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Showing 39,976 through 40,000 of 62,012 results

Outsider Art and Psychoanalytic Psychiatry: The “Nativity of Fools” at the Cogoleto Psychiatric Hospital (The International Psychoanalytical Association Psychoanalytic Ideas and Applications Series)

by Cosimo Schinaia

Outsider Art and Psychoanalytic Psychiatry is a study of psychiatric institutes and psychiatric violence as seen through art created by the inhabitants of a psychiatric hospital.Cosimo Schinaia explores the history of the Cogoleto Psychiatric Hospital, now abandoned, and how its architecture and ideology influenced treatment of the patients who lived there. At the book’s core is an in-depth historical, anthropological, and psychoanalytical study of the “Nativity of Fools,” a large art installation constructed from 1980 to 1984 by patients, nurses, and psychiatrists, representing their everyday lives in the asylum. Schinaia’s understanding of the scenes considers questions of nostalgia, isolation, privacy, and freedom and reflects on the risks of institutionalised segregation. The book proposes original psychoanalytic reflections on the subject of the obsolescence of psychiatric hospitals and treating mental suffering without institutionalising people.This book will be of great interest to psychoanalysts in practice and in training, psychiatrists, psychologists, social workers, and nurses as well as readers interested in outsider art, Arte Povera, and the history of psychiatric institutions and contemporary psychiatry.

Outsiders in a Hearing World: A Sociology of Deafness

by Paul C. Higgins

Sociological observations on several topics in the deaf community: identity, deviance among the deaf, stigma, and encounters with the hearing.

Outsmart Your Pain: Mindfulness And Self-compassion To Help You Leave Chronic Pain Behind

by Christiane Wolf

“Mindfulness and compassion practices should be in everybody’s toolbox for a happier and healthier life. [This] book is essential reading for providers who treat chronic illnesses and for those suffering from them.”—Arianna Huffington Pain can be a big, unwieldy box that we struggle to carry all day. But what if we could put down this box, unpack it, and tackle the contents one by one? Outsmart Your Pain is Dr. Christiane Wolf’s radically clear, evidence-based guide to relieving chronic pain with mindfulness, complete with twenty easy guided meditations and self-compassion practices, including: rewriting the “pain story” you tell yourself practicing loving acceptance of your body as it is mindfully working through negative emotions strengthening your inner and outer support systems. By separating your pain from the stressful thoughts and troubled feelings that come with it, you can lay down your burden and live with joy.

Outsmarting the Next Pandemic: What Covid-19 Can Teach Us

by Elizabeth Anne Kirley Deborah Porter

This book examines the role of law and policy in addressing the public health crisis of COVID-19 and offers reforms that could improve pandemic preparedness for future outbreaks. Focusing on a number of countries most expected to provide agility and organization in their crisis response – the United States, Canada, Australia, the United Kingdom and Taiwan – the book shows how failures in leadership from governments, executives, and institutions created a vacuum that was quickly filled by naysayers, conspiracy theorists, vaccine hucksters, and fake news generators. Through the key themes of healthcare, leadership, security, and education, the chapters address critical questions: Why have masks become such a polarizing force? How do you self-isolate if you don’t have a home? How should equitable triage models for overwhelmed frontline healthcare workers be developed? Can we utilize artificial intelligence to educate the public about manipulated information they access concerning the pandemic? The book was written during the pandemic and weaves in to each chapter vignettes with personal revelations from a broad range of countries, including some also grappling with poverty, war, natural disasters, or revolution. It will appeal to academics, professionals, and policymakers interested in how law and health policy can converge on solutions for global infectious disease. It is suitable for use in upper-level courses.

Outsourcing in Clinical Drug Development

by Graham Hughes Roy Drucker

Sponsor companies and CROs alike will appreciate the industry-wide analysis, practical, how-to advice, and helpful charts and checklists provided by Outsourcing in Clinical Drug Development. A panel of experts discuss supplier identification and selection, financial considerations, and the ethical issues. They cover contracting out laboratory analy

Ovarian Aging

by Shixuan Wang

Ovarian aging is a core factor in female aging, leading not only to reduced reproductive function such as infertility, recurrent pregnancy loss and congenital anomalies, but also to perimenopausal syndromes, genitourinary syndrome of menopause and related diseases (osteoporosis, cognitive disorders, cardiovascular disease, etc.). This book comprehensively presents the latest research progress of ovarian aging worldwide, and systematically explain the mechanism of the rise and fall of ovarian function. It will be a valuable reference for gynecologists and practitioner working in ovarian aging.

