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Neurovascular Surgery: Surgical Approaches For Neurovascular Diseases
by Julius July Eka J. WahjoepramonoThis open access book presents the diagnosis, investigation and treatment of neurovascular diseases, and offers expert opinions and advice on avoiding complications in neurovascular surgery. It also covers complication management and post-operative follow-up care. The book is divided in to three parts; the first part discusses common approaches in neurovascular surgery, describing the steps, indications for and limitations of the approach, as well as the associated complications and how to avoid them. The second part addresses surgical treatment based on pathology, taking the different locations of lesions into consideration. The third part focuses on the technological developments that support neurovascular surgery, which may not be available everywhere, but have been included to help vascular surgeon understand the principles. This book is a guide for young neurosurgeons, neurosurgery residents and neurosurgery fellows, as well as for medical students and nurses who are interested in neurosurgery or are associated with this field in any way. It is also a useful teaching aid for senior neurosurgeons.
Neuroviral Infections: General Principles and DNA Viruses
by Sunit K. Singh Daniel RůžekNeurovirology is an interdisciplinary field representing a melding of virology, clinical neuroscience, molecular pathogenesis, diagnostic virology, molecular biology, and immunology. Neuroviral Infections: General Principles and DNA Viruses covers recent developments in the area of neuroviral infections and discusses their role in related fields su
Neuroviral Infections: RNA Viruses and Retroviruses
by Sunit K. Singh Daniel RuzekNeurovirology is an interdisciplinary field representing a melding of virology, clinical neuroscience, molecular pathogenesis, diagnostic virology, molecular biology, and immunology. Neuroviral Infections: RNA Viruses and Retroviruses presents an up-to-date overview of the general principles of infections and major neuroviral infections caused by RNA viruses and retroviruses. It is designed for virologists, specialists in infectious diseases, teachers of virology, and postgraduate students of medicine, virology, neurosciences, and immunology.
Neurovirology: Measuring, Interpreting, and Understanding Viruses (Cambridge Manuals in Neurology)
by Richard B. TenserThe plethora of miscommunication and disinformation about how SARS-CoV-2 (COVID-19) spreads suggests a widespread misunderstanding of how viruses work. This book will focus on the interpretation of scientific and medical results, giving the reader guidance on interpreting virological data, including the concepts of 'live' versus infectious virus. The first section covers the background of virology and immunology, introducing the reader to the science of virology (using COVID-19 as an illustration) and considers the measurement of infectious disease, using polymerase chain reaction (PCR), molecular biology and the immune system. The second section looks at clinical virology and neurovirology. Taking a novel perspective on how viruses may play a role in evolution, this book discusses antivirals and how autoimmune disorders may be caused or triggered by viruses. Concise and practical, this is a key resource for those working in neurology, infectious disease and virology.
Neurovision Rehabilitation Guide
by Amy Chang Xiao Xi Yu Steven E. RitterNeurovision Rehabilitation Guide is a valuable resource for the health care professional working with patients with visual dysfunction as a consequence of traumatic brain injury and neurological disorders. It covers the concepts of visual dysfunction as well as assessment and step-by-step treatment plans. <P><P>The guide covers the neurology of visual processing before and after a brain injury. It explains the concepts behind neurovision rehabilitation and how to go about examining and treating the patient’s visual deficits. It also covers the evaluation of visual perceptual deficits and treatment of the traumatic brain injury patient. <P><P>The guide contains more than 80 vision therapy procedures, with step-by-step instructions as well as sequencing guides for each category of therapy (oculomotor, accommodation, binocular, perceptual).
Neurowetenschappen: Een overzicht
by Ben van CranenburghDit boek geeft een overzicht over het immense gebied van de neurowetenschappen en kan beschouwd worden als een basistekst met een sterk praktische signatuur. Opvattingen over zenuwstelsel en hersenen worden vanuit veel invalshoeken belicht, o.a. vanuit de neuroanatomie, de neurofysiologie, de klinische neurologie, de psychologie en evolutiebiologie. De auteur heeft getracht de werking van het zenuwstelsel op diverse niveaus inzichtelijk te maken: het microniveau (neuron, synaps), het macroniveau (hersengebieden, hemisferen), het mentale niveau (emoties, cognities) en het gedragsniveau (aangepast handelen). Een klassiek fundament van de neurofysiologie, het reflexmodel, wordt in dit boek gerelativeerd en genuanceerd: menselijk gedrag is niet alleen maar reactief, maar kan ook spontaan geïnitieerd zijn. De hersenen verwerken en verwekken informatie. Simplistische ideeën over de hersenen worden ontzenuwd, bijvoorbeeld de lokalisatie van functies in specifieke centra, het misverstand dat functies als creativiteit en muziek in de rechter hemisfeer gelokaliseerd zijn, het idee dat het volwassen brein niet of minder plastisch zou zijn. Alternatieven die meer in overeenstemming zijn met de huidige opvattingen, worden gepresenteerd. Neurowetenschappen, Een overzicht maakt deel uit van een zesdelige serie ‘Toegepaste neurowetenschappen’. In het boek worden voortdurend verbindingen gelegd met diverse toepassingsgebieden. Motoriek wordt losgemaakt van spieren: de hersenen sturen een ‘symphony of movements’. Het belang van zintuiglijke functies bij (het leren van) motorische vaardigheden (sport, muziek, revalidatie) wordt benadrukt, en de plasticiteit van het zenuwstelsel wordt gepresenteerd als biologische basis voor flexibiliteit, adaptatie, ontwikkeling, leren en herstelprocessen. Nieuwe inzichten betreffende de werking van de hersenschors, de lokalisatie van functies in zogenoemde neurale ensembles (connectomen) en hemisfeerspecialisatie kunnen inspireren tot toepassingen op allerlei gebieden. Geregeld komt het ‘mind-body’-probleem aan de orde: de onscheidbaarheid van soma en psyche die in het zenuwstelsel zijn biologische basis heeft, wordt met talrijke voorbeelden toegelicht. Het boek is ook digital beschikbaar met bij elk hoofdstuk vragen en antwoorden en samenvattingen. Met praktische voorbeelden op het gebied van dagelijks leven, kliniek, therapie, sport, muziek en onderwijs heeft de auteur getracht om de grote kloof tussen neurowetenschappen en praktijk te overbruggen en plaatst daarmee de neurowetenschappen midden in het leven. Kortom, een belangwekkend boek voor medici, paramedici en psychologen, en zeer bruikbaar voor diverse opleidingen.
Neurowetenschappen: een overzicht
by Ben Cranenburgh'Neurowetenschappen, een overzicht', is het eerste deel van de vierdelige reeks 'Toegepaste neurowetenschappen'. Het boek geeft een overzicht over het immense gebied van de neurowetenschappen en kan beschouwd worden als een basistekst met een sterk praktische signatuur. Opvattingen over zenuwstelsel en hersenen worden vanuit veel invalshoeken belicht, o. a. vanuit de neuroanatomie, de neurofysiologie, de klinische neurologie, de psychologie en evolutiebiologie. De auteur heeft getracht de werking van het zenuwstelsel op diverse niveaus inzichtelijk te maken: het microniveau (neuron, synaps), het macroniveau (hersengebieden, hemisferen), het mentale niveau (emoties, cognities) en het gedragsniveau (aangepast handelen). Een klassiek fundament van de neurofysiologie, het reflexmodel, wordt in dit boek gerelativeerd en genuanceerd: menselijk gedrag is niet alleen maar reactief, maar kan ook spontaan geinitieerd zijn. De hersenen verwerken en verwekken informatie. Veel simplistische ideeen over de hersenen worden ontzenuwd, bijvoorbeeld de lokalisatie van functies in specifieke centra, het misverstand dat functies als creativiteit en muziek in de rechter hemisfeer gelokaliseerd zijn, het idee dat het volwassen brein niet of minder plastisch zou zijn. Alternatieven die meer in overeenstemming zijn met de huidige opvattingen, worden