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Non-Heart-Beating Organ Transplantation: Medical and Ethical Issues in Procurement
by Roger Herdman Study DirectorNon-heart-beating donors (individuals whose deaths are determined by cessation of heart and respiratory function rather than loss of whole brain function) could potentially be of major importance in reducing the gap between the demand for and available supply of organs for transplantation. Prompted by questions concerning the medical management of such donors--specifically, whether interventions undertaken to enhance the supply and quality of potentially transplantable organs (i.e. the use of anticoagulants and vasodilators) were in the best interests of the donor patient--the U.S. Department of Health and Human Services asked the Institute of Medicine to examine from scientific and ethical points of view "alternative medical approaches that can be used to maximize the availability of organs from [a] donor [in an end-of-life situation] without violating prevailing ethical norms...."This book examines transplantation supply and demand, historical and modern conceptions of non-heart-beating donors, and organ procurement organizations and transplant program policies, and contains recommendations concerning the principles and ethical issues surrounding the topic.
Non-Heart-Beating Organ Transplantation: Practice and Protocols
by Committee on Non-Heart-Beating Transplantation II: The Scientific Ethical Basis for Practice ProtocolsThe National Academies Press (NAP)--publisher for the National Academies--publishes more than 200 books a year offering the most authoritative views, definitive information, and groundbreaking recommendations on a wide range of topics in science, engineering, and health. Our books are unique in that they are authored by the nation's leading experts in every scientific field.
Non-Hodgkin Lymphoma
by Andrew M. Evens Kristie A. BlumThis book provides clinical practitioners and the research community with detailed information on the diagnosis, prognosis, and treatment of non-Hodgkin lymphoma, taking into account the significant growth in knowledge including multiple therapeutic advances that have been achieved over the past 5-10 years. The work is subdivided into epidemiology, pathogenesis, pathology, imaging, and therapy of the non-Hodgkin lymphomas. The full range of therapeutic options are examined according to the major subtypes of non-Hodgkin lymphoma and the most up-to-date information is provided on current standard treatment options, including stem cell transplantation as well as new cutting-edge therapeutics.
Non-Hodgkin Lymphoma
by Jorge J. Castillo Peter J. QuesenberryThis book will be the first that focuses on solely on model organisms for lymphoma. It's editors are internationally recognized in the field.
Non-Hodgkin's Lymphoma in Childhood and Adolescence
by Oussama Abla Andishe AttarbaschiThis text provides a state-of-the-art overview on Non-Hodgkin's lymphoma (NHL) in children and adolescents. The volume is divided into seven sections, each of which focuses on a critical component of pediatric NHL, including history and epidemiology, pathology and molecular biology, disease evaluation and response, common and rare sub-types of NHL, and current and novel treatment strategies. The text also comprehensively reviews the late effects of treatment, quality of patient life, and NHL treatment in countries with limited resources.Written by experts in the field, Non-Hodgkin's Lymphoma in Childhood and Adolescence is a valuable resource for clinicians and practitioners who treat children and adolescents with NHL.
Non-Idiopathic Spine Deformities in Young Children
by Muharrem YaziciNon-idiopathic early onset scoliosis represents a true challenge to the physician due to the significance of the ongoing growth of the spine, the risk of curve progression, and the risk of pulmonary insufficiency. A comprehensive review of the growth mechanisms of spine in infancy forms the basis of the book. Clinical evaluation and imaging of early onset scoliosis contribute to the diagnostic overview. The main causes of non-idiopathic early onset scoliosis are briefly described in the second part of the book. The last group of chapters presents the conservative and surgical treatments that are available along with their results, chances and challenges. This comprehensive guide is an opportunity for every specialist involved in the treatment of these severe deformities, to obtain an update of the actual trends and knowledge in the field in a one-point reference.
Non-Intentionally Added Substances in PET-Bottled Mineral Water (SpringerBriefs in Molecular Science)
by Pasqualina Laganà Maria Anna Coniglio Cristian FioriglioThis book discusses a major issue in the food contact materials industry: non-intentionally added substances (NIAS), and their impact on PET-bottled water. NIAS are chemical compounds that are present in food contact materials but have not been added for technical reasons during the production process, and consumers are usually unaware of their presence. NIAS can include decomposition or degradation products, impurities in the raw materials, unwanted by-products or contaminants from recycling processes, and they pose a challenge for packaging manufacturers.In Europe, the EU Regulations No. 1935/2004 and 10/2011 set out, respectively, the general principles of safety and inertness for all packaging materials, and rules on the composition of plastic food-contact materials. Among the plastics commonly used for bottled water and other non-alcoholic refreshment beverages, polyethylene terephthalate (PET) is the most favoured thanks to its chemical and physical stability, its transparency, low weight and good recyclability. Further, very few additives are used for its manufacture. Nonetheless, due to the complex formulations of polymers, processes and storage, NIAS can also be found in PET-bottled water, with potential cancerogenic or toxic effects.This book provides an overview of the European regulation of NIAS in plastic packaging materials, offering insights into their chemical composition in PET-bottled water. Lastly, it provides a useful discussion on NIAS and their toxicity.
