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Sample Preparation in Biological Mass Spectrometry
by Alexander R. Ivanov Alexander V. LazarevThe aim of this book is to provide the researcher with important sample preparation strategies in a wide variety of analyte molecules, specimens, methods, and biological applications requiring mass spectrometric analysis as a detection end-point. In this volume we have compiled the contributions from several laboratories which are employing mass spectrometry for biological analysis. With the latest inventions and introduction of highly sophisticated mass spectrometry equipment sample preparation becomes an extremely important bottleneck of biomedical analysis. We have a goal of giving the reader several successful examples of sample preparation, development and optimization, leading to the success in analytical steps and proper conclusions made at the end of the day. This book is structured as a compilation of contributed chapters ranging from protocols to research articles and reviews. The main philosophy of this volume is that sample preparation methods have to be optimized and validated for every project, for every sample type and for every downstream analytical technique.
Sample Preparation of Pharmaceutical Dosage Forms
by Beverly NickersonThis book is intended to serve as a resource for analysts in developing and troubleshooting sample preparation methods. These are critical activities in providing accurate and reliable data throughout the lifecycle of a drug product. This book is divided into four parts: * Part One covers dosage form and diluent properties that impact sample preparation of pharmaceutical dosage forms and the importance of sampling considerations in generating data representative of the drug product batch. * Part Two reviews specific sample preparation techniques typically used with pharmaceutical dosage forms. * Part Three discusses sample preparation method development for different types of dosage forms including addressing drug excipient interactions and post extraction considerations, as well as method validation and applying Quality by Design (QbD) principles to sample preparation methods. * Part Four examines additional topics in sample preparation including automation, investigating aberrant potency results, green chemistry considerations for sample preparation and the ideal case where no sample preparation is required for sample analysis.
Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research (Chapman & Hall/CRC Biostatistics Series #71)
by Song Zhang Chul Ahn Moonseoung HeoAccurate sample size calculation ensures that clinical studies have adequate power to detect clinically meaningful effects. This results in the efficient use of resources and avoids exposing a disproportionate number of patients to experimental treatments caused by an overpowered study. Sample Size Calculations for Clustered and Longitudinal Outcom
Sample Size Calculations in Clinical Research (Chapman & Hall/CRC Biostatistics Series)
by Shein-Chung Chow Jun Shao Hansheng Wang Yuliya LokhnyginaPraise for the Second Edition: "… this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics "This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered …" – Journal of the Royal Statistical Society Sample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation. Features: Compares the relative merits and disadvantages of statistical methods for sample size calculations Explains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages Presents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women’s health Provides sample size calculations for dose response studies, microarray studies, and Bayesian approaches This new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.
Sample Size Determination and Power
by Thomas P. RyanA comprehensive approach to sample size determination and power with applications for a variety of fieldsSample Size Determination and Power features a modern introduction to the applicability of sample size determination and provides a variety of discussions on broad topics including epidemiology, microarrays, survival analysis and reliability, design of experiments, regression, and confidence intervals.The book distinctively merges applications from numerous fields such as statistics, biostatistics, the health sciences, and engineering in order to provide a complete introduction to the general statistical use of sample size determination. Advanced topics including multivariate analysis, clinical trials, and quality improvement are addressed, and in addition, the book provides considerable guidance on available software for sample size determination. Written by a well-known author who has extensively class-tested the material, Sample Size Determination and Power: Highlights the applicability of sample size determination and provides extensive literature coveragePresents a modern, general approach to relevant software to guide sample size determination including CATD (computer-aided trial design)Addresses the use of sample size determination in grant proposals and provides up-to-date references for grant investigatorsAn appealing reference book for scientific researchers in a variety of fields, such as statistics, biostatistics, the health sciences, mathematics, ecology, and geology, who use sampling and estimation methods in their work, Sample Size Determination and Power is also an ideal supplementary text for upper-level undergraduate and graduate-level courses in statistical sampling.
