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PCR for Clinical Microbiology
by Catriona L. Halliday Ian W.J. Carter Gregory S. James Margret Schuller Theo P. SlootsNot another textbook, but a valuable tool for doctors and microbiologists wanting to know how to set up a PCR diagnostic microbiology laboratory according to current regulatory standards and perform assays supplied with patient clinical diagnostic criteria and easy to follow protocols. Whether laboratories are using commercial kits or in-house methods developed in their own laboratories or adopted from published methods, all clinical microbiology laboratories need to be able to understand, critically evaluate, perform and interpret these tests according to rigorous and clinically appropriate standards and international guidelines. The cost and effort of development and evaluation of in-house tests is considerable and many laboratories do not have the resources to do so. This compendium is a vehicle to improve and maintain the clinical relevance and high quality of diagnostic PCR. It is a unique collection of; guidelines for PCR laboratory set up and quality control, test selection criteria, methods and detailed step by step protocols for a diagnostic assays in the field of molecular microbiology. The structure of the book provides the PCR fundamentals and describes the clinical aspects and diagnosis of infectious disease. This is followed by protocols divided into; bacteria, virus, fungi and parasites, and susceptibility screens. The inclusion of medical criteria and interpretation adds value to the compendium and benefits clinicians, scientists, researchers and students of clinical diagnostic microbiology
PDR Nurse's Drug Handbook
by Pdr StaffNurses are on the front line when it comes to safe medication use and counseling patients. The 2014 PDR® Nurse's Drug Handbook provides all nursing professionals, no matter what the clinical setting, with an accurate, up-to-date, and easily accessible guide to over 1,500 of the most commonly prescribed drugs. Based on the FDA-approved prescribing information, PDR's staff of pharmacists has developed concise monographs that highlight the most important information on each drug, including its approved use; dosages; interactions with other drugs, food, and alcohol; side effects; safety information; and more. Clear, straightforward nursing considerations provide guidance on proper patient assessment and monitoring, as well as patient counseling and drug administration. In addition, product comparison tables are updated for each edition, with new tables added to reflect the latest information and current practice standards.
PDR Nurse's Drug Handbook 2013
by Pdr StaffNurses are in the forefront when it comes to safe medication use and counseling patients. This new edition of PDR Nurse's Drug Handbook provides all nursing professionals in any clinical setting with an accurate, up-to-date, and easily accessible guide to the most commonly prescribed drugs - over 1,500 in this edition. Based on the FDA-approved labeling, PDR's staff of pharmacists have developed concise monographs that highlight the most important information on each drug, including its approved use, dosages, interactions with other drugs, food and alcohol, side effects, safety information, and more. In addition, clear, straightforward nursing considerations provide guidance on proper patient assessment and monitoring as well as patient counseling and drug administration.
PDR for Nonprescription Drugs 2013
by Pdr StaffThe 34th edition of PDR for Nonprescription Drugs is the most comprehensive and valuable to date. The 2013 book offers an updated guide to hundreds of the most commonly used over-the-counter medications, including analgesics, cough and cold preparations, fever reducers, allergy medications, and more. Organized for easy use, PDR for Nonprescription Drugs offers comprehensive drug information such as usage, dosage, warnings and precautions, side effects, ingredients, and more.