Non-Invasive Health Systems based on Advanced Biomedical Signal and Image Processing (Prospects in Biomedical Engineering and Applications)
by Ali Mansour Adel Al-Jumaily Paolo Crippa Claudio TurchettiThis book contains up-to-date noninvasive monitoring and diagnosing systems closely developed by a set of scientists, engineers, and physicians. The chapters are the results of different biomedical projects and theoretical studies that were coupled by simulations and real-world data.Non-Invasive Health Systems based on Advanced Biomedical Signal and Image Processing provides a multifaceted view of various biomedical and clinical approaches to health monitoring systems. The authors introduce advanced signal- and image-processing techniques as well as other noninvasive monitoring and diagnostic systems such as inertial sensors in wearable devices and novel algorithm-based hybrid learning systems for biosignal processing. The book includes a discussion of designing electronic circuits and systems for biomedical applications and analyzes several issues related to real-world data and how they relate to health technology including ECG signal monitoring and processing in the operating room. The authors also include detailed discussions of different systems for monitoring various conditions and diseases including sleep apnea, skin cancer, deep vein thrombosis, and prosthesis controls. This book is intended for a wide range of readers including scientists, researchers, physicians, and electronics and biomedical engineers. It will cover the gap between theory and real life applications.
Non-Invasive Instrumentation and Measurement in Medical Diagnosis (Biomedical Engineering)
by Robert B. NorthropNon-Invasive Instrumentation and Measurement in Medical Diagnosis, Second Edition discusses NIMD as a rapidly growing, interdisciplinary field. The contents within this second edition text is derived from Professor Robert B. Northrop’s experience teaching for over 35 years in the Biomedical Engineering Department at the University of Connecticut. The text focusses on the instruments and procedures which are used for non-invasive medical diagnosis and therapy, highlighting why NIMD is the preferred procedure, whenever possible, to avoid the risks and expenses associated with surgically opening the body surface. This second edition also covers a wide spectrum of NIMD topics including: x-ray bone densitometry by the DEXA method; tissue fluorescence spectroscopy; optical interferometric measurement of nanometer tissue displacements; laser Doppler velocimetry; pulse oximetry; and applications of Raman spectroscopy in detecting cancer, to name a few. This book is intended for use in an introductory classroom course on Non-Invasive Medical Instrumentation and Measurements taken by juniors, seniors, and graduate students in Biomedical Engineering. It will also serve as a reference book for medical students and other health professionals intrigued by the topic. Practicing physicians, nurses, physicists, and biophysicists interested in learning state of the art techniques in this critical field will also find this text valuable. Non-Invasive Instrumentation and Measurement in Medical Diagnosis, Second Edition concludes with an expansive index, bibliography, as well as a comprehensive glossary for future reference and reading.
Non-Invasive Management of Gynecologic Disorders
by Emre Seli Aydin AriciNon-invasive options for the management of gynecologic conditions continue to grow in popularity, as they offer considerable benefits in reduced patient stress, hospitalization time, and cost. Non-invasive Management of Gynecologic Disorders provides an informative, concise, and highly practicable resource for the diagnosis and management of gyneco
Non-Invasive Measurements of Bone Mass & Their Clinical Application (Routledge Revivals)
by Stanton H. CohnFirst Published in 1981, this book offers a full, comprehensive guide to measuring bone mass. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of osteology, and other practitioners in their respective fields.
Non-Invasive Monitoring of Transdermal Drug Delivery
by Pasquale Arpaia Umberto Cesaro Nicola Moccaldi Isabella SanninoThe book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.
Non-Invasive Neuromodulation of the Central Nervous System: Workshop Summary
by Lisa BainBased on advances in biotechnology and neuroscience, non-invasive neuromodulation devices are poised to gain clinical importance in the coming years and to be of increasing interest to patients, clinicians, health systems, payers, and industry. Evidence suggests that both therapeutic and non-therapeutic applications of non-invasive neuromodulation will continue to expand in coming years, particularly for indications where treatments are currently insufficient, such as drug-resistant depression. Given the growing interest in non-invasive neuromodulation technologies, the Institute of Medicine's Forum on Neuroscience and Nervous System Disorders convened a workshop, inviting a range of stakeholders - including developers of devices and new technologies, researchers, clinicians, ethicists, regulators, and payers - to explore the opportunities, challenges, and ethical questions surrounding the development, regulation, and reimbursement of these devices for the treatment of nervous system disorders as well as for non-therapeutic uses, including cognitive and functional enhancement. This report highlights the presentation and discussion of the workshop.
Non-Invasive Surrogate Markers of Atherosclerosis
by Steven B FeinsteinNon-Invasive Surrogate Markers of Atherosclerosis details the scientific and clinical support for using non-invasive imaging modalities to evaluate the presence of surrogate markers of atherosclerosis, in conjunction with traditional methods of diagnosing cardiovascular disease. This new book covers the topic completely
Non-Invasive Ventilation and Weaning: Principles and Practice, Second Edition
by Mark Elliott Stefano Nava Bernd SchönhoferNow in full-colour, this eagerly-anticipated second edition continues to be the most comprehensive resource available on non-invasive ventilation (NIV), both in the hospital and at home. Reflecting a global perspective with expert contributors from more than 15 countries, the book: <li>provides clinical examples of NIV in practice with insightful vignettes <li>covers home- and intensive care-based ventilation <li>details NIV use in acute and chronic respiratory failure, plus paediatric and other specialty applications. <P><P>Disease-specific sections provide best practice in the science, diagnostics and management of conditions such as COPD, cardiac failure, neuromuscular disease and obesity, while features such as ‘Common Clinical Questions & Answers’, abundant tables and illustrations, chapter summaries and new clinical vignettes showcase the realities of NIV in practice. This is essential reading for pulmonologists, critical care physicians and intensive care medicine specialists.
Non-Linear Differential Equations and Dynamical Systems (Mathematics and Physics for Science and Technology)
by Luis Manuel Braga da Costa CamposNon-Linear Differential Equations and Dynamical Systems is the second book within Ordinary Differential Equations with Applications to Trajectories and Vibrations, Six-volume Set. As a set, they are the fourth volume in the series Mathematics and Physics Applied to Science and Technology. This second book consists of two chapters (chapters 3 and 4 of the set). The first chapter considers non-linear differential equations of first order, including variable coefficients. A first-order differential equation is equivalent to a first-order differential in two variables. The differentials of order higher than the first and with more than two variables are also considered. The applications include the representation of vector fields by potentials. The second chapter in the book starts with linear oscillators with coefficients varying with time, including parametric resonance. It proceeds to non-linear oscillators including non-linear resonance, amplitude jumps, and hysteresis. The non-linear restoring and friction forces also apply to electromechanical dynamos. These are examples of dynamical systems with bifurcations that may lead to chaotic motions. Presents general first-order differential equations including non-linear like the Ricatti equation Discusses differentials of the first or higher order in two or more variables Includes discretization of differential equations as finite difference equations Describes parametric resonance of linear time dependent oscillators specified by the Mathieu functions and other methods Examines non-linear oscillations and damping of dynamical systems including bifurcations and chaotic motions
Non-Linear Filters for Mammogram Enhancement: A Robust Computer-aided Analysis Framework for Early Detection of Breast Cancer (Studies in Computational Intelligence #861)
by Vikrant Bhateja Shabana Urooj Mukul MisraThis book presents non-linear image enhancement approaches to mammograms as a robust computer-aided analysis solution for the early detection of breast cancer, and provides a compendium of non-linear mammogram enhancement approaches: from the fundamentals to research challenges, practical implementations, validation, and advances in applications.The book includes a comprehensive discussion on breast cancer, mammography, breast anomalies, and computer-aided analysis of mammograms. It also addresses fundamental concepts of mammogram enhancement and associated challenges, and features a detailed review of various state-of-the-art approaches to the enhancement of mammographic images and emerging research gaps. Given its scope, the book offers a valuable asset for radiologists and medical experts (oncologists), as mammogram visualization can enhance the precision of their diagnostic analyses; and for researchers and engineers, as the analysis of non-linear filters is one of the most challenging research domains in image processing.
