- Table View
- List View
Pancreatic Cancer: What You Need To Know
by John P. Neoptolemos Markus W. Büchler Raul Urrutia James L. AbbruzzeseIn organizing the second edition of this renowned Handbook, Dr. Neoptolemos and his co-editors have produced and updated a revised edition to the distinguished Major Reference Work devoted to pancreatic cancer. Like its preceding edition, the second edition continues to have a widespread appeal among clinicians, pathologists and basic scientists, who are now struggling to understand this complex and rapidly expanding field. Because of the recent and vast growth in both the clinical and scientific research being done in pancreatic cancer, (there is currently an unprecedented investment by academia and industry in this field), each research’s knowledge of other specialty areas outside his or her own is often quite limited. The aim of the new edition is to place the tangible advances, including new developments in surgical approaches with regards to resection techniques, the state of laparoscopic approaches, the growing impact of surgical approaches in the management of recurrent pancreatic cancer, controversies in the management of IMPN as the precursor lesion for PDAC and others – readily at hand. The second edition focuses on advances that will not become dated, and the editors have chosen authors, who are the very best in each area.
Pancreatic Cystic Neoplasms
by Michael G. Sarr George H. Sakorafas Vassileios SmyrniotisThis book provides a thorough overview of the detection of PCNs using modern imaging techniques and a clear guide to the recognition of the different subtypes of PCN based on their radiologic and histopathologic features. This volume will serve as an excellent aid to the selection of optimal therapeutic strategies based on preoperative diagnosis. A further important feature is the emphasis placed on radiologic, clinical, and surgical correlations. Pancreatic cystic neoplasms (PCNs) have been increasingly recognized during the past decade, mainly because of the widespread use of modern imaging modalities for the investigation of often unrelated abdominal symptoms. The three most common subtypes of PCN are serous cystic neoplasms, mucinous cystic neoplasms, and intraductal papillary mucinous neoplasms. These subtypes have distinct radiologic and histopathological features, and their biological behavior differs greatly. Accurate preoperative diagnosis is of prime importance in selecting the optimal therapeutic strategy: while serous cystic neoplasms are almost always benign, and may be treated conservatively, mucinous cystic neoplasms and intraductal papillary mucinous neoplasms have malignant potential, warranting an aggressive surgical approach, i. e. , pancreatectomy. Pancreatic Cystic Neoplasms will be of great interest to surgeons, gastroenterologists, radiologists, oncologists, and pathologists, and also to internists and residents in these specialties.
Pancreatic Disease
by Colin D. Johnson Clement W. ImrieThis book will contain the conclusions of a meeting from March 2007, of about 25 experts in pancreatology working together in small groups and plenary sessions to define the current state of knowledge in specific areas, and to develop ideal protocols and research questions for future investigation.
Pancreatic Imaging
by Elliot K. Fishman Atif Zaheer Meredith E. Pittman Ralph H. HrubanThis comprehensive teaching atlas covers virtually all pancreatic anatomy (including variants) and diseases in a pattern-based radiologic approach. Cases are presented as "unknowns", allowing the reader to analyze the findings and learn key points. Each teaching case includes a brief clinical history, images, a description of imaging findings, differential diagnoses, final diagnosis with images of gross pathology, and a discussion of key teaching points. The presented images have been acquired with the full range of relevant modalities, including state of the art technologies such as multidetector row dual-phase CT, 3D reformatting, and multiple MRI sequences. The book will help radiologists, radiology residents and fellows to sharpen their diagnostic skills by looking at a vast array of pathology from a major tertiary hospital (Johns Hopkins) and will also assist in preparation for radiology board examinations.
Pancreatic Islet Biology
by Anandwardhan A. HardikarThis comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology--from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology. Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes.
Pancreatic Masses
by Mihir S. Wagh Peter V. DraganovThis volume provides a comprehensive, state-of-the art review of the management of pancreatic lesions. The book reviews the differential diagnosis and pathology of different pancreatic lesions, profiles new advances in endoscopic evaluation, highlights new perspectives about imaging modalities, describes current treatment strategies and provides an algorithmic approach to management of pancreatic tumors. Recently published literature is placed in context with current management recommendations. The text also discusses the latest advances in minimally invasive techniques, such as Endoscopic Retrograde Cholangio-Pancreatography (ERCP) and Endoscopic Ultrasound (EUS). Written by experts in their fields, Pancreatic Masses: Advances in Diagnosis and Therapy is a valuable resource for gastroenterologists, surgeons and internists that helps guide patient management and stimulate investigative efforts.
