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Aortic Aneurysms: Pathogenesis and Treatment (Contemporary Cardiology #Vol. 1088)
by Gilbert R. Upchurch Jr. Enrique CriadoAs life expectancy is extended, the incidence and occurrence of Aortic Aneurysms are becoming increasingly common. Until recently, the treatment of aortic disease was primarily surgical, carrying a high mortality rate among the high risk elderly population. In Aortic Aneurysms: Pathogenesis and Treatment, Gilbert R. Upchurch Jr., Enrique Criado, and a panel of distinguished physicians comprehensively assess the rapidly evolving field of aneurysm treatment, focusing on aneurysms of the descending thoracic and abdominal aorta. The discussion of Aortic Aneurysms covers endovascular aortic repair as well as the recent significant improvements in stent graft design. This volume provides a concise and authoritative view of the current state of patient management, serving as a primer on clinical care and surgical procedures for aortic aneurysms. Comprehensive and up-to-date, Aortic Aneurysms: Pathogenesis and Treatment, offers Cardiologists, Vascular Surgeons, and Thoracic and Cardiac Surgeons a multidisciplinary approach to the management and treatment of patients with aortic disease.
Aortic Dissection and Acute Aortic Syndromes
by Joseph S. Coselli Frank W. Sellke Thoralf M. Sundt Joseph E. Bavaria Neel R. SodhaThis book comprehensively covers aortic dissection and acute aortic syndromes. Topics covered include the pathology, genetics, diagnosis, medical treatment and surgical management of uncomplicated and complicated aortic dissection, including endovascular stenting. In addition, imaging and follow-up procedures after initial surgical treatment are reviewed along with acute and chronic type A and type B dissection. Potential complications that can be encountered at various treatment stages and management strategies are also detailed. Aortic Dissection and Acute Aortic Syndromes comprehensively reviews aortic dissection in an easy to read, illustration-rich book. It is therefore an essential resource for both trainee and experienced cardiologist, cardiac surgeon and any other medical professionals involved in the management of these patients.
Aortic Regurgitation
by Jan Vojacek Pavel Zacek Jan DominikThis title is a comprehensive resource of aortic regurgitation suitable for both the novice and experienced practitioner. Detailed attention is given to the recently growing field of aortic valve-sparing surgery and aortic valve repair. Guidelines are also provided for general practitioners on how to treat patients after various aortic procedures. Also included are many operative photos, original medical illustrations and schematics. <P><P> Aortic Regurgitation synthesizes current knowledge of aortic valve repair into an easy-to-follow, illustration-rich text. It is therefore an indispensable guide suitable for use by cardiologists and trainees in cardiology, cardiac surgeons, echocardiographers, general practitioners and radiologists.
Aortic Stenosis: Case-Based Diagnosis and Therapy
by Amr E. AbbasWith the advent of less invasive treatments for aortic stenosis including percutaneous and apical replacement, more patients are being offered this technology. As such, determining the true severity of aortic stenosis is becoming paramount. Many clinical scenarios occur where the area and gradient estimates of severity do not match. This book will present case by case examples of different patients with a wide variety of aortic stenosis. It will assist cardiologists in identifying patients with true aortic stenosis who may benefit from valve replacement. It will also highlight the role and advent of new technology as the role of CTA, MRI, and 3D echo for diagnosis and TAVR and mini surgery for treatment. The audience will range from clinical cardiologists,imaging cardiologists and interventionalists alike.
Aortic Valve Preservation: Concepts and Approaches
by Takashi Kunihara Shuichiro TakanashiThis book provides comprehensive, state-of-the art insights into aortic valvuloplasty. Aortic valve repair is a relatively new procedure. Since first being successfully performed in the 1990s was objectively assessed in the 2000s, this procedure has now become standardized, reproducible, and popular around the globe. Written by experts in surgery and cardiology and richly illustrated, it discusses the aspects of anatomy, pathophysiology, diagnosis and surgical procedure that are essential for successful repair. Contributing to the popularization and development of aortic repair, it is a valuable resource for surgeons, cardiologists, cardio-anesthetists and paramedical staff interested in the field and will be good resource for popularizing and developing aortic valve repair.
