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SARS-CoV-2 Spike Protein Convergent Evolution: Impact of Virus Variants on Efficacy of COVID-19 Therapeutics and Vaccines (SpringerBriefs in Microbiology)

This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.

SARS-CoV-2 and Coronacrisis: Epidemiological Challenges, Social Policies and Administrative Strategies

This book is useful for administrators of different levels involved in counteracting COVID-19, surveillance professionals, clinicians, researchers specializing in epidemiology, microbiology, and infectious diseases, and politicians / legislators engaged in public health sector.We use an innovative approach of combining both epidemiological and sociological analyses, as the very problem is mainly an issue of correct governance. A team of authors from Europe, Russia and China summarizes their experience and knowledge useful for containing SARS-CoV-2 and overcoming social and managerial consequences of the pandemic. The editors are sure that sharing our different experience would help to elaborate necessary strategies, protocols, and principles that may be effectively applied in the future to avoid dramatic consequences of not only COVID-19 but also any possible epidemiological hazards for people and medicine.

SARS-CoV-2: Methods and Protocols (Methods in Molecular Biology #2452)

This detailed volume provides the increasing number of SARS-CoV-2 researchers with a useful handbook covering multidisciplinary approaches on various aspects of SARS-CoV-2 research, brought together by leading laboratories across the globe. Topics covered include techniques in clinical and diagnostic virology, basic protocols in cell and virus culture, as well as bioinformatics and proteomics approaches in cellular response studies. This comprehensive collection also covers methods in immunology, animal models, antivirals and vaccine development strategies, as well as biorisk and mitigation measurements for SARS-CoV-2 research. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that is vital for success in the lab. Practical and timely, SARS-CoV-2: Methods and Protocols serves as an ideal guide for scientists investigating this prevalent and perilous RNA virus and the novel coronavirus disease that results from it.

SARS-CoV2 (COVID-19) Pandemic Control and Prevention: An Epidemiological Perspective

This is the first comprehensive text to provide not only a detailed explanation of how the SARS-CoV2 (COVID-19) virus is spread within human populations, but also an epidemiological analysis and interpretation of viral pandemics to enable better measures for prevention and control. Providing an introduction to the physiology of both the human immune system and the SARS-CoV2 virus, specifically the virus’s replicative potential and our own vulnerability, the book offers an in-depth understanding of how the pandemic evolved. It also highlights the aberrant epigenomic mechanistic process in pathogenic microbe’s replication and survival, implying gene and environment interaction that affected different populations. Citing a range of environmental conditions, from structural and systemic racism to malnutrition and low-socioeconomic status, the book examines how these factors exacerbated existing health disparities, resulting in a disproportionate burden of morbidity and mortality on certain social groups. Also providing invaluable guidance on how future iterations of this pandemic may be better prevented and controlled, this will be a defining book for students, researchers and professionals within Public Health and Clinical Medicine to better understand the SARS-CoV2 (COVID-19) virus, and how to protect the most vulnerable social groups.

SAS for Epidemiologists

This comprehensive text covers the use of SAS for epidemiology and public health research. Developed with students in mind and from their feedback, the text addresses this material in a straightforward manner with a multitude of examples. It is directly applicable to students and researchers in the fields of public health, biostatistics and epidemiology. Through a "hands on" approach to the use of SAS for a broad number of epidemiologic analyses, readers learn techniques for data entry and cleaning, categorical analysis, ANOVA, and linear regression and much more. Exercises utilizing real-world data sets are featured throughout the book. SAS screen shots demonstrate the steps for successful programming. SAS (Statistical Analysis System) is an integrated system of software products provided by the SAS institute, which is headquartered in California. It provides programmers and statisticians the ability to engage in many sophisticated statistical analyses and data retrieval and mining exercises. SAS is widely used in the fields of epidemiology and public health research, predominately due to its ability to reliably analyze very large administrative data sets, as well as more commonly encountered clinical trial and observational research data.

