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Oligonucleotide-Based Therapies: Methods and Protocols (Methods in Molecular Biology #2036)
by Olof Gissberg Rula Zain Karin E. LundinThis book provides a collection of comprehensive, up-to-date, and broadly applicable guides to the research and development fields of oligonucleotide (ON) therapeutics. Covering topics from the study of antisense and anti-gene effects to oligonucleotides in the context of drug discovery and development, the volume explores a wide-ranging and useful spectrum of methods and protocols needed to take full advantage of therapeutic applications involving ONs. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Oligonucleotide-Based Therapies: Methods and Protocols aims to be a great aid in the laboratory as well as an ideal reference guide when designing antisense and anti-gene oligonucleotides for therapeutic applications.
Oligosaccharides of Chitin and Chitosan: Bio-manufacture and Applications
by Liming ZhaoThe book provides an overview of bio-manufacturing techniques for the production, purification, characterization and modification of chito/chitin oligosaccharides and their monomers. In addition, it explores potential applications in the food, biomedical and agricultural industry on the basis of their bioactivities and biomaterial properties. Lastly, it shares a range of cutting-edge insights to help solve problems in industrial processes and promote further academic investigation. Given its scope, it offers a valuable resource for researchers and graduate students in the fields of bioengineering, food science, biochemistry, etc.
Olive Oil: Minor Constituents and Health
by Dimitrios BoskouEpidemiological studies indicate that the consumption of natural antioxidants from such plant-derived sources as olive oil produces beneficial health effects. Olive Oil: Minor Constituents and Health provides a balanced understanding of the pharmacological properties of phenols and other bioactive ingredients in the composition of olive oil. It dis
Oliver Sacks: The Last Interview
by Oliver SacksAn extraordinary collection of interviews with the beloved doctor and author, whose research and books inspired generations of readers.Oliver Sacks--called "the poet laureate of medicine" by the New York Times--illuminated the mysteries of the brain for a wide audience in a series of richly acclaimed books, including Awakenings and The Man Who Mistook His Wife for a Hat, and numerous The New Yorker articles. In this collection of interviews, Sacks is at his most candid and disarming, rich with insights about his life and work. Any reader of Oliver Sacks will find in this book an entirely new way of looking at a brilliant writer.
Olivia: My Life of Exile in Kalaupapa
by Olivia Robello BreithaOlivia Robello Breitha was diagnosed with Hansen's disease (leprosy) when she was a young woman in the 1930s. At the time, there was no treatment for the disease and in Hawaii many people with leprosy were exiled to Kalaupapa, a community on the island of Molokai. Breitha, who had a 6th grade education, wrote her powerful story about living with the disease. At times they were treated inhumanely, mostly by doctors and medical professionals, and Breitha was unafraid to fight for patient rights and reducing stigma.
Omega Balance: Nutritional Power for a Happier, Healthier Life (A Johns Hopkins Press Health Book)
by Anthony John HulbertLearn how to live a happier and healthier life by finding the right balance of omega fatty acids in your diet.Omega-3 and omega-6 fatty acids are essential in the human diet. In Omega Balance, noted scientist Anthony J. Hulbert explains how the balance between these fatty acids in the human food chain has changed over the last half-century and the very serious negative health impacts this imbalance has created. An imbalance of these omega fats contributes to increased rates of obesity, diabetes, cardiovascular diseases, allergies, asthma, as well as cancer and a variety of other inflammatory diseases. Omega balance is also important for normal brain function, and an imbalance in these fatty acids is associated with depression, mood disorders, and neurodegenerative diseases. Hulbert provides extensive information on the omega balance of different foods and discusses fascinating details about human evolution, dietary changes throughout history, the effect of diet on human development and physiological processes, and more. He investigates the paleo diet of our ancestors and describes the dramatic changes that have accompanied the increased ultra-processing of modern foods. Omega Balance is an essential guide to understanding a significant problem in our modern food chain and will make us rethink the food we eat.
Omega-3 Fatty Acids
by Mahabaleshwar V. Hegde Anand Arvind Zanwar Sharad P. AdekarThis volume argues for the importance of essential nutrients in our diet. Over the last two decades there has been an explosion of research on the relationship of Omega-3 fatty acids and the importance of antioxidants to human health. Expert authors discuss the importance of a diet rich in Omega-3 Fatty acids for successful human growth and development and for the prevention of disease. Chapters highlight their contribution to the prevention and amelioration of a wide range of conditions such as heart disease, diabetes, arthritis, cancer, obesity, mental health and bone health. An indispensable text designed for nutritionists, dietitians, clinicians and health related professionals, Omega-3 Fatty Acids: Keys to Nutritional Health presents a comprehensive assessment of the current knowledge about the nutritional effects of Omega-3 fatty acids and their delivery in foods.
