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Obesity (Biographies of Disease)
by Jennifer Petrelli Kathleen Y. Wolin Jennifer M. PetrelliWhat makes obesity a disease instead of just a matter of overeating? What are the genetic and environmental factors behind it? What new breakthroughs are being developing to combat it?
Obesity Before Birth
by Robert H LustigThis volume will explore the epidemiology and the basic mechanisms of each of these prenatal phenomena, in an attempt to explain the role of the prenatal environment in promoting postnatal weight gain. This information will contribute to resolving the nature-nurture controversy. This information provides guidance to clinical practitioners involved in both prenatal and postnatal care. This volume further stimulates research into underlying mechanisms and prevention and treatment of this phenomenon.
Obesity During Pregnancy in Clinical Practice
by Wanda Nicholson Kesha Baptiste-RobertsThis book summarizes the effects of overweight/obesity in the childbearing years that can be effectively communicated to patients by their providers in a busy practice setting, and provides concise and understandable summaries of the evidence-based, theory-driven lifestyle interventions that have been shown to be effective for weight loss and modifying the risk of developing diabetes and obesity.
Obesity Interventions in Underserved Communities: Evidence and Directions
by Virginia M. Brennan, Shiriki K. Kumanyika and Ruth Enid ZambranaGroundbreaking approaches to preventing and reducing obesity among minority, low-income, and other medically underserved communities in the United States.The obesity epidemic has a disproportionate impact on communities that are hard-hit by social and economic disadvantages. In Obesity Interventions in Underserved Communities, a diverse group of researchers explores effective models for treating and preventing obesity in such communities. The volume provides overviews of the literature at specific junctures of society and health (e.g., the effectiveness of preschool obesity prevention programs), as well as commentaries that shape our understanding of particular parts of the obesity epidemic and field reports on innovative approaches to combating obesity in racial/ethnic minority and other medically underserved populations in the United States. Authors make specific recommendations to policy makers which are designed to reverse the rising rate of obesity dramatically. The thirty-one literature reviews, commentaries, and field reports collected here address obesity prevention and treatment programs implemented across a spectrum of underserved populations, with particular attention paid to children and adolescents. Aimed at students, clinicians, and community workers in public health and health policy, as well as family medicine and pediatrics, sociology, childhood education, and nutrition—and deeply informed by fieldwork—this book demonstrates the importance of taking a full contextual view, both historical and current, when considering the challenge of reversing upward obesity trends among ethnic minorities, impoverished people, and other underserved populations.
Obesity Management: A Clinical Casebook
by Louis J. Aronne Rekha B. KumarComprised exclusively of clinical cases illustrating current strategies for obesity management across various types of conditions, this concise, practical casebook will provide obesity medicine specialists and all physicians who treat obesity with the best real-world strategies to properly diagnose and treat patients struggling with weight management. Each section includes a pair of cases that open with a unique clinical presentation, followed by a description of the diagnosis, assessment and management technique recommended and employed, as well as the case outcome and clinical pearls and pitfalls. Cases included in the first sections depict issues involved in obesity management in metabolic syndrome, cardiovascular disease, insulin resistance syndromes, genetic predisposition, and type 2 diabetes. Subsequent sections present cases highlighting particular management strategies, such as psychiatric medication induced weight gain, behavioral interventions, bariatric surgery and pharmacotherapy for obesity. Pragmatic and reader-friendly, Obesity Management: A Clinical Casebook is an excellent resource for physicians who treat overweight and obesity and the complications of these conditions.
Obesity Medicine Made Easy
by Ananda ChatterjeeObesity is a complex disease, and this brief resource offers a comprehensive review of the most recent evidence on the multitude of ways to help treat this condition. Practically oriented for the reader to understand and easily apply the knowledge to patients, it specifically focuses on the lifestyle medicine approach to obesity management. This means applying the science of nutrition, movement, sleep, and stress with the help of cognitive behavioural therapy, motivational interviewing skills, positive psychology, and the circadian rhythm. This approach is combined with information on anti-obesity medications and bariatric surgery in a concise manner, immensely useful for the busy clinician. Key Features:• Captures the attention of the readers through a concise, lucid style of text and its organization.• Offers clarity on a common yet complex topic to physicians, dieticians, nurse practitioners and healthcare providers, leading to a change in practice and helping patients improve their weight which would impact underlying medical conditions.• Includes a comprehensive approach to management which combines the importance of medication, lifestyle habits and behavioural change.
Obesity and Breast Cancer
by Kristy A. Brown Evan R. SimpsonObesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research.