SAVING WOMEN'S LIVES: Strategies for Improving Breast Cancer Detection and Diagnosis

The National Academies Press (NAP)--publisher for the National Academies--publishes more than 200 books a year offering the most authoritative views, definitive information, and groundbreaking recommendations on a wide range of topics in science, engineering, and health. Our books are unique in that they are authored by the nation's leading experts in every scientific field.

SBA Questions for the Part 2 MRCOG

SBA Questions for the Part 2 MRCOG is a valuable preparation resource aimed at those specialising in Obstetrics and Gynaecology who are planning to take the Part 2 MRCOG examination. It contains two hundred practice single best answer questions written by MRCOG question writers, with accompanying explanations and references. It also contains an introduction to the new format of the examination and the rationale for the changes. The first section consists of two hundred single best answers allowing the reader to test their knowledge. The second section lists the correct response accompanied by an explanation and suggestions for further reading. SBA Questions for the Part 2 MRCOG is the only official preparation book produced by the RCOG and is therefore essential reading for candidates sitting this examination in its new format.

SBA and MTF MCQs for the Final FRCA

Preparing for the Final FRCA? Wondering what to expect of the SBA questions? Help is at hand. This practical book contains 60 single best answer and 120 multiple true/false questions to help you revise for the Final FRCA MCQ exam. Each question is accompanied by detailed explanations, giving additional information on each topic to enhance revision. SBA and MTF MCQs for the Final FRCA may be used both for examination practice and as a source of knowledge on many of the key topics in the syllabus. A helpful introductory section gives practical advice on how to approach revision and sitting the exam. From the writing team behind the FRCAQ.com website (www.frcaq.com), an outstanding exam preparation source for both the Primary and Final FRCA, this book provides challenging questions and well researched explanations to help you through the Final FRCA MCQ paper. An invaluable tool for your MCQ exam preparation.

SBAs and EMQs for MRCOG II

This book is a comprehensive collection of questions in the "single best answer (SBA)" format for the MRCOG2 theory exam. This new format has been introduced in the exam paper from March 2015 and most candidates are still getting used to the change. This book will provide them ample opportunity to familiarize themselves with the concept and then practice answering the questions based on almost all subjects included in the MRCOG 2 theory syllabus. Preparing for the MRCOG2 exam is a daunting task for all Obstetrics and Gynecology doctors. The college constantly reforms the exam structure in an effort to optimize the evaluation process. The endeavor of the authors is to equip the candidates with a vision of the holistic nature of the exam so that they master the art of answering SBA questions.

SBAs and EMQs in Obstetrics and Gynaecology for Medical Students (Masterpass Ser.)

'Regardless of your level of obstetrics and gynaecology knowledge and experience, this book will most definitely have something to offer you.'- Tiago Villanueva in his Foreword. Undergraduate medical students often struggle with at least some of the specialty elements of their studies. Some face a further challenge with the advent of the Medical Schools Council Assessment Alliance (MSC-AA, formerly known as UMAP), with a move away from testing specific clinical facts to an assessment focused on preparing to be a foundation doctor and the knowledge such a trainee needs on a daily basis. Neel Sharma has written three self-assessment books - on psychiatry, obstetrics and gynaecology, and paediatrics - designed to help students tackle both the new form of assessment as well as the traditional style of examination. Questions covering all common presentations are included in SBA and EMQ formats with relevant, concise explanations as answers.

SBAs and EMQs in Paediatrics for Medical Students (MasterPass)

Dr Sharma has definitely mastered the art of producing a comprehensive, evidence-based review tool of core paediatric knowledge whilst at the same time appealing to a broad audience, which in my opinion is quite a remarkable achievement. You're definitely looking at an invaluable resource and buying this book will help you to rise up to the challen

SBAs and EMQs in Psychiatry for Medical Students (Radcliffe Ser.)