Omega-3 Fatty Acids and the DHA Principle
by Raymond C. Valentine David L. ValentineThe physical-chemical properties of the omega-3 fatty acid DHA (docosahexaenoic acid) enable it to facilitate rapid biochemical processes in the membrane. This effect has numerous benefits, including those involved in the growth of bacteria, rapid energy generation, human vision, brain impulse, and photosynthesis, to name a few. Yet DHA also carrie
Omega-3 Fatty Acids in Health and Disease
by Robert S. LeesA report from research in the MIT Sea Grant College Program. Discusses the relationship between particular fatty acids found only in fish oil, and human health. Presents and evaluates information on the health effects of dietary fats generally; evidence that fish oil consumption affects the incidenc
Omega-3 Fatty Acids: Keys to Nutritional Health and Disease
by Mahabaleshwar V. Hegde Anand Arvind Zanwar Sharad P. AdekarThis book argues for the importance of omega-3 fatty acids in our diet. Omega-3 fatty acids are a must in our daily diet, as the human body cannot synthesize it. The human body is crippled in evolution; we are deprived of the genes that are needed to synthesize these vital molecules. Except for regular fish eaters, the majority of the human population does not get adequate omega-3 fatty acid in their food. Fatty acids provide a structural framework for cells, tissues, and organs, as well as the building blocks for several bioactive ingredients, and they provide a wide range of benefits from general improvements in health to protection against inflammation and disease. Omega-3 Fatty Acids discusses various sources of omega-3 fatty acid, health implications of omega-3 fatty acid intake, and remedial measures that can improve diet for those lacking in fatty acids. The book opens with a discussion of various sources of omega-3 fatty acids, such as flaxseed, milk, eggs, and marine algae. Following this, is a detailed discussion of the effect omega-3 intake has on different conditions, like pregnancy, psoriasis, aging disorders, cardiovascular events, obesity, and non-communicable diseases, such as diabetes and Alzheimer’s. This much-expanded edition includes new chapters on topics such as the linoleic-to-linolenic dietary intake ratio, the role of omega-3 fatty acids in eye health, the effects of omega-3 fatty acids on metabolic syndrome and fatty liver disease, and the influence of omega-3 fatty acids on bone turnover and energy metabolism. An indispensable text designed for nutritionists, dietitians, clinicians and health-related professionals, Omega-3 Fatty Acids presents a comprehensive assessment of the current knowledge about the nutritional effects of omega-3 fatty acids and their delivery in foods.
Omega-6/3 Fatty Acids
by Ronald Ross Watson Sherma Zibadi Fabien De MeesterOver the last several years developing human research suggests that a component of omega-3 fatty acids, long chain ones, contribute particularly to health benefits. Omega-6/3 Fatty Acids: Functions, Sustainability Strategies and Perspectives focuses on developing information on this newly recognized key component. This volume uniquely, and for the first time, focuses on sustainability of natural sources of omega-3 fatty acids variants including long chain ones, and on ways to increase their use and availability to reduce major diseases. The authors review cardiovascular disease, neurological changes and mental health and other diseases like diabetes where long chain omega-3 fatty acids play protective roles from recent human trials. Each chapter evaluates developing information on the possible mechanistic role of long chain omega-3 fatty acids. After showing their requirement and involvement in health promotion there are reviews of various sources and ways to protect and promote them. Authors provide support for the benefits and sources of long chain omega-3 fatty acids and their increased dietary intake that reduce various physical and mental illnesses. Omega-6/3 Fatty Acids: Functions, Sustainability and Perspectives is a unique and important new volume that provides the latest data and reviews to physicians who need to assess serum omega-6/3 and fatty acids to help diagnose risks and change diets and to inform industry and the scientific community with reviews of research for actions including new studies and therapies.
Omgaan met een scheiding
by J.P. van de Ven BVEr gaan in Nederland elke dag driehonderd stellen uit elkaar (dit zijn op jaarbasis 219. 000 mensen). Zij raken veelal verwikkeld in het afhandelen van allerhande juridische en praktische zaken. Maar over gevoelens zoals verwarring, angst, woede, wantrouwen, jaloezie, verdriet, opluchting, schuld en schaamte die met een scheiding gepaard gaan, en over hoe je daarmee omgaat is weinig informatie voorhanden. Het boek omgaan met een scheiding voorziet hierin. Het behandelt de gevolgen van een scheiding op emotioneel, mentaal en sociaal gebied.