Obesity and Cancer
by Tobias Pischon Katharina NimptschThis book provides a comprehensive and up-to-date review of the relationship between obesity and cancer. It opens with a global perspective on obesity and cancer incidence, followed by in-depth discussions of those cancers for which we have sufficient evidence of a causal relationship with obesity. It addresses topics such as the effects of obesity on cancer incidence and cancer survival, the effects of weight gain and weight loss in adulthood on cancer risk, the effects of childhood and adolescent obesity, and the role of body fat distribution in cancer risk. Individual chapters discuss potential pathways for the observed associations and explore possible mechanisms from both an epidemiological and an experimental perspective. It concludes with a population perspective on the cancer risk that is attributable to obesity and is thus potentially avoidable. This book is of particular value to researchers and epidemiologists and is also of interest to public health workers and clinicians.
Obesity and Cancer
by Sanjay Gupta Shashank KumarThis book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry.
Obesity and Cardiovascular Disease (Fundamental and Clinical Cardiology)
by Malcolm K. Robinson Abraham ThomasAlthough cardiovascular disease remains the leading proximate cause of death in the United States, it is now estimated that obesity may be equivalent to smoking as the leading cause of preventable death in America. In light of these statistics, this reference presents our current understanding of the epidemiology, pathology, and genetics of the obe
Obesity and Diabetes
by Joel Faintuch Salomão FaintuchThis timely and clinically oriented book uniquely addresses the entire spectrum of treatment for severe obesity and diabetes. It thoroughly examines all aspects from robotic surgery to cell therapy, from the latest antidiabetic drugs to endoscopic procedures and devices, from appetite-inhibiting signals and nutrients to gastric arterial embolization. It offers objective and authoritative information for practicing professionals; not only are successful interventions discussed and updated, but cutting-edge and experimental pathways are also anticipated. Obesity is the foremost nutritional challenge worldwide. Its companion is type-2 diabetes, the most prevalent metabolic disease. Together they represent the diabesity epidemic, which is draining resources, overwhelming healthcare facilities, and impacting life expectancy and quality of life everywhere. No country has been spared, and most medical specialties have been affected. Many books focus on the surgical options for obesity and diabetes, namely bariatric and metabolic operations. Information on the clinical and pharmacological treatment is also available, conveyed by standard texts on internal medicine and endocrinology. Yet endoscopic maneuvers and prostheses, cell therapy for diabetes, and other innovative approaches are hard to come by, as conventional texts overlook such therapies. This timely publication bridges the gaps between all different therapeutic options, also covering advances in the conservative, surgical and parasurgical domains. This book will appeal to seasoned specialists, students and healthcare professionals in training alike.
Obesity and Diabetes Mellitus
by E. I. SokolovThis book is the result of the study of metabolic and hormonal disorders in patients suffering obesity and diabetes mellitus, focusing on mechanisms of formation of atherosclerotic changes in the myocardium and vessels in diabetes mellitus patient.
Obesity and Diabetes: Scientific Advances and Best Practice
by Joel Faintuch Salomão FaintuchNow in its second edition, this comprehensive handbook provides a state-of-the-art overview of recent advances in drug and non-drug therapies for obesity and diabetes. It also addresses major comorbidities, covering topics such as, cardiovascular diseases, renal and neuropsychiatric disorders, appetite control and micro RNAs. Special attention is also devoted to pediatric care, including the latest recommendations for therapy and prevention. Obesity and type 2 diabetes are among the top global health-care budget concerns worldwide and impact professional practice at all levels: in hospitals, clinics and physicians’ offices alike. They prominently feature in headlines, and virtually no family, community or country is exempt from their protean, deleterious consequences. Furthermore, given the multiple intersections in their pathways, they often go hand in hand.The good news is that scientific advances in all fields, including genomics, metabolomics, lipidomics and microbiomics, are increasing our understanding of these two disease areas. At the same time, artificial intelligence, machine learning, mobile health and advanced implantable and external devices are rendering prevention and management more available, safe and cost-effective. In addition, bariatric and metabolic surgery has evolved from a niche specialty to an officially endorsed option for several modalities of obesity and diabetes. This book presents the latest lifestyle, pharmacological, surgical and non-surgical treatment options, including endoscopic intervention and cell therapy. Objectively reviewing natural and artificial sweeteners and critically examining issues such as public health initiatives, government mandated taxes for unhealthy foods and environmental planning, no stone is left unturned in gathering the latest practical information. As such, the book will appeal to seasoned specialists, as well as students and healthcare professionals in training.
Obesity and Fertility
by Emily S. JungheimThis book outlines the current understanding of how obesity affects female reproductive function across the lifespan. Topics include physiology of the menstrual cycle and early pregnancy, best practices in the delivery of contraceptive and prenatal care and healthcare policy that weighs the evidence in appropriate balance with principles that respect women's rights. Special attention is devoted to the idea that obesity's adverse effects are likely trans-generational; that is, children born to obese mothers are at increased risk for obesity, diabetes and cardiovascular disease later in life. Patients and their physicians need to be aware of the additional risks obesity confers in pregnancy and outline a plan of care that includes counseling preconceptionally, antepartum, intrapartum and postpartum in order to decrease morbidity. Obesity and Fertility provides advice for reproductive medicine physicians and gynecologists to help guide obese patients toward improved reproductive health and outcomes.
