- Table View
- List View
Nuclear Receptors: From Structure to the Clinic
by Iain J. Mcewan Raj KumarNuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.
Nuclear Receptors: Methods and Experimental Protocols (Methods in Molecular Biology #1966)
by Mostafa Z. BadrThis volume presents valuable techniques for studying the class of ligand-activated transcription factors known as nuclear receptors. After a brief overview of the history of the field, chapters cover methods to detect the receptors and their mRNAs in various tissues, protocols to characterize nuclear receptor modulators and activities, their signaling and roles in certain pathogenesis, molecular modeling of nuclear receptor-ligand interactions, as well as the utility of informatics in the field of nuclear receptors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Nuclear Receptors: Methods and Experimental Protocols seeks to aid researchers working toward furthering our understanding of these vital receptors and their role in numerous pathological conditions.
Nuclear Science and Technology: Isotopes and Radiation (Nuclear Science and Technology)
by Shunzhong LuoThis textbook highlights the fundamentals, applications and research frontiers of the civil-use non-power nuclear technology, especially the radioisotopes and radiation technology. The wide scope of applications and the active research in the subject field calls for a comprehensive textbook that not only explains the basic principles but also links the fundamentals to the various application fields. The book systematically leads students from isotope preparation, to nuclear analysis, and to the civil applications in areas such as chemical engineering, agriculture, medicine, environmental protection and materials modification. The application in the energy field is briefly introduced. The book can be used as good teaching materials for upper undergraduate and graduate students in nuclear science and technology. It is also a handy reference book for researchers and engineers in the above mentioned fields.
Nuclear Signaling Pathways and Targeting Transcription in Cancer
by Rakesh KumarAt the moment, there is no dedicated book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade, and thus, directly impacting the functionality of transcriptional factors in cancer. In addition, this book will offer a comprehensive basic and clinical science behind the functions of representative core transcriptional factors. These chapters will serve as a treasure for all those who have an interest in the basis, progression, and targeting of human cancer. Each chapter will be intended to provide comprehensive, up-to-date information by the leaders about the physiologic and pathologic roles of TFs in specific representative organ systems of prime importance. The book will consist of chapters that will give biomedical students, under and graduate students, basic sciences and clinical cancer fellows, residents and researchers, and oncology educators will get a thorough summary of the overall subject. The readers will be able to understand the important current information and views on specific TFs and its role in cancer in areas outside their own expertise or experience. A special emphasis will be also placed on the "classic" papers as well as perspectives on future directions for the field.
Nuclear and Radiological Emergencies in Animal Production Systems, Preparedness, Response and Recovery
by Gerrit Viljoen Ivancho Naletoski Anthony G. LuckinsThis Open Access volume explains how major nuclear and radiological emergencies (NREs) can have implications at local, national and international level. The response to NREs requires a competent decision-making structure, clear communication and effective information exchange. National veterinary services have the responsibility to plan, design and manage animal production system in their countries. These activities cover animal health, animal movement control, production control and improvement, and control of the products of animal origin before their placement on the market. Release of radionuclides after NREs can cause substantial contamination in the animal production systems. Critical responsibility of veterinary authorities is therefore to prevent such contamination, establish early response mechanisms to mitigate the consequences and prevent placement of contaminated products of animal origin on the market for human consumption. This work summarizes the critical technical points for effective management of NREs for national veterinary services.
Nucleic Acid Amplification Strategies for Biosensing, Bioimaging and Biomedicine
by Shusheng Zhang Sai Bi Xinyue SongThis book describes the rational design, development and application of nucleic acid amplification strategies for biosensing, bioimaging and biomedicine. It consists of fifteen chapters demonstrating the use of these strategies in various areas, including fluorescence techniques, Chemiluminescence biosensors, electrochemiluminescence biosensors, colorimetric assays, surface plasmon resonance technologies, electrochemical DNA sensors, photoelectrochemical biosensor, nanopore sensors, quartz crystal microbalance, fluorescence imaging, surface-enhanced Raman spectroscopy, in vitro and in vivo metal ions detection, theranostics and microdroplet chips. Offering a collection of reviews illustrating the latest advances in biochemical analysis and therapeutics, the book shares valuable insights into current challenges and future prospects, making it a valuable resource for a wide readership in the various fields of biosensing, bioimaging and biomedicine.