gepresenteerd. In het boek worden voortdurend verbindingen gelegd met diverse toepassingsgebieden. Motoriek wordt losgemaakt van spieren: de hersenen sturen een 'symphony of movements'. Het belang van zintuiglijke functies bij (het leren van) motorische vaardigheden (sport, muziek, revalidatie) wordt benadrukt, en de plasticiteit van het zenuwstelsel wordt gepresenteerd als biologische basis voor flexibiliteit, adaptatie, ontwikkeling, leren en herstelprocessen. Nieuwe inzichten betreffende de werking van de hersenschors, de lokalisatie van functies in zogenoemde neurale ensembles en hemisfeerspecialisatie kunnen inspireren tot toepassingen op allerlei gebieden. Geregeld komt het 'mind-body'-probleem aan de orde: de onscheidbaarheid van soma en psyche die in het zenuwstelsel zijn biologische basis heeft, wordt met talrijke voorbeelden toegelicht. Het boek geeft voortdurend praktische voorbeelden op het gebied van dagelijks leven, kliniek, therapie, sport, muziek en onderwijs: de auteur heeft getracht de grote kloof tussen neurowetenschappen en praktijk te overbruggen en plaatst daarmee de neurowetenschappen midden in het leven. Kortom, een belangwekkend boek voor medici, paramedici en psychologen, en zeer bruikbaar voor diverse opleidingen. Nu met online verder studeren op StudieCloud door controlevragen en samenvattingen. Ben van Cranenburgh is neurowetenschapper. Hij studeerde geneeskunde in Amsterdam en werkte daarna vele jaren als wetenschappelijk medewerker o. a. bij het Nederlands Centraal Instituut voor Hersenonderzoek (neurofysiologieonderzoek) en bij het Revalidatiecentrum Amsterdam (klinisch onderzoek bij CVA-patienten). In 1987 richtte hij het Instituut voor Toegepaste Neurowetenschappen op (stichting ITON, Haarlem), waar hij tot op heden werkzaam is. In dit kader houdt hij zich intensief bezig met het overbruggen van de (te grote) kloof tussen wetenschap en praktijk, op het gebied van neurorevalidatie, sport en muziek. "
Neurowissenschaften des Stresses: Von der Neurobiologie zu den Kognitions-, Emotions- und Verhaltenswissenschaften
by Gustavo E. TafetDieses Lehrbuch bietet eine Einführung in das interdisziplinäre Studium von Stress und hilft Studierenden und Fachleuten, die wichtigsten neurobiologischen und psychologischen Ursachen und Folgen von Stress beim Menschen zu verstehen. Es zielt darauf ab, das Konzept von Stress auf verschiedenen Ebenen zu verstehen, von den Auswirkungen von Umweltstressoren bis zu seiner Verarbeitung im Gehirn und von den neuronalen Mechanismen, die an dieser Verarbeitung beteiligt sind, bis zum Ausdruck verschiedener adaptiver Reaktionen. Alle diese neuronalen Mechanismen werden auf verschiedenen Komplexitätsebenen klar erläutert, von der neurobiologischen Ebene, einschließlich der zellulären und molekularen Mechanismen, bis zur psychologischen Ebene, einschließlich der kognitiven und emotionalen Verarbeitung und der Verhaltensäußerungen.Der Inhalt ist fundiert und wird von anschaulichen Grafiken begleitet, die Details sehr hilfreich verdeutlichen und somit eine vollständige Integration aller dargestellten Konzepte ermöglichen. Darüber hinaus werden klinische Ausdrucksformen von Stress, wie z.B. Stimmungs- und Angststörungen, ausführlich behandelt. Auch erhalten Sie einen Überblicks über verschiedene Faktoren der Anfälligkeit und Widerstandsfähigkeit, wodurch ein einzigartiger und grundlegender Einblick in dieses interdisziplinäre Gebiet geboten wird. Aufgrund seines interdisziplinären Ansatzes bietet Neuroscience of Stress: From Neurobiology to Cognitive, Emotional and Behavioral Sciences (Von der Neurobiologie zu den Kognitions-, Emotions- und Verhaltenswissenschaften) Studierenden und Fachleuten aus verschiedenen Bereichen der Verhaltens- und Gesundheitswissenschaften eine umfassende und klare Einführung in die Erforschung von Stress und ist bestens geeignet für den Einsatz in einer Vielzahl von Studiengängen, die sich mit psychischer Gesundheit und Wohlbefinden befassen, u. a. in den Bereichen Gesundheit und klinische Psychologie, Gesundheitsförderung undKrankheitsprävention, Psychiatrie und Verhaltensmedizin.