Aortic Valve Transcatheter Intervention: Complications and Solutions
by Ron Waksman Corrado Tamburino Marco Zimarino Ignacio J. Amat-SantosAortic Valve Transcatheter Intervention Calcific aortic stenosis (AS) is the most common heart valve anomaly, with a largely age-dependent prevalence, a calculated annual incidence rate in the range of 4-5% in general populations and up to 6% in patients aged 75 years and over.Surgical aortic valve replacement (SAVR) was previously the only option available to patients with symptomatic, severe aortic stenosis. After the first-in-human transcatheter aortic valve implantation (TAVI) was performed by Alain Cribier in 2002, the treatment strategy for patients with symptomatic AS has been revolutionized. Since then, TAVI has grown exponentially, as a result of accruing evidence demonstrating safety and efficacy, and reduced invasiveness compared with SAVR. TAVI devices are continuously expanding to include several valve design options. As this strategy is continuously evolving to treat younger patients and lower-risk populations, aside from the long-term durability of the valve systems, procedural safety will become the focus of newer-generation devices.This book is a practical handbook devoted to the optimization of TAVI procedures, through a focused containment of complications. Through an integrated evaluation of the clinical status, imaging techniques and laboratory findings, the authors provide readers with clear messages on preventive and therapeutic recommendations.
Aortopathy
by Koichiro Niwa Harald KaemmererThis is the first textbook to focus on Aortopathy, a new clinical concept for a form of vasculopathy. The first section of the book starts from discussing general concept and history of Aortopathy, and then deals with its pathophysiology, manifestation, intrinsic factor, clinical implication, management and prevention. The second part closely looks at various disorders of the Aortopathy such as bicuspid aortic valve and coarctation of aorta. The book editors have published a lot of works on the topic and have been collecting relating data in the field of congenital heart disease for the past 20 years, thus present the book with confidence. The topic - an association of aortic pathophysiological abnormality, aortic dilation and aorto-left ventricular interaction - is getting more and more attention among cardiovascular physicians. This is the first book to refer for cardiologists, pediatric cardiologists, surgeons, ACHD specialists, etc. to acquire thorough knowledge on Aortopathy.
Ap4a and Other Dinucleoside Polyphosphates
by Alexander G. McLennanAp4A and Other Dinucleoside Polyphosphates is the first compilation of contributions from major investigators involved in studying the chemistry and biology of dinucleoside polyphosphates. The book features reviews and original research (including unpublished and anecdotal material) covering the whole area of dinucleoside polyphosphate research from its inception to the present day. Ap4A and Other Dinucleoside Polyphosphates will be a useful reference for biological scientists studying nucleotide metabolism, cell signalling, DNA replication and repair, and cellular response to stress.
Aphasia and Related Neurogenic Communication Disorders
by Patrick Coppens Ilias PapathanasiouAphasia and Related Neurogenic Communication Disorders, Third Edition reviews the definition, terminology, classification, symptoms, and neurology of aphasia, including the theories of plasticity and recovery.
Aphasie: ICF-orientierte Diagnostik und Therapie (Praxiswissen Logopädie)
by Barbara Schneider Meike Wehmeyer Holger GrötzbachDas erfolgreiche Lehrbuch in der 7. Auflage vermittelt Lernenden und Lehrenden in der Logopädie Grundlagen und evidenzbasiertes Wissen für eine Therapie von Aphasie nach ICF. Die detaillierte Beschreibung spezifischer Beeinträchtigungen, z.B. von Alexien, Agraphien und Akalkulien, ermöglicht eine umfassende Diagnostik und Therapie kommunikativer Störungen nach Schlaganfall. Hinweise zur Phase der Rehabilitation und zu Erholungsprozessen des Gehirns helfen gezielt bei der Planung und Durchführung der Aphasietherapie.Zu den einzelnen Störungsbereichen wie beim Sprachverständnis, der Wortfindung oder des Wortabrufs oder der Satzbildung finden Therapeuten bewährte Übungen, Hilfen und ausgewähltes Übungsmaterial. Auch auf Krankheitsbewältigung, soziale Integration und berufliche Reintegration wird eingegangen.Die 7. Auflage wurde umfassend überarbeitet und um zahlreiche Themen ergänzt, z.B. Bildgebung und Neuromodulation, partizipationsorientierte Diagnostik, Methoden der Unterstützten Kommunikation und technologiegestützten Aphasietherapie. Plus: Exkurse ermöglichen gezielt eine thematische Vertiefung.Ein Standard für die Behandlung von Patienten mit Aphasie für Auszubildende und Studierende der Logopädie sowie bereits erfahrene Sprachtherapeutinnen und Sprachtherapeuten zum Nachschlagen und Vertiefen.