'If you're looking for a structured and comprehensive framework to enable you to review the complete ins and outs of psychiatry then this book is most definitely for you.' Tiago Villanueva in his Foreword. Undergraduate medical students often struggle with at least some of the specialty elements of their studies. Some face a further challenge with the advent of the Medical Schools Council Assessment Alliance (MSC-AA, formerly known as UMAP), with a move away from testing specific clinical facts to an assessment focused on preparing to be a foundation doctor and the knowledge such a trainee needs on a daily basis. Neel Sharma has written three self-assessment books - on psychiatry, obstetrics and gynaecology, and paediatrics - designed to help students tackle both the new form of assessment as well as the traditional style of examination. Questions covering all common presentations are included in SBA and EMQ formats with relevant, concise explanations as answers.

SBAs and EMQs in Surgery for Medical Students (Masterpass Ser.)

The key to passing the written finals is practice, practice, practice. With hundreds of sample SBAs and EMQs to test your knowledge, this unique revision guide offers a great foundation. The highly detailed answers explain each concept fully and help to develop an understanding of this notoriously vast subject. More than a traditional question and

SBAs for the FRCEM

SBAs for the FRCR 2A

SBAs for the Final FRCR is an invaluable guide to the new Single Best Answer (SBA) paper for the Final FRCR examination, providing over 350 SBA-style questions and referenced answers written in the style of the Royal College of Radiologists. Each question is accompanied by a concise yet detailed model answer carrying references and additional notes. The answers also act as a useful reference source for many of the key topics found in the syllabus. Questions are categorised in the same six modules that compose the FRCR 2A: • Cardiothoracic and vascular • Musculoskeletal and trauma • Gastro-intestinal • Genito-urinary, adrenal, obstetrics and gynaecology, breast • Paediatric • Central nervous system, head and neck Written by a group of authors who have recently successfully completed the exams, SBAs for the Final FRCR is an essential revision aid for all candidates undertaking the FRCR Part 2A.

SBAs for the Final FRCA

This is the first book dedicated to providing exam practice in the new required single best answer question style for the FRCA. It contains 300 single best answer multiple choice questions and advice on how to approach revision and sitting the exam. There are also four 75-question exam papers, each with an answer section containing detailed explanations of the reasoning behind the answer and providing background information about each topic. SBAs for the Final FRCA may be used for examination practice and as a source of knowledge on many of the key topics in the syllabus. From the writing team behind SAQs for the Final FRCA, this book uses a similar style of challenging questions and well researched explanations to help the candidate through the new FRCA written paper. This is an invaluable tool for your exam preparation.

SBAs for the MRCS Part A: A Bailey & Love Revision Guide

The four Surgical Royal Colleges have recently received approval from the GMC to make changes to the MRCS Part A Examination. The second edition of this popular book,SBAs and EMQs for the MRCS Part A is an invaluable guide to sitting and passing the new MRCS examination.There is an increased emphasis on Anatomy and Basic Sciences,which now account for 60% of the exam. College-approved,systematic and coherent questions for all the main systems are included, providing comprehensive coverage of the curriculum. The Question and Answer format, including many more Single Best Answers aids revision.Expanded to reflect the new 2017curriculum

SCAI Interventional Cardiology Review

Whether you’re studying for the interventional cardiology board exam, preparing for recertification, or simply want a concise review of the field, SCAI Interventional Cardiology Review, 3rd Edition, brings you up to date with recent changes in interventional cardiology while also preparing you for exam success. Written by global experts who are Society for Cardiovascular Angiography and Interventions (SCAI) members and leaders, coverage includes all topics on the exam, with the addition of new review questions, new topics, and revised information throughout.

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.

SCID-I Administration Booklet: Structured Clinical Interview for DSM-IV Axis I Disorders. Clinician Version

The Administration Booklet contains interview questions and DSM-IV diagnostic criteria. It is designed to be used with the Scoresheet during a 45- to 90-minute session and is tabbed to help the clinician move from one section to another.