Sample Size Determination in Clinical Trials with Multiple Endpoints
by Toshimitsu Hamasaki Scott R. Evans Takashi Sozu Tomoyuki SugimotoThis book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area. The determination of sample size and the evaluation of power are fundamental and critical elements in the design of clinical trials. If the sample size is too small, important effects may go unnoticed; if the sample size is too large, it represents a waste of resources and unethically puts more participants at risk than necessary. Recently many clinical trials have been designed with more than one endpoint considered as multiple primary or co-primary, creating a need for new approaches to the design and analysis of these clinical trials. The book focuses on the evaluation of power and sample size determination when comparing the effects of two interventions in superiority clinical trials with multiple endpoints. Methods for sample size calculation in clinical trials where the alternative hypothesis is that there are effects on ALL endpoints are discussed in detail. The book also briefly examines trials designed with an alternative hypothesis of an effect on AT LEAST ONE endpoint with a prespecified non-ordering of endpoints.
Sample Size Tables for Clinical Studies
by Michael J. Campbell David Machin Sze-Huey Tan Say-Beng TanThis book provides statisticians and researchers with the statistical tools - equations, formulae and numerical tables - to design and plan clinical studies and carry out accurate, reliable and reproducible analysis of the data so obtained. There is no way around this as incorrect procedure in clinical studies means that the researcher's paper will not be accepted by a peer-reviewed journal. Planning and analysing clinical studies is a very complicated business and this book provides indispensible factual information.
Sample Sizes for Clinical Trials
by Steven A. JuliousSample Sizes for Clinical Trials, Second Edition is a practical book that assists researchers in their estimation of the sample size for clinical trials. Throughout the book there are detailed worked examples to illustrate both how to do the calculations and how to present them to colleagues or in protocols. The book also highlights some of the pitfalls in calculations as well as the key steps that lead to the final sample size calculation. Features: Comprehensive coverage of sample size calculations, including Normal, binary, ordinal, and survival outcome data Covers superiority, equivalence, non-inferiority, bioequivalence and precision objectives for both parallel group and crossover designs Highlights how trial objectives impact the study design with respect to both the derivation of sample formulae and the size of the study Motivated with examples of real-life clinical trials showing how the calculations can be applied New edition is extended with all chapters revised, some substantially, and four completely new chapters on multiplicity, cluster trials, pilot studies, and single arm trials The book is primarily aimed at researchers and practitioners of clinical trials and biostatistics, and could be used to teach a course on sample size calculations. The importance of a sample size calculation when designing a clinical trial is highlighted in the book. It enables readers to quickly find an appropriate sample size formula, with an associated worked example, complemented by tables to assist in the calculations.
Sample Sizes for Clinical, Laboratory and Epidemiology Studies (Fourth Edition)
by Michael J. Campbell David Machin Sze-Huey Tan Say-Beng TanNow in its fourth and extended edition, Sample Sizes for Clinical, Laboratory and Epidemiology Studiesincludes the sample size software (SSS) and formulae and numerical tables needed to design valid clinical studies. The text covers clinical as well as laboratory and epidemiology studies and contains the information needed to ensure a study will form a valid contribution to medical research. <p><p> The authors, noted experts in the field, explain step by step and explore the wide range of considerations necessary to assist investigational teams when deriving an appropriate sample size for their when planned study. The book contains sets of sample size tables with companion explanations and clear worked out examples based on real data. In addition, the text offers bibliography and references sections that are designed to be helpful with guidance on the principles discussed.
