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Neuroimaging in Developmental Clinical Neuroscience
by Judith M. Rumsey Monique Ernst Husseini K. ManjiModern neuroimaging offers tremendous opportunities for gaining insights into normative development and a wide array of developmental neuropsychiatric disorders. Focusing on ontogeny, this text covers basic processes involved in both healthy and atypical maturation, and also addresses the range of neuroimaging techniques most widely used for studying children. This book will enable you to understand normative structural and functional brain maturation and the mechanisms underlying basic developmental processes; become familiar with current knowledge and hypotheses concerning the neural bases of developmental neuropsychiatric disorders; and learn about neuroimaging techniques, including their unique strengths and limitations. Coverage includes normal developmental processes, atypical processing in developmental neuropsychiatric disorders, ethical issues, neuroimaging techniques and their integration with psychopharmacologic and molecular genetic research approaches, and future directions. This comprehensive volume is an essential resource for neurologists, neuropsychologists, psychiatrists, pediatricians, and radiologists concerned with normal development and developmental neuropsychiatric disorders.
Neuroimaging in Forensic Psychiatry
by Henry Greely Joseph R. SimpsonThis important volume is the first to address the use of neuroimaging in civil and criminal forensic contexts and to include discussion of prior precedents and court decisions. Equally useful for practicing psychiatrists and psychologists, it reviews both the legal and ethical consideraitons of neuroimaging.
Neuroimaging in Forensic Psychiatry: From the Clinic to the Courtroom
by Joseph R. SimpsonThis important volume is the first to address the use of neuroimaging in civil and criminal forensic contexts and to include discussion of prior precedents and court decisions. Equally useful for practicing psychiatrists and psychologists, it reviews both the legal and ethical consideraitons of neuroimaging.
Neuroimaging in Psychiatry
by Carl Senior Cynthia H Y Fu Tamara A Russell Daniel Weinberger Robin MurrayNew neuroimaging techniques are developing at a break neck pace-every academic journal contains glossy pictures of brain activity corresponding to a particular task emblazoned in glorious technicolor. Discoveries about brain function in psychiatric disorders have been made at an equally rapid rate. However, most books on the subject have been writt
Neuroimaging in Schizophrenia
by Martha E. Shenton Marek KubickiThis comprehensive book explains the importance of imaging techniques in exploring and understanding the role of brain abnormalities in schizophrenia. The findings obtained using individual imaging modalities and their biological interpretation are reviewed in detail, and updates are provided on methodology, testable hypotheses, limitations, and new directions for research. The coverage also includes important recent applications of neuroimaging to schizophrenia, for example in relation to non-pharmacological interventions, brain development, genetics, and prediction of treatment response and outcome. Written by world renowned experts in the field, the book will be invaluable to all who wish to learn about the newest and most important developments in neuroimaging research in schizophrenia, how these developments relate to the last 30 years of research, and how they can be leveraged to bring us closer to a cure for this devastating disorder. Neuroimaging in Schizophrenia will assist clinicians in navigating what is an extremely complex field and will be a source of insight and stimulation for researchers.
Neuroimaging of Consciousness
by Steven Laureys Andrea Eugenio Cavanna Andrea Nani Hal BlumenfeldWithin the field of neuroscience, the past few decades have witnessed an exponential growth of research into the brain mechanisms underlying both normal and pathological states of consciousness in humans. The development of sophisticated imaging techniques to visualize and map brain activity in vivo has opened new avenues in our understanding of the pathological processes involved in common neuropsychiatric disorders affecting consciousness, such as epilepsy, coma, vegetative states, dissociative disorders, and dementia. This book presents the state of the art in neuroimaging exploration of the brain correlates of the alterations in consciousness across these conditions, with a particular focus on the potential applications for diagnosis and management. Although the book has a practical approach and is primarily targeted at neurologists, neuroradiologists, and psychiatrists, it will also serve as an essential reference for a wide range of researchers and health care professionals.