Ovarian Cancer

by David A. Fishman M. Sharon Stack

Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to achieve detection of early (rather than advanced) stage disease and the lack of effective tumor-specific therapeutics. Ovarian carcinogenesis, invasion, and metastatic dissemination require a complex cascade of interrelated genetic, molecular, and biochemical events that regulate the neoplastic transition of normal ovarian surface epithelium. This updated second edition includes exciting new advances in ovarian cancer detection and treatment and provides an analysis of current research into aspects of malignant transformation, growth control, and metastasis. A more detailed understanding of these processes may ultimately translate into the development of novel approaches for the detection and control of ovarian cancer.

Ovarian Cancer

by John M. Bartlett

Over one hundred well-respected scientists comprehensively review every aspect of the biology underlying ovarian cancer and present a remarkably detailed collection of easy-to-follow methods for illuminating basic mechanisms underlying all forms of cancer. Here today's investigators will find the broadest imaginable array of molecular biology techniques specially designed to determine not only tumor genetics, expression, and protein function, but also to elucidate the genetic mechanisms by which gene and immunotherapies may be perfected. Versatile and comprehensive, Ovarian Cancer Methods and Protocols constitutes a veritable treasury of well-proven expert methods that will help basic scientists and clinical researchers alike master the powerful technologies required for effective cancer research today.

Ovarian Cancer

by Malte Renz

This volume is the first of a new series dedicated to the historical developments in topics that are central to gynecological cancers. The six essays on ovarian cancer included here provide context from the perspective of experts in the field, illustrating what is required for the development and realization of medical innovation: (i) time consuming, decades-long basic research of the tumor genome and cancer cell biology, which may then set the basis for dramatic accelerations of recent therapeutic options; and (ii) the diligent assessment and fine-tuning of surgical techniques and concepts of patient prehabilitation and rehabilitation.

Ovarian Cancer Biomarkers: Mapping to Improve Outcomes

by Khalid El Bairi

This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.

Ovarian Cancer in Elderly Patients

by Gilles Freyer

This practical book provides up-to-date information on the particular features of ovarian cancer in older women and the best management approach. The full range of relevant topics is covered. Guidance is provided on geriatric assessment, screening, pathology, diagnosis, and follow-up. The various treatment options are carefully explained, covering surgical approaches, chemotherapy as a first-line strategy, the use of anti-angiogenic agents, and treatment of relapse. The cognitive problems that may arise in elderly women during and after treatment of ovarian cancer are documented, with advice on response. Guidance is also provided on the design of clinical trials, and current directions in biological research are reviewed. This book will be of value to both practitioners and researchers with an interest in ovarian cancer and the elderly.

Ovarian Cancer: Methods and Protocols

by Anastasia Malek Oleg Tchernitsa

Ovarian cancer is the most lethal malignancy of the female reproductive system and is also the fifth leading cause of cancer death in women. Sharing common characteristics of cancer, ovarian malignancy possess several clinical and biological particularities In Ovarian Cancer: Methods and Protocols, expert researchers in the field provide methods that have been created or adapted to study various aspects of ovarian cancer. These methods and techniques are applicable to study genetic alterations present in ovarian cancer, structural and metabolic features of ovarian cancer cells, include in vitro and in vivo models that recapitulate ovarian cancer development and progression, and describe ovarian cancer-oriented drug delivery approaches. Methodological chapters are grouped into seven thematic parts, any of them is introduced by short subject review. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Ovarian Cancer: Methods and Protocols seeks to aid scientist to optimize study designs, to correctly select the most applicable methods, and to produce interesting and novel results.

Ovarian Cancer: Methods and Protocols (Methods in Molecular Biology #2424)

by Pamela K. Kreeger

This detailed volume provides a robust set of methods to understand variation between patients with ovarian cancers, in vitro models to better study different stages of the disease, and in vivo models to test therapies. Beginning with clinical perspectives to orient basic scientists, the book continues with sections exploring methods to characterize features of the tumor microenvironment (TME), techniques to isolate cells for in vitro study, and in vitro and in vivo models to study the disease. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Ovarian Cancer: Methods and Protocols serves as an ideal guide for researchers seeking to improve their study of ovarian cancer and find new therapeutic approaches.

