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Point-of-care testing: Principles and Clinical Applications

by Peter Luppa Ralf Junker

The underlying technology and the range of test parameters available are evolving rapidly. The primary advantage of POCT is the convenience of performing the test close to the patient and the speed at which test results can be obtained, compared to sending a sample to a laboratory and waiting for results to be returned. Thus, a series of clinical applications are possible that can shorten the time for clinical decision-making about additional testing or therapy, as delays are no longer caused by preparation of clinical samples, transport, and central laboratory analysis. Tests in a POC format can now be found for many medical disciplines including endocrinology/diabetes, cardiology, nephrology, critical care, fertility, hematology/coagulation, infectious disease and microbiology, and general health screening. Point-of-care testing (POCT) enables health care personnel to perform clinical laboratory testing near the patient. The idea of conventional and POCT laboratory services presiding within a hospital seems contradictory; yet, they are, in fact, complementary: together POCT and central laboratory are important for the optimal functioning of diagnostic processes. They complement each other, provided that a dedicated POCT coordination integrates the quality assurance of POCT into the overall quality management system of the central laboratory. The motivation of the third edition of the POCT book from Luppa/Junker, which is now also available in English, is to explore and describe clinically relevant analytical techniques, organizational concepts for application and future perspectives of POCT. From descriptions of the opportunities that POCT can provide to the limitations that clinician’s must be cautioned about, this book provides an overview of the many aspects that challenge those who choose to implement POCT. Technologies, clinical applications, networking issues and quality regulations are described as well as a survey of future technologies that are on the future horizon. The editors have spent considerable efforts to update the book in general and to highlight the latest developments, e.g., novel POCT applications of nucleic acid testing for the rapid identification of infectious agents. Of particular note is also that a cross-country comparison of POCT quality rules is being described by a team of international experts in this field.

Point-of-Care Testing of COVID-19: Current Status, Clinical Impact, and Future Therapeutic Perspectives (SpringerBriefs in Applied Sciences and Technology)

by Abilash Gangula Brandon Kim Benjamin Casey Allison Hamill Hariharan Regunath Anandhi Upendran

This book highlights the role of point-of-care (POC) testing in the effective management of the coronavirus disease 2019 (COVID-19) pandemic with an in-depth focus on the recent developments in the field, existing gaps, and future directions. POC tests are of utmost importance as they facilitate rapid and decentralized testing without much instrumentation and technical expertise. The book describes the current status of POC COVID-19 testing in three broad categories: Molecular, antigen, and antibody. The advantages, limitations, and adaption of each of the POC tests are reviewed while highlighting their clinical impact in real-world settings. The role of POC testing for COVID-19 screening, diagnosis, and surveillance has been emphasized. The subtle difference between POC and at-home tests is discussed while elaborating on the necessity for the latter for enhancing clinical impacts. A spotlight on the influence of variants on the performance of POC-COVID-19 tests is provided. The consideration of clinical implications of POC testing in hospitals with regards to improving therapeutic options, patient flow, enhancing the infection control measures, and early recruitment of patients into clinical trials is explained. Finally, the future perspectives that will aid the research community in the development of POC tests for COVID-19 or any infectious disease, in general, are presented. Overall, we believe this book can benefit the research community as it (i) presents a comprehensive understanding of current COVID-19 POC testing methods (ii) highlights features required to transform the current tests developed during the past year as POC diagnostics, and (iii) provides insights to address the unmet challenges in the field.

Point-of-Care Tests for Severe Hemorrhage

by Paolo Simioni Marco Ranucci

This book is a rich source of information on point-of-care (POC) tests for the diagnosis and treatment of severe hemorrhage, including thromboelastography, thromboelastometry, heparin monitoring systems, and platelet function analyzers (Multiplate, PFA-100, VerifyNow, etc. ). The opening chapters focus on the pathophysiology of coagulation and the general characteristics of POC devices. The relevance of POC tests in specific scenarios is then carefully explained, with guidance on their use in contexts including trauma, cardiovascular surgery, ECMO, liver surgery, postpartum hemorrhage, and disorders of hemostasis in the critically ill. An individual chapter is devoted to practical issues when applying POC tests, and the book closes by presenting a set of informative clinical cases. As POC devices gain increasing popularity as bedside diagnostic tools in different clinical settings, it is important for practitioners to understand their role and value. Point-of-Care Tests for Severe Hemorrhage will be a useful and reliable source of information for anesthesiologists, intensivists, cardiologists, and hematologists.