Neurowissenschaften für die Organisationskommunikation: Ein Leitfaden für Kommunikatoren und Führungskräfte
by Laura McHaleDie Unternehmenskommunikation steht am Scheideweg, und sowohl professionelle Kommunikatoren als auch Führungskräfte müssen ihr Spiel verbessern. In diesem aufschlussreichen und praktischen Leitfaden zeigt die Führungspsychologin Dr. Laura McHale, wie die Neurowissenschaften dabei helfen können. Sie untersucht das Feld, um die Forschungsergebnisse zu ermitteln, die am besten auf Organisationen anwendbar sind, und bietet einen evidenzbasierten Ansatz, um die Effektivität und Wirkung der Kommunikation drastisch zu steigern. Von strukturellen Dynamiken bis hin zu berufsbedingten Aprosodien, von der Bedrohung (und den Chancen) von GPT-3 bis hin zur Neurowissenschaft der Zoom-Müdigkeit nimmt sie den Leser mit auf eine faszinierende Reise, wie die Neurowissenschaft dazu beitragen kann, das Potenzial von Kommunikatoren und den Organisationen, für die sie arbeiten, zu erschließen.
Neurowissenschaften: Ein Grundlegendes Lehrbuch Für Biologie, Medizin Und Psychologie
by Mark F. Bear Michael A. Paradiso Monika Niehaus-Osterloh Barry W. Connors Andreas K. Engel Andreas HeldDer perfekte Einstieg in die Neurowissenschaften – ideal zum Verstehen und LernenSeit vielen Jahren zählt diese didaktisch durchdachte, verständlich geschriebene und hervorragend illustrierte Einführung international zu den führenden Lehrbüchern im Bereich der Neurowissenschaften. Das moderne Grundlagenwerk richtet sich an Studierende der Biologie, der Medizin und der Psychologie gleichermaßen. Die wieder von Andreas Engel herausgegebene deutsche Ausgabe ist an die hiesige Studiensituation angepasst und stellenweise erweitert. Der Bogen spannt sich von der Anatomie des Gehirns bis zur Sinnesphysiologie, von der Entwicklungsbiologie bis zum Verhalten, von den Störungen des Nervensystems bis zur Kognitionswissenschaft, von den molekularen Mechanismen bis zu den neuen bildgebenden Verfahren. Ein eigenständiger „Bildatlas der menschlichen Neuroanatomie“ erlaubt dem Lernenden, seine Kenntnisse der Hirnstrukturen zu überprüfen und zu erweitern. Jedes Kapitel endet mit Verständnisfragen und Übungsaufgaben sowie einer Zusammenstellung wichtiger weiterführender Literatur. In spannenden Exkursen berichten renommierte Wissenschaftler, wie sie zu ihren entscheidenden Entdeckungen kamen. So führt das Buch den Leser von den Grundlagen zu den aktuellen Forschungsthemen des Faches.In der durchgehend aktualisierten 4. Auflage sind unter anderem neue Forschungsergebnisse zu Optogenetik, Konnektomik, tiefer Hirnstimulation, molekularer Medizin und Neuroökonomie eingearbeitet worden. Zahlreiche neue oder aktualisierte Abbildungen veranschaulichen in bewährter Manier die im Text beschriebenen Prozesse, Strukturen und Methoden. Wer Neurowissenschaften in ihrer ganzen Bandbreite verstehen will, ist mit "dem Bear" bestens bedient. Den drei Verfassern des Buches gelingt, womit Lehrbuchautoren im deutschsprachigen Raum sich nach wie vor schwer tun: anschaulich und spannend den Leser vom Einstieg in die Grundlagen bis an die vorderste Front der Forschung mitzunehmen und ohne überflüssigen Ballast wissenschaftliche Erkenntnis mehr erzählend als erklärend zu vermitteln … Ein didaktisches Meisterwerk ist nun topaktuell auch in deutscher Sprache neu aufgelegt verfügbar. Aus dem Vorwort von Prof. Andreas K. Engel, Universitätsklinikum Hamburg-Eppendorf
Neutron Capture Therapy
by Andrea Wittig Raymond Moss Wolfgang A.G. Sauerwein Yoshinobu NakagawaNeutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
Neutron Capture Therapy: Principles and Applications
by Andrea Wittig Yoshinobu Nakagawa Wolfgang A. G. Sauerwein Raymond L. Moss Koji OnoThis book, now in a revised and updated second edition, provides a comprehensive summary of recent progress in boron neutron capture therapy (BNCT). BNCT is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and to release instantaneously two heavy particles with a path length of one cell diameter or less. This in principle allows for tumor cell-selective high-LET particle radiotherapy. In the past BNCT depended solely on fission reactor-based irradiation facilities, but the appearance of accelerator-based neutron sources placed in hospitals has opened a new chapter for BNCT. This edition covers all the important aspects of BNCT, including neutron sources, boron chemistry, drugs for BNCT, boron analysis and imaging, dosimetry, and radiation biology. The use of BNCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. BNCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in a language that will be readily understood by all participating disciplines.