Obesity and Lipotoxicity
by Atilla Engin Ayse Basak EnginDue to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. "Obesity and Lipotoxicity" is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. "Lipotoxicity and Obesity" will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.
Obesity and Lipotoxicity (Advances in Experimental Medicine and Biology #1460)
by Atilla Engin Ayse Basak EnginThis book is a comprehensive review of the recent research on the lipotoxicity-related mechanisms in obesity and the development of new treatment strategies. In this second edition, the possible molecular treatment methods and their recent clinical approaches are discussed in addition to the basic mechanisms that are available and thoroughly reviewed previously. Moreover, all chapters have been reviewed, according to the current concepts and seven new chapters are added, covering obesity-related epigenetic modifications, senescence, obesity-related cancer development, endocrine disruptors, as well as nanotechnology-based clinical approaches. This book is an essential resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, and cardiologists, as well as all researchers or students who want to learn the mysteries of obesity.
Obesity and Lung Disease
by Emmanuelle M. Clerisme-Beaty Anne E. DixonAs a result of the rapidly growing rate of obesity worldwide, clinicians are struggling to provide the best strategies for treating obese patients with concomitant pulmonary conditions. Obesity does not simply change the epidemiology of pulmonary disease; obesity has a profound impact on the pathophysiology of common pulmonary diseases. Obesity affects the severity of asthma, response to treatment, and is likely a major modifier of the phenotype of asthma. Obesity also appears to affect response to pathogens, and as such has a major influence on response to pneumonia, and has a significant impact on outcomes pertaining to acute lung injury in the intensive care unit. Obesity and Lung Disease: A Guide to Management is the first text in the field to cover the full range of issues related to managing obese patients with pulmonary problems. All the relevant conditions, in the context of obesity, are covered, including airway inflammation, sleep apnea, asthma, pulmonary hypertension, obesity hypoventilation, as well as others. Written by an international group of experts, this important new volume is an invaluable resource for all clinicians and scientists concerned with the challenging problems surrounding obesity and lung diseases.
Obesity and Lung Disease: A Guide to Pathophysiology, Evaluation, and Management (Respiratory Medicine)
by Anne E. Dixon Erick FornoThis new edition provides a fully updated guide to obesity’s relation to lung disease. Over forty percent of the U.S. population is obese, and obesity is increasing in much of the world. Obesity has a major impact on health conditions such as diabetes and cardiovascular disease. The effects of obesity on lung disease have drawn increasing attention in recent years. Furthermore, the COVID pandemic has dramatically illustrated how obesity affects respiratory disease, constitutes a major risk factor for COVID-19, and presents challenges to pulmonary care in the ICU. Obesity changes physiology, immune and metabolic function, and is associated with changes in diet and the microbiome, all of which combine to have a major impact on the pathogenesis of respiratory diseases. Obesity is thus a risk factor for many respiratory diseases such as asthma, pulmonary hypertension, thromboembolic disease, obstructive sleep apnea and ARDS. Obesity also complicates the management of manyother respiratory diseases and conditions such as COPD, thromboembolic disease, and the care of the critically ill patient.The objectives of this book are three-fold: To review how physiological, immune and metabolic factors might contribute to lung disease. To discuss the impact of obesity on common lung diseasesTo outline important considerations in the management of critically ill obese patients. There have been major advances in our understanding of the relationship between obesity and lung disease since the first edition in 2013, in addition to the major lessons learned about the importance of obesity during the COVID-19 pandemic. This has led to the addition of eight new chapters on topics such as, the microbiome, lung transplant, and COVID-19 in the ICU. This is an ideal guide for all clinicians taking care of patients with pulmonary and critical care diseases, as well as basic and translational scientists interested in how obesity affects respiratory health.
Obesity and Mental Disorders
by George A. Bray David B. Allison Susan L. McElroyCurrently, there are a limited amount of guidelines to help clinicians manage patients with obesity and comorbid mental disorders. This expertly written source fills the gap in the literature by providing a clear overview of obesity and its relationship to mental illness while reviewing the most recent methods to manage and control the condition wi
Obesity and Metabolic Surgery
by Jürgen Ordemann Ulf ElbeltThis book presents the surgical therapy of obesity and metabolic diseases in a practice-oriented and detailed way. The specific surgical procedures with their indications, performance and risks are described precisely in words and pictures. Special emphasis is placed on the choice of the appropriate surgical procedure for the individual patient. In addition to the mechanisms of action, interdisciplinary preoperative evaluation of the patient and postoperative aftercare are explained. Furthermore, surgical, internal and psychosomatic complications and complication management are described. Information on obesity center organization and alternative bariatric therapies complete the volume.This book is a translation of the original German 1st edition Adipositas- und metabolische Chirurgie by Jürgen Ordemann & Ulf Elbelt, published by Springer-Verlag GmbH Germany, part of Springer Nature in 2017. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.