Neuroimaging of Covid-19. First Insights based on Clinical Cases
by Simonetta GereviniThis book presents the variability of the effects of Covid-19 on the nervous system (NS), with the purpose to update content and images based on improved scientific evidence. Current available data show that involvement of the NS is frequent in patients with SARS-CoV-2 infection. The most common neurologic syndromes include cerebrovascular disorders, encephalopathies, inflammatory Central Nervous System (CNS) syndromes, peripheral neurologic disorders, psychiatric disorders. The pathophysiology of neurological manifestations is far from being understood. They can be coincidental, common complications of severe viral infection, or direct consequence of the viral infection either via indirect para-infective mechanisms or direct viral penetration of NS. Experimental animal models had previously demonstrated the neuroinvasive potential of SARS-CoV and the detection of viral particles in special structures such as the thalamus, nucleus ambiguous and nucleus of the solitary tract, suggesting that CNS invasion can contribute significantly to the severe outcome not only through direct damage to neurological structures, but also through a potential detrimental effect on cardiorespiratory responses. Up to now, the detection of SARS-CoV-2 RNA in the cerebrospinal fluid of COVID-19 patients has been reported occasionally and conclusive pathological demonstration of the virus in the CNS is lacking. In this scenario, the role of neuroimaging is fundamental. These considerations highlight the urgent need to better clarify the neurotropic potential of the SARS-CoV-2 virus, and to verify on human autoptic tissue the mechanisms demonstrated in the experimental animal model in order to develop potential strategies to prevent CNS invasion and to adapt treatment protocols based on neurological involvement. CT scan is useful to detect large hemorrhage and ischemic lesions, that have been reported in Covid-19 patients, but lacks identifying other possible neurological complications, such as microhemorrhage or encephalitis. MRI could overcome these limitations; in particular the use of specific sequences may reveal microvascular lesions that can occur during the disease course, according to the described pathogenesis. This book will be an invaluable tool for neuroradiologists, radiologists, neurologists, and all physicians involved in the pandemic.
Neuroimaging of Headache Disorders (Headache)
by Igor Petrušić Yonggang WangThis book offers a comprehensive overview of structural and functional neuroimaging findings related to the pathophysiology of primary and secondary headaches. In addition, it provides recommendations for best practice and decision-making in ordering neuroimaging investigation when faced with patients suffering from a vast range of headache types, whether in everyday practice, or in an ambulance or emergency room. Hopefully, this book will promote the adequate use of cutting-edge neuroimaging in headache research and in ongoing clinical trials in major neurology centers in Europe and worldwide. The structure of the book is designed to cover the basic principles of neuroimaging that neurologists should be aware of when making decisions about headache management, scientifically based recommendations for the application of different neuroimaging protocols in the emergency department and in the neurological clinic, the latest findings from advanced neuroimaging related to migraine without and with aura, chronic migraine and medication overuse headache, cluster headache, trigeminal neuralgia and other forms of headache and orofacial pain. Finally, the book contains a chapter on future directions in headache neuroimaging and the implementation of machine and deep learning algorithms in the neuroimaging and classification of headaches and the prediction of treatment outcomes. Neurologists, radiologists and physicians involved in pain medicine will benefit from this book, by having access to comprehensive, state-of-the-art knowledge on research and clinical practice in the field of headache neuroimaging. Furthermore, it could be a compendium for medical students and residents who are usually introduced to headache neuroimaging through multidisciplinary university programmes. Headache patients will also benefit from this book, being helped to better understand their condition from a neuroimaging techniques perspective.
Neuroimaging of Movement Disorders
by Fatta B. Nahab Noriaki HattoriIn the diagnosis and treatment of movement disorders, the use of neuroimaging has expanded widely and has been an exciting, important modality for unlocking the causes of abnormal motor control. With ever improving machinery, data collection techniques and analysis methods, researchers are now being presented with an exponentially increasing amount of data that they must wade through and interpret in the context of existing knowledge about movement disorders. In Neuroimaging in Movement Disorders, the editors have produced a gold-standard resource that brings together an impressive international group of authorities in their respective fields to outline the current state of knowledge. Controversies, such as conflicting findings and methodological limitations, are covered and provide the reader with a comprehensive yet pragmatic understanding of the state of science. The chapters offer both comprehensive reviews of various neuroimaging methods and also more in-depth summaries of the contributions made by neuroimaging in individual movement disorders. Although many of the neuroimaging methods that are discussed have not been routinely used in clinical practice, the authors skillfully provide the reader with adequate detail to understand the requirements for using these methods and in some cases even the starting knowledge to begin local implementation. Neuroimaging in Movement Disorders is an indispensable reference that will be of value to all physicians and researchers involved in the care of patients with movement disorders.