Neutron Imaging and Applications
by Ian S. Anderson Robert Mcgreevy Hassina Z. BilheuxNeutron Imaging and Applications offers an introduction to the basics of neutron beam production in addition to the wide scope of techniques that enhance imaging application capabilities. An instructional overview of neutron sources, detectors, optics and spin-filters allows readers to delve more deeply into the discussions of radiography, tomography and prospective applications available in neutron holography techniques. A section devoted to current applications describes imaging single grains in polycrystalline materials, neutron imaging of geological materials and other materials science and engineering areas. Coverage of thermal neutron imaging of biological tissues, plant physiology, Homeland Security and contraband detection explore the future prospects of this cutting-edge research. Written by key experts in the field, researchers and engineers involved with imaging technologies will find Neutron Imaging and Applications a valuable reference.
Neutrophil Methods and Protocols
by Gary M. Bokoch Frank R. Deleo Mark T. QuinnThis book provides a concise set of protocols for assessing basic neutrophil functions, investigating specialized areas in neutrophil research, and completing step-by-step diagnostic assays of common neutrophil disorders. Each of the protocols is written by leading researchers in the field and includes hints for success, as well as guidance for troubleshooting. Scientists and clinicians will find this collection an invaluable aid.
Neutrophil Methods and Protocols
by Frank R. Deleo Mark T. QuinnNeutrophils, the most abundant white cells in humans, serve as the primary cellular defense against infection. "Neutrophil Methods and Protocols," "Second Edition" provides a concise set of protocols written by leading researchers in the field for assessing basic neutrophil functions, investigating specialized areas in neutrophil research, and completing step diagnostic assays of common neutrophil disorders. Topics covered include an overview of neutrophils and their role in host defense and inflammation; methods most commonly used for isolating neutrophils from humans and other animal species; procedures for subcellular fractionation of human neutrophils, analysis of "in vivo" transmigrated neutrophils, generation of mature neutrophils from induced pluripotent stem cells and analysis of neutrophil gene expression; methods for investigating priming, oxidant production, phagocytosis, bactericidal activity and extracellular trap formation and protocols for investigating neutrophil adhesion, chemotaxis and outside-in signaling via integrins. Written in the successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, "Neutrophil Methods and Protocols," "Second Edition" is a comprehensive source for detailed explanations and applications of the most modern methodological advances in neutrophil biology. Both basic scientists and clinicians will find a collection of this caliber to be an invaluable aid in their work with neutrophils.