Nucleic Acid Biology and its Application in Human Diseases
by Subhrangsu Chatterjee Samit ChattopadhyayThis book reviews the structure-function relationship of nucleic acids, their role in the pathophysiology of the diseases, and as therapeutic targets for human diseases. The chapters discuss the role of nucleic acids in inflammatory diseases, neurodegenerative diseases, and cancer. The book also describes recent advancements in nucleic acid-based therapy, the application of nucleic acids in diagnostics, in the development of nano-carriers, logic gates, and sensors. It explores the use of nucleic acids (RNA and DNA) as a unique and multifunctional platform for numerous applications, including therapeutics, diagnostics, nanodevices, and materials. It further examines the role of DNA methylation, histone modifiers and readers, chromatin remodelers, microRNAs, and other components of chromatin in the progression of cancer. The book also discusses the applications of nucleic acid as a vaccine and as a gene-editing tool. It also provides an overview of the clinical trials using genome editing platforms for disease treatment and the challenges in implementing the editing technology. Finally, the book elucidates a representative description of challenges associated with nucleic acid-mediated therapy.
Nucleic Acid Drugs
by Akira MurakamiNew Antisense Strategies: Chemical Synthesis of RNA Oligomers, by Junichi Yano und Gerald E. Smyth Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application, by Mariana Kiomy Osako, Hironori Nakagami und Ryuichi Morishita Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides, by Ekambar R. Kandimalla und Sudhir Agrawal Delivery of Nucleic Acid Drugs, by Yan Lee und Kazunori Kataoka Aptamer: Biology to Applications, by Yoshikazu Nakamura Development and Clinical Applications of Nucleic Acid Therapeutics, by Veenu Aishwarya, Anna Kalota und Alan M. Gewirtz
Nucleic Acid Testing for Human Disease
by Attila LorinczNucleic Acid Testing for Human Disease describes various techniques including target and signal amplification-based NAT procedures, microarrays, bead-based multiplex assays, in situ hybridization, and SNP techniques. This book discusses RNA expression profiling and laboratory issues such as the need for proper validation of tests intended fo
Nucleic Acids in Innate Immunity
by Ken J. Ishii Shizuo AkiraUntil recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation
Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications (Wiley Series in Drug Discovery and Development)
by Zhen Xi Jyoti Chattopadhyaya Lihe Zhang Xinjing TangNucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field. Readers will also find: A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry Comprehensive explorations of the methods used to determine the development of nucleic acid drugs Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry Perfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.
Nucleoside Analogs in Cancer Therapy
by Bruce D. Cheson Michael J. Keating William PlunkettOffering the most current and complete coverage of nucleoside analog activity in oncology and hematology, this single-source volume includes topics from pharmacology to previously unpublished clinical findings on the pivotal role of fludarabine, cladribine, and pentostatin in the management of diseases, such as chronic lymphocytic and hairy cell leukemia, non-Hodgkin's lymphoma, membranous nephropathy, and rheumatoid and psoriatic arthritis.
Nucleoside Mimetics: Their Chemistry and Biological Properties
by Claire SimonsNucleosides exhibit a broad spectrum of biological activity that generally results from their ability to inhibit specific enzymes. This activity has led to their use in the development of various pharmaceutical agents used in the treatment of cancers and to combat harmful viruses, bacteria and parasites.An introduction to the chemistry of nucleoside mimetics, which combines carbohydrate, heterocyclic, and asymmetric synthesis, this book examines the diversity of nucleosides and the range of elegant chemistry involved. It emphasizes the importance of nucleosides as both therapeutic agents and as probes for studying biochemical processes.
Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications
by Morteza VaghefiWhile adenosine triphosphate (ATP) is described as the universal currency of energy in all living organisms at the cellular level, the actual power lies in its phosphate tail. This book is the first dedicated to the field of nucleoside triphosphate (NTP). Its 13 chapters encompass the contributions of twenty scientists from both academia and industry. It provides collective information on the chemical, physiochemical, and biological properties of both natural and modified NTP and their application in life sciences. Three chapters review families of enzymes that depend on nucleotides for assembling DNA and RNA molecules. The appendix includes supporting NMR data.
Nucleotides and Regulation of Bone Cell Function
by Geoffrey Burnstock Timothy R. ArnettATP's powerful impact on the heart and blood vessels was first described in 1929, but it was not until the 1970s that ATP was proposed as the 'purinergic' neurotransmitter in autonomic nerves. The door to this area of research was thrown open when receptors for ATP and its ectoenzymatic breakdown product adenosine were first cloned in the early 199
Nucleus of the Solitary Tract (Routledge Revivals)
by I. Robin BarracoFirst Published in 1994, this book provides a comprehensive, up-to-date compilation of reviews of recent literature on the anatomy, physiology, and pharmacology of the nucleus of the solitary tract (NTS). The chapters are written by internationally recognized experts in the field and include never-before-published data, diagrams, and figures.
Nudging Health: Health Law and Behavioral Economics
by I. Glenn Cohen, Holly Fernandez Lynch, and Christopher T. RobertsonA deep look at the role of behavioral "nudges" for improving health.Winner of the CHOICE Outstanding Academic Title of the Choice ACRLBehavioral nudges are everywhere: calorie counts on menus, automated text reminders to encourage medication adherence, a reminder bell when a driver’s seatbelt isn’t fastened. Designed to help people make better health choices, these reminders have become so commonplace that they often go unnoticed. In Nudging Health, forty-five experts in behavioral science and health policy from across academia, government, and private industry come together to explore whether and how these tools are effective in improving health outcomes.Behavioral science has swept the fields of economics and law through the study of nudges, cognitive biases, and decisional heuristics—but it has only recently begun to impact the conversation on health care. Nudging Health wrestles with some of the thorny philosophical issues, legal limits, and conceptual questions raised by behavioral science as applied to health law and policy. The volume frames the fundamental issues surrounding health nudges by addressing ethical questions. Does cost-sharing for health expenditures cause patients to make poor decisions? Is it right to make it difficult for people to opt out of having their organs harvested for donation when they die? Are behavioral nudges paternalistic? The contributors examine specific applications of behavioral science, including efforts to address health care costs, improve vaccination rates, and encourage better decision-making by physicians. They wrestle with questions regarding the doctor-patient relationship and defaults in healthcare while engaging with larger, timely questions of healthcare reform.Nudging Health is the first multi-voiced assessment of behavioral economics and health law to span such a wide array of issues—from the Affordable Care Act to prescription