Obesity and Overeating: Research Fundamentals (Life Science Research Fundamentals)
by WileyWith the increasing worldwide incidence of obesity and the resulting increase in metabolic disorders such as diabetes, cardiovascular diseases and some cancers, an understanding of the multitude of factors that contribute to obesity is crucial for researchers to develop more effective treatments. This collection of overviews and protocols provides the reader with an introduction to the major features of obesity research, including the interplay between energy balance, hormones and neurobiological networks. An overview is provided which describes the animal models of obesity most commonly utilized in research. A standardized laboratory protocol for producing diet?]induced obesity (DIO) in both mouse and rat is provided as are protocols that describe how diet formulation can be modified to generate mouse models of human metabolic pathologies. Protocols are also provided for testing the effects of dietary manipulations, caloric restriction and potential therapeutics. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of obesity research for students or interdisciplinary collaborators.
Obesity and Pregnancy
by Margaret Rees Louis Keith M A KaroshiUnlike other areas of medicine where statistics are meticulously kept by governments and global organizations, there are no accurate data to describe the number of the world's inhabitants who are overweight, obese, or morbidly obese. Despite this knowledge deficit, it should come as no surprise to readers that the medical community is facing an epidemic. Obesity is present in many of the developed countries and can also be observed in some urban areas of developing nations. The cause of this epidemic, simply stated, is overeating, but the overriding concern is more complex. Social factors, such as growing affluence since the 1950s, increasing reliance on pre-prepared meals, and the popularity of fast foods and sweetened drinks, have all contributed to the problem.Without doubt, the obesity epidemic has had adverse effects on both men and women, but in the case of women, some of its worse complications occur with those who are severely obese and pregnant. Obviously, this combination has been seen in the past, but it has increased so dramatically in its frequency that research has yet to catch up. Studies may discuss one or another aspect of caring for the obese pregnant patient, but until now, there has been no attempt to draw all such material together to try and present a comprehensive appraisal of the problem.Written by international experts, this practical guide draws on evidence-based material and is an invaluable resource for healthcare professionals dealing with obese pregnant women on a day-to-day basis.
Obesity and its Impact on Health
by Methil Kannan Kutty Asita ElengoeThis book summarizes the effects of obesity on health and its correlation with a wide range of debilitating and life-threatening conditions in humans. It discusses the possible pathological mechanisms that are involved in the development of obesity and highlights obesity-associated molecular mechanisms that contribute to reproductive dysfunctions in men and women. The book provides mechanistic insights on the role of obesity in cardiovascular and respiratory disorders, and examines the role of the complementary molecular mechanism of the gut microbiota in the development of obesity. It also reviews the interaction between the metabolic system and immune cells in the pathogenesis of obesity-associated diseases. Lastly, it assesses the latest advances in nanomedicine as an emerging strategy for the treatment of obesity.
Obesity in Canada: Critical Perspectives
by Wendy Mitchinson By Jenny Ellison Deborah McphailMedical professionals, social policy makers, and the media have all declared that Canada is in the grip of an obesity epidemic. Conceptualizing obesity as a biological condition, these experts insist that it needs to be "prevented" and "managed. " Obesity in Canada takes a broader, critical perspective of our supposed epidemic. Examining obesity in its cultural and historical context, the book's contributors ask how we measure health and wellness, where our attitudes to obesity develop from, and what the consequences are of naming and targeting as "obese" those who body weights do not match our expectations. A broad survey of the issues surrounding the obesity panic in Canada, it is the first collection of fat studies and critical obesity studies from a distinctly Canadian perspective.
Obesity in the 21st Century
by Alfred PoulosIn recent years, the focus of obesity prevention has been on diet. However, diet is only one of many factors which play a role in the development of obesity. This book looks at these factors and the latest research on how they contribute to the development of obesity, and the many different methods that have been and are being used to treat and prevent obesity. Written in an accessible language, this book provides the latest and most up to date information on research into the causes, health consequences and treatment of obesity. It educates and advocates for healthier lifestyles, a better understanding of diets and weight loss programs, and associated chronic diseases. It is written for everyone interested in obesity and enables the reader to take informed action to reduce the likelihood of putting on weight and the risk of developing chronic illnesses.