Neuroimaging of Sleep and Sleep Disorders
by Michael J. Thorpy Eric Nofzinger Pierre MaquetThis up-to-date, superbly illustrated book is a practical guide to the effective use of neuroimaging in the patient with sleep disorders. There are detailed reviews of new neuroimaging techniques - including CT, MRI, advanced MR techniques, SPECT and PET - as well as image analysis methods, their roles and pitfalls. Neuroimaging of normal sleep and wake states is covered plus the role of neuroimaging in conjunction with tests of memory and how sleep influences memory consolidation. Each chapter carefully presents and analyzes the key findings in patients with sleep disorders indicating the clinical and imaging features of the various sleep disorders from clinical presentation to neuroimaging, aiding in establishing an accurate diagnosis. Written by neuroimaging experts from around the world, Neuroimaging of Sleep and Sleep Disorders is an invaluable resource for both researchers and clinicians including sleep specialists, neurologists, radiologists, psychiatrists, psychologists.
Neuroimaging of Traumatic Brain Injury
by Natalia Zakharova Valery Kornienko Alexander Potapov Igor ProninThe main purpose of this book is to present emerging neuroimaging data in order to define the role of primary and secondary structural and hemodynamic disturbances in different phases of traumatic brain injury (TBI) and to analyze the potential of diffusion tensor MRI, tractography and CT perfusion imaging in evaluating the dynamics of TBI. The authors present a new MRI classification of brain stem and hemispheric cortical/subcortical damage localization that is of significant prognostic value. New data are provided regarding the pathogenesis and dynamics of diffuse and focal brain injuries and qualitative and quantitative changes in the brain white matter tracts. It is shown that diffuse axonal injury can be considered a clinical model of multidimensional "split brain" with commissural, association and projection fiber disorders. The book will be of interest for neuroradiologists, neurosurgeons, neurologists and others with an interest in the subject.
Neuroimaging, Software, and Communication: The Social Code of Source Code
by Edison BicudoThis book analyses the social contexts in which programmers design neuroimaging software used in brain studies. It shows that in the same way people engage in everyday communication, programmers are involved in a series of communicative processes to realize the negotiations and discussions generated by software development. In this way, highly technical activities such as computer code writing are also underpinned by values, preferences, and power relations.At the same time, the book sheds new light on scientists’ increasing dependence on software. On the one hand, many scientific tasks can no longer be performed without the help of computational technologies. On the other hand, most scientists have only superficial computing knowledge. As a result, inequalities emerge whereby some scientists take the most strategic methodological decisions whereas other scientists can only rely on the technical help provided by user-friendly computer applications.
Neuroimaging: Anatomy Meets Function
by Nivedita Agarwal John D. PortThis book combines classic MR anatomy with current understanding of human brain function. Recent advances in neuroscience have highlighted the importance of correlating brain anatomy with underlying brain function, since the brain contains a highly sophisticated organization of anatomical and functional relationships that are not readily "visible" with standard imaging. The use of magnetic resonance imaging is rapidly increasing in the field of neuroscience, and remains at the forefront for offering insights into the normal and pathologic structure and function of the human brain. The relatively recent concepts of structural and functional connectivity make it even more important to visualize the brain as a whole rather than looking at its individual parts. This holistic approach is vital in understanding concepts such as neuroplasticity that are currently incorporated into physical and cognitive rehabilitation programs for patients with stroke or neurodegenerative diseases. Ultimately this combined approach may reduce both overdiagnosis and misdiagnosis when integrated into routine clinical routine. This book will be of interest to neuroradiologists, general radiologists and neurologists alike, as well as medical students, residents and fellows.
Neuroimaging: Self-Assessment Colour Review (Medical Self-Assessment Color Review Series)
by Kirsten Forbes Sanjay Shetty Michael Lev Joseph HeisermanThis self-assessment colour review will be useful to neurologists and neuroradiologists in training and practice as it covers the full spectrum of neurological disease using modern imaging techniques - MRI, CT, invasive and non-invasive vascular imaging. The emphasis is on diagnostic neuroimaging in adults and children, with some interventional neu
Neuroimmune Diseases: From Cells to the Living Brain
by Mario Manto Hiroshi MitomaThis Springer Major Reference Work provides a detailed translational overview of neuroimmune diseases for neuroscientists and clinicians, clarifying the pathological mechanisms underlying neuroimmune diseases and building a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The new edition features updated chapters throughout, including coverage of new findings, new diagnostic criteria, and therapeutic algorithms. Neuroimmune Diseases, 2nd edition, also includes new chapters with a translational approach. The book will be invaluable for use in clinical practice of neuroimmune diseases.
Neuroimmune Diseases: From Cells to the Living Brain (Contemporary Clinical Neuroscience)
by Mario Manto Hiroshi MitomaA translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases
Neuroimmune Interactions in Pain: Mechanisms and Therapeutics
by Jianguo Cheng Ru-Rong Ji Jasmine JiAs lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.