PEGylated Nanocarriers in Medicine and Pharmacy
by Rakesh Kumar Tekade Narendra Kumar JainThis book shelters the central principles, cutting-edge methodologies, and incipient thought processes applied to PEGylation research. The content also expounds on the critical properties of PEG and other polymers that can be applied to formulate a prolonged-circulating nanocarrier system for the delivery of gene, nucleic acid, drugs, protein, and peptide and diagnostic agents. The book summarizes the methodologies and effects of PEGylation on drug delivery and highlights recent developments in PEGylated drugs. It also aims to present vital biopharmaceutical fates of PEGylated therapeutics and examines the approaches involved in the preparation, physicochemical properties, and biological applications of long-circulating PEGylated pharmaceutical nanocarriers. This book also cross-talks and offers expert viewpoints on mucus-penetrating PEGylated nanocarrier, reversible PEGylation of nanocarriers, and Bio-PEGylation as well as PEGylation and its alternatives. The book also deals with hottopics including the current status and regulatory aspects of PEGylated Nanoproducts, and medicinal and pharmaceutical applications of PEGylated Nanocarriers. The book provides a comprehensive literature resource for the students, biologists, chemists, toxicologists, medical researchers, scientists in industries, research institutes, universities, and consultants involved in the development and testing of new advanced medicines
PET Radiopharmaceutical Business: An Insider's View
by Andrea Pecorale Maria Carmela Inzerillo Piero A. SalvadoriThe book tells the reader how a niche business can develop in a complex context and a peculiar market, such as that of PET radiopharmaceuticals. The narrative gathers three different views, and allows the reader to focus on multiple aspects that may remain hidden at the beginning of a PET radiotracer project. Nevertheless, many of the considerations in the book may be useful to approach other emerging high-tech fields of biomarkers and health indicators. The successful implementation of the Quality Assurance system is a key point of a PET organization, as well as skill identification and the selection of personnel in operational and managerial duties. The development of a GMP PET manufacturing site inside a public organization from an in-house hospital radiopharmacy and the hurdles to face and become a third party site in a public-private cooperation, are detailed and commented. Finally, the book discusses how a PET site can achieve great results despite limited resources, and what are the key strategies to choose and develop new radiotracers or ensure coexistence of multiple tracers on the market. Globally, the book provides "food for thought" and may be a valuable tool for professionals in the radiopharmaceuticals industry and managers at universities or hospital willing to develop a GMP PET Production site.
PET Radiopharmaceuticals: Chemical, Biological, and Clinical Data (Clinicians’ Guides to Radionuclide Hybrid Imaging)
by James R. BallingerThis book presents in a consistent format data on ~50 PET radiopharmaceuticals in clinical use. Parameters include basic chemical data, normal biodistribution and excretion, activity administered, radiation dosimetry, patient preparation, and clinical utility, together with a few key references. In some cases a representative image is presented. The organisation is first by clinical specialty (oncology, cardiology, neurology) and within each section by radionuclide (F-18, C-11, etc). This book will be of interest mostly to nuclear medicine physicians and trainees, but also to a wider medical community including radiologists, oncologists and radiotherapists.
PET Scan in Hodgkin Lymphoma
by Andrea GallaminiThis book describes the various contributions of positron emission tomography (PET) to the management of Hodgkin lymphoma and considers key issues in its use. A full explanation of the value of PET in disease staging and restaging is followed by discussion of its role in guiding individualized, response-adapted therapy in both early and advanced disease based on assessment of treatment sensitivity. Further chapters explore in detail the current application of PET for determination of tumor metabolic volume and planning of involved field radiotherapy. The book concludes by discussing PET scan reporting in clinical practice and the rules that have now been formally set following a number of international workshops designed to develop standard reporting criteria based on expert agreement. The authors are leading authorities who adopt an interdisciplinary approach in covering the most important aspects of the use of PET in Hodgkin lymphoma in a readily understandable way. PET Scan in Hodgkin Lymphoma will be of value to oncologists, hematologists, medical physicists, radiotherapists, and nuclear medicine specialists.
PET and PET/CT Study Guide
by Andrzej Moniuszko Adam SciukThe PET and PET/CT Study Guide presents a comprehensive review of nuclear medicine principles and concepts necessary for passing PET specialty board examinations. The practice questions and content are similar to those found on the Nuclear Medicine Technology Certification Board (NMTCB) exam, allowing test takers to maximize their chances of success. The book is organized by test sections of increasing difficulty, with over 650 multiple-choice questions covering all areas of positron emission tomography, including radiation safety; radionuclides; instrumentation and quality control; patient care; and diagnostic and therapeutic procedures. Detailed answers and explanations to the practice questions follow. Supplementary appendices include common formulas, numbers, and abbreviations, along with a glossary of terms for easy access by readers. The PET and PET/CT Study Guide is a valuable reference for nuclear medicine technologists, nuclear medicine physicians, and all other imaging professionals in need of a concise review of the basics of PET and PET/CT imaging.
PET and SPECT in Neurology
by Andreas Otte Rudi A.J.O. Dierckx Aren Waarde Erik F.J. Vries Klaus L. LeendersPET and SPECT in Neurology highlight the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable not only to neurologists and radiologists/nuclear medicine specialists but also to interested general practitioners and geriatricians. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.