Neutrophil: Methods and Protocols (Methods in Molecular Biology #2087)
by Mark T. Quinn Frank R. DeLeoNeutrophils, the most abundant white cells in humans, serve as the primary cellular defense against infection. This volume provides a concise set of protocols for assessing basic neutrophil functions and investigating specialized areas in neutrophil biology. Each of the protocols is written by leading researchers in the field and includes hints for success, as well as guidance for troubleshooting. In the third edition of Neutrophils: Methods and Protocols, chapters retained from previous editions have been have been updated and include many new approaches. In addition, the Third Edition contains a number of new chapters that were not included in the first or second editions. Part I contains overviews of neutrophil biology, function, and disorders. Part II describes commonly used methods to isolate neutrophils from humans and other animal species. Part III details methods for investigating chemotaxis, transmigration, phagocytosis, and bactericidal activity. Part IV includes protocols that measure neutrophil apoptosis, calcium signal transduction, degranulation and detection of cytoplasmic granules, gene expression, transcription factors, and apoptosis. Part V provides multiple assays for measuring production of intracellular and/or extracellular reactive oxygen species, and a method that details use of the cell-free NADPH oxidase assay, an iconic assay for studies of the neutrophil NADPH oxidase. Part VI provides chapters that describe how to analyze formation and function of neutrophil extracellular traps. Neutrophil Methods and Protocols: Third Edition is a comprehensive source for detailed explanations and applications of the most modern methodological advances in neutrophil biology. Both basic scientists and clinicians will find a collection of this caliber to be an invaluable aid in their work with neutrophils.Features• Provides neutrophil protocols that are broadly applicable to leukocyte biology• Includes protocols for isolation of neutrophils from humans and animal species• Presents an interesting and informative overview of the field of neutrophil biology• Facilitates a better understanding of the role of neutrophils in host defenseReadershipMolecular and Cell Biologists, Immunologists, Infectious Disease Specialists, Microbiologists
Neutrophilic Dermatoses
by Daniel Wallach Marie-Dominique Vignon-Pennamen Angelo Valerio MarzanoThis book provides an in depth overview of Neutrophilic Dermatoses, a group of diseases that includes Sweet’s syndrome, pyoderma gangrenosum and subcorneal pustular dermatosis. Although there are still some gaps in the knowledge, it is now clear that their pathophysiology implies that mechanisms associated with auto-inflammation are involved, while many of these dermatoses occur in the setting of other systemic inflammatory diseases (colitis, arthritis) and of malignancies (blood malignancies, solid cancers). As such it is an important area of study within internal medicine. Neutrophilic Dermatoses represents an extensive clinical review of the group of diseases and is a critical resource for all medical professionals managing these patients, including clinicians in dermatology, gastro-enterology,, rheumatology, hematology, and internal medicine.
Never Bet Against Occam
by Lawrence B. Afrin Kendra Neilsen Myles Carol Schaengold Kristi Posival Sisters MediaNever Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemics of Chronic Illness and Medical Complexity
Never Better: Two Kids, Their Dad, and His Wife's Ghost
by Gonzalo RiedelHis wife died before their second son turned one. How can he keep her memory alive when there’s so much he wants to forget?There was a time before his wife got sick when Gonzalo could think about other things. They had full lives where death didn’t factor. Where humour was more than a coping mechanism. Life wasn’t all about treatments and recovery, or the emptiness he felt when she died.They had kids together. Young kids. Less than a year after their youngest was born and suddenly he was strapping them both into their car seats to drive to their mother’s funeral.He used to think he was the glue holding the household together. It didn’t take long for him to realize how wrong he’d been. A grieving husband is in no condition to raise kids alone. There were times when he wanted to toss himself into a raging river that would suck him under and bash his skull on the rocks. That’s always an option for another day. For now, he’ll just squash those feelings and drive the kids to daycare.Does it get easier? Of course. But not right away. They say that hope only comes at the end of a long dark journey, but that isn’t entirely true because the journey never really ends. But that means there’s good news: hope is everywhere you look.
Never Enough: The Neuroscience and Experience of Addiction
by Judith GriselFrom a renowned behavioral neuroscientist and recovered drug addict, an authoritative and accessible guide to understanding drug addiction: clearly explained brain science and vivid personal stories reveal how addiction happens, show why specific drugs--from opioids to alcohol to coke and more--are so hard to kick, and illuminate the path to recovery for addicts, loved ones, caregivers, and crafters of public policy.Addiction is epidemic and catastrophic. With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions. Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick. Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.
Never Home Alone: From Microbes to Millipedes, Camel Crickets, and Honeybees, the Natural History of Where We Live
by Rob DunnA natural history of the wilderness in our homes, from the microbes in our showers to the crickets in our basements <P><P>Even when the floors are sparkling clean and the house seems silent, our domestic domain is wild beyond imagination. In Never Home Alone, biologist Rob Dunn introduces us to the nearly 200,000 species living with us in our own homes, from the Egyptian meal moths in our cupboards and camel crickets in our basements to the lactobacillus lounging on our kitchen counters. You are not alone. <P><P>Yet, as we obsess over sterilizing our homes and separating our spaces from nature, we are unwittingly cultivating an entirely new playground for evolution. These changes are reshaping the organisms that live with us--prompting some to become more dangerous, while undermining those species that benefit our bodies or help us keep more threatening organisms at bay. <P><P>No one who reads this engrossing, revelatory book will look at their homes in the same way again.