Omgaan met hoogtevrees.
by S. J. Swaen Vogelbescheming Nederland W. A. Sterk IpzoHoogtevrees is een van de bekendste vormen van angst. De klachten treden niet alleen op grote hoogtes op. Sommige mensen durven bijvoorbeeld niet in diep helder water te zwemmen of hebben moeite om naar een kerktoren op te kijken. Iedereen heeft in zekere mate last van hoogtevrees. Hoogtes kunnen gevaarlijk zijn en het is dan ook logisch om op grote hoogte op je hoede te zijn. Maar wanneer de angst uit de hand loopt en je bang wordt in situaties die geen angst hoeven op te wekken, dan belemmert de hoogtevrees je dagelijks leven. Mensen met hoogtevrees gaan immers steeds meer situaties uit de weg waarin ze met hoogteverschillen te maken kunnen krijgen. Overmatige hoogtevrees is daarom een vervelende klacht, maar doorgaans goed te verhelpen. Dit boek laat zien dat iedereen met wat motivatie, begeleiding en tijdsinvestering zijn hoogtevrees onder controle kan krijgen. Hierbij wordt uitgegaan van de principes van de gedragstherapie. Door de stapsgewijze beschrijving van de gedragstherapeutische weg met duidelijke tips en opdrachten is Omgaan met hoogtevrees een waardevol zelfhulpboek. De heldere beschrijvingen van andere therapieën met een indicatie van de effectiviteit ervan maken het ook een handige wegwijzer voor wie liever een beroep doet op de hulpverlening. Omgaan met hoogtevrees verschijnt in de reeks Van A tot ggZ.
Omgaan met onverklaarde lichamelijke klachten
by A. Blok J. HoutveenInformatief boek voor mensen met onverklaarde lichamelijke klachten.
Omgaan met slaapproblemen
by C. Kluft G. KerkhofBijna een derde van de Nederlandse bevolking heeft regelmatig of vaak last van slapeloosheid. Slapeloosheid houdt in dat je moeite hebt om in slaap te komen en lang wakker ligt. Ook kan het voorkomen dat je in de loop van de nacht meerdere malen wakker wordt. We spreken van een slaapprobleem wanneer de slapeloosheid niet vanzelf overgaat en klachten oplevert in het functioneren overdag. Wat zijn de kenmerken van chronische slapeloosheid? Wat zijn veelvoorkomende oorzaken? En welke behandelmethoden kunnen toegepast worden? De auteurs geven antwoord op deze vragen, en laten zien wat cognitieve gedragstherapie voor insomnie inhoudt. Zij nemen het slaapgedrag onder de loep en bespreken mogelijke aanpassingen, met het doel om de kans op goed in- en doorslapen te vergroten. Omgaan met slapeloosheid is een nieuw deel in de reeks Van A tot ggZ. Deze reeks is geschikt voor iedereen die te maken heeft met psychische of sociale problemen, zowel voor de betrokkenen zelf als voor de omgeving. De boeken worden veelvuldig gebruikt door (huis)artsen, psychologen, psychiaters, psychotherapeuten, hulpverleners, maatschappelijk werkers en andere professionals in de gezondheidszorg. Niet alleen om zelf meer inzicht te krijgen in de verschillende problemen en hoe mensen deze beleven, maar vooral om hun cliënten voor te lichten.
Omgaan met stress en burnout
by Bart Verkuil Arnold Van EmmerikStress is vaak erg nuttig. Wie kent niet de gezonde spanning die vooraf gaat aan het leveren van een belangrijke prestatie? Door de stress presteer je vaak nét iets beter. Diezelfde stress zorgt er ook voor dat je in gevaarlijke situaties de kracht vindt om in actie te komen: om te vluchten of om je te verdedigen. Stress speelt dus een duidelijke rol in ons vermogen te overleven. Maar soms lukt het niet om stress om te zetten in actie. De spanning maakt dan geen plaats voor voldoening of opluchting, maar blijft langdurig hangen. Dat is vervelend en kan ook gevaarlijk zijn. Die ongezonde stress kost namelijk veel energie en kan uiteindelijk leiden tot overspannenheid, burnout en zelfs depressie. Omgaan met stress en burnout laat zien hoe je in zo'n situatie terecht kunt komen en leert je uit te zoeken welke activiteiten jou energie kosten en welke je juist energie opleveren. Je leert prioriteiten te stellen en voor jezelf op te komen. De auteurs beschrijven hoe je met je gedachten je gevoel beïnvloedt en geven diverse technieken waarmee je kunt ontspannen en de controle leert houden over je gedachten. De praktische tips en oefeningen uit dit boek helpen je zo om ongezonde stress te verminderen en je leven (weer) in balans te brengen.