Non-Medical Prescribing: A Course Companion
by Alison PoolerThis accessible textbook provides a comprehensive resource for healthcare students and professional students studying non-medical prescribing, taking into account the Royal Pharmaceutical Society (RPS) competency framework for non-medical prescribing. Non-Medical Prescribing: A Course Companion includes chapters on the context of non-medical prescribing; pharmacology; professional, legal and ethical issues; psychological influences; working in multidisciplinary teams; working with patients with complex conditions and co-morbidities; understanding antibiotics and resistances; prescription writing; and the role of non-medical prescribing leads. Each chapter acts as a self-contained study module, with key facts and areas highlighted, illustrative clinical cases to link learning to practice, and a self-test quiz. Designed for professionals from a range of non-medical disciplines including nursing, midwifery, pharmacy, physiotherapy and occupational therapy, this book can be used at both pre- and post-registration level.
Non-Melanoma Skin Cancer and Cutaneous Melanoma: Surgical Treatment and Reconstruction
by Othon Papadopoulos Nikolaos A. Papadopulos Grigorios ChampsasThis book describes and illustrates the reconstructive surgical techniques appropriate in patients with skin cancer and melanoma, according to anatomic region, with a view to enabling readers to perform these techniques optimally. An extensive introductory section discusses skin cancer and melanoma from the points of view of dermatology, oncology, pathology, radiotherapy, nuclear medicine, and plastic and reconstructive surgery. The surgical treatment and reconstruction of localized skin cancer and melanoma in each anatomic region are then explained step by step with the aid of a wealth of color photos. The final section similarly presents the techniques and procedures appropriate for the surgical treatment and reconstruction of lymph node metastases, covering the sentinel node, lymphadenectomy, and lymphedema. This book will be immensely valuable for plastic and general surgeons, and also of interest for dermatologists, pathologists, oncologists, and nuclear medicine physicians.
Non-Migraine Primary Headaches in Medicine: A Machine-Generated Overview of Current Research
by Paolo MartellettiThis book on tension-type headache is the second machine-generated scientific book in medicine published by Springer and reflects a new publication format which focuses on literature reviews: state-of-the-art computer algorithms were applied to select relevant sources from Springer Nature journal, rearrange them in a topical order, and provide short summaries of these articles. The result is the auto-summarization of current texts, organized by means of a similarity-based clustering routine in coherent chapters and sections. The human intervention of a world-renowned expert in this field grants the scientific soundness and appropriate organization of the contents identified. The AI-based approach seemed especially suitable to provide an innovative perspective as the topics are indeed both complex, interdisciplinary, and multidisciplinary, as is tension-type headache, the most diffuse among the chronic non communicable diseases. The result of this innovative process will of help especially for readers with limited time, interested in migraine and wishing to learn more about the subject quickly and if they are new to the topic. Springer seeks to support anyone who needs a fast and effective start in their content discovery journey, from the undergraduate student exploring interdisciplinary content, to Master- or PhD-thesis developing research questions, to the practitioner seeking support materials, this book can serve as an inspiration, to name a few examples.
Non-Neoplastic Cytology: A Comprehensive Guide
by Guoping Cai Syed M. GilaniCytology evaluates cellular details, and in contrast, histology relates to tissue assessment with rather preserved architecture. During daily cytology practice, we frequently encounter certain situations which are often challenging such as differentiating normal cytology components or non-neoplastic lesions from a neoplastic process, abnormality versus artifact, contaminants from lesional sampling, immunostain expression in unexpected cells, identifying/or characterizing infectious microorganisms and use of special stains. In-depth knowledge about normal tissue cytology, the pattern of immunohistochemical expression in various organs, and recognizing diagnostic pitfalls would help to overcome diagnostically challenging situations. This book presents a detailed and state-of-the-art approach to non-neoplastic cytology. High-yield content, mostly used in daily practice, is in tabular format. The book provides detailed information about cytomorphologic features of infectious microorganisms and the use of special stains, the use of immunohistochemistry along with expression in normal cell types, artifacts/contaminants or incidental findings, and cytomorphologic features of non-tumor related lesions in an organ-based structure. There is a further elaboration of differential diagnosis and mimickers of cytologic material from normal parenchymal tissue, infectious/inflammatory conditions, and benign cystic lesions. The last chapter describes a quick overview of important reference material in tables, which is useful for daily anatomic pathology sign-out. Non-Neoplastic Cytology: A Comprehensive Guide provides practical information about non-neoplastic cytology in one concise format using tables and images. It aims to be a practical resource for cytotechnologists, pathologists, pathology residents, and fellows.