Aphasie: Wege aus dem Sprachdschungel (Praxiswissen Logopädie)
by Barbara Schneider Meike Wehmeyer Holger GrötzbachPlötzlich sprachlos sein …… heißt für viele Patienten mit Aphasie, in einem „Dschungel“ aus Buchstaben, Wörtern und Sätzen sich zurechtfinden zu müssen. Welche Wege können Sie als Sprachtherapeut gemeinsam mit Ihren Patienten einschlagen, um sie aus diesem Dickicht zu führen, damit eine Teilhabe an Gesprächen und am sozialen Leben wieder möglich ist?Dieses erfolgreiche Lehrbuch – inzwischen in der 6. Auflage – vermittelt Ihnen die einzelnen Schritte dieses Weges in einer ausgewogenen Mischung aus Hintergrund- und Praxisinformationen. Sie erhalten alle für die Therapien erforderlichen Kenntnisse über Symptome und Syndrome, Anamnese und Diagnostik, Planung und Durchführung der Behandlung. Unterschiedliche Therapiebausteine unterstützen Sie dabei, für jede Störung individuell angepasste Übungen mit „Regieanweisungen“ durchzuführen, Hilfestellungen zu leisten und Materialempfehlungen umzusetzen.NEU in der 6. AuflageLangzeitverlauf von Aphasie bei Kindern und JugendlichenNeue ScreeningverfahrenEinsatz von PCs und TabletsKommunikativ orientierte Aphasietherapie
Aphasietherapie - Aktivitätenorientierter Ansatz: Theorie und Praxis
by Ingrid WengDas Buch stellt einen integrativen aktivitätenorientierten Ansatz der Aphasietherapie nach ICF vor. Es vermittelt Lehrenden, Studierenden und Praktizierenden theoretische Grundlagen sowie konkrete didaktische Prinzipien, deren therapeutische Umsetzung anhand zahlreicher konkreter Beispiele praxisnah aufgezeigt wird. Somit können in der Logopädie und Sprachtherapie begründete therapeutische Entscheidungen getroffen und praktisch umgesetzt werden.
Apical Periodontitis in Root-Filled Teeth: Endodontic Retreatment and Alternative Approaches
by Thomas KvistThis book is a comprehensive guide to apical periodontitis in root-filled teeth that covers not only all aspects of diagnosis and management but also epidemiology, etiology, consequences, clinical decision-making, and prognosis. There is a particular focus on the available surgical and nonsurgical methods of retreatment designed to restore healthy periapical conditions. Alternatives to retreatment are also explored, including a conservative approach involving monitoring of the diseased tooth without intervention and the option of extraction and replacement with an implant or a fixed prosthesis. The goal of root canal treatment is to save the natural tooth even when tissue breakdown has resulted in pathological conditions of the pulp and periradicular tissue. However, population studies reveal that complete healing is often absent in root-filled teeth, and apical periodontitis is frequently observed in conjunction with root fillings of poor technical quality. Under these circumstances, questions arise as to how the apical periodontitis is impacting on the patient and how the condition should be tackled. Readers will find this well-illustrated book to be of great value in directing clinical practice.
Apicomplexa in Livestock
by Johann SchröderThe Apicomplexa is a globally prevalent group of parasitic protozoa that cause disease, from malaria in humans to livestock diseases such as coccidiosis, babesiosis (Red Water, Tick Fever) and East Coast Fever. With significant economic impacts, a number of Apicomplexa are also zoonotic, leading to grave potential public health consequences. Infection prevention efforts by immunisation or management of arthropod vector infestation have not been universally successful, and can have knock-on effects such as pollution of the environment and human food chain, and development of insecticidal or acaricidal resistance. This book highlights the similarities and differences between the various Apicomplexa infections, identifying those of greatest significance and suggesting sustainable approaches to better manage their impact on livestock productivity. The book: Reviews Australian livestock as a case study, but highlights global applications, biosecurity concerns and lessons learned; Covers Apicomplexa-caused disease across cattle, pigs, poultry and sheep; Considers human health and environmental impacts, and how sustainable management methods can better outcomes for all. Suitable for researchers and students of veterinary parasitology and related disciplines, this book is a valuable resource covering this important set of parasites.
Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development (Drug Discovery in Infectious Diseases #2)
by Paul M. SelzerThis handbook is the first dealing with the discovery of drugs directed against apicomplexan parasites. Amongst others, this group of endoparasites includes the causative agents of Malaria, Toxoplasmosis, and Babesiosis, the latter occurring mainly in animals. Written by renowned scientific experts from academia and industry, the book focuses on currentdrug development approaches for all apicomplexan diseases making it appealing to a large audience, ranging from research labs in academia to the human and veterinarian pharmaceutical industry. This work is the second volume of the new book series 'Drug Discovery in Infectious Diseases', edited by Prof. Dr Paul M. Selzer.
