- Table View
- List View
Reviews of Physiology, Biochemistry and Pharmacology 156
by S. Offermanns S. G. Amara E. Bamberg S. Grinstein S. C. Hebert R. Jahn W. J. Lederer R. Lill A. Miyajima H. Murer G. Schultz M. SchweigerH. Wegele, L. M ller, and J. Buchner: Hsp70 and Hsp90 A Relay Team for Protein Folding R. Sch lein: The Early Stages of the Intracellular Transport of Membrane Proteins: Clinical and Pharmacological Implications L. Schild: The Epithelial Sodium Channel: From Molecule to Disease
Reviews of Physiology, Biochemistry and Pharmacology 157
by S. Offermanns S. G. Amara E. Bamberg S. C. Hebert R. Jahn W. J. Lederer R. Lill A. Miyajima T. GudermannThis volume presents a neural network architecture for the prediction of conditional probability densities - which is vital when carrying out universal approximation on variables which are either strongly skewed or multimodal. Two alternative approaches are discussed: the GM network, in which all parameters are adapted in the training scheme, and the GM-RVFL model which draws on the random functional link net approach. Points of particular interest are: - it examines the modification to standard approaches needed for conditional probability prediction; - it provides the first real-world test results for recent theoretical findings about the relationship between generalisation performance of committees and the over-flexibility of their members; This volume will be of interest to all researchers, practitioners and postgraduate / advanced undergraduate students working on applications of neural networks - especially those related to finance and pattern recognition.
Reviews of Physiology, Biochemistry and Pharmacology 158
by William J. Lederer S. Offermanns S. G. Amara E. Bamberg S. C. Hebert R. Jahn R. Lill A. Miyajima T. Gudermann R. Zechner B. FleischmannThis volume presents a neural network architecture for the prediction of conditional probability densities - which is vital when carrying out universal approximation on variables which are either strongly skewed or multimodal. Two alternative approaches are discussed: the GM network, in which all parameters are adapted in the training scheme, and the GM-RVFL model which draws on the random functional link net approach. Points of particular interest are: - it examines the modification to standard approaches needed for conditional probability prediction; - it provides the first real-world test results for recent theoretical findings about the relationship between generalisation performance of committees and the over-flexibility of their members; This volume will be of interest to all researchers, practitioners and postgraduate / advanced undergraduate students working on applications of neural networks - especially those related to finance and pattern recognition.
Reviews of Physiology, Biochemistry and Pharmacology 159
by S. Offermanns S. G. Amara E. Bamberg S. C. Hebert R. Jahn W. J. Lederer R. Lill A. Miyajima T. Gudermann R. Zechner B. FleischmannThis volume presents a neural network architecture for the prediction of conditional probability densities - which is vital when carrying out universal approximation on variables which are either strongly skewed or multimodal. Two alternative approaches are discussed: the GM network, in which all parameters are adapted in the training scheme, and the GM-RVFL model which draws on the random functional link net approach. Points of particular interest are: - it examines the modification to standard approaches needed for conditional probability prediction; - it provides the first real-world test results for recent theoretical findings about the relationship between generalisation performance of committees and the over-flexibility of their members; This volume will be of interest to all researchers, practitioners and postgraduate / advanced undergraduate students working on applications of neural networks - especially those related to finance and pattern recognition.
Reviews of Physiology, Biochemistry and Pharmacology 161
by William J. Lederer Bernd Nilius Reinhard Jahn Stefan Offermanns Roland Lill Susan G. Amara Bernd K. Fleischmann Ernst Bamberg Thomas GudermannF. Schweda and A. Kurtz: Regulation of Renin Release by Local and Systemic FactorsM. Krauss and V. Haucke: Shaping Membranes for EndocytosisB.M. Jockusch and P.L. Graumann: The Long Journey: Actin on the Road to Pro- and Eukaryotic CellsB. Colsoul, R. Vennekens and B. Nilius: Transient Receptor Potential (TRP) Cation Channels in Pancreatic ß cells
Reviews of Physiology, Biochemistry and Pharmacology 166
by Ole H. Petersen Bernd Nilius Reinhard Jahn Stefan Offermanns Roland Lill Thomas GudermannThe highly successful Reviews of Physiology, Biochemistry and Pharmacology continue to offer high-quality, in-depth reviews covering the full range of modern physiology, biochemistry and pharmacology. Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology Vol. 169
by Ole H. Petersen Bernd Nilius Reinhard Jahn Roland Lill Thomas Gudermann Pieter P. de TombeLeading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology Vol. 170
by Ole H. Petersen Bernd Nilius Reinhard Jahn Roland Lill Thomas Gudermann Pieter De TombeLeading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology Vol. 174 (Reviews of Physiology, Biochemistry and Pharmacology #174)
by Ole H. Petersen Bernd Nilius Reinhard Jahn Roland Lill Thomas Gudermann Pieter De TombeLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 163
by Ole H. Petersen Bernd Nilius Reinhard Jahn Stefan Offermanns Roland Lill Susan G. Amara Thomas GudermannInduced pluripotent stem cells in cardiovascular research.- TRPs in the brain.- The channel physiology of the skin.