Sampling of Populations: Methods and Applications (Wiley Series in Survey Methodology #Vol. 318)
by Stanley Lemeshow Paul S. LevyA trusted classic on the key methods in population sampling—now in a modernized and expanded new edition Sampling of Populations, Fourth Edition continues to serve as an all-inclusive resource on the basic and most current practices in population sampling. Maintaining the clear and accessible style of the previous edition, this book outlines the essential statistical methodsfor survey design and analysis, while also exploring techniques that have developed over the past decade. The Fourth Edition successfully guides the reader through the basic concepts and procedures that accompany real-world sample surveys, such as sampling designs, problems of missing data, statistical analysis of multistage sampling data, and nonresponse and poststratification adjustment procedures. Rather than employ a heavily mathematical approach, the authors present illustrative examples that demonstrate the rationale behind common steps in the sampling process, from creating effective surveys to analyzing collected data. Along with established methods, modern topics are treated through the book's new features, which include: A new chapter on telephone sampling, with coverage of declining response rates, the creation of "do not call" lists, and the growing use of cellular phones A new chapter on sample weighting that focuses on adjustments to weight for nonresponse, frame deficiencies, and the effects of estimator instability An updated discussion of sample survey data analysis that includes analytic procedures for estimation and hypothesis testing A new section on Chromy's widely used method of taking probability proportional to size samples with minimum replacement of primary sampling units An expanded index with references on the latest research in the field All of the book's examples and exercises can be easily worked out using various software packages including SAS, STATA, and SUDAAN, and an extensive FTP site contains additional data sets. With its comprehensive presentation and wealth of relevant examples, Sampling of Populations, Fourth Edition is an ideal book for courses on survey sampling at the upper-undergraduate and graduate levels. It is also a valuable reference for practicing statisticians who would like to refresh their knowledge of sampling techniques.
Samudra kesadaran tak terbatas
by Dr. Tony NaderJawaban sederhana untuk pertanyaan-pertanyaan besar dalam kehidupan. Prolog oleh David Lynch. «Dalam buku fenomenal ini, Dr. Nader menawarkan ide-ide yang dapat mengubah dunia. Beliau memberikan solusi mendalam untuk pertanyaan-pertanyaan yang telah lama memikat dan menggugah para filsuf dan ilmuwan dari berbagai bidang, seperti tujuan hidup, kebaikan, dan kejahatan. Apa itu kesadaran? Apakah kita memiliki kebebasan? Apakah ada hukum, keteraturan, atau kekacauan di alam semesta? Bagaimana cara mengatasi perbedaan antara ateis dan mukmin, takdir dan pilihan? Bagaimana cara menjadikan hidup seseorang menjadi versi terbaiknya, memenuhi keinginannya, serta menciptakan perdamaian dan harmoni di antara manusia dan bangsa? Dr. Nader menawarkan solusi berdasarkan satu paradigma dasar sederhana yang menyatukan pikiran, tubuh, dan lingkungan dalam satu samudra wujud yang murni, kesadaran yang murni. Bacaan wajib bagi setiap pencari jawaban atas misteri kehidupan serta kebenaran yang mutlak dan hakiki».David Lynch «Saya ingin semua orang tahu apa itu Kesadaran dan bagaimana mengembangkannya untuk menikmati potensi penuh dari kehidupan pribadi dan sosial».Dr. Tony Nader
Samuel's Manual of Neurologic Therapeutics
by Martin Samuels Allan H. RopperThe best-selling Samuels’s Manual of Neurologic Therapeutics is a practical, accessible handbook for the diagnosis and treatment of neurologic disorders. Completely updated to reflect the most recent developments in the field, the book features a concise, intuitive outline format that makes today’s best approaches easy to find and apply. Implement the current strategies to combat neurological diseases. Highlights include new pharmacologic and non-pharmacologic treatments for seizures; new molecular techniques and personalized approaches to neurologic cancers; new approaches for treating pain; the most recent intra-arterial therapies for acute stroke; and new treatments for neurologic infectious diseases. Manage benign autoimmune conditions with the aid of a new chapter that discusses diagnosis via serological testing as well as therapies involving immune modulation. Treat patients in resource-limited environments, thanks to a new chapter that focuses on cost-effective management options. Locate the information you need quickly through accessible and well-organized chapters and an outline format.