drugs.Contributors: David A. Asch, Jerry Avorn, Jennifer Blumenthal-Barby, Alexander M. Capron, Niteesh K. Choudhry, I. Glenn Cohen, Sarah Conly, Gregory Curfman, Khaled El Emam, Barbara J. Evans, Nir Eyal, Andrea Freeman, Alan M. Garber, Jonathan Gingerich, Michael Hallsworth, Jim Hawkins, David Huffman, David A. Hyman, Julika Kaplan, Aaron S. Kesselheim, Nina A. Kohn, Russell Korobkin, Jeffrey T. Kullgren, Matthew J.B. Lawrence, George Loewenstein, Holly Fernandez Lynch, Ester Moher, Abigail R. Moncrieff, David Orentlicher, Manisha Padi, Christopher T. Robertson, Ameet Sarpatwari, Aditi P. Sen, Neel Shah, Zainab Shipchandler, Anna D. Sinaiko, Donna Spruijt-Metz, Cass R. Sunstein, Thomas S. Ulen, Kristen Underhill, Kevin G. Volpp, Mark D. White, David V. Yokum, Jennifer L. Zamzow, Richard J. Zeckhauser
Nudging für ein gesundes Unternehmen: Endlich erfolgreiche Gesundheitsförderung am Arbeitsplatz mit dem AEIOU-Modell (essentials)
by Mathias KrisamSie sind aktiv in der betrieblichen Gesundheitsförderung und stehen vor der Herausforderung, dass Ihre Maßnahmen Ihre Zielgruppe nicht im gewünschten Maße erreichen? Dann ist dieses Buch genau das richtige für Sie!Es bietet Ihnen einen schnellen Einstieg in das Thema Nudging zur Gesundheitsförderung am Arbeitsplatz. Sie erfahren die verhaltenswissenschaftlichen Hintergründe und Theorien des Nudgings und lernen anschaulich, wie Sie dieses erfolgreich zur Gesundheitsförderung einsetzen können. Sie werden in das Nudging-Modell AEIOU eingeführt, und Sie erhalten zahlreiche Nudging-Beispiele zu Bewegung, Ernährung, Entspannung, Tabakreduktion und digitaler Gesundheitsförderung. Starten Sie schon morgen mit der Entwicklung eines Nudging-Konzepts für Ihr Unternehmen!
Nuklearmedizin bei endokrinen Erkrankungen: Diagnose und Therapie
by George Barberio Coura-Filho Mayara Torres Silva de Oliveira Ana Luiza Morais de CamposDieses Buch enthält aktuelle Informationen über die allgemeinen Grundsätze der diagnostischen und therapeutischen Nuklearmedizin im Kontext der Endokrinologie.Der Inhalt ist in sechs Teile gegliedert. In Abschnitt I werden allgemeine Aspekte der Radiopharmaka, der Szintigraphie, der Single-Photon-Emissions-Computertomographie (SPECT), der Positronen-Emissions-Tomographie (PET), der Radionuklidtherapien und der strahlengesteuerten Chirurgie behandelt. Abschnitt II befasst sich mit diagnostischen Anwendungen bei gutartigen Schilddrüsenerkrankungen und der Beurteilung von Schilddrüsenknoten. Abschnitt III gibt einen Überblick über die Behandlung von Nebenschilddrüsenerkrankungen. In Abschnitt IV werden diagnostische Verfahren bei gut differenziertem Schilddrüsenkrebs vorgestellt. Abschnitt V befasst sich mit Verfahren und Therapie bei gut- und bösartigen Erkrankungen der Nebenniere (Phäochromozytome und Paragangliome). Schließlich werden in Abschnitt VI die Diagnose und Behandlung neuroendokriner Tumoren vorgestellt.Nuklearmedizin bei endokrinen Erkrankungen: Diagnose und Therapie richtet sich an nicht spezialisierte Nuklearmediziner, die auf dem Gebiet der Endokrinologie arbeiten, und ist auch für Forscher und Studenten eine wertvolle Ressource.
Numb: A Novel
by Sean FerrellA captivating debut from exciting new talent Sean Ferrell, Numb is the endearing tale of a man with no memory or ability to feel pain, who attracts a colorful crowd of sycophants and exploiters while trying to come to terms with who he really is. Fans of the work of Richard Powers, Gary Shteyngart, and Thomas Pynchon—and of the films The Curious Case of Benjamin Button, The Truman Show, and the cinematic oeuvre of Charlie Kaufman—will love the unique and entertaining Numb.