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 167
by Ole H. Petersen Bernd Nilius Reinhard Jahn Stefan Offermanns Roland Lill Thomas GudermannThe highly successful Reviews of Physiology, Biochemistry and Pharmacology continue to offer high-quality, in-depth reviews covering the full range of modern physiology, biochemistry and pharmacology. Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 171
by Ole H. Petersen Bernd Nilius Reinhard Jahn Roland Lill Thomas Gudermann Pieter De TombeLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 172
by Ole H. Petersen Bernd Nilius Reinhard Jahn Roland Lill Thomas Gudermann Pieter De TombeLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 175 (Reviews of Physiology, Biochemistry and Pharmacology #175)
by Bernd Nilius Reinhard Jahn Roland Lill Thomas Gudermann Pieter De TombeLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews on Biomarker Studies in Aging and Anti-Aging Research (Advances in Experimental Medicine and Biology #1178)
by Paul C. GuestUsing both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies. Reviews on Biomarker Studies in Aging and Anti-Aging Research presents a series of reviews in various aspects of aging and age-related disease research along with several methods which have shown progress as potential anti-aging approaches. The book is aimed at researchers in the areas of aging and chronic disease, as well as to clinical scientists, physicians and major drug companies. It provides important information on disease mechanisms, and each chapter is presented in the context of the aging process, specific chronic diseases or different therapeutic areas.
Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders (Advances in Experimental Medicine and Biology #1118)
by Paul C. GuestThis book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.
Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders (Advances in Experimental Medicine and Biology #1134)
by Paul C. GuestThe book recognizes that throughout the scientific, medical, and economic communities, new tests incorporating biomarkers are needed to improve the diagnosis of patients suffering from metabolic disorders. The early identification of those at risk of developing obesity will help to place these individuals on the best treatment course as early as possible for improved treatment outcomes. This will also help to cut costs incurred by the healthcare services. For all of this to occur, new research efforts are needed to identify novel biomarkers that can be used to predict the disease in the presymptomatic stage, for disease monitoring and for prediction of treatment response. It is also possible that new drug targets can be identified using these approaches which, in turn, can lead to the development of new treatment approaches. This volume also includes a series of reviews on biomarker discovery and usage in the study of diseases marked by perturbations in metabolism. It will describe the pros and cons of the various approaches and cover the successes and failures in this important research field.
Reviews on New Drug Targets in Age-Related Disorders (Advances in Experimental Medicine and Biology #1260)
by Paul C. GuestAging is an inevitable part of life and is becoming a worldwide social, economic and health problem. This is mainly due to the fact that the increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders, such as type II diabetes mellitus, cardiovascular disorders, sarcopenia, and neurodegenerative conditions. New therapeutic approaches are still needed to decrease or slow the effects of such diseases. Advances in -omic technologies, such as genomics, transcriptomics, proteomics and metabolomics, have significantly advanced our understanding of disease in multiple medical areas, as the analysis of multiple molecular networks has simultaneously provided a more integrated view of disease pathways. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan. In turn, this will lead to new therapeutic strategies as well as drug development projects by the pharmaceutical industry. This book presents a series of reviews describing studies that have resulted in identification of new potential drug targets for age-related disorders. Much of this information has come from -omic comparisons of healthy and disease states or from testing the effects of new therapeutic approaches. Authored by experts from around the globe, each chapter is presented in the context of specific chronic diseases or therapeutic strategies. This book is designed for researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians and stakeholders in major drug companies.