SCN2A-Related Disorders (Elements in Genetics in Epilepsy)

SCN2A encodes a voltage-gated sodium channel (designated NaV1.2) vital for generating neuronal action potentials. Pathogenic SCN2A variants are associated with a diverse array of neurodevelopmental disorders featuring neonatal or infantile onset epilepsy, developmental delay, autism, intellectual disability and movement disorders. SCN2A is a high confidence risk gene for autism spectrum disorder and a commonly discovered cause of neonatal onset epilepsy. This remarkable clinical heterogeneity is mirrored by extensive allelic heterogeneity and complex genotype-phenotype relationships partially explained by divergent functional consequences of pathogenic variants. Emerging therapeutic strategies targeted to specific patterns of NaV1.2 dysfunction offer hope to improving the lives of individuals affected by SCN2A-related disorders. This Element provides a review of the clinical features, genetic basis, pathophysiology, pharmacology and treatment of these genetic conditions authored by leading experts in the field and accompanied by perspectives shared by affected families. This title is also available as Open Access on Cambridge Core.

SDG 14: A Machine-Generated Overview of Recent Literature

This book focuses, in seven chapters, on the perspectives and solutions that different research groups offer to try to address problems related to SDG 14: Life Below Water. The different objectives developed in SDG 14 are treated independently, with an attempt to give a global vision of the issues. The mechanism used to select the book's content was through an Artificial Intelligence program, choosing articles related to the topics by means of keywords. The program selected those articles, and those that were not related to the topic or did not focus on SDG 14 were discarded by a subject matter expert. Obviously, the selection was partial and the entire subject is not covered, but the final product gives a very solid idea of ​​how to orient ourselves to delve deeper into the topic of SDG 14 using published chapters and articles. The AI program itself selected the text of these contributions to show the progress in different topics related to SDG 14. This mode of operation will allow specialists (and non-specialists) to collect useful information for their specific research purposes in a short period of time. At a time when information is essential in order to move quickly by providing concrete answers to complex problems, this type of approach will become essential for researchers, especially for a subject as vast as SDG 14.

SH Domains

This book covers structure, function, and important roles of the SH domains, structure-function relationships, the versatile nature of their action, mechanisms of aggregation, specificity of interactions, impact of mutations on protein functional dysregulation, and cell signaling. Their involvement in various cellular processes such as migration, invasiveness, actin reorganization, shaping spines, determination of the morphology assembly of fibrils, and mechanotransduction makes these molecules attractive drug targets. Substrates, inhibitors and activators of PTKs present a wide variety of therapeutic agents in the context of delivering treatments for numerous pathologies. The new emerging field of stem cell therapies and design of biomaterials for treatments relies on the directed regulation of stem cell growth, differentiation and morphology, as well as the production of biomimetic scaffolds that respond to programmed signals. Advances in deciphering the mechanisms of action of these important molecules will lead to the implementation and success of their vital applications.

SIR - Modell durch eine neue Dichte unterstützt: Handlungsdokument für ein angepasstes COVID – Management

Das durch eine neue Dichte unterstützte SIR – Modell und dessen Derivate erhalten einen statistischen Datenhintergrund aus Häufigkeitsverteilungen, aus deren Parameterwerten über die neue Dichteverteilung auf eine qualitätsorientierte Wahrscheinlichkeit des jeweiligen Infektionsprozesses und seiner Zukunft geschlossen werden kann. Dadurch erhält das COVID - Management eine funktionsgemäße modellhafte Grundlage zur vorbeugenden Steuerung der Komponenten Zeitplanung, Kostenentwicklung, Qualitätsmanagement und Personal- und Materialeinsatz.

SIRT6 Activities in DNA Damage Repair and Premature Aging: Functions of SIRT6 (Springer Theses)

This book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation etc. Taken together, these studies reveal the various regulatory roles of SIRT6, which are of substantial biological relevance in DNA damage repair, aging and longevity, and can have significant implications in devising therapeutic strategies to combat age-associated pathologies. Given its scope, the book offers a valuable resource for students and researchers in the fields of genetics, cell biology, molecular biology etc.