Sanar el mundo: La edad dorada de la medicina (1840-1914)
by Ronald D. GersteLa invención de la medicina moderna. Ocho décadas prodigiosas que revolucionaron nuestra comprensión del cuerpo humano y nuestras vidas. «Un libro de lo más entretenido sobre una época asombrosa en la que la medicina realizó avances revolucionarios. De lectura obligada para cualquier persona interesada en la historia».Spektrum Hoy es impensable que algún día el mundo se deshaga de las enfermedades. Sin embargo, hubo un tiempo en que los avances parecían imparables. Los años extraordinarios entre 1840 y 1914 vieron cambios inconcebibles no solo en medicina, sino también en la cultura, la política y la sociedad. Aprendimos a controlar el dolor y las epidemias y encontramos curas para enfermedades que hasta entonces eran sentencias de muerte. Fue una época de optimismo desenfrenado, de ideas nuevas, emocionantes y heréticas, de fe inquebrantable en la ciencia y en el futuro. Es difícil imaginar nuestras vidas hoy sin las aportaciones de figuras como John Snow, Florence Nightingale, Sigmund Freud o Robert Koch, que cambiaron por completo nuestro enfoque del diagnóstico y el tratamiento. Sanar el mundo es un maravilloso encuentro con estos y otros pioneros y un viaje a una era en la que el ferrocarril y el barco de vapor llevaron a la gente a aventurarse más allá del horizonte y el mundo se volvió verdaderamente globalizado. Ronald Gerste cuenta el apasionante relato de un periodo en el que la ciencia transformó el mundo, un giro cuyas consecuencias nos acompañan hasta hoy. Pero esta serie de impresionantes innovaciones se vio truncada por la catástrofe: la Primera Guerra Mundial y una terrible pandemia causada por un virus, la gripe española, pusieron fin a una historia de triunfo y progreso con un trágico epílogo. La crítica ha dicho:«Con destreza y visión histórica, el autornos cuenta los logros médicos vinculándolos a las circunstancias de su tiempo. Un libro de lo más entretenido sobre una época asombrosa en la que la medicina realizó avances revolucionarios. De lectura obligada para cualquier persona interesada en la historia».Spektrum «Gerste muestra el progreso con toda su ambivalencia. Su libro combina la mirada cercana a los individuos, incluso a los días, con la visión de conjunto del siglo y nuestra mirada sobre él. Nos hace sentir que en todo momento estamos ahí».Frankfurter Rundschau «En la época que retrata Gerste, el mundo de los virus era aún desconocido, y ni siquiera existía el microscopio electrónico. Este libro nos hace testigos de una época de progreso sin precedentes que terminó en una guerra mundial».Die Presse am Sonntag «Un libro entretenido y revelador que, en tiempos de pandemia, suscita nuestro agradecimiento por los avances de la medicina».Falter «La pandemia catapultó a la medicina hasta el centro de la atención pública, y este libro de enfoque progresista sobre las innovaciones y descubrimientos médicos en la época victoriana es de lo más oportuno».Neue Zürcher Zeitung «Descubrir, a partir de logros concretos, la forma en que la medicina moderna transformó la relación de los seres humanos con su cuerpo es fascinante, y nos hace sentirnos afortunados».Die Presse «El autor integra hábilmente los detalles de los fundamentos médicos en el contexto social y político. Ofrece una panorámica muy recomendable de un tiempo mucho más marcado por las enfermedades y las epidemias que el nuestro».Biologie in unserer Zeit
Sanatoriums and Asylums of Eastern North Carolina (Postcard History Series)
by Dr Randy KearnsFrom Wilmington, Fayetteville, Greenville, New Bern, Elizabeth City, Wilson, Kinston, Goldsboro, and many points in between, this book offers a brief look at many of the historical asylums and sanatoriums, as well as temporary hospitals of war and disaster, in Eastern North Carolina. It shows what they were and what they became as they transformed into the great hospitals of today. Many of these old buildings have long since been torn down or reused in a variety of ways seldom connected to their past. This book provides a glimpse of these great buildings, several of their artifacts, and images of what health care used to be in Eastern North Carolina and the role medicine has played as the region has grown.
