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Neuroinflammation and Neurodegeneration

by Phillip K. Peterson Michal Toborek

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e. g. , Alzheimer's disease, Parkinson's disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Neuroinflammation and Schizophrenia (Current Topics in Behavioral Neurosciences #44)

by Golam M. Khandaker Urs Meyer Peter B. Jones

This book provides a comprehensive summary of the cutting edge scientific evidence regarding the role of immune system in the pathogenesis and treatment of schizophrenia and related psychotic disorders. It illustrates the role of inflammation and immunity in schizophrenia drawing on both basic science and clinical research. The chapters provide up-to-date summaries of immunological risk factors for schizophrenia and related psychotic disorders, and underlying mechanisms as informed by neuroimaging, genetic, clinical and animal experimental studies. In addition, the book will illuminate the scope for immunological treatment for schizophrenia.

Neuroinflammation und Neuroinfektion in der Neuropädiatrie

by Mustafa A. M. Salih

Dieses Buch beleuchtet Aspekte neuroinflammatorischer Erkrankungen bei Kindern und Jugendlichen sowie das Gebiet der Neuroinfektionen in der Pädiatrie. Verfasst von Experten aus führenden Universitätskliniken und Gesundheitszentren sowohl in den Industrieländern als auch in den Entwicklungsländern, verfolgt das praxisorientierte Werk einen problemorientierten Ansatz zu diesen speziellen Erkrankungen des Nervensystems im Kindesalter. Das Buch wurde aus dem Englischen mithilfe von Künstlicher Intelligenz unter Verwendung der DeepL-Software übersetzt. Die Kapitel sind ursprünglich im Werk Clinical Child Neurology erschienen, das von Mustafa A.M. Salih im Springer-Verlag herausgegeben wurde..

Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders (Advances in Experimental Medicine and Biology #1411)

by Yong-Ku Kim

This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.

Neuroinformatics

by S. H. Koslow Chiquito J. Crasto

Neuroinformatics presents cutting-edge techniques for the synergistic study of neuroinformatics. The book facilitates the efforts of discovering neuroscience through the sharing of data and the use of computational models. It demonstrates the use of neuroinformatic components as a mechanism for understanding complex disorders. It contains detailed explanations, advantages, and disadvantages of traditional and non-invasive imaging methods.

Neuroinformatics for Neuropsychology

by Vinoth Jagaroo

Bioinformatics involves specialized application of computer technology to investigative and conceptual problems in biology and medicine; neuroinformatics (NI) is the practice of bioinformatics in the neurosciences. Over the past two decades the biomedical sciences have been revolutionized by databases, data mining and data modeling techniques. The Human Genome Project, which depended on informatics methods, has been the most well recognized bioinformatics undertaking. Bioinformatics has since been applied all across biology and medicine, and has also transformed almost every avenue in neuroscience. Yet in neuropsychology, NI perspectives remain largely unrealized. Ironically, NI offers enormous potential to the essential praxis of neuropsychology - assessing cognitive behavior and relating cognition to neural systems. Neuroinformatics can be applied to neuropsychology as richly as it has been applied across the neurosciences. Neuroinformatics for Neuropsychology is the first book to explain the relevance and value of NI to neuropsychology. It systematically describes NI tools, applications and models that can enhance the efforts of neuropsychologists. It also describes the implications of NI for neuropsychology in the 21st century - fundamental shifts away from the conventional modes of research, practice and communication that have thus far characterized the field. One of the foremost experts on the subject: Illustrates the vital role NI is playing throughout the neurosciences. Provides a sampling of NI tools and applications in neuroscience research, and lays out current organization structures that support NI. Describes the lack of NI in neuropsychology, differentiates between NI systems for neuropsychology and conventional computerized assessment methods, and proposes criteria for neuropsychology-specific NI systems. Describes NI applications and models currently in use in neuropsychology, and NI models for neuropsychology that are being pioneered in phenomics research. Discusses potential obstacles and aids to NI in neuropsychology, including issues such as data sharing, standardization of methods, and data ontology. Projects the future of neuropsychological research and practice in light of the new generation of the internet, Web 2.0, geared to collective knowledge building. A vital introduction to a profound technological practice, Neuroinformatics for Neuropsychology is important reading for clinical neuropsychologists, cognitive neuroscientists, behavioral neurologists, and speech-language pathologists. Researchers, clinicians, and graduate students interested in informatics for the brain-behavioral sciences will especially welcome this unique volume.