Pancreatic Neuroendocrine Neoplasms
by Stefano La Rosa Fausto SessaThis book provides a broad overview of pancreatic neuroendocrine neoplasms, focusing on the most important developments in the technologies used to diagnose, classify and treat them. After a historical and epidemiological overview, the opening chapters examine the various diagnostic approaches (radiology, nuclear medicine, endocrinology, cytology and immunohistochemistry) and discuss the WHO classification. The functioning and nonfunctioning tumor types are then fully discussed, covering epidemiology, diagnosis, morphology and prognosis of each entity. Careful consideration is given to the molecular features that have contributed in understanding the pathogenesis of such neoplasms and may have potential implications for the diagnostic and therapeutic pathways. The final chapters consider the surgical and medical approaches to therapy, providing a practical and analytical overview of the available options. The book is written by a multidisciplinary team of worldwide-recognized experts and is addressed to radiologists, nuclear medicine physicians, endocrinologists, pathologists, surgeons and oncologists.
Pancreatic Stem Cells
by Juan Domínguez-BendalaFrom the discovery of Pdx1, the first "master gene" of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.
Pancreatic, 2nd Edition
by Gloria H. Suepigenetic alterations in cancer-causing genes such as oncogenes and tumor-suppressor genes. The second edition of Pancreatic Cancer: Methods and Protocols provides a broad range of protocols for molecular, cellular, pathological, and statistical analyses of sporadic and familial pancreatic cancer. It covers topics from in-vitro cell cultures to in-vivo mouse models, DNA to protein manipulation, and genetic and epigenetic analyses to treatment development. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.<P><P> Authoritative and practical, written by highly renowned investigators with expertise in pancreatic cancer, Pancreatic Cancer: Methods and Protocols, Second Edition is an invaluable source of proven protocols to those who are interested in joining the fight against pancreatic cancer.
Pancreaticobiliary Maljunction and Congenital Biliary Dilatation
by Terumi Kamisawa Hisami AndoFrom embryology to epidemiology, pathophysiology, diagnosis, complications, treatment and prognosis, this book provides a comprehensive overview and the latest evidence-based data on pancreaticobiliary maljunction (PBM), a congenital malformation in which the pancreatic and bile ducts join anatomically outside the duodenal wall. Resulting in various pathologic conditions, such as biliary cancer and pancreatitis, immediate prophylactic surgery is recommended upon diagnosis. The standard operative procedure for congenital biliary dilatation (CBD) is extrahepatic bile duct resection with bilioenteric anastomosis, but the optimal treatment of adult patients with PBM without biliary dilatation remains highly debatable. This book, written by pioneering editors and authors provides latest data, sheds new light on the disease. With abundant figures to aid understanding, Pancreaticobiliary Maljunction and Congenital Biliary Dilatation appeals to a wide readership, especially adult and pediatric surgeons, physicians including gastroenterologists and endoscopists, as well as radiologists and pathologists.
Pancreatitis: Medical and Surgical Management
by Peter B. Cotton David B. Adams John A. Windsor Nicholas J. ZyromskiPancreatitis: medical and surgical management provides gastroenterologists and GI surgeons, both fully qualified and in training, with a focused, evidence-based approach to the most exciting developments in the diagnosis and clinical management of pancreatitis. Focusing mainly on the rapidly changing and innovative medical and surgical strategies to manage the disease, new surgical procedures such as endoscopic biliary intervention and minimally invasive necrosectomy to exciting new medical therapies like Antiprotease, Lexipafant, probiotics and enzyme treatment are all discussed. Full colour throughout, with over 250 colour illustrations and with reference to the latest clinical guidelines from the AGA, ACG and UEGW at all times, it is an essential consultation tool for all those managing patients with this increasingly common condition.