Omics Applications for Systems Biology (Advances in Experimental Medicine and Biology #1102)
by Wan Mohd Aizat Hoe-Han Goh Syarul Nataqain BaharumThis book explains omics at the most basic level, including how this new concept can be properly utilized in molecular and systems biology research. Most reviews and books on this topic have mainly focused on the technicalities and complexity of each omics’ platform, impeding readers to wholly understand its fundamentals and applications. This book tackles such gap and will be most beneficial to novice in this area, university students and even researchers. Basic workflow and practical guidance in each omics are also described, such that scientists can properly design their experimentation effectively. Furthermore, how each omics platform has been conducted in our institute (INBIOSIS) is also detailed, a comprehensive example on this topic to further enhance readers’ understanding. The contributors of each chapter have utilized the platforms in various manner within their own research and beyond. The contributors have also been interactively integrated and combined these different omics approaches in their research, being able to systematically write each chapter with the conscious knowledge of other inter-relating topics of omics. The potential readers and audience of this book can come from undergraduate and postgraduate students who wish to extend their comprehension in the topics of molecular biology and big data analysis using omics platforms. Furthermore, researchers and scientists whom may have expertise in basic molecular biology can extend their experimentation using the omics technologies and workflow outlined in this book, benefiting their research in the long run.
Omics Approaches for Sugarcane Crop Improvement
by Rajarshi Kumar GaurIn this book, the information encompasses various researchable biotechnology aspects of sugarcane, its genomic structure, diversity, comparative and structural genomics, data mining, etc. This book explores both the theoretical and practical aspects of sugarcane crops, focusing on innovative processes. This book argues in favor of developing an integrated research and development system to strengthen the research and development capabilities of all the areas of sugarcane. Further, it covers the recent trends of sugarcane biotechnology, especially in the next-generation sequencing (NGS) era. This book will be very useful for professors and scientists who are working in the area of sugarcane crops by using molecular biology and bioinformatics. It is also useful for students to use as a reference for their classes or thesis projects. Key features: • Discusses an integral part of molecular biology and pivotal tools for molecular breeding; enables breeders to design cost-effective and efficient breeding strategies for sugarcane • Discusses the harnessing genomics technologies for genetic engineering and pathogen characterization and diagnosis of sugarcane • Provides new examples and problems, added where needed • Provides insight from contributors drawn from around the globe
Omics Approaches in Breast Cancer
by Debmalya BarhBreast cancer is the most common cancer in females that accounts for highest cancer specific deaths worldwide. In the last few decades research has proven that breast cancer can be treated if diagnosed at early stages and proper therapeutic strategy is adopted. Omics-based recent approaches have unveiled the molecular mechanism behind the breast tumorigenesis and aid in identification of next-generation molecular markers for early diagnosis, prognosis and even the effective targeted therapy. Significant development has taken place in the field of omics in breast cancer in the last decade. The most promising omics approaches and their outcomes in breast cancer have been presented in this book for the first time. The book covers omics technologies and budding fields such as breast cancer miRNA, lipidomics, epigenomics, proteomics, nutrigenomics, stem cell, pharmacogenomics and personalized medicine and many more along with conventional topics such as breast cancer management etc. It is a research-based reference book useful for clinician-scientists, researchers, geneticists and health care industries involved in various aspects of breast cancer. The book will also be useful for students of biomedicine, pathology and pharmacy.
Omics Approaches in Veterinary Parasitology: Diagnosis, Biomarkers, and Drug Development
by Muhammad Sohail Sajid and Hafiz Muhammad RizwanOmics Approaches in Veterinary Parasitology: Diagnosis, Biomarkers, and Drug Development explores applications of omics approaches for diagnosis, biomarker discovery, and drug development against parasites of veterinary importance. It presents the fundamental principles of parasite biology and their complex physiological processes. The chapters review key aspects such as parasite life cycles, host-parasite interactions, and the molecular mechanisms that underlie parasitic diseases. The subsequent chapters delve into the principles and applications of genomics, transcriptomics, proteomics, and metabolomics in understanding parasites at a molecular level. The use of next-generation sequencing, PCR-based assays, and metagenomics in identifying and characterizing parasites for accurate and efficient diagnosis are also covered in detail. Toward the end, the book focuses on target identification, drug repurposing, and the optimization of drug efficacy while minimizing drug resistance using omics data. The book is useful for researchers, students, and professionals in the field of veterinary parasitology.