Neurointensive Care

by Katja E. Wartenberg Khalid Shukri Tamer Abdelhak

This book provides guidance for physicians confronted with acute neurological crises in the context of patient safety centred practice standards. It highlights how the implementation of patient safety standards in the neurointensive care unit leads to better clinical outcomes and emphasizes the importance of utilizing appropriate resources, ensuring evidence-based practice is followed. Cost effectiveness, continuous performance improvement and the creation of a non-punitive culture are also discussed. Neurointensive Care: A Clinical Guide to Patient Safety is aimed at physicians around the world caring for critically ill neurological patients either in the emergency department or intensive care unit, and may also be valuable for nurses working in these settings. Neurointensivists, neurologists, neurosurgeons, anesthesiologists, general intensivists, emergency physicians, and trainees dealing with neurological catastrophes will find this book of interest. ​

Neurointensive Care Unit: Clinical Practice and Organization (Current Clinical Neurology)

by Sarah E. Nelson Paul A. Nyquist

This book offers valuable guidance to neurointensivists, other neurocritical care staff, and those desiring to develop a neurocritical care unit via a thorough discussion of neurological emergencies and neurocritical care unit organization.This comprehensive volume begins with a review of acute neurological emergencies as managed clinically in the neurocritical care unit. Topics include acute cerebrovascular, neurological, and neurosurgical disorders. The unique aspect of this book is its description of the organization of the neurocritical care unit. We focus on how other services in the hospital interact with and assist neurocritical care operations, telemedicine/telestroke, and neurocritical care personnel and their roles. A review of expected outcomes of neurocritical care conditions is also included.Neurointensivists, neurocritical care unit staff leadership, hospital administrators, and those interested in developing a neurocritical care unit will find Neurointensive Care Unit: Clinical Practice and Organization to be an invaluable guide.

Neurointervention in the Medical Specialties

by Randall C. Edgell Sean I. Savitz John Dalfino

Neurointervention in the Medical Specialties is a first-of-its-kind reference that serves as a bridge between the neurointerventionalist and the physicians who most frequently look to these specialists for answers to some of the most intractable problems they face. Providing background on the wide range of diseases treated through neurointervention along with the indications and alternatives to such treatments, this landmark title is grouped into four parts: an introduction to the tools and anatomical structures that are integral to the field; disease processes most often encountered by neurologists, cardiologists, and vascular surgeons; those diseases more frequently treated by neurosurgeons; and finally those diseases first seen by several other specialties including ophthalmologists and head and neck surgeons. Importantly, each chapter includes details of neurointerventional technique and case discussions that are sufficiently detailed to provide a treatment template and guidance to neurointerventionalists in training and practice. At the same time, the descriptions provide referring physicians with insight into how neurointerventional procedures are performed. Finally, there are several concluding, thought-provoking chapters that examine what new opportunities await the field of neurointervention on the horizon. Neurointervention in the Medical Specialties is a major contribution to the literature and invaluable resource for all clinicians and researchers interested in this exciting field.

Neurointervention in the Medical Specialties: A Comprehensive Guide (Current Clinical Neurology)

by Randall C. Edgell Kara M. Christopher

This book covers the intersections between neurointervention and neurology, neurointervention and neurosurgery, and neurointervention and other specialties. It fills the gap in the literature by placing specific emphasis on appropriate patient selection, preparation, and post-procedural management. Concise and comprehensive, this text covers the increasingly important aspects of the neurointerventionalist profession, as it has moved away from a purely technical role to a focus on clinical care. In addition, the most rapidly expanding area of neurointervention, ischemic stroke, is thoroughly examined in this text, where other texts on this subject fail. It is also meant as a reference for non-neurointerventionalists who may desire to learn more about how their patients can benefit from the therapeutic or adjunctive techniques that the neurointerventionalist can provide. Neurointervention in the Medical Specialties, Second Edition is an essential guide written for neurointerventional specialists from all backgrounds, both in practice and in training

Neurointerventional Management: Diagnosis and Treatment

by Robert W. Hurst Robert H. Rosenwasser

Crossing the boundaries of classically delineated medical and surgical specialties including neurosurgery, neuroradiology, and neurology, Interventional Neuroradiology uses advanced neuroimaging combined with endovascular techniques to guide catheters and devices through blood vessels to treat disease involving structures of the head, neck, and cen

Neurolaryngology

by Christian Sittel Orlando Guntinas-Lichius

This book, endorsed by the European Laryngological Society, is a comprehensive guide to key topics in neurolaryngology, which enables readers to quickly identify and implement solutions in concrete situations likely to arise in everyday clinical practice. It includes detailed information on conditions such as vocal cord paresis/paralysis, laryngeal dystonia, and upper motor neuron disorders and offers clear advice on imaging and assessment, highlighting the role and performance of electromyography. Treatment options are extensively described, and there are individual chapters on functional therapy, botulinum toxin injection, the full range of phonosurgery options (including transoral endoscopic techniques, office-based phonosurgery, framework surgery, and laryngeal reinnervation), and laryngeal transplantation. With numerous accompanying videos, the book is a valuable resource for otorhinolaryngologists, speech pathologists and neurologists.