Numeracy in Children's Nursing
by Arija ParkerAn accessible, user-friendly guide to the essential skills associated with maths and numeracy in children's nursing Full of interactive features throughout to bring the subject to life Offers hints and tips throughout that link numeracy into children's nursing practice Supported by an online resource centre featuring downloadable templates, links to further reading, and activities
Numeracy in Nursing and Healthcare: Calculations and Practice
by Pearl ShihabDo you find maths challenging? Do you struggle with drug calculations or clinical applications of numeracy? If you need to brush up your maths skills, Numeracy in Nursing and Healthcare is the perfect textbook to help you through your nursing programme. The text starts out with basic adding and subtracting and works up to more advanced principles like SI units, drug administration, common clinical measurements and how to understand statistics in research articles. By illustrating how maths is relevant to clinical practice, Numeracy in Nursing and Healthcare is a great tool to help you increase your confidence and excel in your studies and career. Key features: Step-by-step examples make understanding concepts easy Look Out sections highlight common mistakes Time to Try and What Did You Learn? questions help you apply what you have learned Key Point boxes provide helpful hints for good problem-solving technique Web links direct you to further reading and examples.
Numerical Ecology with R
by Francois Gillet Daniel Borcard Pierre LegendreNumerical Ecology with R provides a long-awaited bridge between a textbook in Numerical Ecology and the implementation of this discipline in the R language. After short theoretical overviews, the authors accompany the users through the exploration of the methods by means of applied and extensively commented examples. Users are invited to use this book as a teaching companion at the computer. The travel starts with exploratory approaches, proceeds with the construction of association matrices, then addresses three families of methods: clustering, unconstrained and canonical ordination, and spatial analysis. All the necessary data files, the scripts used in the chapters, as well as the extra R functions and packages written by the authors, can be downloaded from a web page accessible through the Springer web site(http://adn.biol.umontreal.ca/~numericalecology/numecolR/). This book is aimed at professional researchers, practitioners, graduate students and teachers in ecology, environmental science and engineering, and in related fields such as oceanography, molecular ecology, agriculture and soil science, who already have a background in general and multivariate statistics and wish to apply this knowledge to their data using the R language, as well as people willing to accompany their disciplinary learning with practical applications. People from other fields (e.g. geology, geography, paleoecology, phylogenetics, anthropology, the social and education sciences, etc.) may also benefit from the materials presented in this book. The three authors teach numerical ecology, both theoretical and practical, to a wide array of audiences, in regular courses in their Universities and in short courses given around the world. Daniel Borcard is lecturer of Biostatistics and Ecology and researcher in Numerical Ecology at Université de Montréal, Québec, Canada. François Gillet is professor of Community Ecology and Ecological Modelling at Université de Franche-Comté, Besançon, France. Pierre Legendre is professor of Quantitative Biology and Ecology at Université de Montréal, Fellow of the Royal Society of Canada, and ISI Highly Cited Researcher in Ecology/Environment.
Numerical Methods for Chemical Engineers Using Excel, VBA, and MATLAB
by Victor J. LawWhile teaching the Numerical Methods for Engineers course over the last 15 years, the author found a need for a new textbook, one that was less elementary, provided applications and problems better suited for chemical engineers, and contained instruction in Visual Basic for Applications (VBA). This led to six years of developing teaching notes that
Numerical Methods for Fractional Differentiation (Springer Series in Computational Mathematics #54)
by Kolade M. Owolabi Abdon AtanganaThis book discusses numerical methods for solving partial differential and integral equations, as well as ordinary differential and integral equations, involving fractional differential and integral operators. Differential and integral operators presented in the book include those with exponential decay law, known as Caputo–Fabrizio differential and integral operators, those with power law, known as Riemann–Liouville fractional operators, and those for the generalized Mittag–Leffler function, known as the Atangana–Baleanu fractional operators. The book reviews existing numerical schemes associated with fractional operators including those with power law, while also highlighting new trends in numerical schemes for recently introduced differential and integral operators. In addition, the initial chapters address useful properties of each differential and integral fractional operator. Methods discussed in the book are subsequently used to solved problems arising in many fields of science, technology, and engineering, including epidemiology, chaos, solitons, fractals, diffusion, groundwater, and fluid mechanics. Given its scope, the book offers a valuable resource for graduate students of mathematics and engineering, and researchers in virtually all fields of science, technology, and engineering, as well as an excellent addition to libraries.