- Table View
- List View
Resistance to Aromatase Inhibitors in Breast Cancer
by Alexey LarionovAromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.
Resistance to COVID-19 Vaccination: Drivers, Impact on Human Wellbeing, and Policy Implications (Human Well-Being Research and Policy Making)
by Stephanie Rossouw Talita GreylingThis book presents advanced methodologies for analyzing attitudes towards the COVID-19 vaccine across 10 countries spanning both the Northern and Southern hemispheres, employing cutting-edge Big Data and Fourth Industrial Revolution (4IR) techniques. Serving as an important resource for policymakers, it addresses attitudes towards and causes of growing vaccine hesitancy —a pressing concern identified by the World Health Organization as a top 10 global health threat. Moreover, the book sheds light on key factors associated with positive vaccine attitudes, aiming to bolster vaccine uptake rates. The authors explore the role of happiness in shaping health-related decision-making, offering actionable policy recommendations for governments. By sharing best-case practices, they equip policymakers and health officials worldwide with the necessary strategies to address future pandemics effectively.
Resistance to Ibritumomab in Lymphoma (Resistance to Targeted Anti-Cancer Therapeutics #18)
by Makoto Hosono Jean-François ChatalThis volume, in discussing resistance to ibritumomab, will focus on the mechanism, hematological aspects, radiological and nuclear medicine aspects, and medical physics that deal with radiation dosimetry, and will outline future prospects for overcoming resistance and enhancing efficacy of ibritumomab.
Resistance to Immunotherapeutic Antibodies in Cancer: Strategies to Overcome Resistance
by Benjamin BonavidaThe traditional approaches to treat various cancers include chemotherapy, radiation and/or hormonal therapy. While these therapies continue to be effective in large part, they are not selective and highly toxic. There have been encouraging results in alternative therapeutic approach called antibody-mediated anti-cancer therapy, which is less toxic, more selective, and can also reverse drug/radiation resistance. Monoclonal antibodies or mAbs can be used to destroy malignant tumor cells and prevent tumor growth by blocking specific cell receptors. mAbs can bind only to cancer cell-specific antigens and induce an immunological response against the target cancer cell. The book covers the common and unique features of mAbs agains various cancer, gives the latest developments on the molecular, biochemical and genetic mechanisms of resistance by various mAbs, as well as discuss novel mAbs to overcome resistance.
Resistance to Immunotoxins in Cancer Therapy
by Benjamin Bonavida Rama Shanker VermaThis book will be a guide to understanding resistance against targeted therapeutic approaches for cancer using immunotoxins. It contains a detailed review of the history and development of targeted therapy. As well, it includes an in-depth description of the molecular and cellular mechanisms involved in cancer resistance and several novel methods to overcome resistance. Each chapter discusses different aspects of resistance and covers all the factors that may contribute to resistance in cancer cells. Finally, this volume highlights the recent findings and advances associated with tackling cancer resistance.
Resistance to Molecular Therapies for Hepatocellular Carcinoma
by Augusto VillanuevaThis volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.
Resistance to Photodynamic Therapy in Cancer
by Valentina Rapozzi Giulio JoriThis volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.
Resistance to Proteasome Inhibitors in Cancer
by Q. Ping DouThe book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e. g. , ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume. This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.
Resistance to Targeted ABC Transporters in Cancer
by Thomas EfferthThis critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors. The chapters provided complement basic research by including investigations from translational applications to clinical oncology. The development of resistance is a major obstacle in cancer chemotherapy and the field has been moving rapidly in terms of determining the mechanisms for blocking ABC transporter-mediated drug efflux by specific inhibitors and thereby overcoming multidrug resistance. The volume covers these issues in careful detail. Additional topics include the relevance of ABC transporters in resistance to novel and established anticancer drugs and prognosis of patients to compounds, compounds used in photodynamic therapy, tyrosine kinase inhibitors and others. Furthermore, the potential of radiopharmaceuticals for diagnosis of multidrug-resistant tumors and of nanotechnology to combat drug-resistant tumors is also discussed.
