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SPSS for Starters, Part 2
by Aeilko H. Zwinderman Ton J. CleophasThe first part of this title contained all statistical tests that are relevant for starters on SPSS, and included standard parametric and non-parametric tests for continuous and binary variables, regression methods, trend tests, and reliability and validity assessments of diagnostic tests. The current part 2 of this title reviews multistep methods, multivariate models, assessments of missing data, performance of diagnostic tests, meta-regression, Poisson regression, confounding and interaction, and survival analyses using log tests and segmented time-dependent Cox regression. Methods for assessing non linear models, data seasonality, distribution free methods, including Monte Carlo methods and artificial intelligence, and robust tests are also covered. Each method of testing is explained using a data example from clinical practice,including every step in SPSS, and a text with interpretations of the results and hints convenient for data reporting. In order to facilitate the use of this cookbook the data files of the examples is made available by the editor through extras.springer.com. Both part 1 and 2 of this title contain a minima amount of text and maximal technical details, but we believe that this property will not refrain students from mastering the SPSS software systematics, and that, instead, it will be a help to that aim. Yet, we recommend that it will used together with the textbook "Statistics Applied to Clinical Trials" (5th edition, Springer, Dordrecht 2012) and the e-books "Statistics on a Pocket Calculator Part 1 and 2 (Springer, Dordrecht, 2011 and 2012) from the same authors.
SPSS for Starters, Part 2 (SpringerBriefs in Statistics)
by Aeilko H. Zwinderman Ton J. CleophasThe first part of this title contained all statistical tests that are relevant for starters on SPSS, and included standard parametric and non-parametric tests for continuous and binary variables, regression methods, trend tests, and reliability and validity assessments of diagnostic tests. The current part 2 of this title reviews multistep methods, multivariate models, assessments of missing data, performance of diagnostic tests, meta-regression, Poisson regression, confounding and interaction, and survival analyses using log tests and segmented time-dependent Cox regression. Methods for assessing non linear models, data seasonality, distribution free methods, including Monte Carlo methods and artificial intelligence, and robust tests are also covered. Each method of testing is explained using a data example from clinical practice,including every step in SPSS, and a text with interpretations of the results and hints convenient for data reporting. In order to facilitate the use of this cookbook the data files of the examples is made available by the editor through extras.springer.com. Both part 1 and 2 of this title contain a minima amount of text and maximal technical details, but we believe that this property will not refrain students from mastering the SPSS software systematics, and that, instead, it will be a help to that aim. Yet, we recommend that it will used together with the textbook "Statistics Applied to Clinical Trials" (5th edition, Springer, Dordrecht 2012) and the e-books "Statistics on a Pocket Calculator Part 1 and 2 (Springer, Dordrecht, 2011 and 2012) from the same authors.
STAT Inhibitors in Cancer
by Alister C. WardThis volume, which includes contributions from leading scientists and clinicians in the field, provides definitive, state-of-the-art information on STAT inhibitors in a biological and clinical context. It gives an overview of the biology of the STAT family of transcription factors and their role in cancer etiology. Additionally, it describes the raft of therapeutic approaches being used to inhibit STATs in the context of various cancers, covering the full spectrum of therapeutic approaches to inhibiting STATs, and presenting emerging data from clinical trials.
STEMI vs. “FEMI”: A Real STEMI or a Fake STEMI
by Henry K. SiuPublisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. For patients presenting with chest discomfort or other suspicious cardiac symptoms, distinguishing between ST-elevation myocardial infarction (STEMI) and “fake ST elevation MI” (“FEMI”) is of utmost importance. Although efficient and accurate ECG interpretation is vital, it is often difficult in nuanced clinical situations that contribute to diagnostic uncertainty. Now you can sharpen your clinical skills in this critical area with a unique resource that offers real-world practice in identifying actual STEMI events vs. FEMI.