Point-of-Care Ultrasound for the Neonatal and Pediatric Intensivist: A Practical Guide on the Use of POCUS

by Yogen Singh Cécile Tissot María Victoria Fraga Thomas Conlon

This book, written by internationally renowned experts, is a comprehensive text covering all aspects and recommendations regarding the use of POCUS for critically ill neonates and children. Point of Care Ultrasound (POCUS) for the Neonatal and Pediatric Intensivist is structured to address and expand upon recently published international evidence-based POCUS guidelines endorsed by the European Society of Paediatric and Neonatal Intensive Care (ESPNIC). The book is richly illustrated and includes a robust collection of individual POCUS images and cases. The Electronic Supplementary Materials offer high quality and interesting video clips complementing reader learning, particularly for neonatology, pediatric critical care, and general pediatric providers. Chapter authors provide a practical, experience-based approach to clinical integration of POCUS applications and highlight relevant supportive literature as well as important limitations to POCUS use in the management of critically ill children. The information within the book is also intended to support further clinical and educational research in the practice of pediatric POCUS.

Point of Care Ultrasound Made Easy

by John McCafferty and James M Forsyth

Point of Care Ultrasound Made Easy (POCUSME) is an exciting and innovative book that aims to teach all healthcare professionals how to do simple and clinically relevant ultrasound scanning at the point of care. This book will help you solve clinical problems at the bedside across a range of specialty areas, including: trauma, emergency medicine, respiratory medicine, cardiology, general surgery, otolaryngology and vascular surgery. Straightforward and practical, and designed for clinicians who are generally unfamiliar with ultrasound scanning, it will make a positive difference to your clinical practice, and help improve the delivery of optimised patient care. So read the book, grab an ultrasound machine, and please embrace the Point of Care Ultrasound movement!

Point-of-Care Ultrasound Techniques for the Small Animal Practitioner

by Gregory R. Lisciandro

This book offers a thorough revision and update to the first landmark book that presented a standardized approach to focused point-of-care ultrasound exams of the abdomen, thorax, musculoskeletal and eye in veterinary practice. Now incorporating new applications for focused ultrasound exams and additional species, this Second Edition continues to be a state-of-the-art reference for using abbreviated ultrasound exams in clinical practice. A companion website features supplementary video clips of these point-of-care techniques depicting actual ultrasound exams for comparison and comprehension. New chapters in Point-of-Care Ultrasound Techniques for the Small Animal Practitioner, Second Edition cover ultrasound-guided nerve blocks, musculoskeletal, brain imaging, and applications of focused ultrasound techniques in cats, exotics and marine mammals—making it an essential purchase for veterinarians wanting to incorporate point-of-care ultrasound techniques into their veterinary practices. Presents a standardized approach to point-of-care ultrasound as an extension of the physical exam, including trauma, non-trauma, and monitoring applications Includes coverage of new techniques for focused ultrasound exams, including lung, anesthesia and ultrasound guided nerve blocks, transcranial brain imaging, musculoskeletal, volume status evaluation, and rapid assessment for treatable forms of shock Adds cats, exotic and wildlife mammals, and marine mammals to the existing canine coverage Emphasizes the integration of point-of-care ultrasound techniques for optimizing patient care and accurate patient assessment Offers access to a companion website with supplementary video clips showing many clinically relevant didactic examples The second edition of Point-of-Care Ultrasound Techniques for the Small Animal Practitioner is an excellent resource for veterinary practitioners, ranging from the general practitioner to nearly all clinical specialists, including internal medicine, oncology, cardiology, emergency and critical care, anesthesiology, ophthalmology, exotics, and zoo medicine specialists, and veterinary students.