Never Mind the Sprouts: Simple and Easy Food That All the Family Will Enjoy...Especially Fussy Eaters
by Alastair Williams Claire PlimmerMealtimes can often feel like a battle of wills when there are fussy eaters to cater for. This handy cookbook, packed with mouth-watering, quick and easy-to-execute, nutritious recipes is your one-stop guide to introducing new flavours to a developing palate.
Never Pay the First Bill: And Other Ways to Fight the Health Care System and Win
by Marshall AllenFrom award-winning ProPublica reporter Marshall Allen, a primer for anyone who wants to fight the predatory health care system--and win.Every year, millions of Americans are overcharged and underserved while the health care industry makes record profits. We know something is wrong, but the layers of bureaucracy designed to discourage complaints make pushing back seem impossible. At least, this is what the health care power players want you to think.Never Pay the First Bill is the guerilla guide to health care the American people and employers need. Drawing on 15 years of investigating the health care industry, reporter Marshall Allen shows how companies and individuals have managed to force medical providers to play fair, and shows how you can, too. He reveals the industry's pressure points and how companies and individuals have fought overbilling, price gouging, insurance denials, and more to get the care they deserve. Laying out a practical plan for protecting yourself against the system's predatory practices, Allen offers the inspiration you need and tried-and-true strategies such as: Analyze and contest your medical bills, so you don't pay more than you should Obtain the billing codes for a procedure in advance Write in an appropriate treatment clause before signing financial documents Get your way by suing in small claims courtFew politicians and CEOs have been willing to stand up to the medical industry. It is up to the American people to equip ourselves to fight back for the sake of our families--and everyone else.
Never Pure: Historical Studies of Science as if It Was Produced by People with Bodies, Situated in Time, Space, Culture, and Society, and Struggling for Credibility and Authority
by Steven ShapinSteven Shapin argues that science, for all its immense authority and power, is and always has been a human endeavor, subject to human capacities and limits. Put simply, science has never been pure. To be human is to err, and we understand science better when we recognize it as the laborious achievement of fallible, imperfect, and historically situated human beings.Shapin’s essays collected here include reflections on the historical relationships between science and common sense, between science and modernity, and between science and the moral order. They explore the relevance of physical and social settings in the making of scientific knowledge, the methods appropriate to understanding science historically, dietetics as a compelling site for historical inquiry, the identity of those who have made scientific knowledge, and the means by which science has acquired credibility and authority.This wide-ranging and intensely interdisciplinary collection by one of the most distinguished historians and sociologists of science represents some of the leading edges of change in the scholarly understanding of science over the past several decades.
Never Somewhere Else: Book 1 in the Sunday Times bestselling detective series (DSI William Lorimer #1)
by Alex GrayDiscover your next reading obsession with this iconic first novel in Alex Gray's bestselling Scottish detective series. Perfect for fans of Ian Rankin, Val McDermid and Ann Cleeves Don't miss the latest thrilling instalment of the Lorimer series - BEFORE THE STORM IS OUT NOW WHAT THEY'RE SAYING ABOUT THE LORIMER SERIES:'Warm-hearted, atmospheric' ANN CLEEVES'Relentless and intriguing' PETER MAY'Move over Rebus' DAILY MAIL'Exciting, pacey, authentic' ANGELA MARSONS'Superior writing' THE TIMES'Immensely exciting and atmospheric' ALEXANDER MCCALL SMITH_______________When three young women are discovered strangled and mutilated in a Glasgow park, it is up to DCI Lorimer to find their killer. Frustrated by a lack of progress in the investigation, Lorimer is forced to enlist the services of Dr Solomon Brightman, psychologist and criminal profiler. Together they form an uneasy alliance. But when a homeless man is brought in for questioning the investigation takes a bizarre turn. Soon Lorimer has to scratch the surface of the polished Glasgow art world and reveal the dark layers hidden beneath...