PET and SPECT in Neurology
by Andreas Otte Erik F. J. de Vries Rudi A. J. O. Dierckx Klaus L. Leenders Aren Van WaardeThis book provides a comprehensive overview of the use of PET and SPECT in not only classic neurodegenerative disorders but also cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The new edition has been revised and updated to reflect recent advances and includes additional chapters, for example on the use of artificial intelligence and machine learning in imaging data analysis, the study of brain connectivity using PET and SPECT images, and the role of PET imaging in modulation of brain functioning by deep brain stimulation. The authors are renowned experts whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state of the art compendium will be invaluable for neurologists and radiologists/nuclear medicine specialists and will also be informative for interested general practitioners and geriatricians. Companion volumes on PET and SPECT in psychiatry and in neurobiological systems complete a trilogy.
PET and SPECT in Psychiatry
by Andreas Otte Rudi A.J.O. Dierckx Erik F. J. de Vries Aren Waarde Johan A. den BoerPET and SPECT in Psychiatry showcases the combined expertise of renowned authors whose dedication to the investigation of psychiatric disease through nuclear medicine technology has achieved international recognition. The classical psychiatric disorders as well as other subjects - such as suicide, sleep, eating disorders, and autism - are discussed and the latest results in functional neuroimaging are detailed. Most chapters are written jointly by a clinical psychiatrist and a nuclear medicine expert to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all who have an interest in the field of neuroscience, from the psychiatrist and the radiologist/nuclear medicine specialist to the interested general practitioner and cognitive psychologist. It is the first volume of a trilogy on PET and SPECT imaging in the neurosciences; other volumes will focus on PET and SPECT in neurology and PET and SPECT of neurobiological systems.
PET and SPECT in Psychiatry
by Andreas Otte Erik F. J. de Vries Rudi A. J. O. Dierckx Aren Van Waarde Iris E. SommerThis book provides a comprehensive overview of the use of PET and SPECT in the classic psychiatric disorders such as depression, bipolar disorder, anxiety disorders, and schizophrenia. In addition, it discusses the application of these functional neuroimaging techniques in a variety of other conditions, including sleep disorders, eating disorders, autism, and chronic fatigue syndrome. The new edition has been extensively revised and updated to reflect the latest advances and results in nuclear imaging within the field. Most chapters are written jointly by a clinical psychiatrist and a nuclear medicine expert to ensure a multidisciplinary approach. This state of the art compendium will be of value for all who have an interest in the field of neuroscience, from psychiatrists and radiologists/nuclear medicine specialists to interested general practitioners and cognitive psychologists. Companion volumes on the use of PET and SPECT in neurology and for the imaging of neurobiological systems complete a trilogy.
PET and SPECT of Neurobiological Systems
by Andreas Otte Erik F. J. de Vries Rudi A. J. O. Dierckx Aren Van Waarde Adriaan A. LammertsmaThis book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.
PET and SPECT of Neurobiological Systems
by Andreas Otte Aren Waarde Rudi A. J. O. Dierckx Erik F. J. Vries Paul G. M. LuitenPET and SPECT of Neurobiological Systems combine the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Various aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow and the metabolic rate of glucose. The latest results in probe development are also detailed. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable to all with an interest in the field of clinical or preclinical neuroscience. Other volumes focus on PET and SPECT in psychiatry and PET and SPECT in neurology".
PET in the Evaluation of Alzheimer's Disease and Related Disorders
by Dan SilvermanThis practical guide contains all the science and clinical information needed to help the reader make informed decisions about the applications of brain PET to improve the care of patients with symptoms of Alzheimer's disease and related disorders. Beginning with an introduction to goals and limitations of the clinical evaluation of dementia, Dr. Dan Silverman and his distinguished group of contributors cover the role of functional imaging, clinical interpretation of brain FDG-PET scans, FDG-PET in the evaluation of early dementia, microstructural imaging of neurodegenerative changes, amyloid imaging, imaging non-neurodegenerative causes of cognitive impairment, tools for assisting PET scan interpretation in the clinical setting, and PET evaluation of central motor disorders. There is also a complete collection of clinical cases that practitioners are likely to encounter in daily practice. Enhanced with numerous PET brain scans, this book fills a rapidly growing need in the medical imaging field.