Point-of-care US for Acute Abdomen

by Mauro Zago Marina Troian Diego Mariani

This book focuses on surgical decision-making, a key topic for both surgeons and emergency physicians who are faced with patients with acute abdominal pain. Providing easy-to-understand technical details and discussing the interpretation of normal and pathological images, it is a valuable resource for surgeons and emergency physicians who are not used to applying clinical US in this field, enabling them to shorten the diagnostic path and avoid unnecessary costs and exposure to radiation. It is also a practical reference guide for surgeons and doctors wanting to apply US as a decision-making tool in the context of acute abdominal pain.

Point Of Origin (Kay Scarpetta)

by Patricia Cornwell

Carrie Grethen, partner in crime to William Temple Gault, has escaped from prison. Before she does so she sends Kay Scarpetta a message which makes it all too clear that she blames her (and Lucy, and Benton Wesley, and Pete Marino) for Gault's death, and has specific - if cryptic - plans for revenge. Wary and quite shaken, Scarpetta still has a professional life to get on with, including investigating the death of an unknown female in a fire which has destroyed the isolated farmhouse home of her erstwhile political boss. The post mortem reveals that the woman was stabbed before the fire was started, but while Scarpetta and her colleagues are puzzling over means and motive they are called out to the scene of another fire and another murder. The pattern is the same, the answers as elusive and then Benton disappears while following up a tip-off. Suddenly, and with appalling clarity, Scarpetta sees that Carrie has set up a scenario in which she can manipulate them all and in which she appears to have the inescapable upper hand. A novel of high suspense from the acknowledged mistress of the forensic thriller.

Point Of Origin (Kay Scarpetta #9)

by Patricia Cornwell

The ninth book in the Kay Scarpetta series, from No. 1 bestselling author Patricia Cornwell. 'America's most chilling writer of crime fiction' The TimesA farmhouse destroyed by fire. A body amongst the ruins.Dr Kay Scarpetta, Chief Medical Examiner and consulting pathologist for the federal law enforcement agency ATF, is called out to a farmhouse in Virginia which has been destroyed by fire. In the ruins of the house she finds a body which tells a story of a violent and grisly murder. The fire has come at the same time as another, even more incendiary horror: Carrie Grethen, a killer who nearly destroyed the lives of Scarpetta and those closest to her, has escaped from a forensic psychiatric hospital. Her whereabouts is unknown, but her ultimate destination is not, for Carrie has begun to communicate with Scarpetta, conveying her deadly - if cryptic - plans for revenge. Chillingly mesmeric in tone, labyrinthine in structure, Point of Origin is Patricia Cornwell at her most dazzling.Praise for the groundbreaking series: 'One of the best crime writers writing today' Guardian 'Devilishly clever' Sunday Times 'The top gun in this field' Daily Telegraph 'Forget the pretenders. Cornwell reigns' Mirror 'The Agatha Christie of the DNA age' Express

Poised for Peak Performance in Healthcare: A Practical Approach to Execute Expense Reduction and Revenue Enhancement Initiatives

by Ali Birjandi

The current healthcare system is under attack by market, government, and consumer forces. To stay solvent, organizations must be performing at the top of their game. This book provides detailed instructions to bring organizations to the next level of performance by teaching all the secrets straight from the healthcare consultant’s playbook in less than 100 days. This book defines the coming challenges in the healthcare environment and provides a 10-step solution to develop the infrastructure for peak performance. These solutions include detailed implementation plans, software, reports, metrics, and the top projects that yield the highest financial rewards. This is the first book of its kind to not just discuss the top strategies, but also provide step-by-step instructions to achieve results. The book defines the strategy, the tactics, the infrastructure, the targets, the solutions, the barriers, and the leadership required to achieve a high performing organization. With these simple instructions, any organization with the will to achieve a brighter future can be poised for success in the next decade in less than 100 days.