Neurolaw

by Eugenio Picozza

This volume illustrates to the public, and legal experts, the basic principles of the field of neuroscience, that commonly goes under the name of Neurolaw. First, it illustrates the relationship between neuroscience, natural sciences and social sciences. Furthermore, it highlights numerous problems concerning the fundamental philosophical concepts used by Neurolaw and evaluates the validity of the method and the limits of a neuroscientific approach to the problems of law and justice. The volume explores the possibility of application of these concepts on the fundamentals of the general theory of law and legal dogmatics. It also examines the main problems of Neurolaw in relation to public, private, criminal and procedural law. In conclusion, the book follows a systematic method that makes it an thorough manual for the introduction to Neurolaw.

Neurolaw and Responsibility for Action: Concepts, Crimes, and Courts

by Dennis Patterson Peter Raynor Donnelly-Lazarov Bebhinn

Law regulates human behaviour, a phenomenon about which neuroscience has much to say. Neuroscience can tell us whether a defendant suffers from a brain abnormality or injury, and it can correlate these neural deficits with criminal offending. Using fMRI and other technologies it might indicate whether a witness is telling lies or the truth. It can further propose neuro-interventions to ‘change’ the brains of offenders and so to reduce their propensity to offend. And, it can make suggestions about whether a defendant knows or merely suspects a prohibited state of affairs, so drawing distinctions among the mental states that are central to legal responsibility. Each of these matters has philosophical import; is a neurological ‘deficit’ inculpatory or exculpatory; what is the proper role for law if the mind is no more than the brain; is lying really a brain state, and can neuroscience really ‘read’ the brain? In this edited collection, leading contributors to the field provide new insights on these matters, bringing to light the great challenges that arise when disciplinary boundaries merge.

Neurolaw: Advances in Neuroscience, Justice & Security (Palgrave Studies in Law, Neuroscience, and Human Behavior)

by Gerben Meynen Sjors Ligthart Dave Van Toor Tijs Kooijmans Thomas Douglas

This edited book provides an in-depth examination of the implications of neuroscience for the criminal justice system. It draws together experts from across law, neuroscience, medicine, psychology, criminology, and ethics, and offers an important contribution to current debates at the intersection of these fields. It examines how neuroscience might contribute to fair and more effective criminal justice systems, and how neuroscientific insights and information can be integrated into criminal law in a way that respects fundamental rights and moral values.The book’s first part approaches these questions from a legal perspective, followed by ethical accounts in part two. Its authors address a wide range of topics and approaches: some more theoretical, like those regarding the foundations of punishment; others are more practical, like those concerning the use of brain scans in the courtroom. Together, they illustrate the thoroughly interdisciplinary nature of the debate, in which science, law and ethics are closely intertwined. It will appeal in particular to students and scholars of law, neuroscience, criminology, socio-legal studies and philosophy.Chapter 8 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Neuroleadership - Grundlagen, Konzepte, Beispiele

by Theo Peters Argang Ghadiri

,,Neuroleadership" - international in aller Munde, im deutschsprachigen Raum jedoch bisher nicht wissenschaftlich aufgearbeitet. Diese Lücke schließt dieses Buch, das nun in der 2. , überarbeiteten und aktualisierten Auflage erscheint. Die beiden Autoren beschreiben zunächst den Stand der Forschung und berücksichtigen dabei sowohl die englischsprachige als auch deutsche Literatur. Nach einer Einführung in die neurowissenschaftlichen Grundlagen erfolgt ein Überblick vorhandener Ansätze zum Thema Neuroleadership. Darauf folgt wird ein eigener Ansatz vorgestellt, wie ganzheitliches Neuroleadership auf Organisations- und Personalebene aussehen kann. Abschließend werden aktuelle Forschungsansätze in diesem Themenkomplex vorgestellt. Das Buch verdeutlicht dem Leser, dass wissenschaftliche Grundlagen der Neurowissenschaften die BWL verändern, und zeigt die Anwendung anhand eines konkreten Modells. Denn: Die Erkenntnisse der Neurowissenschaften werden über kurz oder lang auch in die betriebswirtschaftliche Personalarbeit einfließen.