STOP, THAT and One Hundred Other Sleep Scales
by Shai Marcu Azmeh Shahid Kate Wilkinson Colin M ShapiroThere are at least four reasons why a sleep clinician should be familiar with rating scales that evaluate different facets of sleep. First, the use of scales facilitates a quick and accurate assessment of a complex clinical problem. In three or four minutes (the time to review ten standard scales), a clinician can come to a broad understanding of the patient in question. For example, a selection of scales might indicate that an individual is sleepy but not fatigued; lacking alertness with no insomnia; presenting with no symptoms of narcolepsy or restless legs but showing clear features of apnea; exhibiting depression and a history of significant alcohol problems. This information can be used to direct the consultation to those issues perceived as most relevant, and can even provide a springboard for explaining the benefits of certain treatment approaches or the potential corollaries of allowing the status quo to continue. Second, rating scales can provide a clinician with an enhanced vocabulary or language, improving his or her understanding of each patient. In the case of the sleep specialist, a scale can help him to distinguish fatigue from sleepiness in a patient, or elucidate the differences between sleepiness and alertness (which is not merely the inverse of the former). Sleep scales are developed by researchers and clinicians who have spent years in their field, carefully honing their preferred methods for assessing certain brain states or characteristic features of a condition. Thus, scales provide clinicians with a repertoire of questions, allowing them to draw upon the extensive experience of their colleagues when attempting to tease apart nuanced problems. Third, some scales are helpful for tracking a patient's progress. A particular patient may not remember how alert he felt on a series of different stimulant medications. Scale assessments administered periodically over the course of treatment provide an objective record of the intervention, allowing the clinician to examine and possibly reassess her approach to the patient. Finally, for individuals conducting a double-blind crossover trial or a straightforward clinical practice audit, those who are interested in research will find that their own clinics become a source of great discovery. Scales provide standardized measures that allow colleagues across cities and countries to coordinate their practices. They enable the replication of previous studies and facilitate the organization and dissemination of new research in a way that is accessible and rapid. As the emphasis placed on evidence-based care grows, a clinician's ability to assess his or her own practice and its relation to the wider medical community becomes invaluable. Scales make this kind of standardization possible, just as they enable the research efforts that help to formulate those standards. The majority of Rating Scales in Sleep and Sleep Disorders: 100 Scales for Clinical Practice is devoted to briefly discussing individual scales. When possible, an example of the scale is provided so that readers may gain a sense of the instrument's content. Groundbreaking and the first of its kind to conceptualize and organize the essential scales used in sleep medicine, Rating Scales in Sleep and Sleep Disorders: 100 Scales for Clinical Practice is an invaluable resource for all clinicians and researchers interested in sleep disorders.
STRATEGIES TO LEVERAGE RESEARCH FUNDING: Guiding DOD's Peer Reviewed Medical Research Programs
by Committee on Alternative Funding Strategies for DOD's Peer Reviewed Medical Research ProgramsSince 1992 the Department of Defense (DOD), through the U. S. Army Medical Research and Material Command, has received congressionally earmarked appropriations for programs of biomedical research on prostate, breast, and ovarian cancer; neurofibromatosis; tuberous sclerosis; and other health problems. Appropriations for these Congressionally Directed Medical Research Programs are used to support peer reviewed extramural research project, training, and infrastructure grants. Congress has become concerned about funding increases for these programs given current demands on the military budget. At the request of Congress, the Institute of Medicine (IOM) examined possibilities of augmenting program funding from alternative sources. The resulting IOM book, Strategies to Leverage Research Funding: Guiding DOD’s Peer Reviewed Medical Research Programs, focuses on nonfederal and private sector contributions that could extend the appropriated funds without biasing the peer review project selection process.
SUBMARINE EXPOSURE GUIDANCE LEVELS FOR SELECTED HYDROFLUOROCARBONS: HFC-236fa, HFC-23, and HFC-404a
by Subcommittee on Exposure Guidance Levels for Selected HydrofluorocarbonsThe National Academies Press (NAP)--publisher for the National Academies--publishes more than 200 books a year offering the most authoritative views, definitive information, and groundbreaking recommendations on a wide range of topics in science, engineering, and health. Our books are unique in that they are authored by the nation's leading experts in every scientific field.
SUMMARY OF A WORKSHOP ON RESEARCH IN MULTIPLE SCLEROSIS April 5-6, 2001
by Board On Neuroscience Behavioral HealthThe National Academies Press (NAP)--publisher for the National Academies--publishes more than 200 books a year offering the most authoritative views, definitive information, and groundbreaking recommendations on a wide range of topics in science, engineering, and health. Our books are unique in that they are authored by the nation's leading experts in every scientific field.