Resistance to Targeted Therapies Against Adult Brain Cancers
by Amanda TivnanThis volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.
Resistance to Targeted Therapies in Lymphomas (Resistance to Targeted Anti-Cancer Therapeutics #21)
by Ana C. Xavier Mitchell S. CairoOver the past few decades, lymphoma patient outcomes have improved as a result of multidrug chemotherapy and radiation therapy, intensification of treatment, improvement in supportive care, and better imaging and staging systems. Even more recently, there has been tremendous progress in the understanding of cancer cell biology and its microenvironment which has resulted in the development of biologic agents, also called "target" therapies. These therapies are more specific in targeting cancer cells either directly or via enhancement of the immune system. Many clinical studies have focused on biological agents in combination with traditional chemotherapy with the goal of improved outcomes, or reduced acute long term complications that are associated with lymphoma therapy. This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but will also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.
Resistance to Targeted Therapies in Multiple Myeloma (Resistance to Targeted Anti-Cancer Therapeutics #22)
by Silvia Cw Ling Steven TrieuMultiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.
Resistant
by Michael PalmerThey fight without conscience or remorse. Their only job is to kill. They are the most ruthless enemy we have ever faced. And they are one millionth our size. When Dr. Lou Welcome fills in last minute for his boss at a national conference in Atlanta he brings along his best friend, Cap Duncan. But an accident turns tragic when Cap injures his leg while running. Surgeons manage to save the leg, but the open wound is the perfect breeding ground for a deadly microbial invader committed to eating Cap alive from the inside out. Meanwhile, hundreds of miles away, a teenaged girl is fighting for her life against the same bacteria. The germ is resistant toany known antibiotic and the government scientist tasked with finding a cure has been kidnapped. Turning to the Centers for Disease Control for help, Lou Welcome uncovers a link to a shadowy group known as One Hundred Neighbors that has infiltrated our society and is using our health institutions as hostages. Like the deadly germs they can unleash, One Hundred Neighbors will stop at nothing to further their agenda. From the hospital corridors where anything you touch can mean your end, to the top corridors of power in this race against time, Lou must stop an epidemic, save his best friend, and face even his own most terrifying demons. From the New York Times bestselling author comes another heart stopping thriller that will make you look at the world around you in a new and frightening way.
Resistant Hypertension
by Massimo SalvettiThis book is designed to assist physicians in the everyday management of hypertensive patients, with a particular focus on difficult-to-treat and resistant hypertension. The selected clinical cases are representative of the patients who are seen in the real world, rather than rare clinical cases, and provide examples of management according to current international guidelines. The scenarios considered include not only cases in which arterial hypertension is truly resistant but also instances of pseudo-resistant hypertension, including cases in which resistance is related to comorbidities, concomitant treatments, or the use of drugs. The ultimate objective is to provide paradigmatic examples of evidence-based approaches to difficult-to-treat patients that will help physicians to select the most appropriate diagnostic tools and evidence-based treatment strategy for each individual patient. "
Resistant Hypertension in Chronic Kidney Disease
by Edgar V. Lerma Adrian Covic Mehmet KanbayThis comprehensive volume provides a detailed review on the general work up of chronic kidney disease-associated resistant hypertension. This title is separated into four parts; the first of which provides definitions, epidemiology, characteristics, risk stratification and outcomes of resistant and apparent treatment resistant hypertension. The next two sections explore pathophysiology and diagnosis, treatment in the light of new guidelines, as well as procedures and devices for neural modulation. Part four discusses public health approaches to resistant hypertension, educational programs, and resistant hypertension for general practitioners. Resistant Hypertension in CKD brings up-to-date information to nephrologists, internists, cardiologists and a wide array of other clinicians and health professionals taking care of chronic kidney disease patients.