Sanctorius Sanctorius and the Origins of Health Measurement
by Teresa HollerbachThis open access book offers new insights into the Venetian physician Sanctorius Sanctorius (1561–1636) and into the origins of quantification in medicine. At the turn of the seventeenth century, Sanctorius developed instruments to measure and quantify physiological change. As trivial as the quantitative assessment of health issues might seem to us today – in times of fitness trackers and smart watches – it was highly innovative at that time. With his instruments, Sanctorius introduced quantitative research into the field of physiology. Historical accounts of Sanctorius and his work tend to tell the story of a genius who, almost out of the blue, invented a new medical science, based on measurement and quantification, that profoundly influenced modernity. Abandoning the “genius narrative,” this book examines Sanctorius and his work in the broader perspective of processes of knowledge transformation in early modern medicine. It is the first systematic study to include the entire range of the physician’s intellectual and practical activities. Adopting a material culture perspective, the research draws on the contemporary reconstruction of Sanctorius’s most famous instrument: the Sanctorian weighing chair. And here it departs from past studies that focus mainly on Sanctorius’s thinking rather than on his making and doing. The book also re-evaluates Sanctorius’s role in the wider process of the early transformation of medical culture in the early modern period, a process that ultimately led to the abandonment of Galenic medicine and to the introduction of a new medical science, based on the use of quantification and measurement in medical research. The book is therefore an important contribution to the history of medicine and historical epistemology aimed at historians of science and philosophy.
Sander/Müller, Meine Zahnarztpraxis – Ökonomie
by Thomas Sander Michal-Constanze MüllerDas einzige Buch zum Thema speziell für Zahnmediziner zeigt, wie niedergelassene Zahnärzte Kosten und Steuern sparen können - in der Praxis und im Privatbereich. Die Autoren stellen die Möglichkeiten einer strategischen Finanz-, Liquiditäts- und Investitionsplanung vor. Als Teil eines optimierten Gesamtkonzepts lassen sich mithilfe dieser Instrumente das Praxismanagement und die Wettbewerbsposition wesentlich verbessern.
Sanders' Paramedic Textbook
by American Academy of Orthopaedic Surgeons (AAOS) Mick J. Sanders Kim McKenna.
Sandra Brown Goes Digital (C): Raising Quality in a Healthcare Company
by Rosabeth Moss Kanter Jonathan CohenSupplement
Sandra van der Weide: Werkboek voor kwalificatieniveau 4, generieke fase (Zorggericht)
by M. Swaay W. Kok J. ZandtZorgcategorie: Moeder en kind Setting: Thuiszorg, consultatiebureau Korte inhoud: Deze casus behandeld het gezin van Sandra van der Weide waarin het derde kind wordt geboren. Deze baby heeft extra aandacht nodig. De zorg voor de kinderen en het huishouden valt soms erg zwaar voor deze moeder.
Sane Asylums: The Success of Homeopathy before Psychiatry Lost Its Mind
by Jerry M. Kantor• Examines the success of homeopathic psychiatric asylums in the United States from the 1870s until 1920 • Focuses on New York&’s Middletown State Homeopathic Hospital for the Insane, which had a treatment regime with thousands of successful outcomes • Details a homeopathic blueprint for treating mental disorders based on Talcott&’s methods, including nutrition and side-effect-free homeopathic prescriptions In the late 1800s and early 1900s, homeopathy was popular across all classes of society. In the United States, there were more than 100 homeopathic hospitals, more than 1,000 homeopathic pharmacies, and 22 homeopathic medical schools. In particular, homeopathic psychiatry flourished from the 1870s to the 1930s, with thousands of documented successful outcomes in treating mental illness. Revealing the astonishing but suppressed history of homeopathic psychiatry, Jerry M. Kantor examines the success of homeopathic psychiatric asylums in America from the post–Civil War era until 1920, including how the madness of Mary Todd Lincoln was effectively treated with homeopathy at a &“sane&” asylum in Illinois. He focuses in particular on New York&’s Middletown State Homeopathic Hospital, where superintendent Selden Talcott oversaw a compassionate and holistic treatment regime that married Thomas Kirkbride&’s moral treatment principles to homeopathy. Kantor reveals how homeopathy was pushed aside by pharmaceuticals, which often caused more harm than good, as well as how the current critical attitude toward homeopathy has distorted the historical record. Offering a vision of mental health care for the future predicated on a model that flourished for half a century, Kantor shows how we can improve the care and treatment of the mentally ill and stop the exponential growth of terminal mental disorder diagnoses that are rampant today.