SUMO Regulation of Cellular Processes
by G. WilsonOver a decade ago, a small cellular protein of 12 kDa, with 18% homology to the well-known ubiquitin protein, was co-discovered and termed Small Ubiquitin-like Modifier, or SUMO. Sumoylation is a post-translational modification that utilizes SUMO as the modifier group covalently attached to target substrates. This state-of-the art review on the sumoylation system deals with protein modification as it pertains to regulation of diverse cellular functions. Each chapter has been written by a leading researcher and covers the role of sumoylation in fundamental biochemical activities (transcription, RNA processing, chromatin remodelling, DNA repair, nucleocytoplasmic transport, ion channel regulation, and metabolic pathways). The text also examines the part sumoylation plays in critical cellular processes such as mitosis, meiosis, differentiation, senescence, and apoptosis. Lastly, the emerging role of sumoylation in specific diseases, including cancer and diabetes as well as neurodegenerative ones, is explored with an emphasis on defining molecular mechanisms that may provide new targets for treatment or prevention. While SUMO was discovered more than 10 years ago, this is still a relatively young field, and much remains to be discovered about the biochemical and biological properties of this modification system. In just the last few years, it has become clear that sumoylation modifies hundreds of cellular proteins, and there has been increased appreciation for the breadth of cellular functions that are impacted by this post-translational modification.
SUMO Regulation of Cellular Processes
by Van G. WilsonOver a decade ago, a small cellular protein of 12 kDa, with 18% homology to the well-known ubiquitin protein, was co-discovered and termed Small Ubiquitin-like Modifier, or SUMO. Sumoylation is a post-translational modification that utilizes SUMO as the modifier group covalently attached to target substrates. This state-of-the art review on the sumoylation system deals with protein modification as it pertains to regulation of diverse cellular functions. Each chapter has been written by a leading researcher and covers the role of sumoylation in fundamental biochemical activities (transcription, RNA processing, chromatin remodelling, DNA repair, nucleocytoplasmic transport, ion channel regulation, and metabolic pathways). The text also examines the part sumoylation plays in critical cellular processes such as mitosis, meiosis, differentiation, senescence, and apoptosis. Lastly, the emerging role of sumoylation in specific diseases, including cancer and diabetes as well as neurodegenerative ones, is explored with an emphasis on defining molecular mechanisms that may provide new targets for treatment or prevention. While SUMO was discovered more than 10 years ago, this is still a relatively young field, and much remains to be discovered about the biochemical and biological properties of this modification system. In just the last few years, it has become clear that sumoylation modifies hundreds of cellular proteins, and there has been increased appreciation for the breadth of cellular functions that are impacted by this post-translational modification.
Saber comer
by Michael PollanUna guía sencilla para comer de manera inteligente Comer no tiene por qué ser tan complicado. En esta época de dietas milagrosas demasiado elaboradas y consejos contradictorios sobre salud y nutrición, Saber comer nos ofrece 64 reglas básicas para nuestra alimentación diaria. Escrito con claridad, precisión y una agudeza que lo ha llevado a convertirse en un bestseller, este manual indispensable bebe de una gran variedad de tradiciones y nos muestra cómo las distintas culturas han alcanzado a través de los siglos una sabiduría común sobre la comida. Saber comer es un manual perfecto para gente con sentido común y para todo aquel que alguna vez se haya preguntado "¿qué, cuándo, y cómo debería comer?".
Sacred Knowledge: Psychedelics and Religious Experiences
by William RichardsSacred Knowledge is the first well-documented, sophisticated account of the effect of psychedelics on biological processes, human consciousness, and revelatory religious experiences. Based on nearly three decades of legal research with volunteers, William A. Richards argues that, if used responsibly and legally, psychedelics have the potential to assuage suffering and constructively affect the quality of human life.Richards's analysis contributes to social and political debates over the responsible integration of psychedelic substances into modern society. His book serves as an invaluable resource for readers who, whether spontaneously or with the facilitation of psychedelics, have encountered meaningful, inspiring, or even disturbing states of consciousness and seek clarity about their experiences. Testing the limits of language and conceptual frameworks, Richards makes the most of experiential phenomena that stretch our understanding of reality, advancing new frontiers in the study of belief, spiritual awakening, psychiatric treatment, and social well-being. His findings enrich humanities and scientific scholarship, expanding work in philosophy, anthropology, theology, and religious studies and bringing depth to research in mental health, psychotherapy, and psychopharmacology.