Poison Arrows: North American Indian Hunting and Warfare

by David E. Jones

Biological warfare is a menacing twenty-first-century issue, but its origins extend to antiquity. While the recorded use of toxins in warfare in some ancient populations is rarely disputed (the use of arsenical smoke in China, which dates to at least 1000 BC, for example) the use of "poison arrows" and other deadly substances by Native American groups has been fraught with contradiction. At last revealing clear documentation to support these theories, anthropologist David Jones transforms the realm of ethnobotany in Poison Arrows. Examining evidence within the few extant descriptive accounts of Native American warfare, along with grooved arrowheads and clues from botanical knowledge, Jones builds a solid case to indicate widespread and very effective use of many types of toxins. He argues that various groups applied them to not only warfare but also to hunting, and even as an early form of insect extermination. Culling extensive ethnological, historical, and archaeological data, Jones provides a thoroughly comprehensive survey of the use of ethnobotanical and entomological compounds applied in wide-ranging ways, including homicide and suicide. Although many narratives from the contact period in North America deny such uses, Jones now offers conclusive documentation to prove otherwise. A groundbreaking study of a subject that has been long overlooked, Poison Arrows imparts an extraordinary new perspective to the history of warfare, weaponry, and deadly human ingenuity.

Poison Pills: The Untold Story of the Vioxx Drug Scandal

by Tom Nesi

To the millions of Americans who suffer from chronic pain and arthritis, Vioxx seemed like a miracle. One of the most widely promoted and prescribed pain medications in the world -- used by more than twenty million people -- it was endorsed by the medical establishment and celebrities such as Olympic champion figure skater Dorothy Hamill. With annual sales of $2.5 billion, Vioxx became a pharmaceutical bonanza before being abruptly taken off the market in September 2004, after it was revealed that it led to an increased risk of heart-related disease and death.Drawing on internal documents, video footage, court testimony, and exclusive interviews, as well as three decades of experience inside the medical industry, Tom Nesi tells the dramatic story of what the drug's manufacturer, Merck, knew and when. It is a compelling narrative of business and medical science run amok, with a cast of characters ranging from those at the highest levels of the multibillion-dollar pharmaceutical industry to research scientists, marketers, and drug company sales reps. Here also are accounts from physicians, lawyers, financial analysts, and patients and their families whose lives have been forever altered by Vioxx.Set against a fascinating history of the origins of the modern pharmaceutical industry, POISON PILLS is a shocking tale that involves the breakdown of the United States medical system, the failures of the Food and Drug Administration, and enormous profits made by a large pharmaceutical corporation at the potential cost of thousands of lives.

Poison Prescriptions: Power Plant Medicine, Magic & Ritual

by The Seed Sistas

Poison Prescriptions is a stunningly illustrated grimoire of some of the most notorious plants: henbane, datura, belladonna, among others. It is also a practical guide to plant magic, medicine and ritual, offering advice to professional and home herbalists, to those interested in forgotten lore and the old ways, and to all those who wish to reclaim control of their own wellbeing.This book urges the resurrection of the ancient tradition of using these witching herbs in ritual and medicine. Now is the time to relink magic and medicine in the context of modern herbalism and contemporary witchcraft.Discover: Safe ways of interacting with the witching herbs to usher in wellbeing and healing.Practical activities ranging from meditations and folklore writing to wreath making and beer brewing.Step-by-step instructions to creating the powerful witches' Flying Ointment and using it in ritual, sex magic and lucid dreaming.

Poisoned: How a Crime-Busting Prosecutor Turned His Medical Mystery into a Crusade for Environmental Victims

by Alan Bell Jan Schlichtmann

After years of prosecuting hard-core criminals, rising legal star Alan Bell took a private sector job in South Florida’s newest skyscraper. Suddenly, he suffered such bizarre medical symptoms, doctors suspected he’d been poisoned by the Mafia. Bell’s rapidly declining health forced him to flee his glamorous Miami life to a sterile “bubble” in the remote Arizona desert. As his career and marriage dissolved, Bell pursued medical treatments in a race against time, hoping to stay alive and raise his young daughter, his one desperate reason to keep going. He eventually discovered he wasn’t poisoned by a criminal, but by his office building. His search for a cure led him to discover the horrifying truth: his tragedy was just the tip of the iceberg. Millions of people fall ill and die each year because of toxic chemical exposures—without knowing they’re at risk. Stunned by what he discovered, Bell chose to fight back, turning his plight into an opportunity. Despite his precarious health, he began collaborating with scientists dedicated to raising awareness about this issue. Soon, he also found himself drawn back into the legal field, teaming up with top lawyers fighting for those who had already fallen ill. Both a riveting medical mystery and a cautionary tale, this book puts a human face on the hidden truths behind toxic dangers assaulting us in our everyday environments—and offers practical ways to protect ourselves and our children.

