neuroproteomics methods that encompass both global-scale as well as targeted and specialized topics, which are timely additions for the molecular and phenotypic analysis of the central nervous system and CNS-related disorders. The detailed contents of this book include the exploration of several exciting areas of advanced methods used for neuroproteomics research including relative and absolute protein quantitation by mass spectrometry, characterization of post-translational modifications, as well as bioinformatics and computational approaches. Written for the highly successful Methods in Molecular Biology series, methodology chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Updated and accessible, Neuroproteomics: Methods and Protocols, Second Edition serves researchers and clinical scientists involved in the area of biomarker research and protein biochemistry, as well as molecular biologists and biochemists who have been involved in proteomics research already or even for those new to the field.
Neuroproteomics
by Ka Wan LiIn the past few years, the application of proteomics to examine the molecular mechanisms underlying (mal-)functioning of the nervous system and brain disorders has risen steeply, which in many cases has yielded novel insights. As neuroproteomics is a new research field involving the use of a number of high-end analytical instruments and technologies, both promises and pitfalls may not be well appreciated by the researchers, and the design of a proper proteomics experiment may not be obvious. Neuroproteomics brings together a collection of detailed protocols written by experienced professionals in the field in order to cover aspects of various dimensions of this new technology, together with some established methods that have supporting roles in the workflow of neuroproteomics. Written for the popular Neuromethods series, the chapters in this book contain step-by-step, easy to follow instruction along with practical tips and key implementation advice essential for successful implementation of the techniques. Authoritative and cutting-edge, Neuroproteomics will be of great assistance to all researchers seeking to design and execute their own proteomics experiments in an optimal way and continue moving forward this exciting area of study.
Neuroproteomics
by Oscar AlzateIn this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg