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Outsmarting the Next Pandemic: What Covid-19 Can Teach Us
by Elizabeth Anne Kirley Deborah PorterThis book examines the role of law and policy in addressing the public health crisis of COVID-19 and offers reforms that could improve pandemic preparedness for future outbreaks. Focusing on a number of countries most expected to provide agility and organization in their crisis response – the United States, Canada, Australia, the United Kingdom and Taiwan – the book shows how failures in leadership from governments, executives, and institutions created a vacuum that was quickly filled by naysayers, conspiracy theorists, vaccine hucksters, and fake news generators. Through the key themes of healthcare, leadership, security, and education, the chapters address critical questions: Why have masks become such a polarizing force? How do you self-isolate if you don’t have a home? How should equitable triage models for overwhelmed frontline healthcare workers be developed? Can we utilize artificial intelligence to educate the public about manipulated information they access concerning the pandemic? The book was written during the pandemic and weaves in to each chapter vignettes with personal revelations from a broad range of countries, including some also grappling with poverty, war, natural disasters, or revolution. It will appeal to academics, professionals, and policymakers interested in how law and health policy can converge on solutions for global infectious disease. It is suitable for use in upper-level courses.
Outsourcing in Clinical Drug Development
by Graham Hughes Roy DruckerSponsor companies and CROs alike will appreciate the industry-wide analysis, practical, how-to advice, and helpful charts and checklists provided by Outsourcing in Clinical Drug Development. A panel of experts discuss supplier identification and selection, financial considerations, and the ethical issues. They cover contracting out laboratory analy
Ovarian Aging
by Shixuan WangOvarian aging is a core factor in female aging, leading not only to reduced reproductive function such as infertility, recurrent pregnancy loss and congenital anomalies, but also to perimenopausal syndromes, genitourinary syndrome of menopause and related diseases (osteoporosis, cognitive disorders, cardiovascular disease, etc.). This book comprehensively presents the latest research progress of ovarian aging worldwide, and systematically explain the mechanism of the rise and fall of ovarian function. It will be a valuable reference for gynecologists and practitioner working in ovarian aging.
Ovarian Cancer
by David A. Fishman M. Sharon StackOvarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to achieve detection of early (rather than advanced) stage disease and the lack of effective tumor-specific therapeutics. Ovarian carcinogenesis, invasion, and metastatic dissemination require a complex cascade of interrelated genetic, molecular, and biochemical events that regulate the neoplastic transition of normal ovarian surface epithelium. This updated second edition includes exciting new advances in ovarian cancer detection and treatment and provides an analysis of current research into aspects of malignant transformation, growth control, and metastasis. A more detailed understanding of these processes may ultimately translate into the development of novel approaches for the detection and control of ovarian cancer.
Ovarian Cancer
by John M. BartlettOver one hundred well-respected scientists comprehensively review every aspect of the biology underlying ovarian cancer and present a remarkably detailed collection of easy-to-follow methods for illuminating basic mechanisms underlying all forms of cancer. Here today's investigators will find the broadest imaginable array of molecular biology techniques specially designed to determine not only tumor genetics, expression, and protein function, but also to elucidate the genetic mechanisms by which gene and immunotherapies may be perfected. Versatile and comprehensive, Ovarian Cancer Methods and Protocols constitutes a veritable treasury of well-proven expert methods that will help basic scientists and clinical researchers alike master the powerful technologies required for effective cancer research today.
Ovarian Cancer Biomarkers: Mapping to Improve Outcomes
by Khalid El BairiThis book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.
Ovarian Cancer in Elderly Patients
by Gilles FreyerThis practical book provides up-to-date information on the particular features of ovarian cancer in older women and the best management approach. The full range of relevant topics is covered. Guidance is provided on geriatric assessment, screening, pathology, diagnosis, and follow-up. The various treatment options are carefully explained, covering surgical approaches, chemotherapy as a first-line strategy, the use of anti-angiogenic agents, and treatment of relapse. The cognitive problems that may arise in elderly women during and after treatment of ovarian cancer are documented, with advice on response. Guidance is also provided on the design of clinical trials, and current directions in biological research are reviewed. This book will be of value to both practitioners and researchers with an interest in ovarian cancer and the elderly.
Ovarian Cancer: Methods and Protocols
by Anastasia Malek Oleg TchernitsaOvarian cancer is the most lethal malignancy of the female reproductive system and is also the fifth leading cause of cancer death in women. Sharing common characteristics of cancer, ovarian malignancy possess several clinical and biological particularities In Ovarian Cancer: Methods and Protocols, expert researchers in the field provide methods that have been created or adapted to study various aspects of ovarian cancer. These methods and techniques are applicable to study genetic alterations present in ovarian cancer, structural and metabolic features of ovarian cancer cells, include in vitro and in vivo models that recapitulate ovarian cancer development and progression, and describe ovarian cancer-oriented drug delivery approaches. Methodological chapters are grouped into seven thematic parts, any of them is introduced by short subject review. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Ovarian Cancer: Methods and Protocols seeks to aid scientist to optimize study designs, to correctly select the most applicable methods, and to produce interesting and novel results.
Ovarian Cancer: Methods and Protocols (Methods in Molecular Biology #2424)
by Pamela K. KreegerThis detailed volume provides a robust set of methods to understand variation between patients with ovarian cancers, in vitro models to better study different stages of the disease, and in vivo models to test therapies. Beginning with clinical perspectives to orient basic scientists, the book continues with sections exploring methods to characterize features of the tumor microenvironment (TME), techniques to isolate cells for in vitro study, and in vitro and in vivo models to study the disease. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Ovarian Cancer: Methods and Protocols serves as an ideal guide for researchers seeking to improve their study of ovarian cancer and find new therapeutic approaches.
Ovarian Cancer: Molecular & Diagnostic Imaging and Treatment Strategies (Advances in Experimental Medicine and Biology #1330)
by Heide SchattenThe present book on Molecular & Diagnostic Imaging and Treatment Strategies of ovarian cancer is one of two companion books with the second one being focused on Cell and Molecular Biology of Ovarian Cancer. Both books include new exciting aspects of ovarian cancer research with chapters written by experts in their respective fields who contributed their unique expertise in specific ovarian cancer research areas and include cell and molecular details that are important for the specific subtopics. Comprehensive and concise reviews are included of key topics in the field.
Ovarian Cancers
by Eric Pujade-Lauraine Isabelle Ray-Coquard Fabrice LécuruThis book provides an overview of the latestdevelopments in the concepts and management of ovarian cancer. The new datapresented throughout opens the way to radically different therapeuticapproaches. Surgery remains the core of ovarian cancer treatment, but itsultimate goal and the standard surgical procedure have evolved, giving rise tothe question of how to label expert centers for debulking surgery. Neo-adjuvantchemotherapy is becoming more popular and is also a new field for testing noveldrug combinations. Over recent years, ovarian cancer managementhas embraced molecular biology. It is now more correct to talk about cancers ofthe ovary rather than ovarian cancer, since it is not a unique disease butseveral entities with different molecular drivers. The significant advances indrugs targeting the microenvironment or the tumor cell DNA repair mechanismsare presented in detail together with exciting future perspectives. All these advances would not have been possiblewithout collaborative groups such as the GINECO group in France and theirintegration in wider clinical research networks at the European (ENGOT) andinternational (GCIG) level.
Ovarian Cancers: Evolving Paradigms in Research and Care
by Engineering Medicine National Academies of SciencesIn an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease—several distinct subtypes exist with different origins, risk factors, genetic mutations, biological behaviors, and prognoses. However, persistent questions have impeded progress toward improving the prevention, early detection, treatment, and management of ovarian cancers. Failure to significantly improve morbidity and mortality during the past several decades is likely due to several factors, including the lack of research being performed by specific disease subtype, lack of definitive knowledge of the cell of origin and disease progression, and incomplete understanding of genetic and non-genetic risk factors. Ovarian Cancers examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others. This study makes recommendations for public- and private-sector efforts that could facilitate progress in reducing the incidence of morbidity and mortality from ovarian cancers.
Ovarian Hyperstimulation Syndrome (Reproductive Medicine and Assisted Reproductive Techniques Series)
by Jan Gerris François Olivennes Annick DelvigneMajor advances have recently been made in our understanding of Ovarian Hyperstimulation Syndrome (OHSS). These include improving classification, recognizing primary and secondary risk factors, manipulating and monitoring ovarian stimulation, handling risky situations, and elucidating the underlying pathophysiologic mechanisms of the syndrome. As su
Ovarian Neoplasm Imaging
by Jasjit S. Suri U. Rajendra Acharya Luca Saba Stefano GuerrieroDiagnostic and pre-operative imaging has become increasingly adopted throughout the field of gynecology. In particular accurate preoperative analysis of ovarian pathology can improve the selection of the correct therapeutical approach, to reduce the length of operations, maximize surgical technique, and can ultimately improve a range of operative outcomes. New imaging modalities have advanced to the point of high resolution, three-dimensional analysis of tissue anatomy, composition and perfusion. Ultrasonography (US), Computed tomographic (CT) and magnetic resonance (MR) imaging have recently emerged as outstanding non-invasive techniques for the detection and characterization of ovarian pathology. In particular, US has probably now imposed itself as the "state-of-the-art" technique to explore the ovarian neoplasm, thanks the technical advancement like texture analysis (MGV) and 3D potentialities, although MR with new sequences like the diffusion-weighted imaging and greater magnetic fields (3 Tesla or more) may become leading methods in the future. The purpose of this book is to cover all the imaging techniques, potential for applying such imaging clinically, and to offer present and future applications as applied to ovarian pathology with the most world renowned scientists in these fields. The book is designed according to the pathological classification of the benign and malignant ovarian neoplasm by presenting for each pathology the clinical setting followed by the imaging approach. At the end of each chapter a "focus concept" paragraph will be presented with take-home point for the readers.
Ovarian Stimulation
by Botros Rizk Mohamed AboulgharOvarian stimulation is the starting point of reproductive medicine but the procedure can result in adverse reactions particularly the dangerous ovarian hyperstimulation syndrome. Fully revised in line with modern practice of ovarian stimulation, this new edition is divided into six sections that cover mild forms, non-conventional forms, IVF, complications and their management, alternatives, and the practicalities of procedures. All aspects of ovarian stimulation are discussed including the different stimulation protocols from which to choose, the management of poor responders and hyper-responders, as well as stimulation in patients with PCOS. Comprehensively reviewing the modern approach to ovarian stimulation, the alternative procedures are also described, both in IVF and other methods of assisted reproduction. Written by leading experts on reproductive health and fertility, this book will assist infertility specialists, gynecologists, reproductive endocrinologists and radiologists in determining successful treatment for their patients.
Ovarian Stimulation Protocols
by Gautam N. Allahbadia Yoshiharu MorimotoOvarian Stimulation Protocols is a concise handbook that aims to deliver everything the reader needs to know for performing a risk-free ovarian stimulation for assisted reproductive technique (ART) and get a favorable outcome. Review of crucial issues such as the significance of monitoring ovarian stimulation, advantages and disadvantages of ovarian hyperstimulation versus minimal stimulation, and the use of various drug regimens and stimulation protocols for various patient sub-sets, will help clinicians in selecting the better or more appropriate protocols. The contributors of this book have leading scientific and clinical backgrounds, with years of experience to support their views. The book serves as a handy practical guide, targeting and settling clinical dilemma that ART practitioners commonly experience in their clinics, while providing a window to the newer developments.
Ovarian Toxicology
by Patricia B. HoyerToday, we are exposed to an increasing number of chemicals in the environment and there is a growing awareness of the effects of these chemicals on the ovaries. Infertility resulting from environmental exposures may not be obvious until the reproductive life span is waning. As such, the potential for xenobiotic-induced infertility needs to be bette
Over My Head
by Claudia L. OsbornFrom the Book: A Doctor's own story of head injury from the inside looking out.
Over My Head: A Doctor's Own Story Of Head Injury From The Inside Looking Out
by Claudia L. OsbornLocked inside a brain-injured head looking out at a challenging world is the premise of this extraordinary autobiography. Over My Head is an inspiring story of how one woman comes to terms with the loss of her identity and the courageous steps (and hilarious missteps) she takes while learning to rebuild her life. The author, a 45-year-old doctor and clinical professor of medicine, describes the aftermath of a brain injury eleven years ago which stripped her of her beloved profession. For years she was deprived of her intellectual companionship and the ability to handle the simplest undertakings like shopping for groceries or sorting the mail. Her progression from confusion, dysfunction, and alienation to a full, happy life is told with restraint, great style, and considerable humor.
Over My Head: A Doctor's Own Story of Head Injury from the Inside Looking Out
by Claudia L. OsbornThis physician&’s &“inspiring&” account of overcoming a devastating brain injury &“will assist patients, families, and friends enduring the same difficulties&” (Library Journal). Locked inside a brain-injured head looking out at a challenging world is the premise of this extraordinary memoir chronicling the long process of adjustment and rehabilitation after a fateful, helmetless bike ride. In Over My Head, Claudia Osborn, a doctor and clinical professor of medicine, recounts coming to terms with the loss of her identity and the courageous steps (and hilarious missteps) she took while learning to rebuild her life. For years, Osborn was deprived of the career she loved and the intellectual companionship of her professional colleagues—and the ability to handle the simplest undertakings like shopping for groceries or sorting the mail. Her progression from confusion, dysfunction, and alienation to a full, happy life is told here with restraint, great style, and considerable humor. &“Exceptionally well-written and engaging.&” —Publishers Weekly
Over the Influence
by Patt Denning Jeannie LittleTwelve-step programs that insist on abstinence are beneficial to many--but what about the millions of Americans who try to quit and fail, just want to cut down, or wish to work toward sobriety gradually? This groundbreaking book presents the Harm Reduction approach, a powerful alternative to traditional treatment that helps users set and meet their own goals for gaining control over drinking and drugs. The expert, empathic authors guide readers to figure out which aspects of their own habits may be harmful, what they would like to change, and how to put their intentions into action while also dealing with problems that stand in the way, such as depression, stress, and relationship conflicts. Based on solid science and 40+ years of combined clinical experience, the book is packed with self-discovery tools, fact sheets, and personal accounts. It puts the reader in the driver's seat with a new and empowering roadmap for change.
Over the Influence, Second Edition: The Harm Reduction Guide to Controlling Your Drug and Alcohol Use
by Patt Denning Jeannie Little"Just say no" just doesn't work for everyone. If you've tried to quit and failed, simply want to cut down, or wish to work toward sobriety gradually, join the many thousands of readers who have turned to this empathic, science-based resource--now thoroughly revised. A powerful alternative to abstinence-only treatments, harm reduction helps you set and meet your own goals for gaining control over alcohol and drugs. Step by step, the expert authors guide you to figure out: *Which aspects of your habits may be harmful. *How to protect your safety and make informed choices. *What changes you would like to make. *How to put your intentions into action. *When it's time to seek help--and where to turn. Updated to reflect a decade's worth of research, the fully revised second edition is even more practical. It features additional vivid stories and concrete examples, engaging graphics, new worksheets (which you can download and print for repeated use), "Self-Reflection" boxes, and more. Mental health professionals, see also the authors' Practicing Harm Reduction Psychotherapy, Second Edition.