Ovarian Cancer: Molecular & Diagnostic Imaging and Treatment Strategies (Advances in Experimental Medicine and Biology #1330)

by Heide Schatten

The present book on Molecular & Diagnostic Imaging and Treatment Strategies of ovarian cancer is one of two companion books with the second one being focused on Cell and Molecular Biology of Ovarian Cancer. Both books include new exciting aspects of ovarian cancer research with chapters written by experts in their respective fields who contributed their unique expertise in specific ovarian cancer research areas and include cell and molecular details that are important for the specific subtopics. Comprehensive and concise reviews are included of key topics in the field.

Ovarian Cancers

by Eric Pujade-Lauraine Isabelle Ray-Coquard Fabrice Lécuru

This book provides an overview of the latestdevelopments in the concepts and management of ovarian cancer. The new datapresented throughout opens the way to radically different therapeuticapproaches. Surgery remains the core of ovarian cancer treatment, but itsultimate goal and the standard surgical procedure have evolved, giving rise tothe question of how to label expert centers for debulking surgery. Neo-adjuvantchemotherapy is becoming more popular and is also a new field for testing noveldrug combinations. Over recent years, ovarian cancer managementhas embraced molecular biology. It is now more correct to talk about cancers ofthe ovary rather than ovarian cancer, since it is not a unique disease butseveral entities with different molecular drivers. The significant advances indrugs targeting the microenvironment or the tumor cell DNA repair mechanismsare presented in detail together with exciting future perspectives. All these advances would not have been possiblewithout collaborative groups such as the GINECO group in France and theirintegration in wider clinical research networks at the European (ENGOT) andinternational (GCIG) level.

Ovarian Cancers: Evolving Paradigms in Research and Care

by Engineering Medicine National Academies of Sciences

In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease—several distinct subtypes exist with different origins, risk factors, genetic mutations, biological behaviors, and prognoses. However, persistent questions have impeded progress toward improving the prevention, early detection, treatment, and management of ovarian cancers. Failure to significantly improve morbidity and mortality during the past several decades is likely due to several factors, including the lack of research being performed by specific disease subtype, lack of definitive knowledge of the cell of origin and disease progression, and incomplete understanding of genetic and non-genetic risk factors. Ovarian Cancers examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others. This study makes recommendations for public- and private-sector efforts that could facilitate progress in reducing the incidence of morbidity and mortality from ovarian cancers.

Ovarian Hyperstimulation Syndrome (Reproductive Medicine and Assisted Reproductive Techniques Series)

by Jan Gerris François Olivennes Annick Delvigne

Major advances have recently been made in our understanding of Ovarian Hyperstimulation Syndrome (OHSS). These include improving classification, recognizing primary and secondary risk factors, manipulating and monitoring ovarian stimulation, handling risky situations, and elucidating the underlying pathophysiologic mechanisms of the syndrome. As su

Ovarian Neoplasm Imaging

by Jasjit S. Suri U. Rajendra Acharya Luca Saba Stefano Guerriero

​Diagnostic and pre-operative imaging has become increasingly adopted throughout the field of gynecology. In particular accurate preoperative analysis of ovarian pathology can improve the selection of the correct therapeutical approach, to reduce the length of operations, maximize surgical technique, and can ultimately improve a range of operative outcomes. New imaging modalities have advanced to the point of high resolution, three-dimensional analysis of tissue anatomy, composition and perfusion. Ultrasonography (US), Computed tomographic (CT) and magnetic resonance (MR) imaging have recently emerged as outstanding non-invasive techniques for the detection and characterization of ovarian pathology. In particular, US has probably now imposed itself as the "state-of-the-art" technique to explore the ovarian neoplasm, thanks the technical advancement like texture analysis (MGV) and 3D potentialities, although MR with new sequences like the diffusion-weighted imaging and greater magnetic fields (3 Tesla or more) may become leading methods in the future. The purpose of this book is to cover all the imaging techniques, potential for applying such imaging clinically, and to offer present and future applications as applied to ovarian pathology with the most world renowned scientists in these fields. The book is designed according to the pathological classification of the benign and malignant ovarian neoplasm by presenting for each pathology the clinical setting followed by the imaging approach. At the end of each chapter a "focus concept" paragraph will be presented with take-home point for the readers.