Neuroimmune Pharmacology
by Howard E. Gendelman Tsuneya IkezuNeuroimmune pharmacology seeks to harness the immune system to provide pharmacological intervention to combat neurodegenerative diseases. This book provides a comprehensive overview of topics that embrace the link between the immune system and the pathogenesis of neurodegenerative disorders. Results from recent studies strongly suggest that a major part of the process in diseases including Alzheimer's and Parkinson's as well as Prion diseases, comes from changes in the innate and adaptive arms of the brain and peripheral immune systems. Thus, the book provides an in-depth study of numerous fields including immunology, pharmacology, neuroscience and neurovirology. It is accompanied by a CD-ROM that includes access to lectures, slide presentations, and question and answers on neuroimmune pharmacology.
Neuroimmune Pharmacology and Therapeutics
by Howard E. Gendelman Tsuneya IkezuBridging neuroscience, immunology, and pharmacology, and bringing together the foremost authorities, Neuroimmune Pharmacology and Therapeutics, 3rd edition, is an invaluable reference and textbook. The text discusses the immunology of the nervous system. New chapters are offered on innate, humoral, and cellular immune responses (innate and adaptive immunity). The additions join each component of the immune response in descriptions for how each affects nervous system function in both health and disease. Next, discussions of neuropharmacology now include both drug development and delivery into brain subregions to optimize clinical responses. This edition features greatly expanded coverage of therapeutics. The new extensions have blossomed into focused therapies engaging the immune system directly, deploying it for drug delivery, attracting the newly evolving field of genetics, vaccinations, and bioengineering, ultimately leading to improved therapeutic disease outcomes. All of the revisions in this edition are designed to bring an early trainee together with a skilled clinical and translational scientist to discuss the state of the art in each part of the emerging field of immunity as it affects the nervous system during steady state and disease and how it can be harnessed for therapeutics and clinical benefit.
Neuroimmunity: A New Science That Will Revolutionize How We Keep Our Brains Healthy and Young
by Michal Schwartz Anat LondonHow pathbreaking research into the brain’s connections to the immune system offers new hope for treating diseases, injuries, and the effects of aging. PROSE Awards Honorable Mention, Biomedicine & Neuroscience categoryIn the past, the brain was considered an autonomous organ, self-contained and completely separate from the body’s immune system. But over the past twenty years, neuroimmunologist Michal Schwartz, together with her research team, not only has overturned this misconception but has brought to light revolutionary new understandings of brain health and repair. In this book Schwartz describes her research journey, her experiments, and the triumphs and setbacks that led to the discovery of connections between immune system and brain. Schwartz, with Anat London, also explains the significance of the findings for future treatments of brain disorders and injuries, spinal cord injuries, glaucoma, depression, and other conditions such as brain aging and Alzheimer’s and Parkinson’s diseases.Scientists, physicians, medical students, and all readers with an interest in brain function and its relationship to the immune system in health and disease will find this book a valuable resource. With general readers in mind, the authors provide a useful primer to explain scientific terms and concepts discussed in the book.
Neuroimmunological Diseases
by Susumu KusunokiThis book offers a detailed review of the remarkable advances that have been made in research on the pathogenesis of a number of neuroimmunological diseases, as well as outlining novel treatments including the use of monoclonal antibodies. Written by renowned experts who have made major contributions in the field, such as identifying neuromyelitis optica as an immunopathological clinical condition, identifying the role of ganglioside and ganglioside-complex antibodies in Guillain-Barré syndrome, and developing a novel treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, the book summarizes recent advances in basic and clinical research. Neuroimmunological Diseases is a useful resource for not only researchers but also neurologists who are engaged in the management of neuroimmunological diseases.
Neuroimmunology: Multiple Sclerosis, Autoimmune Neurology and Related Diseases
by Amanda L. Piquet Enrique AlvarezThis book provides a clinical focus on neuroinflammatory diseases as well as a review in pathophysiology and treatment approaches. Organized into six parts, the book begins with a basic review of the immune system and concepts for learning and treating neuroimmune conditions. The next four sections cover specific subfields of neuroimmunology and autoimmune neurology - the clinical and diagnostic features of multiple sclerosis, other autoimmune conditions of the central nervous system, autoimmune conditions of the peripheral nervous system, and systemic autoimmune conditions that affect the nervous system. To conclude, Section six discusses various clinical approaches to specific presentations in neuroimmunology, including pediatric demyelinating diseases. These sections provide practical clinical information to improve the reader’s knowledge in this complex field. The chapters are written by world renown authors with extensive knowledge to help provide up to date information. The full scope of autoimmune neurology is discussed, which is a unique feature of this book. Neuroimmunology serves as a resource for those in training including residents and fellows to provide clear clinical reasoning and background in a rapidly advancing field.