Poisoned: The True Story of the Deadly E. Coli Outbreak That Changed the Way Americans Eat

by Jeff Benedict

NOW A NETFLIX DOCUMENTARY From Jeff Benedict, the #1 New York Times bestselling author of Tiger Woods and The Dynasty, Poisoned chronicles the events surrounding the worst food-poisoning epidemic in US history: the deadly Jack in the Box E. coli infections in 1993.On December 24, 1992, six-year-old Lauren Rudolph was hospitalized with excruciating stomach pain. Less than a week later she was dead. Doctors were baffled: How could a healthy child become so sick so quickly? After a frenzied investigation, public-health officials announced that the cause was E. coli O157:H7, and the source was hamburger meat served at a Jack in the Box restaurant. During this unprecedented crisis, four children died and over seven hundred others became gravely ill. In Poisoned, award-winning investigative journalist and #1 New York Times bestselling author Jeff Benedict delivers a jarringly candid narrative of the fast-moving disaster, drawing on access to confidential documents and exclusive interviews with the real-life characters at the center of the drama—the families whose children were infected, the Jack in the Box executives forced to answer for the tragedy, the physicians and scientists who identified E. coli as the culprit, and the legal teams on both sides of the historic lawsuits that ensued. Fast Food Nation meets A Civil Action in this riveting account of how we learned the hard way to truly watch what we eat.

Poisoned Eden: Cholera Epidemics, State-Building, and the Problem of Public Health in Tucumán, Argentina, 1865-1908

by Carlos S. Dimas

In 1895, after enduring two previous cholera epidemics and facing horrific hygienic conditions and the fear of another epidemic, officials in the Argentine province of Tucumán described their home as the &“Poisoned Eden,&” a play on its official title, &“Garden of the Republic.&” Cholera elicited fear and panic in the nineteenth century, and although the disease never had the demographic impact of tuberculosis, malaria, or influenza, cholera was a source of consternation that often illuminated dormant social problems. In Poisoned Eden Carlos S. Dimas analyzes the social, political, and cultural effects of three epidemics, in 1868, 1886, and 1895, that shook the northwestern province of Tucumán to understand the role of public health in building the Argentine state in the late nineteenth century. Through a reading of medical and ethnographic material, Dimas shows that cholera became intertwined in all areas of the social fabric and that Tucumanos of all classes created public health services that expanded the state&’s presence in the interior. In each outbreak, provincial powers contended with how to ensure the province&’s autonomy while simultaneously meeting the needs of the state to eradicate cholera. Centering disease, Poisoned Eden demonstrates how public health and debates on cholera&’s contagion became a central concern of the nineteenth-century Latin American state and promoted national cohesion.

Poisoned Love

by Caitlin Rother

Case seen on Inside Edition, Good Morning America, and 48 Hours Accident, Suicide. . . Or Murder? On November 6, 2000, paramedics answered a call to find Kristin Rossum, 24, sobbing. Her husband, Greg de Villers, wasnt breathing and she claimed he had overdosed on drugs after learning she was leaving him. But family and friends who knew of Gregs distaste for drugs werent buying Kristins story--particularly the idea that he would take his own life. American Beauty The daughter of a well-to-do California family, Rossum was a brainy blonde beauty whose talent for toxicology had won her a post at the San Diego County Medical Examiners Office. But her sweet smile masked a dark side. Shed developed a taste for methamphetamine in high school, and six months after her marriage to Greg, shed begun seeking secret trysts with other men. Toxic Passion At the time of her husbands death, Rossum was engaged in an illicit affair with her married boss. Investigators found that the Medical Examiners Office was missing supplies of meth and fentanyl, the narcotic that had killed her husband. With each clue discovered, another piece of Rossums "good girl" façade fell away. What the world would eventually see was the true face of a murderer--and the hand of justice. . .