Sacred Plant Medicine: Explorations in the Practice of Indigenous Herbalism
by Stephen H. BuhnerIn Sacred Plant Medicine Stephen Buhner examines how indigenous peoples throughout the world learned the use of plant medicines. He explores the sacred dimension of plant and human interactions--a territory where humans experience communications from plants as expressions of Spirit. Indigenous peoples were clear, and Buhner's firsthand accounts bear this out, they did not learn the uses of plant medicines through trial and error but directly from the plants themselves. Sacred Plant Medicine develops a map of the territory of plant intelligence and the human interaction with it by focusing on the earliest and most basic human form of that contact between differing intelligences. For each healing plant described in the book, he presents medicinal uses, preparatory guidelines, and ceremonial elements such as prayers and medicine songs associated with the use of the plant. Each of us can communicate with the plants and become one with them.
Sacrifice: How the Deadliest Vaccine in History Targeted the Most Vulnerable
by Celia Farber James ThorpSacrifice documents the true story of Dr. James Thorp, a respected doctor of maternal fetal medicine, who in 2020, finds his entire profession has lost its mind, as well as its soul. Stunned to find his colleagues take the bribe money, drink the Kool-Aid, and push the COVID-19 shots, Thorp is one of the few Ob-Gyns to bear witness and broadcast the multitude of pregnancy complications including miscarriages, stillbirths, and many other tragic outcomes resulting from the shots. One of the few doctors from the maternal-fetal medicine realm who publicly protested the Covid shots as directly deadly to his patients—unborn babies—Thorp witnessed the carnage on a daily basis firsthand, documented it, published papers, and spoke up on countless media platforms, and in Senate hearings in Washington, DC. He was terminated, without any cause, and went on to campaign around the country to get the truth out. This is his story.
Sacrificing the WHO to the Highest Bidder
by James Raftery Theodore MacdonaldThis remarkable book offers enlightening reading for everyone interested in international law, human rights, global health, public health and health promotion. Public health and health promotion professionals, including international healthcare organisations, care agencies, and international charities will find the analysis illuminating. It is also of great interest to policy makers and shapers in communities and government, political activists and all those with an interest in equality and globalisation.
Sacroiliac Joint Disorder: Accurately Diagnosing Low Back Pain
by Eiichi MurakamiThis book focuses on low back pain, comprehensively covering the concept, etiology, diagnosis and treatment for those types of pain specifically caused by sacroiliac joint dysfunction. Particular attention is given to understanding the pathology, diagnostic techniques and useful methods for successfully treating patients. Sacroiliac joint pain, which is one of the most common causes of non-specific low back pain, shows no specific abnormal imaging findings on X-ray, CT or MRI; as a result, it is difficult to diagnose or even misdiagnosed. Further, in recent years the sacroiliac joint has become the subject of growing interest, and innovative implant systems such as iFuse and DIANA are now being developed for its treatment. Accordingly, Sacroiliac Joint Pain offers a valuable resource for healthcare professionals such as orthopedic surgeons, family doctors, spine surgeons, pain clinicians, rehabilitation doctors, physical therapists, osteopathists and patients suffering from low back pain.
Sacroiliac Joint Dysfunction and Piriformis Syndrome: The Complete Guide for Physical Therapists
by Paula ClaytonThis complete guide to treating patients with sacroiliac joint dysfunction, or piriformis syndrome, combines multiple techniques--rather than the usual single approach--to get quicker and more resilient results. Focusing on the practical application of skills acquired in twenty years of treating elite athletes, Paula Clayton provides a comprehensive guide to the latest discussions of the therapeutic handling of fascial tissue, dry needling, instrument-assisted soft-tissue manipulation, and dynamic taping. Presenting material formerly unavailable in one volume, this book provides evidence-based information on fundamental principles that enable practitioners to map approaches to dysfunction and injury before attempting hands-on treatments. Superbly designed for ease of use and supported with full-color illustrations that clarify and complement the text, this book puts decades of experience and research at readers' fingertips, expanding their ability to both improve their practice and educate their patients.