Pancreatology
by Juan Iovanna Uktam IsmailovBasic research discusses the implication of pancreatic stress protein in acute pancreatitis and pancreatic cancer and their possible role as therapeutic targets. Also, very original results show the unexpected role of lipids as mediators during acute pancreatitis. Gene screening strategies allow the detection of the genes responsbile for gemcitabine resistance of pancreatic cancer cells. They lead to the selection of several target genes, in order to suppress the resistance of cells to gemcitabine treatment. The mechanism by which tetrahydrocannabinol is anti-tumoral in pancreatic cancer cells is presented and the use of THC as a promising new therapeutic agent is discussed. Genetic data are shown concerning hundreds of families with hereditary chronic pancreatitis and their possible role in the pathogenesis of the disease. Another very original study addresses the prevention and treatment of pancreatic diseases with diat. In clinical research, convincing data about the use of endoscopic sphicterotomy in the management of acute bilary pancreatitis is presented, based on the experience of a Center highly specialized in pancreatic diseases.
Pancreatology
by Timothy B. Gardner Kerrington D. SmithThis clinical casebook provides a comprehensive yet concise state-of-the-art review of pancreatic disease. Presented in a case-based format, each case focuses on a different varient of pancreatic disease and pancreatic cancer, with sections on diagnosis and early detection, management of the disease, and treatment of complications from the disease. The role of neoadjuvant therapy for pancreatic cancer and emerging treatment algorithms for chronic pancreatitis are also highlighted in the text. Written by experts in the field, Pancreatology: A Clinical Casebook is a valuable resource for clinicians, surgeons, and researchers interested in caring for patients with pancreatic disease.
Pandemia: How Coronavirus Hysteria Took Over Our Government, Rights, and Lives
by Alex BerensonThe most important fact about the coronavirus pandemic that turned the world upside down in 2020 is that our response to it has been an epic overreaction driven by a disastrous confluence of public and private interests—all of them purporting to &“follow the science.&” Since the lockdowns began, millions of Americans have relied on the reporting of Alex Berenson. Exposing the hysteria and manipulation behind the worst failure of public policy since World War I, this clear-eyed journalist has been a critical source of reason and truth. The product of relentless investigation and research, Pandemia explains how an illness that many people will never even know they had became the occasion for economically ruinous lockdowns and the suppression of personal freedom on a previously unimaginable scale. Dispassionate, factual, and untainted by any agenda other than telling the truth, this is the account that pandemic-weary Americans desperately need.
Pandemia: Una historia sobre ciencia, enfermedades y el virus que cambió nuestras vidas
by GABRIEL LEONLa historia de las enfermedades infecciosas, los desaciertos de la medicina para enfrentarlas y la arremetida de una pandemia sin precedentes. Ameno y didáctico, el bioquímico y escritor Gabriel León relata el estudio de las enfermedades a través de la historia, y cómo la ciencia descubrió y controló, tardíamente muchas veces, a virus y bacterias. El gran avance que significó para la medicina el lavado de manos y cómo pudieron evitarse las cientos de miles de muertes de mujeres durante el parto, provocadas justamente por faltas de higiene. Su libro desclasifica estos desaciertos y, también, los avances de las sociedades y de la medicina en la lucha contra las pandemias que asolaron la población mundial a lo largo de la historia. Dedica un capítulo especial y detallado sobre la pandemia de covid-19 y gripes similares presentes en las últimas décadas.
Pandemic
by Daniel KallaHumanity is overdue for a new killer flu. So when a mysterious new strain of flu is reported in China, he expects trouble.
Pandemic
by Scott SiglerScott Sigler's Infected shocked readers with a visceral, up-close account of physical metamorphosis and one man's desperate fight for sanity and survival, as "Scary" Perry Dawsey suffered the impact of an alien pathogen's early attempts at mass extinction. In the sequel Contagious, Sigler pulled back the camera and let the reader experience the frantic national response to this growing cataclysm. And now in Pandemic, the entire human race balances on the razor's edge of annihilation, beset by an enemy that turns our own bodies against us, that changes normal people into psychopaths or transforms them into nightmares. To some, Doctor Margaret Montoya is a hero--a brilliant scientist who saved the human race from an alien intelligence determined to exterminate all of humanity. To others, she's a monster--a mass murderer single-handedly responsible for the worst atrocity ever to take place on American soil. All Margaret knows is that she's broken. The blood of a million deaths is on her hands. Guilt and nightmares have turned her into a shut-in, too mired in self-hatred even to salvage her marriage, let alone be the warrior she once was. But she is about to be called into action again. Because before the murderous intelligence was destroyed, it launched one last payload -- a soda can-sized container filled with deadly microorganisms that make humans feed upon their own kind. That harmless-looking container has languished a thousand feet below the surface of Lake Michigan, undisturbed and impotent . . . until now. Part Cthulhu epic, part zombie apocalypse and part blockbuster alien-invasion tale, Pandemic completes the Infected trilogy and sets a new high-water mark in the world of horror fiction.