Non-Neoplastic Hematologic Disorders: A Quick Review of Modern Diagnostic and Therapeutic Approaches
by Ling Zhang Lubomir SokolIn the current digital era with the exponential growth of medical knowledge, voluminous textbooks have gradually been replaced by the pocketbooks with tables, figures, images, and e-links to digital book versions with supplemental materials available online. The advent of novel next-generation sequencing (NGS) and multi-omics single cell methods have uncovered causative molecular mechanisms in most of the known non-neoplastic hematologic disorders. There is an urgent need for a concise and up-to-date handbook focused on non-malignant hematology. The book describes characteristic clinical features and state-of-the-art diagnostic approaches of non-neoplastic hematologic disorders. It introduces modern molecular biomarkers with enormous diagnostic and prognostic value and novel targeted gene therapy. Differential diagnosis also includes relevant hematologic malignancies that could represent diagnostic pitfalls. Chapters include take home points for each disorder in concise and easy memorable manner. The book also provides diagnostic algorithms, novel prognostic and predictive factors, up-to-date treatment options, clinically relevant molecular signatures, and ongoing promising clinical trials if available. There are more than 100 questions and answers with comments on laboratory values, updated cytogenetic and mutational profiles. Non-Neoplastic Hematologic Disorders: A Quick Review of Modern Diagnostic and Therapeutic Approaches provides concise clinical and laboratory information about most common non-neoplastic hematologic disorder for practicing hematologists, oncologists, hematopathologists, molecular pathologists, internal medicine specialists, pediatricians, research nurses, nurse practitioners, and trainees at all levels.
Non-Neoplastic Hematopathology and Infections
by Hernani Cualing Parul Bhargava Ramon L. SandinMost books on hematopathology are neoplastic in scope and offer little non-neoplastic content. In Non-Neoplastic Hematopathology and Infections, the authors fully describe the hematologic manifestations in tissue and blood of infectious agents, including many rare and exotic diseases found in both Western and Eastern hemispheres, in order to assist pathologists and medical laboratory professionals all over the world in better diagnosing and treating such infections. Thoroughly illustrated with photographs, tables and text, this book features a wide range of non-neoplastic hematologic disorders, as well as reactive patterns of non-infectious and infectious agents. Comprehensive and state-of-the-art diagnostic materials are described, as are the epidemiology, pathobiology, clinical and pathologic manifestations in blood and lymphatic organs—as well as the approaches to treatment. In addition, Non-Neoplastic Hematopathology and Infections: Contains detailed information on the pathology and patterns of blood, lymph node, and a number of bone marrow and splenic infections and infectious agent manifestations Thoroughly updates the classic pathology of reactive lymphadenopathies and extends this pattern-based approach to tropical and emergent infections Promotes the multidisciplinary integration of hematopathologists and microbiologists in the analysis and diagnostic work-up of tissue and blood Complements current major treatises on such tropical diseases as Manson's, Ashworth's, and Doerr's and updates the classic tomes of William St. Clair Symmers and current texts on neoplastic hematopathology Non-Neoplastic Hematopathology and Infections is an important book for any medical professional interested in non-neoplastic hematology, infections and tissue hematopathology, infectious diseases and tropical medicine, and tropical hematopathology.
Non-Neoplastic Liver Pathology
by Raul S. Gonzalez Kay WashingtonThis book provides a quick, pattern-based reference for interpreting histologic changes in non-neoplastic liver. It is designed to guide the reader based on morphologic pattern and basic clinical information. Each chapter covers a broad but identifiable pattern of pathologic liver findings (e. g. , "portal inflammation" or "steatosis") and discusses the major disease entities that manifest as such a pattern. As liver biopsies can be complex and daunting, such an approach should improve the reader's ability to identify a likely diagnosis or differential and to distinguish among the possible disease entities. Sample reports at the end of each chapter offer guidance on how to sign out cases. Non-Neoplastic Liver Pathology: A Pathologist's Survival Guide will be of value to practicing pathologists without specialized training in hepatic pathology, pathology residents and fellows trying to learn the basics of non-neoplastic liver pathology, and hepatologists interested in reviewing liver biopsies with pathologists
Non-Neurogenic Bladder Dysfunctions (Urodynamics, Neurourology and Pelvic Floor Dysfunctions)
by Vincenzo Li Marzi Matteo BalzarroThis book is exclusively devoted to the often-challenging diagnosis, management and treatment of patients with non-neurogenic bladder dysfunction. A unique team of experts in the field report on the state of the art and the latest trends concerning overactive and underactive bladder dysfunctions, while also discussing detrusor overactivity impaired contractility. Given its scope, the book will benefit all urologists, and offers a valuable tool for professionals and physicians who care and deal with patients with non-neurogenic bladder dysfunctions.