Sad Janet
by Lucie BritschA whip-smart black comedy for fans of Fleabag and My Year of Rest and Relaxation'Loved this book' EMMA GANNON'Surprising and irreverent...Be prepared for edginess, dark humor and profanity' NEW YORK TIMES'Hilarious, wise, wicked' CYNTHIA D'APRIX SWEENEYNamed one of the Best Books of the Summer by LitHub, The Millions, Refinery29, and Hey Alma.***Meet Janet. Janet is sad. Not about her life, about the world. Have you seen it these days? The thing is, she's not out to make anyone else sad. She's not turning up to weddings shouting that most marriages end in divorce. She just wants to wear her giant coat, get rid of her passive-aggressive boyfriend, and avoid human interaction at the rundown dog shelter where she works.That is, until word spreads about a new pill that promises cynics like her one day off from being sad. When her family stages an intervention, and the prospect of making it through Christmas alone seems like too much, Janet finally decides to give them what they want. What follows is life-changing for all concerned - in ways no one quite expects.Hilarious, provocative and profound, Sad Janet is the antidote to our happiness-obsessed world.***PRAISE FOR SAD JANET:'If you're a Halle Butler fan or like despair cut with humour, you'll love this' Leigh Stein, author of SELF CARE'As I was reading this, my partner kept asking why I was laughing. This book is dark and hilarious and will speak to everyone who's ever wondered why they spend time with humans and not just dogs' Rowan Hisayo Buchanan, author of Starling Days and Harmless Like You'A tragicomic riot of a book - charging, foul-mouthed and tender, across the modern condition' Claudia Dey, author of Heartbreaker'Try reading Sad Janet ... It might just make you happy' Marcy Demansky, author of Very Nice'A biting, pitch-perfect novel about one woman's desire to stay true to herself in a world that rewards facile happiness ... a dazzling debut' Cynthia D'Aprix Sweeney'The narrative voice of Janet in Britsch's debut novel is a skin-tingling combination of new and necessary' Booklist starred review'Loved this book... it made me lol via the dark humour and dry observations. An artful take on the "happiness economy"' Emma Gannon, author of Olive'I loved SAD JANET'S cynical humour. Superbly original, with spot-on one-liners. Brilliantly bleak, but with a spark of hope' Caroline Hulse, author of The Adults
Sadie X (Literature in Translation Series)
by Aimee Wall Clara Dupuis-MorencyHaving followed the brilliant virologist RÉgnier from Montreal to Marseille many years ago, Sadie now works as a researcher in a lab, spending most of her time among microscopic creatures who teach her about life as a parasite. By day, she pushes the limits of her understanding alongside RÉgnier, who taught her that to study viruses, she must think infectiously, allow herself to be contaminated by dangerous ideas. By night, Sadie loses herself in bars, music, drugs, sensuality. Until she gets a call from the past that lures her back across the Atlantic. When her estranged father tells her that a bizarre virus has been found in his hospital, Sadie returns to Montreal and her family, and all the unexpected changes time has wrought, to solve this new puzzle. Soon she realizes that the person she thought she was—someone who can leave everything behind—no longer exists. What is left for her instead is sinking into the unknown to find out what happens when ideas come to life. This is a deeply inventive and singular novel about the power of metamorphosis and symbiosis. Combining the cerebral and the sensual, Sadie X explores humanity's relationship to the rest of the world, and the role of rationale—and its limits in our multilayered, regenerative existences.
Safe Filler Injection Techniques: An Illustrated Guide
by Won LeeFiller injection is one of the most common aesthetic procedure. There are a lot of guidelines but there are no illustrated step by step instructions on safe filler injection procedures. The book will offer guidance to clinicians who wish to expand their practice to minimally invasive cosmetic procedures. Injection techniques for hyaluronic acid filler is highlighted to help practitioners perform the procedures more effectively and safely with evidence based approach. The most safe procedure including vascular anatomical illustration and ultrasound findings, rheological data is presented.