Pandemic (A\medical Thriller Ser.)
by Robin CookNew York Times-bestselling author Robin Cook takes on the cutting-edge world of gene-modification in this pulse-pounding new medical thriller.When an unidentified, seemingly healthy young woman collapses suddenly on the New York City subway and dies upon reaching the hospital, her case is an eerie reminder for veteran medical examiner Jack Stapleton of the 1918 flu pandemic. Fearful of a repeat on the one hundredth anniversary of the nightmarish contagion, Jack autopsies the woman within hours of her demise and discovers some striking anomalies: first, that she has had a heart transplant, and second, that, against all odds, her DNA matches that of the transplanted heart. Although the facts don't add up to influenza, Jack must race against the clock to identify the woman and determine what kind of virus could wreak such havoc--a task made more urgent when two other victims succumb to a similar rapid death. But nothing makes sense until his investigation leads him into the fascinating realm of CRISPR/CAS9, a gene-editing biotechnology that's captured the imagination of the medical community. . . and the attention of its most unethical members. Drawn into the dark underbelly of the organ transplant market, Jack will come face-to-face with a megalomaniacal businessman willing to risk human lives in order to conquer a lucrative new frontier in medicine--and if Jack's not careful, the next life lost might be his own.
Pandemic 1918: Eyewitness Accounts from the Greatest Medical Holocaust in Modern History
by Catharine ArnoldBefore AIDS or coronavirus, there was the Spanish Flu — Catharine Arnold's gripping narrative, Pandemic 1918, marks the 100th anniversary of an epidemic that altered world history. In January 1918, as World War I raged on, a new and terrifying virus began to spread across the globe. In three successive waves, from 1918 to 1919, influenza killed more than 50 million people. German soldiers termed it Blitzkatarrh, British soldiers referred to it as Flanders Grippe, but world-wide, the pandemic gained the notorious title of “Spanish Flu”. Nowhere on earth escaped: the United States recorded 550,000 deaths (five times its total military fatalities in the war) while European deaths totaled over two million. Amid the war, some governments suppressed news of the outbreak. Even as entire battalions were decimated, with both the Allies and the Germans suffering massive casualties, the details of many servicemen’s deaths were hidden to protect public morale. Meanwhile, civilian families were being struck down in their homes. The City of Philadelphia ran out of gravediggers and coffins, and mass burial trenches had to be excavated with steam shovels. Spanish Flu conjured up the specter of the Black Death of 1348 and the great plague of 1665, while the medical profession, shattered after five terrible years of conflict, lacked the resources to contain and defeat this new enemy. Through primary and archival sources, historian Catharine Arnold gives readers the first truly global account of the terrible epidemic.
Pandemic Cities: The COVID-19 Crisis and Australian Urban Regions (Cities Research Series)
by Elizabeth Taylor John Stone Emma Baker Amanda Davies Scott BaumThis book highlights the impact of the COVID-19 pandemic on cities. The COVID-19 pandemic and the associated economic and social impacts have been felt around the world. In large cities and other urban areas, the pandemic has highlighted a number of issues from pressures on urban labour and housing markets, shifts in demographic processes including migration and mobility, changes in urban travel patterns and pressures on contemporary planning and governance processes. Despite Australia’s relatively mild COVID exposure, Australian cities and large urban areas have not been immune to these issues. The economic shutdown of the country in the early stages of the pandemic, the sporadic border closures between states, the effective closure of international borders and the imposition of widespread public health orders that have required significant behavioural change across the population have all changed our cities in some and the way we live and work in them in some way. Some of the challenges have reflected long-standing problems including intrenched inequality in labour markets and housing markets, others such as the impact on commuting patterns and patterns of migration have emerged largely during the pandemic. This book, co-authored by experts in their field, outlines some of the major issues facing Australian cities and urban areas as a result of the pandemic and sets a course for future of the cities we live in.