Omics Approaches to Understanding Muscle Biology (Methods in Physiology)
by Jatin George Burniston Yi-Wen ChenThis book is a collection of principles and current practices in omics research, applied to skeletal muscle physiology and disorders. The various sections are categorized according to the level of biological organization, namely, genomics (DNA), transcriptomics (RNA), proteomics (protein), and metabolomics (metabolite). With skeletal muscle as the unifying theme, and featuring contributions from leading experts in this traditional field of research, it highlights the importance of skeletal muscle tissue in human development, health and successful ageing. It also discusses other fascinating topics like developmental biology, muscular dystrophies, exercise, insulin resistance and atrophy due to disuse, ageing or other muscle diseases, conveying the vast opportunities for generating new hypotheses as well as testing existing hypotheses by combining high-throughput techniques with proper experiment designs, bioinformatics and statistical analyses. Presenting the latest research techniques, this book is a valuable resource for the physiology community, particularly researchers and grad students who want to explore the new opportunities for omics technologies in basic physiology research.
Omics Technologies and Crop Improvement
by Noureddine BenkebliaIncreased world population, decreased water supply, and climate change all put stresses on the global food supply. An exploration of the challenges and possible solutions to improve yields of the main crops, such as cereals, roots, tubers, and grasses, Omics Technologies and Crop Improvement reviews data on food sciences and omics. The book covers
Omics for Environmental Engineering and Microbiology Systems
by Vineet KumarBioremediation using microbes is a sustainable technology for biodegradation of target compounds, and an omics approach gives more clarity on these microbial communities. This book provides insights into the complex behavior of microbial communities and identifies enzymes/metabolites and their degradation pathways. It describes the application of microbes and their derivatives for the bioremediation of potentially toxic and novel compounds. It highlights the existing technologies along with industrial practices and real-life case studies. Features: Includes recent research and development in the areas of omics and microbial bioremediation. Covers the broad environmental pollution control approaches such as metagenomics, metabolomics, fluxomics, bioremediation, and biodegradation of industrial wastes. Reviews metagenomics and waste management, and recycling for environmental cleanup. Describes the metagenomic methodologies and best practices, from sample collection to data analysis for taxonomies. Explores various microbial degradation pathways and detoxification mechanisms for organic and inorganic contaminants of wastewater with their gene expression. This book is aimed at graduate students and researchers in environmental engineering, soil remediation, hazardous waste management, environmental modeling, and wastewater treatment.
Omphaloplasty: A Surgical Guide Of The Umbilicus
by William L. MurilloThis book offers an essential guide to surgical approaches to the umbilicus. The navel is the only natural scar in the body, accepted for all human beings all over the world. Its absence or distortions can have negative psychological impacts, as it normally lends beauty and harmony to the otherwise unattractive abdomen. The aesthetic importance of the navel justifies the increasing amount of individuals undergoing abdominoplasty and omphaloplasty. However, these surgeries may lead to a series of complications or unintended aesthetic outcomes. Indeed, the postsurgical final aspect of the umbilicus is the main stigma and primary source of problems and complaints following abdominoplasty. In this book readers will find a complete surgical guide to the most important surgical approaches and strategies related to the navel, helping them to deliver a high standard of quality and patient-tailored surgical and aesthetic outcomes. Written by a renowned plastic surgeons with more than 20 years of experience, Omphaloplasty - A Surgical Guide of the Umbilicus offers readers an overview of general and innovative surgical techniques for the umbilicus, helping them to make the best choice when performing abdominoplasties.
On All Frontiers: Four Centuries of Canadian Nursing
by Christina Bates, Dianne Dodd & Nicole RousseauNursing has a long and varied history in Canada. Since the founding of the first hospital by the Augustine nuns in 1637, nurses have contributed greatly to Canadians' quality of life.On All Frontiers is a comprehensive history of Canadian nursing. Editors Christina Bates, Dianne Dodd, and Nicole Rousseau have brought together a vast body of research into one volume. Authored by leading experts, the chapters and vignettes form an overview of the history of Canadian nursing to date.From the midwives of early Canada to urban public health nurses, from remote outposts to the battlefields of Europe, On All Frontiers documents the hardships, challenges, and achievements of Canadian nurses. Richly illustrated with archival photographs, it will prove essential to scholars of Canadian health care history.