Resistant Hypertension: Epidemiology, Pathophysiology, Diagnosis and Treatment
by Giuseppe ManciaA growing number of people suffer from so-called resistant hypertension, that is to say, high blood pressure that does not respond to treatment. This disorder is of great current interest and importance for public health, being a common clinical problem faced by both primary care clinicians and specialists. Furthermore, as older age and obesity are among the strongest risk factors for uncontrolled hypertension, the incidence of resistant hypertension will likely increase as the population becomes more elderly and heavier. While the prognosis of resistant hypertension is unknown, cardiovascular risk is undoubtedly increased since patients often have a history of long-standing, severe hypertension complicated by multiple other cardiovascular risk factors. This volume, compiled by a panel of world-renowned experts, offers a comprehensive exploration of resistant hypertension, covering epidemiology, complex diagnostic aspects, and the therapeutic options currently available, with due attention to overall treatment strategies. New therapeutic agents and procedures, such as renal denervation and baroreceptor stimulation, are also described. In addition, the book addresses the economic aspects of resistant hypertension and the role of the different professional figures, from GPs to hypertension specialists, in dealing with it.
Resisting Her Army Doc Rival
by Sue MacKayTwo military doctors face past trauma and guilt in order to heal their broken hearts—and move into the future together . . . Flirting with danger! Infuriating, irresistible army doc Sam Lowe is the last person Madison Hunter wants to work with. He challenges her, and soon the only thing hotter than their rivalry is their growing chemistry! But Maddy hides scars that tell a heartbreaking story, and Sam has his own emotional wounds. He’s determined to take his heart with him when he leaves the army base, yet as he starts to see beneath Maddy’s tough exterior, it becomes more and more clear that his heart belongs with her . . .
Resisting Her Rebel Doc
by Joanna NeilWorking beneath her bad-boy first love yields trouble for a beautiful doctor in this contemporary romance.Pediatrician Caitlin Braemar has moved back home to Buckinghamshire for a fresh start! She never expected to find her first love, Brodie Driscoll—who’s still drop-dead gorgeous—living next door . . . or that he’d be her new boss!In the past, Brodie always lived up to his bad-boy reputation, but as they work to save the little lives in their care, Caitlin starts to see Brodie in a whole new light!And it’s becoming clear that she might just be the woman to tame him . . .
Resisting Her Rebel Hero
by Lucy RyderEveryone loves a rebel...The county jail is the last place Dr. Cassidy Mahoney expects to be called to when she trades city life for a quiet mountain town. Especially when her patient is notorious national hero turned bad boy Major Sam Kellan!Sam might have enough testosterone to whip all the women of Crescent Lake into a frenzy, but Cassidy is determined to resist his charms-she can't risk her heart on another rebel! But with the shadows haunting Sam's eyes, a scorching hot, unforgettable kiss could lead to more than she's bargained for....
Resisting Her Rescue Doc: A Single Dad To Heal Her Heart (yoxburgh Park Hospital) / Resisting Her Rescue Doc (rescue Docs) (Rescue Docs)
by Alison RobertsAn irresistible attraction…That won’t be denied!Paramedic Cooper Sinclair’s carefully planned first day at New Zealand’s Aratika Rescue Base goes awry when he joins forces with fiery Felicity “Fizz” Wilson to rescue a car crash victim from the sea! The stunning adrenaline junkie should be off-limits to a brooding, guarded man like him, but her skill and vitality are undeniable. Cooper’s avoided love for so long, but can he ignore his attraction to Fizz?“Utterly beautiful and enchanting book, this story was as completely adorable as the photograph on the cover and most definitely a joy to read.”— Goodreads on Their Newborn Baby Gift“The first three books of this series are engrossing and fast-paced and this story is no different. Really, right from the beginning, this story had me hooked….”— Harlequin Junkie on Rescued by Her Mr. Right
Resisting the Off-Limits Pediatrician
by Kate MacGuireTheir wild attraction to one another is a complication these doctors don&’t need! And yet they can&’t seem to shake it… Read on in Kate MacGuire&’s debut novel for Harlequin Medical Romance! RESCUING PATIENTS…AND HER? Dr. Charlotte has traveled the world extensively to outrun her painful past. Yet her latest assignment in a clinic for homeless teens seems different. Maybe it&’s the satisfaction of helping troubled adolescents? Not to mention the attraction she feels for her compassionate colleague, pediatrician John! But he&’s got his hands full as guardian to his niece, so she puts him firmly off-limits. Except their spark is just too powerful to resist!From Harlequin Medical: Life and love in the world of modern medicine.