Neuroleadership: Creative Leadership with a Focus on the Brain

by James Teboul Philippe Damier

This book illustrates, through a number of examples from different domains, how to put in place a disciplined process to develop a creative leadership approach. Today's managers seem to have all the tools at their disposal, leadership training, seminars and executive coaching, to exercise effective leadership, but most continue to take the easy path of raw authority, neglecting the interwoven texture of leadership and followership. The classic models of leadership fail routinely because leaders find it hard to develop an effective way of motivating their followers and do not realize how far they are conditioned by the limitations and biases hardwired in their brains. Just like sports professionals who need a good understanding of their body, leaders need to practice and explore the capabilities of their brains. With some knowledge in the latest discoveries in Neurosciences and mastery of their cognitive predispositions, leaders can draw on a range of resources to engage all parties in learning and collaborating towards common goals and create a culture based on cooperation and innovation. Ideal for organizations or associations, private or public companies, this book offers practical advice on neuroleadership through examples of successful transformation including a case study at Netflix.

Neurologic Differential Diagnosis

by Alan B. Ettinger Deborah M. Weisbrot

The increasing pressure upon clinicians to see more and more patients generates great concern as to how to offer a comprehensive and thorough diagnostic approach and yet maintain efficiency. Neurologic Differential Diagnosis is the answer. Unlike other texts which are divided into disease entities, this book uses a case study approach to focus on the patients' symptoms. Each chapter is dedicated to a specific presenting symptom or sign and includes a comprehensive, yet succinct table of clinical features to aid clarification of the broad list of diagnostic possibilities. This allows the clinician to quickly reference specific symptoms such as dizziness, mental status change or diplopia; or signs such as foot drop or psychotic behavior, and then immediately generate diagnostic possibilities. Written from the authors' extensive clinical experience, Neurologic Differential Diagnosis is an invaluable text for neurologists and psychiatrists at all stages of training.

Neurologic Disease

by Michael Andrew Meyer

This novel title explores the central and peripheral nervous system in health and disease. By first establishing a fundamental basic science knowledge about the cellular elements of the nervous system, the reader is then presented with clinical cases in a pathophysiologic manner, as exemplified in unifying Guillain Barre and Multiple Sclerosis in one chapter on Demyelinating Disease. The reader is encouraged to adopt a systematic approach of sorting out neurologic problems he or she may face in clinical practice by identifying time and space factors based on the age of a patient. High quality illustrations for each case are included in the book along with novel three-dimensional reconstructions of MR, PET, and CT data whenever possible. Developed largely for medical students as an introduction to the clinical neurosciences, for neurology residents, and for others doing graduate level neuroscience study, Neurology - A Modern, Pathophysiologic Approach to the Diagnosis and Treatment of Neurologic Disease will also be of significant interest to the established neurologist as a comprehensive, up-to-date reference.

Neurologic Interventions for Physical Therapy

by Mary Kessler Suzanne Tink" Martin

Master the role of the physical therapist or physical therapist assistant in neurologic rehabilitation! Neurologic Interventions for Physical Therapy, 3rd Edition helps you develop skills in the treatment interventions needed to improve the function of patients with neurologic deficits. It provides a solid foundation in neuroanatomy, motor control, and motor development, and offers clear, how-to guidelines to rehabilitation procedures. Case studies help you follow best practices for the treatment of children and adults with neuromuscular impairments caused by events such as spinal cord injuries, cerebral palsy, and traumatic brain injuries. Written by physical therapy experts Suzanne 'Tink' Martin and Mary Kessler, this market-leading text will help you prepare for the neurological portion of the PTA certification exam and begin a successful career in physical therapy practice. Comprehensive coverage of neurologic rehabilitation explores concepts in neuroanatomy, motor control and motor learning, motor development, and evidence-based treatment of adults and children with neuromuscular impairments.