Neuroinfektiologie
by Martin Stangel Uta Meyding-Lamadé Jörg WeberDieses praxisorientierte Buch behandelt ein stetig wachsendes Teilgebiet der Neurologie grundlegend. Es stellt sich den bekannten und den neuen Infektionserkrankungen des zentralen Nervensystems und unterstützt behandelnde Ärzte bei der Diagnosefindung und dem Management. Praxisnah mit übersichtlichen Tabellen, Abbildungen und Kernaussagen, kann dieser kompakte Leitfaden eine wertvolle Hilfe im ärztlichen Alltag sein.Das Werk schult den diagnostischen Blick, der neben der interdisziplinären Zusammenarbeit mit einem Tropeninstitut und neben Ausdauer und Besonnenheit in der Patientenbetreuung von entscheidender Bedeutung ist.
Neuroinflammation
by Samuel DavidNeuroinflammation has long been studied for its connection to the development and progression of Multiple Sclerosis. In recent years, the field has expanded to look at the role of inflammatory processes in a wide range of neurological conditions and cognitive disorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers have also started to note the beneficial impacts of neuroinflammation in certain diseases. Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides a comprehensive view of both the detriments and benefits of neuroinflammation in human health. Neuroinflammation: New Insights into Beneficial and Detrimental Functions opens with two chapters that look at some fundamental aspects of neuroinflammation in humans and rodents. The remainder of the book is divided into two sections which examine both the detrimental and beneficial aspects of inflammation on the brain, spinal cord and peripheral nerves, on various disease states, and in normal aging. These sections provide a broad picture of the role neuroinflammation plays in the physiology and pathology of various neurological disorders. Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficial and Detrimental Functions will be an essential volume for neuroimmunologists, neurobiologists, neurologists, and others interested in the field. neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development and progression of Multiple Sclerosis. In recent years, the field has expanded to look at the role of inflammatory processes in a wide range of neurological conditions and cognitive disorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers have also started to note the beneficial impacts of neuroinflammation in certain diseases. Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides a comprehensive view of both the detriments and benefits of neuroinflammation in human health. Neuroinflammation: New Insights into Beneficial and Detrimental Functions opens with two chapters that look at some fundamental aspects of neuroinflammation in humans and rodents. The remainder of the book is divided into two sections which examine both the detrimental and beneficial aspects of inflammation on the brain, spinal cord and peripheral nerves, on various disease states, and in normal aging. These sections provide a broad picture of the role neuroinflammation plays in the physiology and pathology of various neurological disorders. Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficial and Detrimental Functions will be an essential volume for neuroimmunologists, neurobiologists, neurologists, and others interested in the field.Neuroinflammation has long been studied for its connection to the development and progression of Multiple Sclerosis. In recent years, the field has expanded to look at the role of inflammatory processes in a wide range of neurological conditions and cognitive disorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers have also started to note the beneficial impacts of neuroinflammation in certain diseases. Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides a comprehensive view of both the detriments and benefits of neuroinflammation in human health. Neuroinflammation: New Insights into Beneficial and Detrimental Functions opens with two chapters that look at some fundamental aspects of neuroinflammation in humans and rodents. The remainder of the book is divided into two sections which examine both the detrimental and beneficial aspects of inflammation on the brain, spinal cord and peripheral nerves, on various disease states, and in normal aging. These sections provide a broad picture of the role neuroinflammation plays in the physiology and pathology of various neurological disorders. Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Bene...
Neuroinflammation and CNS Disorders
by Sandra Amor Nicola WoodroofeThe last decade has seen an upsurge of information on the role of immune responses in neurodegenerative disorders. In many of these diseases it is still unclear whether the innate and adaptive responses are pathogenic or play a role in repair, and thus understanding their precise roles is key to controlling these diseases by designing immune-therapeutic approaches. The connection between many neurological diseases is the realisation that the immune and nervous systems are inextricable linked, and that perturbations in this delicate balance are involved in many disorders. This has opened up new avenues for therapeutic approaches to treatment of CNS inflammatory and neurodegenerative disorders. Neuroinflammation and CNS Disorders brings together the very latest information on the interactions between the immune system and central nervous system. The first section of the book highlights the basic concepts in the field whilst the second section, the main body of the book, covers the role of the immune response in specific disorders of the central nervous system. Neuroinflammation and CNS Disorders will provide an invaluable guide for both researchers and clinicians working in this complex and dynamic field.