Safe Food: The Politics of Food Safety (California Studies in Food and Culture #5)
by Marion NestleFood safety is a matter of intense public concern, and for good reason. Millions of annual cases of food "poisonings" raise alarm not only about the food served in restaurants and fast-food outlets but also about foods bought in supermarkets. The introduction of genetically modified foods—immediately dubbed "Frankenfoods"—only adds to the general sense of unease. Finally, the events of September 11, 2001, heightened fears by exposing the vulnerability of food and water supplies to attacks by bioterrorists. How concerned should we be about such problems? Who is responsible for preventing them? Who benefits from ignoring them? Who decides? Marion Nestle, author of the critically acclaimed Food Politics, argues that ensuring safe food involves more than washing hands or cooking food to higher temperatures. It involves politics. When it comes to food safety, billions of dollars are at stake, and industry, government, and consumers collide over issues of values, economics, and political power—and not always in the public interest. Although the debates may appear to be about science, Nestle maintains that they really are about control: Who decides when a food is safe? She demonstrates how powerful food industries oppose safety regulations, deny accountability, and blame consumers when something goes wrong, and how century-old laws for ensuring food safety no longer protect our food supply. Accessible, informed, and even-handed, Safe Food is for anyone who cares how food is produced and wants to know more about the real issues underlying today's headlines.
Safe Handling and Restraint of Animals: A Comprehensive Guide
by Stella J. ChapmanProvides all you need to know about the safe and humane handling and restraint of animals. Safe Handling and Restraint of Animals takes a holistic approach to the handling of a wide variety of animal species. This comprehensive resource offers a thorough overview of how to safely handle and restrain a number of commonly encountered species including dogs, cats, small mammals, exotic pets, horses and farm animals. Each chapter discusses the behaviour of the species and then outlines the appropriate handling and restraint methods, including any equipment required, multiple explanatory photographs, and useful further reading. Covers a wide range of species commonly encountered by veterinary staff and those working within animal industries Includes key points and self-assessment questions at the end of each chapter, and a glossary of terms Ideal for students of any animal-related degree or diploma programme, including veterinary medicine, veterinary nursing, and animal studies and husbandry Written for students and professionals who work with animals, Safe Handling and Restraint of Animals: A Comprehensive Guide encompasses all aspects of handling and physical restraint, including biosecurity and welfare issues.
Safe Laparoscopic Cholecystectomy: An Illustrated Atlas
by Mohammad Ibrarullah Sadiq S SikoraLaparoscopic cholecystectomy is a straightforward abdominal surgery performed worldwide, which can occasionally be mired with life-threatening complications when the safety principles are flouted. The tips and tricks of safety given in this book provide a complete insight into the variability of biliary anatomy, the nuances, and the technique of addressing the safety issues during routine and complicated procedures. Additionally, the book also explores the reasons for complications in real-life situations and suggests means for their avoidance. Using high-resolution video grabs, appropriately edited, an attempt has been made to explain all critical issues during laparoscopic cholecystectomy. Key Features Explains the Do’s & Don’ts of laparoscopic cholecystectomy in a concise and focused atlas form. Serves as an illustrated reference to perform a safe uncomplicated cholecystectomy for postgraduate students in general surgery, surgeons practicing minimally invasive surgery and hepatobiliary surgeons. Uses high quality operative videos to provide a detailed understanding of real-life situations and means to comply with safety measures.
Safe Liposuction and Fat Transfer
by Rhoda S. NarinsThis text covers tumescent liposuction and fat transfer techniques and how they have developed into extremely safe, reliable, and efficacious procedures. Thirty-five respected surgeons discuss the safety of tumescent liposuction techniques, an anatomical approach to tumescent liposuction surgery, and the latest and greatest surgical tips from the e
Safe Maternity And Pediatric Nursing Care
by Luanne Linnard-Palmer Gloria Haile CoatsSafe Maternity & Pediatric Nursing Care, 2nd Edition. Online Resources, and Davis Edge work together to create an interactive learning experience that teaches students to think critically and make the best patient care decisions. The text, written specifically for LPNs/LVNs, provides the comprehensive nursing knowledge they need to understand in this key course. Online Resources equip instructors with the lesson plans, teaching resources, and activities to create an active classroom environment where students can apply what they’re learning. Davis Edge online quizzing tracks student progress; assesses their knowledge; prepares students for classroom exams and the NCLEX®; and provides real time analytics to identify their weak concepts and topic areas.