Pandemic Communication and Resilience (Risk, Systems and Decisions)
by David M. BerubeThis book examines how we design and deliver health communication messages relating to outbreaks, epidemics, and pandemics. We have experienced major changes to how the public receives and searches for information about health crises over the last twelve decades with the ongoing shift from text/broadcast-based to digital messaging and social media. Both health theories and practices are examined as it applies to testing, tracking, hoarding, therapeutics, and vaccines with case studies. Challenges to communicate about health to diverse audiences (including the science illiterate) and across (both Western and developing economies) have been complicated by politics, norms and mores, personal heuristics, and biases, such as mortality salience, news avoidance, and quarantine fatigue. Issues of economic development and land use, trade and transportation, and even climate change have increased the exposure of human populations to infectious diseases making risk and resilience more pressing. The book has been designed to support health communicators and public health management professionals, students, and interested stakeholders and university libraries.
Pandemic Genres: Imagining Politics in a Time of AIDS
by Neville Wallace HoadA free ebook version of this title is available through Luminos, University of California Press's Open Access publishing program. Visit www.luminosoa.org to learn more. As HIV/AIDS emerged as a public health crisis of significant proportions across sub-Saharan Africa, it became the subject of local and international interest that was at once prurient, benevolent, and interventionist. Meanwhile, the experience of Africans living with HIV/AIDS became an object of aesthetic representation in multiple genres produced by Africans themselves. These cultural representations engaged public discourse—the public policy pronouncements of officials of postcolonial states, an emerging global NGO-speak, and journalism. In Pandemic Genres, Neville Hoad investigates how cultural production—novels, poems, films—around the pandemic supplemented public discourse. He shows that the long historical imaginaries of race, empire, and sex in Botswana, Kenya, and South Africa underwrote all attempts to bring the pandemic into public representation. Attention to genres that stage themselves as imaginary, particularly on the terrain of feeling, may forecast possibilities for new figurations.
Pandemic Influenza
by John Simpson Jonathan Van-Tam Chloe Sellwood John Watson Chris Packham Andy Wapling Angus Nicoll Ab Osterhaus Lim Wei Shen Martyn Regan John Oxford Peter Grove Michaela Hegermann-Lindencrone Lindsey Davies Geert Leroux-Roels Ben Killingley Elaine Gadd Isaac Weisfuse Lance Jennings David Hagen Jim Mcmenamin Joanne Enstone Peter Carasco Arnold Monto Luc Hessel Thomas Szucs Sophia Desillas Richard Pebody Seema Jain Caroline BrownPandemic influenza is a re-emerging pathogen with serious public health consequences. The A(H1N1) pandemic in 2009/10 and the continuing threat to humans from avian influenza A(H5N1) and other novel influenza viruses have both underlined the importance of preparedness at local, national and international levels. With a strong emphasis on practicality, this book offers comprehensive coverage of the science and operational application of influenza epidemiology, virology and immunology, vaccinology, pharmaceutical and public health measures, biomathematical modelling, policy issues and ethics involved in preparing for and responding to pandemic influenza. Each chapter raises key questions and answers them in clear and concise sections, detailing relevant modelling studies and further reading. Comprehensively updated to incorporate major lessons from the 2009/10 pandemic, this second edition includes new contributions on surveillance, International Health Regulations, clinical management and local health service responses, illustrated with vibrant international case studies. Written in an easily accessible style by global experts, this is an essential text for students of public health and those involved in local, national and international pandemic preparedness and response.
Pandemic Influenza: Emergency Planning and Community Preparedness
by Jeffrey R. RyanThe swine flu emergency needn‘t become a crisis. This critically acclaimed work provides public health officials, doctors, responders, and emergency planners with accurate current information that will help them understand the nature of an outbreak, assess risk, answer public concerns, and develop informed strategies. Devoid of sensationalism and a
Pandemic Pedagogies: Teaching and Learning during the COVID-19 Pandemic (The COVID-19 Pandemic Series)
by J. Michael RyanPandemic Pedagogies: Teaching and Learning during the COVID-19 Pandemic provides critical insights into the impact of the pandemic on the education system, pedagogical approaches, and educational inequalities. Education is often touted as the best way to promote social mobility and produce informed members of society. The pandemic has significantly threatened those goals by temporarily disrupting education and exacerbating disparities in the education system. The scholarship in this volume takes a closer look at many of the issues at the heart of the educational process including teacher self-efficacy, the gendered and racialized impacts of the pandemic on education, school closures, and institutional responses. Drawing on the expertise of scholars from around the world, the work presented here represents a remarkable diversity and quality of impassioned scholarship on the impact of COVID-19 and is a timely and critical advance in knowledge related to the pandemic.