Sanfilippo's Textbook of Pediatric and Adolescent Gynecology: Second Edition
by Joseph S. Sanfilippo Eduardo Lara-Torre Veronica Gomez-LoboThis textbook provides a comprehensive review of all the common and less often encountered pediatric and adolescent gynecology problems in daily practice, both in the ambulatory as well as in the surgical setting. This new edition has been updated to keep it closely aligned to what general gynecologists or family physicians will want to know when dealing with a paediatric or adolescent patient, with accompanying videos.
Santal Women and the Health Care Regime: Pandemic, Predicament and Access
by Faraha Nawaz AN BushraThis book explores the access to healthcare service during a global pandemic by rural ethnic women of Bangladesh. The authors consider different dimensions of accessibility such as- physical access, financial access, health behaviour and different socio-cultural factors of access, and attempts to explore the degree of access to healthcare of rural ethnic women from Santal tribe in Bangladesh during the COVID-19 pandemic. This exploration is likely to be helpful for healthcare providing organizations, international donor agencies, policy makers, and future researchers of gender studies, social policy, development studies among other fields.
Santiago's Convenient Fiancée
by Annie O'NeilCan a convenient arrangement last forever? Saoirse Murphy came to Miami to bury herself in work, determined to forget the canceled wedding she left behind her, and she wants to stay... But only a green card will do! Enter former combat doc Santiago Valentino. Having reluctantly returned to face his dark past, he's only too happy to be distracted by his paramedic partner and her shocking proposal. But when their "convenient" engagement tips into a very inconvenient passion, Santiago wonders...will she be his forever wife?
Santorio Santori and the Emergence of Quantified Medicine, 1614-1790: Corpuscularianism, Technology and Experimentation (Palgrave Studies in Medieval and Early Modern Medicine)
by Jonathan Barry Fabrizio BigottiThis book examines the life and works of Santorio Santori and his impact on the history of medicine and natural philosophy. Reputed as the father of experimental medicine and procedures, he is also known for his invention of numerous scientific instruments, including early precision medical devices (pulsimeters, hygrometers, thermometers, anemometers), as well as clinical and surgical tools. The chapters in this volume explore Santorio’s legacy through the seventeenth and eighteenth centuries. They highlight the role played by medical practitioners such as Santorio in the development of corpuscularian ideas, central to the ‘new science’ of the period, and place new emphasis on the role of the life sciences, chemistry and medicine in encouraging new forms of experimentation and instrument-making.Chapters 1 and 2 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Saphenous Vein-Sparing Strategies in Chronic Venous Disease
by Erika Mendoza Paolo Zamboni Sergio GianesiniThis book is designed to equip the reader with a detailed knowledge of the pathophysiology of chronic venous disease and an understanding of the clinical benefits of restoring venous drainage by saphenous vein-sparing procedures, including minimization of invasiveness and reduction of the recurrence rate. All of the techniques currently available for vein-sparing strategies, including novel endovenous options, are clearly described and illustrated, with explanation of the role and value of recent technical innovations. The reader is guided through the entire management process, starting from diagnosis and proceeding through evaluation of the individual patient’s needs to the successful implementation of appropriate treatment. In addition, the literature on relevant diagnostic and therapeutic protocols is thoroughly reviewed, covering all significant publications to the present day. The content is kept as simple as possible to help those new to the field. At the same time, the deep insights into theoretical and technical aspects will support even the most advanced specialists in their everyday practice.