The Poisoner's Handbook: Murder and the Birth of Forensic Medicine in Jazz Age New York

by Deborah Blum

Video From "The Chemist's War" (Slate Magazine), by Deborah Blum Pulitzer Prize-winning science writer Deborah Blum follows New York City's first forensic scientists to discover a fascinating Jazz Age story of chemistry and detection, poison and murder. Deborah Blum, writing with the high style and skill for suspense that is characteristic of the very best mystery fiction, shares the untold story of how poison rocked Jazz Age New York City. In The Poisoner's Handbook Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Drama unfolds case by case as the heroes of The Poisoner's Handbook—chief medical examiner Charles Norris and toxicologist Alexander Gettler—investigate a family mysteriously stricken bald, Barnum and Bailey's Famous Blue Man, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler work with a creativity that rivals that of the most imaginative murderer, creating revolutionary experiments to tease out even the wiliest compounds from human tissue. Yet in the tricky game of toxins, even science can't always be trusted, as proven when one of Gettler's experiments erroneously sets free a suburban housewife later nicknamed "America's Lucretia Borgia" to continue her nefarious work. From the vantage of Norris and Gettler's laboratory in the infamous Bellevue Hospital it becomes clear that killers aren't the only toxic threat to New Yorkers. Modern life has created a kind of poison playground, and danger lurks around every corner. Automobiles choke the city streets with carbon monoxide; potent compounds, such as morphine, can be found on store shelves in products ranging from pesticides to cosmetics. Prohibition incites a chemist's war between bootleggers and government chemists while in Gotham's crowded speakeasies each round of cocktails becomes a game of Russian roulette. Norris and Gettler triumph over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice during a remarkably deadly time. A beguiling concoction that is equal parts true crime, twentieth-century history, and science thriller, The Poisoner's Handbook is a page-turning account of a forgotten New York. .

The Poisoner's Handbook: Murder and the Birth of Forensic Medicine in Jazz Age New York

by Deborah Blum

Equal parts true crime, twentieth-century history, and science thriller,The Poisoner's Handbookis "a vicious, page-turning story that reads more like Raymond Chandler than Madame Curie"(The New York Observer) A fascinating Jazz Age tale of chemistry and detection, poison and murder, The Poisoner's Handbook is a page-turning account of a forgotten era. <p><p> In early twentieth-century New York, poisons offered an easy path to the perfect crime. Science had no place in the Tammany Hall-controlled coroner's office, and corruption ran rampant. However, with the appointment of chief medical examiner Charles Norris in 1918, the poison game changed forever. Together with toxicologist Alexander Gettler, the duo set the justice system on fire with their trailblazing scientific detective work, triumphing over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice.

The Poisoning of Michigan (Second Edition)

by Joyce Egginton

The highly toxic PBB poisoning of Michigan remains the most widespread chemical contamination known in U.S. history. The Poisoning of Michigan is an investigative journalist's account of the contamination of Michigan's dairy cattle with the highly toxic chemical PBB (polybrominated biphenyl) in 1973. A near relation of PCB, this now-banned substance, designed as a fire retardant, was mistaken for a nutritional supplement at a chemical plant. It ended up in cattle feed that was distributed to farms throughout the state. By the time the error was discovered, virtually all nine million residents of Michigan had been ingesting contaminated milk and meat for almost a year. <p><p>A new introduction by the author and an afterword by three distinguished environmental scientists explain how the legacy of Michigan's poisoning lives on—and how equally toxic substitutes for PBB still invade our homes and lives. This new edition of Egginton's environmental classic—first published in 1980 and long out of print—tells how the tragedy affected both the farm community and the wider populace, and how federal and state authorities failed to respond. "We were mired in a swamp of ignorance," one state official admitted.

Poisonous Pandas: Chinese Cigarette Manufacturing in Critical Historical Perspectives (Studies of the Walter H. Shorenstein Asia-Pacific Research Center)