Apley & Solomon�s System of Orthopaedics and Trauma
by Ashley Blom David Warwick Michael WhitehouseNow in its Tenth Edition and in continuous publication since 1959, Apley & Solomon's System of Orthopaedics and Trauma is one of the world's leading textbooks of orthopaedic surgery. Relied upon by generations of orthopaedic trainees the book remains true to the teaching principles of the late Alan Apley and his successor Professor Louis Solomon. This new edition is fully revised and updated under the leadership of new editors. It retains the familiar 'Apley' philosophy and structure, and is divided into three major sections: General Orthopaedics, Regional Orthopaedics and Trauma, thus enabling readers to gain the knowledge they need for their lifetime learning.
Apley and Solomon’s Concise System of Orthopaedics and Trauma
by Ashley Blom David Warwick Michael WhitehouseApley & Solomon's Concise System of Orthopaedics and Trauma is firmly established as the leading introductory textbook of orthopaedic practice and the principles of fracture and trauma management. Praised in previous editions for the systematic approach, balanced content and easy-to-read style, this fifth edition has been brought fully up to date under the direction of the new and distinguished authorial team, while remaining true to the teaching principles of Alan Apley and his successor Louis Solomon.Key features: Focused – on diseases and clinical signs with additional detail on anatomy where appropriate International – enhanced coverage of 'global orthopaedics' reflect the changing pattern of musculoskeletal disease and trauma around the world Relevant – provides helpful guidance on simple procedures without unnecessary operative detail Readable – increased emphasis on concise presentation Current – updates reflect developments in molecular biology, genetics and imaging technology This fifth edition remains the first choice for medical students, trainee surgeons and other health professionals seeking a convenient introduction to this large and complex subject and is a natural precursor to the more detailed coverage offered by its larger parent, Apley & Solomon's System of Orthopaedics and Trauma.
ApoB in Clinical Care
by Jacqueline Graaf Patrick Couture Allan D. SnidermanNow, based on the apoB algorithm, that is outlined and illustrated in this book, family physicians as well as cardiologists, endocrinologists and internists will be able to easily and accurately identify and treat these disorders. The apoB dyslipoproteinemias are major common causes of vascular disease. But until now, accurate diagnosis has not been possible. With just total cholesterol, triglycerides and apoB, all the apoB dyslipoproteinemias, with the exception of elevated Lp(a), can be identified using the apoB algorithm. The apoB app, which incorporates this algorithm, is available from both Apple and Android and is free.
Apocarotenoids of Crocus sativus L: From biosynthesis to pharmacology (SpringerBriefs in Plant Science)
by Shoib Ahmad Baba Nasheeman AshrafThis book is a product of years of research on saffron biology. It intends to give a broad but concise overview of the various aspects of apocarotenoid biosynthesis in Crocus sativus, its regulation and pharmacology . Crocus sativus L. of family Iridaceae is an important medicinal plant. The dried stigma of C. sativus flower is considered as the world's costliest spice. Saffron is the sources of unique carotenoid derived molecules called apocarotenoids which include crocin, crocetin, picrocrocin and safranal. These molecules are synthesized in the tissue and developmental stage specific manner. Besides providing colour, aroma and flavour to the spice, these molecules have tremendous medicinal importance. The book uncovers major concepts of apocarotenoids biosynthesis and provides deeper and more complete understanding about their biotechnological and pharmacological applications. The book is divided into three sections - The first section provides a general introduction of C. sativus, its apocarotenoids, their biosynthesis, regulation and transport. Second section provides information about the carotenoid cleavage dioxygenases (CCDs) which are the key players in apocarotenoid biosynthesis. The classification of plant CCDs, their structure, reaction mechanism, biotechnological application are thoroughly discussed. The final section deals with the major pharmacological properties of C. sativus apocarotenoids, ranging from their role as anticancer to their utility as neuroprotective molecules. This is a one of its kind book on Crocus sativus. It will be useful for the researchers working on Crocus sativus, students and also practitioners involved in extraction and bio-synthesis of the useful medical components.