PET-CT Beyond FDG
by Mohsen Farsad Stefano Fanti Luigi MansiAlthough [18F]fluorodeoxyglucose (FDG) generally shows an excellent performance as a cancer-imaging agent when using PET-CT, there are some settings in which other radiopharmaceuticals offer advantages. Such non-FDG tracers are now gaining widespread acceptance not only in research but also in clinical practice. This atlas, including about 500 high-quality images, is a user-friendly guide to PET-CT imaging beyond FDG. A wide range of tracers is covered, such as 18F- and 11C-choline, 11C-methionine, 18F-ethyl-L-tyrosine, 68Ga-DOTA-NOC, 11C-acetate, 11C-thymidine, and 18F-DOPA. Throughout, the emphasis is on image interpretation, with guidance on the recognition of normal, benign, and malignant uptake and clear instruction on learning points and pitfalls. This atlas is designed to serve as a reference text for both nuclear physicians and radiologists, and will also be of great benefit to radiographers, technologists, and nuclear medicine and radiology residents.
PET-CT and PET-MRI in Neurology
by Luigi Mansi Andrea CiarmielloUsing SWOT analysis, this book examines in detail the strengths and weaknesses of the hybrid modalities PET-CT and PET-MRI for imaging of the central nervous system, comparing their merits and evaluating their advantages over the stand-alone modalities. The aim is to employ a truly systematic approach in order to define the potential clinical benefit of these modalities and to identify shortcomings, opportunities, and threats. Clinical application of the modalities is explored in a range of conditions, including dementia and related disorders, movement disorders, psychiatric disorders, cerebrovascular disease, infection/inflammation, brain tumors, and pediatric neurologic disorders. In addition, the basics of hybrid imaging are addressed, covering physics, instrumentation, data analysis and quantitation, radiopharmaceuticals, and contrast media. PET-CT and PET-MRI in Neurology, written by experts from Europe and the United States, will be essential reading for imaging specialists and of value for neurologists, psychiatrists, neurosurgeons, and pediatricians.
PET-CT and PET-MRI in Oncology
by Patrick Peller Rathan Subramaniam Ali GuermaziOver the past decade, PET-CT has achieved great success owing to its ability to simultaneously image structure and function, and show how the two are related. More recently, PET-MRI has also been developed, and it represents an exciting novel option that promises to have applications in oncology as well as neurology. The first part of this book discusses the basics of these dual-modality techniques, including the scanners themselves, radiotracers, scan performance, quantitation, and scan interpretation. As a result, the reader will learn how to perform the techniques to maximum benefit. The second part of the book then presents in detail the PET-CT and PET-MRI findings in cancers of the different body systems. The final two chapters address the use of PET/CT in radiotherapy planning and examine areas of controversy. The authors are world-renowned experts from North America, Europe, and Australia, and the lucid text is complemented by numerous high-quality illustrations.
PET-CT in Infection and Inflammation
by Sikandar ShaikhThis book covers all aspects of PET-CT including newer applications involving infection and inflammation and basic information on PET-CT new tracers. It explains the approach, protocols and miscellaneous applications about various infections and inflammation that helps in its early and better diagnosis in multiorgan and multisystem involvements in routine clinical practice.Chapters provide systematic approach to the diagnosis of various infections such as bacterial, viral, tuberculosis, inflammatory pathologies and overlap in coexisting tumors and superadded/associated infections. This book offers assistance to medical practitioners in understanding various advantages of PET-CT in single scan as compared to different modalities for diagnosis as well as oncologists dealing with concurrent malignant and non-malignant conditions, students, and interns.
PET-CT: Rare Findings and Diseases
by Stefano Fanti Cristina NanniPET-CT is increasingly being employed in the diagnosis of both oncological and non-oncological patients, yet nuclear medicine physicians may have only limited practical experience of rare diseases and may experience difficulty in recognizing and interpreting rare findings. This unique atlas documents a large number of clinical cases that will help practitioners to identify findings and diseases that, though rare, are sufficiently frequent to be encountered in routine practice. Two types of cases are presented: patients evaluated for rare diseases and patients evaluated for standard diseases in whom atypical PET findings were detected. Each reported case includes a brief description of the clinical history, representative color PET-CT images obtained using FDG or other tracers, and a short explanation of the disease and findings. This atlas will enable practitioners to make conclusive reports of PET-CT scans that would otherwise have been inconclusive.