Revising Oral Pharmacokinetics, Bioavailability and Bioequivalence Based on the Finite Absorption Time Concept
by Panos Macheras Athanasios A. TsekourasThis book casts new light on the field of oral drug absorption. It outlines both the concept of the past and the novel concept of Finite Absorption Time (FAT). In addition, the authors explore the correlated need for re-definition of bioavailability, bioequivalence providing a plethora of experimental data. Accordingly, this book is intended for academics/students or scientists working in pharmaceutical industries, regulatory agencies, and contract research organizations. It can be used for teaching purposes in under- and post-graduate courses dealing with biopharmaceutics, pharmacokinetics and biomedical engineering.
Revision ACL Reconstruction: Indications and Technique
by Robert G. MarxAlthough anterior cruciate ligament (ACL) reconstruction has a success rate of 80-90%, a substantial number of patients are still left with unsatisfactory results. Revision ACL Reconstruction: Indications and Technique is a practical guide to the surgical techniques involved in the repair of failed or compromised ACL reconstructions. Concise chapters by a leading group of international orthopedic surgeons detail the basics of diagnosing a failed ACL reconstruction, imaging and preoperative planning for ACL revision surgery, and common causes of ACL reconstruction failures.
Revision Anterior Cruciate Ligament Reconstruction: A Case-Based Approach
by Michael J. Alaia Kristofer J. JonesAnterior cruciate ligament reconstruction is one of the most common procedures performed in sports medicine centers. However, these procedures can carry a long-term failure rate as high as 5-15%%, and when these procedures fail, revision is significantly more complex. Considerable factors need to be assessed in patients that are indicated for surgery, as revisions carry a higher failure rate and potentially less optimal outcomes and return to sport and activity. These factors include, but are not limited to, the status of the meniscus, overall alignment, graft options, placement of prior implants or tunnels, collateral ligament quality, and whether or not the revision must be staged into two procedures. This text provides a comprehensive, case-based presentation of the most efficient and practical treatment algorithms for patients in need of revision ACL repair and reconstruction. Opening chapters discuss the initial patient work-up, radiography, surgical indications, graft options, and pre-operative considerations and preparations. The main portion of the book then describes both common factors leading to revision surgery as well as the surgical techniques themselves, illustrated via plentiful operative photos and vivid clinical case material. The management of osteolysis, ligamentous laxity, extra-articular tenodesis, plane correction, and meniscus deficiency, among others, are discussed in detail. Special populations, such as the pediatric patient, the elite athlete and the female athlete, are discussed as well. Shedding light on this challenging surgical repair, Revision Anterior Cruciate Ligament Reconstruction is the go-to resource for sports medicine and orthopedic surgeons, knee specialists and residents and fellows in these areas.
Revision Guide for MRCPsych Paper A
by Elizabeth Templeton Richard William Kerslake Lisanne StockThis text covers the key information necessary to pass Paper A of the postgraduate examination to become a member of the Royal College of Psychiatrists (MRCPsych). It emphasises memory aids in the forms of diagrams or tables, a novel presentation of these materials, providing a quick and portable source for pre-exam revision and visual memory aids and prompts.
Revision MCQs and EMIs for the MRCPsych: Practice questions and mock exams for the written papers
by Roger Ho Basant K Puri Ian TreasdenThis new revision guide with over 1500 questions, reasoned answers and links to explanatory text gives a comprehensive range of multiple choice questions (MCQs) and extended matching items (EMIs). Complete with sample papers, this book provides everything you need for the written parts of the MRCPsych and comparable hi
Revision Notes for MRCPsych Paper 1
by Jawad SarahCompletely up-to-date with the current MRCPsych Paper 1 examination, this list-based revision guide provides comprehensive coverage of the syllabus. It offers a focused set of essential notes that create a solid knowledge base for the candidate, rather than relying only on MCQs and EMIs for self-testing. Individual chapters are dedicated to each of the main topics within the curriculum and the succinct, bullet-point format aids recall and offers a realistic and user-friendly method for retaining knowledge. Key points are presented in manageable portions fostering confidence and encouraging further investigation. Written by a current trainee, Revision Notes for MRCPsych Paper 1 provides the most closely linked and relevant guide for candidates. It is also a highly useful reference for all Royal College candidates and medical and nursing students wanting an accessible introduction to psychiatry.
Revision Notes for the DRCOG: A Textbook of Women's Health, Second Edition
by Jamila Groves Deena El-ShirbinyFirst published as Mastering the DRCOG, this highly acclaimed revision text has been completely updated and revised to follow the syllabus of the DRCOG examination. This book:Provides relevant content arranged in seven chapters, following the DRCOG curriculumDelivers useful information such as references to guidelines and researchPresents content r