Resisting the Single Dad Next Door (Rawhiti Island Medics #1)
by Louisa GeorgeJust when she thought she wanted to leave, she finds an irresistible reason to stay…in the form of a new GP! Find out what happens in the latest Harlequin Medical Romance by Louisa George.New doc in town?Irresistible! Carly lost her husband years ago and it's finally time to move on from the beautiful island they called home. Until she meets new neighbour, GP Owen and his adorable son. Carly hasn&’t felt sparks like this in a long time, but Owen&’s still reeling from his ex-wife&’s abandonment. Since neither can commit to anything long-term, she must resist their undeniable attraction—but that's easier said than done after he kisses her under the stars!From Harlequin Medical: Life and love in the world of modern medicine.Rawhiti Island Medics Book 1: Resisting the Single Dad Next Door
Resisting the Single Dad Surgeon
by Louisa HeatonA close call with the paparazzi leaves a nurse with no choice but to hide out with the very same single dad celebrity surgeon she was photographed with in Louisa Heaton&’s latest Harlequin Medical Romance. RUNNING FROM THE LIMELIGHT… Nurse Isla is starting over. She&’s relocated to the city and has a new job—nothing can distract her. That is, until she meets single dad and handsome celebrity surgeon Gabe! Working with the widower wouldn&’t normally be an issue, but when they share an almost intimate moment and it&’s publicized, the press relentlessly pursues Isla&’s identity. Now, to protect herself, she has no choice but to move in with Gabe and his adorable daughter. Resisting each other soon becomes impossible, but after everything they&’ve been through, can they move on and build a life—together?From Harlequin Medical: Life and love in the world of modern medicine.
Resolving Dilemmas in Ophthalmology: Challenging Cases, Diagnosis and Management
by Sagarika Patyal Tulika ChauhanThis book reflects the ever-changing field of ophthalmology, and includes challenging ophthalmology case scenarios, diagnosis and management. It presents over 50 cases, covering the full spectrum of clinical, preoperative, intraoperative, and postoperative challenges. It is carefully compiled, and presents the material in an accessible form; being concise, and at the same time sufficiently elaborate for ophthalmologists. The book emphasizes the necessity of recognizing the adverse situations and dealing with it using clinical examples. This serves as a pocket guide and assists ophthalmologists in practicing, in training and students. It is a user-friendly manual of evaluation and technique with a wealth of wisdom in the indexed cases chosen by experts for their teaching value with “Take-Home Points” following each presentation.
Resolving Dilemmas in Perimetry: Illustrated Manual of Visual Field Defects
by Monica Gandhi Sagarika PatyalThis book covers interpretation of visual fields by Humphrey and Octopus perimeters and discussion of Humphrey visual fields in a variety of ocular disorders.It examines dilemmas faced by an ophthalmologist while evaluating visual fields which do not match with the clinical picture. Glaucoma, the commonest condition for visual field investigation is discussed in detail. Logical reasoningfor incorporating perimetry in glaucoma management with a clear understanding of the challenges in its interpretation is delved into. The book progresses to advanced glaucoma and glaucoma progression. It discusses a systematic evaluation of various parts of the visual field so that the reader can make a calculated management plan for their patient. Each chapter attempts to clearly enunciate factors that help in the diagnosis and features which may be confused with other conditions. Fields which help diagnosing early, advanced glaucoma and glaucoma progression with images and methods of ensuring reasonable diagnostic accuracy are included. The book incorporates separate chapters on ocular conditions which also mimic visual field defects of glaucoma with detailed modes of correct diagnosis, diagnostic dilemmas arising from retinal, macular, vascular, visual pathway lesions mimicking visual field defects of glaucoma or while coexisting with glaucoma, supported by algorithms to achieve a quick diagnosis in a busy OPD without missing the clinical findings and by using minimal investigative modalities. This book helps clinicians to prevent over diagnosis or under diagnosis of glaucoma and helps diagnose cases with morbidities causing visual field defects.