by Matthew Kohrman, Gan Quan, Liu Wennan, and Robert N. Proctor

Please note that this is a Chinese language edition. A favorite icon for cigarette manufacturers across China since the mid-twentieth century has been the panda, with factories from Shanghai to Sichuan using cuddly cliché to market tobacco products. The proliferation of panda-branded cigarettes coincides with profound, yet poorly appreciated, shifts in the worldwide tobacco trade. Over the last fifty years, transnational tobacco companies and their allies have fueled a tripling of the world's annual consumption of cigarettes. At the forefront is the China National Tobacco Corporation, now producing forty percent of cigarettes sold globally. What's enabled the manufacturing of cigarettes in China to flourish since the time of Mao and to prosper even amidst public health condemnation of smoking? In Poisonous Pandas, an interdisciplinary group of scholars comes together to tell that story. They offer novel portraits of people within the Chinese polity—government leaders, scientists, tax officials, artists, museum curators, and soldiers—who have experimentally revamped the country's pre-Communist cigarette supply chain and fitfully expanded its political, economic, and cultural influence. These portraits cut against the grain of what contemporary tobacco-control experts typically study, opening a vital new window on tobacco—the single largest cause of preventable death worldwide today.

Poisonous Plants and Phytochemicals in Drug Discovery

by Chukwuebuka Egbuna Andrew G. Mtewa G.M. Narasimha Rao

Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery - Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery - Written and edited by leading researchers in phytochemistry, medicinal chemistry, analytical chemistry, toxicology, and more - Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career

A Poisonous Plot: The Twenty First Chronicle of Matthew Bartholomew (Chronicles of Matthew Bartholomew #21)

by Susanna Gregory

The twenty first chronicle in the Matthew Bartholomew series.In 1358, over a century after its foundation in Cambridge, the college of Michaelhouse is facing a serious shortfall of funds and competition from upstarts rivals such as Zachary Hostel. Their problems are made no easier by the hostility of the town's inhabitants who favour the university moving away to the Fens.This simmering tension threatens to break into violence when a well-known tradesman is found dead in one of the colleges. Matthew Bartholomew knows he was poisoned but cannot identify the actual substance, never mind the killer. He also worries that other illnesses and deaths may have been caused by the effluent from his sister's dye works.Torn between loyalties to his kin and to his college, he fears the truth may destroy both his personal and professional life, but he knows he must use his skills as a physician to discover the truth before many more lose their lives entirely.'A first-rate treat for mystery lovers' (Historical Novels Review)'Susanna Gregory has an extraordinary ability to conjure up a strong sense of time and place' (Choice)

A Poisonous Plot: The Twenty First Chronicle of Matthew Bartholomew (Chronicles of Matthew Bartholomew #21)

by Susanna Gregory

In 1358, over a century after its foundation in Cambridge, the college of Michaelhouse is facing a serious shortfall of funds and competition from upstarts rivals such as Zachary Hostel. Their problems are made no easier by the hostility of the town's inhabitants who favour the university moving away to the Fens. This simmering tension threatens to break into violence when a well-known tradesman is found dead in one of the colleges. Matthew Bartholomew knows he was poisoned but cannot identify the actual substance, never mind the killer. He also worries that other illnesses and deaths may have been caused by the effluent from his sister's dye works. Torn between loyalties to his kin and to his college, he fears the truth may destroy both his personal and professional life, but he knows he must use his skills as a physician to discover the truth before many more lose their lives entirely.

Poisons: An Introduction for Forensic Investigators

by David J. George

A unique book on recognition and investigation of criminal poisoning for investigators of all backgrounds and stages of their careers. Poisons: An Introduction for Forensic Investigators is a concise yet comprehensive overview of toxicants and unanticipated circumstances in which poisoning occurs. This book expands awareness of poisoning possibilities, heightens recognition of the toxic potential of many substances, and provides information to aid in focusing investigations. Poisons discusses life-threatening toxic substances and agents that modify behavior to achieve criminal goals. These include drugs that facilitate sexual assaults and robberies, and those found in medical child abuse and drug-product tampering. More than 230 case studies illustrate both unintentional and intentional poisoning and highlight situations where poisoning may not immediately be apparent. Information is included in pertinent criminal poisoning cases to illustrate the temperament of poisoners, their relationship to victims, their basis for poison selection, and their method of administration. Since Poisons is written by a single author, the discussions, format, educational level, and terminology remain consistent to aid crime scene investigators, homicide detectives, forensic scientists, death investigators, toxicologists, medical examiners, attorneys, and students. The book's more than 650 references are an asset to frame knowledge as well as a resource to return to again and again.

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