Overactive Bladder
by Scott Macdiarmid Jacques Corcos John HeesakkersOveractive Bladder: Practical Management provides urologists, gynecologists and other health practitioners with a comprehensive clinical guide to this very common problem, resulting in a perfect resource to consult time and time again. Beginning with an introductory section covering the definition and pathophysiolgy of OAB, it then moves on to cover evaluation, first-line management, second-line management and finally surgery. Well-illustrated throughout, each chapter begins with a key points box outlining the most important take-home messages. Also included are clear management algorithms to aid decision-making, 'Do's and Don't' boxes to help avoid errors made, key references to the top journal articles, and the very latest guidelines from the EAU, AUA and other major urology societies. Chapters are written by the top names in the field and the entire book is expertly edited by Jacques Corcos, John Heesakkers and Scott MacDiarmid. The result is a consistent, comprehensive and fully up to date approach to OAB, providing urologists managing patients with this condition with rapid access, specialist clinical guidance.
Overactive Bladder in Clinical Practice
by Alan J. Wein Christopher R. ChappleThe book provides a timely and comprehensive update on the overactive bladder (OAB) syndrome. The symptoms of urgency, with or without urge incontinence, usually with frequency or nocturia, now defined as the overactive bladder syndrome, have become a hot topic in urology, gynecology and urogynecology. Epidemiological data show very high disease prevalence (19%), particularly when compared with other chronic conditions such as diabetes (2%) and asthma (7%). OAB symptoms impact severely on patient's quality of life, causing significant impairment of patient vitality and limiting their physical role, similar to diabetes. The OAB syndrome involves all age groups, both sexes and is frequently found in neurogenic patients. This book will cover all aspects of OAB epidemiology, economics, pathophysiology, conservative, pharmaceutical and surgical and will be invaluable reading for residents and trainees in urology, gynecology and urogynecology.
Overcoming Acute and Chronic Pain: Keys to Treatment Based on Your Emotional Type
by Marc S. Micozzi Sebhia Marie DibraFind the holistic treatment that will work best for you based on your emotional type and specific pain condition• Provides an easy questionnaire to determine your emotional type and an interactive self-assessment for finding the right pain treatment for your condition• Explores mind-body treatments for many common pain conditions, including arthritis, back pain, fibromyalgia, irritable bowel, migraines, carpal tunnel, and PTSD• Reviews the scientific evidence in support of acupuncture, biofeedback, hypnosis, massage, chiropractic, yoga, herbs, and essential oilsThroughout history many healing traditions have focused on analgesia--the alleviation of pain--an area in which modern medicine provides few options beyond narcotics, steroids, and surgery. For those seeking drug- and surgery-free alternatives or complements to conventional pain management, the choices can be overwhelming. How do you know which method will work for you?In this guide to safe and effective natural therapies for acute and chronic pain, authors Marc S. Micozzi, M.D., Ph.D., and Sebhia Marie Dibra explain how your emotional boundary style--how you react to emotional, social, environmental, and physical stresses--affects which complementary treatments will work best for you. Providing an easy questionnaire to determine your emotional type and an interactive self-assessment for finding the right pain treatment for your condition, they explore the effectiveness of mind-body treatments for each emotional type and for many common pain disorders, including arthritis, back pain, fibromyalgia, irritable bowel, ulcer, migraine headaches, carpal tunnel, anxiety, PTSD, and other chronic pain conditions. They review the available research and scientific evidence in support of each therapy, suggesting only well-established, safe, and clinically proven alternative treatments, such as acupuncture, biofeedback, hypnosis, massage, chiropractic, yoga, herbs, and essential oils.Approaching pain holistically, they reveal how pain should be understood as a dynamic condition--an interaction between mind and body as well as between patient and therapy--and how your emotional type is key to long-lasting and successful results.