PET/CT Imaging: Basics and Practice (Clinicians’ Guides to Radionuclide Hybrid Imaging)
by Kanhaiyalal Agrawal Annah Skillen Abdulredha Esmail Sharjeel UsmaniThe aim of this book is to provide concise information and quick reference on the basics and practice of PET/CT for beginners. The chapters are written by Nuclear Medicine experts from different countries with enormous experience in PET/CT practice. Starting with the basics of PET/CT describing physics and the use of radiopharmaceuticals in PET/CT, the book explores the principle of PET/CT in radiotherapy planning. The last five chapters explore normal variation, pitfalls and artefacts commonly seen with various routinely used PET radiotracers. The text is enriched by tables and highlighted clinical cases for better understanding. This book will be of interest mostly to nuclear medicine physicians and radiologists, but it may be appealing also to a wider medical community including oncologists and radiotherapists.
PET/CT and PET/MR in Melanoma and Sarcoma
by Amir H. KhandaniThis is a comprehensive guide for patient preparation, image acquisition, and image interpretation for PET/CT and PET/MR, specifically relevant to melanoma and sarcoma. Imaging specialists and referring physicians are often not as intimately aware of the particulars of PET imaging in management of patients with melanoma and sarcoma and how it could affect their treatment. This book fills that gap by presenting comprehensive information on melanoma, sarcoma, and the role of PET imaging in their diagnosis and management. The book begins by covering the basics of imaging for practicing physicians and trainees. Expert authors then further cover the biological concepts of melanoma and sarcoma and how they relate to imaging, particularly PET, the oncologist’s perspective, and the surgeon’s perspective on imaging for both the imaging specialist and the referring physician. Chapters review topics such as: PET/CT and PET/MR images in melanoma and sarcoma from a systemic approach, false-positives, false-negatives, pitfalls, and molecular imaging beyond PET. Images are used extensively throughout to enhance understanding for the reader. This is an ideal guide for radiologists, nuclear medicine physicians, oncologists, surgeons, trainees and technologists.
PET/CT for Inflammatory Diseases: Basic Sciences, Typical Cases, and Review
by Hiroshi Toyama Yaming Li Jun Hatazawa Guang Huang Kazuo KubotaThis comprehensive guide sheds new light on the benefits of FDG PET/CT in diagnosing inflammatory diseases. Although FDG PET/CT offers an invaluable tool for diagnosing inflammatory diseases, the clinical evidence on its application remains limited. To remedy this gap, each chapter of this book includes detailed descriptions of how FDG PET/CT can be used in connection with a specific inflammatory disease. Further, the authors discusses the precise clinical presentation, including key images and their interpretation, techniques and diagnosis. As such, it allows readers to see for themselves how valuable FDG PET/CT is for the diagnosis of cardiac sarcoidosis and aortitis syndrome, as well as rheumatic diseases and neuroimflammation, and the detection of the disease focus of inflammation or fever of unknown origin. Given its scope, this excellent collection is a valuable resource for radiologists and physicians who are involved in nuclear medicine, as well as cardiologists, cardiovascular surgeons, and rheumatologists.
PET/CT in Brain Disorders (Clinicians’ Guides to Radionuclide Hybrid Imaging)
by Francesco FraioliThis well-illustrated pocket book offers up-to-date guidance on the clinical and research applications of PET/CT in the most common neurological and neuro-oncological disorders. The opening chapters cover the pros and cons of widely used radiological imaging techniques, scanners, and radiopharmaceuticals, with emphasis on the state of the art hybrid modalities, primarily PET/CT but also PET/MRI. Helpful information is provided on the clinical and research tracers used in neurodegenerative diseases, movement disorders, epilepsy and brain tumours. These four killers are then discussed in detail, highlighting the role of PET/CT and targeted tracers in their assessment and in radiotherapy planning. In addition, the clinical applications of PET/MRI are considered. Throughout, many images are included to better explain the diseases and the role of hybrid imaging, and the final chapter presents a large sample of teaching cases and files that will assist in daily clinical practice. The book has been compiled under the auspices of the British Nuclear Medicine Society. It will be an excellent asset for nuclear medicine physicians, radiologists, radiographers, neurologists and neurosurgeons.