Ovarian Stimulation

by Botros Rizk Mohamed Aboulghar

Ovarian stimulation is the starting point of reproductive medicine but the procedure can result in adverse reactions particularly the dangerous ovarian hyperstimulation syndrome. Fully revised in line with modern practice of ovarian stimulation, this new edition is divided into six sections that cover mild forms, non-conventional forms, IVF, complications and their management, alternatives, and the practicalities of procedures. All aspects of ovarian stimulation are discussed including the different stimulation protocols from which to choose, the management of poor responders and hyper-responders, as well as stimulation in patients with PCOS. Comprehensively reviewing the modern approach to ovarian stimulation, the alternative procedures are also described, both in IVF and other methods of assisted reproduction. Written by leading experts on reproductive health and fertility, this book will assist infertility specialists, gynecologists, reproductive endocrinologists and radiologists in determining successful treatment for their patients.

Ovarian Stimulation Protocols

by Gautam N. Allahbadia Yoshiharu Morimoto

Ovarian Stimulation Protocols is a concise handbook that aims to deliver everything the reader needs to know for performing a risk-free ovarian stimulation for assisted reproductive technique (ART) and get a favorable outcome. Review of crucial issues such as the significance of monitoring ovarian stimulation, advantages and disadvantages of ovarian hyperstimulation versus minimal stimulation, and the use of various drug regimens and stimulation protocols for various patient sub-sets, will help clinicians in selecting the better or more appropriate protocols. The contributors of this book have leading scientific and clinical backgrounds, with years of experience to support their views. The book serves as a handy practical guide, targeting and settling clinical dilemma that ART practitioners commonly experience in their clinics, while providing a window to the newer developments. ​

Ovarian Toxicology

by Patricia B. Hoyer

Today, we are exposed to an increasing number of chemicals in the environment and there is a growing awareness of the effects of these chemicals on the ovaries. Infertility resulting from environmental exposures may not be obvious until the reproductive life span is waning. As such, the potential for xenobiotic-induced infertility needs to be bette

Over My Head

by Claudia L. Osborn

From the Book: A Doctor's own story of head injury from the inside looking out.

Over My Head: A Doctor's Own Story Of Head Injury From The Inside Looking Out

by Claudia L. Osborn

Locked inside a brain-injured head looking out at a challenging world is the premise of this extraordinary autobiography. Over My Head is an inspiring story of how one woman comes to terms with the loss of her identity and the courageous steps (and hilarious missteps) she takes while learning to rebuild her life. The author, a 45-year-old doctor and clinical professor of medicine, describes the aftermath of a brain injury eleven years ago which stripped her of her beloved profession. For years she was deprived of her intellectual companionship and the ability to handle the simplest undertakings like shopping for groceries or sorting the mail. Her progression from confusion, dysfunction, and alienation to a full, happy life is told with restraint, great style, and considerable humor.

Over My Head: A Doctor's Own Story of Head Injury from the Inside Looking Out

by Claudia L. Osborn

This physician&’s &“inspiring&” account of overcoming a devastating brain injury &“will assist patients, families, and friends enduring the same difficulties&” (Library Journal). Locked inside a brain-injured head looking out at a challenging world is the premise of this extraordinary memoir chronicling the long process of adjustment and rehabilitation after a fateful, helmetless bike ride. In Over My Head, Claudia Osborn, a doctor and clinical professor of medicine, recounts coming to terms with the loss of her identity and the courageous steps (and hilarious missteps) she took while learning to rebuild her life. For years, Osborn was deprived of the career she loved and the intellectual companionship of her professional colleagues—and the ability to handle the simplest undertakings like shopping for groceries or sorting the mail. Her progression from confusion, dysfunction, and alienation to a full, happy life is told here with restraint, great style, and considerable humor. &“Exceptionally well-written and engaging.&” —Publishers Weekly

Over the Influence

by Patt Denning Jeannie Little

Twelve-step programs that insist on abstinence are beneficial to many--but what about the millions of Americans who try to quit and fail, just want to cut down, or wish to work toward sobriety gradually? This groundbreaking book presents the Harm Reduction approach, a powerful alternative to traditional treatment that helps users set and meet their own goals for gaining control over drinking and drugs. The expert, empathic authors guide readers to figure out which aspects of their own habits may be harmful, what they would like to change, and how to put their intentions into action while also dealing with problems that stand in the way, such as depression, stress, and relationship conflicts. Based on solid science and 40+ years of combined clinical experience, the book is packed with self-discovery tools, fact sheets, and personal accounts. It puts the reader in the driver's seat with a new and empowering roadmap for change.

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Showing 39,976 through 40,000 of 62,012 results