Apolipoprotein Mimetics in the Management of Human Disease
by G. M. Anantharamaiah Dennis GoldbergThis comprehensive book provides not only the stages in the development of this unique and specialized field but also updates on the current state of research and development of apolipoprotein mimetics as therapeutic modalities for various lipid-mediated disorders. The book consists of 11 chapters all written by leading scientists from well-reputed laboratories in the USA. After an introduction by Dr. Godfrey Getz, Professor of Medicine at the University of Chicago and the Associate Editor of the Journal Lipid Research, the book presents a narration of how a theory can lead to the discovery of treatment modalities to several devastating diseases such as diabetes, Alzheimer's disease, arthritis; asthma; atherosclerosis, chronic rejection of transplanted hearts and cancer. Present therapies for most of these diseases are not adequate. Using the models of two long anti-atherogenic and anti-inflammatory proteins (apolipoprotein A-I and apolipoprotein E with 243 and 299 amino acids, respectively) short mimetic peptides of 18 to 28 amino acid residues in length, which can be produced either synthetically or genetically in edible fruits and vegetables, have been shown to exert profound biological effects in a large number of animal models of diseases. The book also presents novel ideas, highly unexpected mechanisms of action in animal models and even in initial clinical studies in humans, which can lead to additional improvements in basic and clinical research in biological science. All the chapters are written by experts in their respective fields who have contributed immensely to the literature. This is the first compendium of this growing field presented in the form of a book.
Apollo's Arrow: The Profound and Enduring Impact of Coronavirus on the Way We Live
by Nicholas A. ChristakisA piercing and scientifically grounded look at the emergence of the coronavirus pandemic and how it will change the way we live — "this year's must-must-read." (Daniel Gilbert) Apollo's Arrow offers a riveting account of the impact of the coronavirus pandemic as it swept through American society in 2020, and of how the recovery will unfold in the coming years. Drawing on momentous (yet dimly remembered) historical epidemics, contemporary analyses, and cutting-edge research from a range of scientific disciplines, bestselling author, physician, sociologist, and public health expert Nicholas A. Christakis explores what it means to live in a time of plague — an experience that is paradoxically uncommon to the vast majority of humans who are alive, yet deeply fundamental to our species. Unleashing new divisions in our society as well as opportunities for cooperation, this 21st-century pandemic has upended our lives in ways that will test, but not vanquish, our already frayed collective culture. Featuring new, provocative arguments and vivid examples ranging across medicine, history, sociology, epidemiology, data science, and genetics, Apollo's Arrow envisions what happens when the great force of a deadly germ meets the enduring reality of our evolved social nature.
Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification (Methods in Pharmacology and Toxicology)
by Myrtle A. DavisDr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.
Apoptosis Techniques and Protocols (Neuromethods #29)
by Judes PoirierAn indispensable compendium of state-of-the-art theory and detailed how-to instruction essential for understanding and studying apoptosis. The expert contributors cover such important topics as the histological, biological, and molecular criteria for apoptosis and programmed cell death; necrosis and apoptosis in the CNS; and cellular, invertebrate, animal, and human models of apoptosis in Alzheimer's disease, AIDS, and stroke. The techniques they describe examine the critical steps involved in the apoptosis process, and include PCR analysis of cell-cycle-regulated proteins, histochemical analysis of DNA regulation, DNA laddering analysis, and cytochemical alterations of living cells.
Apoptosis Techniques and Protocols (Neuromethods #37)
by Andréa C. LeblancIn this revised and expanded second edition, seasoned experts describe in step-by-step detail their best state-of-the-art techniques for studying neuronal cell death. These readily reproducible methods solve a wide variety of research problems, including the detection of the key proteins involved in neuronal apoptosis (Bax protein, cytochrome c, and caspases), the direct assessment of the role of pro-apoptotic proteins in neurons by viral infections and microinjections, and the detection of pro-apoptotic proteins in situ. There are also hands-on methods for the study of apoptosis mechanisms in neuronal compartments, for studying synaptosis, and for establishing gene expression profiles in neurodegenerative brain tissues by using DNA microarrays.
Apoptosis and Cancer: Methods and Protocols (Methods in Molecular Biology #1219)
by Gil Mor Ayesha B. AlveroIn Apoptosis and Cancer: Methods and Protocols, Second Edition, expert researches in the field detail the performance of molecular and cellular biology techniques for studying and detecting the activation of the apoptotic pathway. Chapters focus on assays developed to detect its activation not only in vitro but also in vivo, optimized multiplex analysis, medium- to high-throughput screens, and the cellular process. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Apoptosis and Cancer: Methods and Protocols, Second Edition aids scientists as a stand-alone resource for the execution and analysis of the described protocols and as a reference for the study and detection of apoptosis within and outside the area of cancer research.