Neurologic Interventions for Physical Therapy (Second Edition)

by Mary Kessler Suzanne Tink Martin

Now completely updated with the latest information on both adult and pediatric patients, this comprehensive book provides a link between the pathophysiology of neurologic deficits and possible rehabilitation interventions for improving movement outcomes. It introduces the structure and function of the nervous system and describes normal motor development, motor control and motor learning, pathophysiology of the nervous system and common treatment techniques used in physical therapy practice. This edition also features updated terminology from the APTA's Guide to Physical Therapist Practice, as well as new chapters on proprioceptive neuromuscular facilitation (PNF) and other neurological conditions seen in the adult. Helpful learning aids and abundant illustrations highlight key concepts and help readers quickly master the material. Helpful learning aids - such as objectives, tables, illustrated intervention boxes, and review questions - reinforce important facts and concepts. Review questions at the end of each chapter allow readers to test their understanding of the material. 700 illustrations clearly depict procedures discussed in the text and clarify descriptions of anatomy, physiology, evaluation, pathology, and treatment. Background information is provided for interventions that can be used in the rehabilitation of adults and children, promoting a complete understanding of techniques. Careful documentation uses current outcomes-based research. Case histories include subjective and objective observation, assessment, planning, and critical decision-making components. Current language of the APTA's Guide to Physical Therapist Practice, 2nd Edition is used throughout, aligning all information with best practices put forth by the APTA. A new chapter on proprioceptive neuromuscular facilitation (PNF) describes how these techniques can be used to improve performance of functional tasks by increasing strength, flexibility, and range of motion.

Neurologic Rehabilitation: Neuroscience And Neuroplasticity In Physical Therapy Practice

by Deborah S. Nichols Larsen Deborah K. Kegelmeyer John A. Buford Anne D. Kloos Jill C. Heathcock D. Michele Basso

Neurorehabilitation in Physical Therapy delivers comprehensive coverage of the structure and function of the human nervous system. It also discusses normal motor development and motor control, as well as common treatment techniques in physical therapy. In order to be engaging to students, cases open each chapter, with questions about those cases appearing throughout the chapter. The text includes numerous tables, flow charts, illustrations, and multiple-choice board-style review questions and is enhanced by a roster of world-renowned clinical contributors.

Neurologic Stem Cell Surgery

by Jeffrey N. Weiss

This is a concise how-to of successfully treating previously poorly or untreatable neurologic conditions with stem cell therapies. The text examines the IRB approved protocols of NEST (Neurologic Bone Marrow Derived Stem Cell Treatment Study), SCiExVr (Stem Cell Spinal Cord Injury Exoskeleton and Virtual Reality Treatment Study), and ACIST (Alzheimer’s and Cognitive Impairment Stem Cell Treatment Study). The discussion focuses on the protocols and informed consents and may be used as a template for specialists to develop clinical trials utilizing stem cell based therapy. Other potential noninvasive treatments for brain injury are also discussed. Neurologic Stem Cell Surgery, the sister text to the recently published Retinal and Optic Nerve Stem Cell Surgery, is an invaluable reference for all physicians with an interest in the development of stem cell based treatments.

Neurologic and Neurodegenerative Diseases of the Larynx

by Philip A. Weissbrod David O. Francis

This comprehensive text summarizes what is known about the myriad of different neurological conditions that cause dysfunction of communication, swallowing, and breathing as it relates to the upper aerodigestive tract. It serves to provide clinicians and scientists, at all levels of experience, a practical and thorough review of these diseases, their management, and frontiers in science. Chapters are written by experts in these conditions from a broad spectrum of medical specialties in order to create a book that is inclusive of diagnostic and therapeutic considerations that clinicians should think about when caring for patients with these conditions. Neurologic and Neurodegenerative Diseases of the Larynx will be an instrumental resource in guiding clinicians to better recognize the subtle and not so subtle voice, swallowing, and airway manifestations of these diseases, and improve management of patient symptoms and concerns in order to maximize both quality of life and longevity. It will aide otolaryngologists, laryngologists, neurologists, speech language pathologists, and other allied health care professionals in developing a more efficient, evidence-based, patient-focused, and multi-specialty approach to managing these complex and challenging patients.

Neurological Clinical Examination: A Concise Guide

by John Morris Joseph Jankovic Victor Fung

This book and video collection provide a practical guide to the clinical neurological examination, an essential tool in the diagnosis of neurological conditions encountered in the outpatient clinic and hospital ward. Each chapter covers a different condition and uses a step-by-step approach selecting those aspects of the clinical examination which are most likely to lead to the correct diagnosis. Video clips accessible via both a companion website and by QR codes within the book provide easy access to view a wide range of neurological signs. The text is illustrated with clear diagrams. Tables are used to list the various causes of particular signs. Primary care physicians, neurologists, and trainees preparing for certifying examinations will find this book an invaluable learning companion and essential tool for the diagnosis of neurological disorders.

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