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Single-Access Laparoscopic Surgery
by Giusto Pignata Francesco Corcione Umberto BracaleSingle-access laparoscopic surgery (SALS), performed using a single transumbilical access, has recently proved to bring advantages over other forms of laparoscopic surgery due to the reduction in the number of incisions and the consequent decrease in morbidity, less blood loss and postoperative pain. Furthermore, cosmesis may be improved because incision within the umbilicus renders surgery virtually scarless. Nevertheless, as with all new surgical concepts, questions may be raised regarding safety, usefulness and appropriateness. This book analyzes the use of SALS for different indications and abdominal surgical procedures based on a careful literature review of the experience of the most important surgical teams employing this approach and also the authors' personal observations. The coverage is broad, encompassing, for example, the role of SALS in appendectomy, repair of abdominal wall defects, cholecystectomy, gastric surgery, nephrectomy, splenectomy, hemicolectomy and pancreatic, liver and gynecological surgery.
Single-Arm Phase II Survival Trial Design (Chapman & Hall/CRC Biostatistics Series)
by Jianrong WuSingle-Arm Phase II Survival Trial Design provides a comprehensive summary to the most commonly- used methods for single-arm phase II trial design with time-to-event endpoints. Single-arm phase II trials are a key component for successfully developing advanced cancer drugs and treatments, particular for target therapy and immunotherapy in which time-to-event endpoints are often the primary endpoints. Most test statistics for single-arm phase II trial design with time-to-event endpoints are not available in commercial software. Key Features: Covers the most frequently used methods for single-arm phase II trial design with time-to-event endpoints in a comprehensive fashion. Provides new material on phase II immunotherapy trial design and phase II trial design with TTP ratio endpoint. Illustrates trial designs by real clinical trial examples Includes R code for all methods proposed in the book, enabling straightforward sample size calculation.
Single-Case Designs for Applied Research
by Craig H. KennedySingle-Case Designs for Applied Research by Craig Kennedy helps readers explore single-subject research designs, grounded in real-world examples drawn from classic and contemporary research in education and beyond. This text aims to give readers precise and highly applicable information and concepts in single-case, or single-subject, designs so readers can apply this knowledge to their own research and practice. By focusing on the experimental nature of this design, students learn about the purposes of single-case research so they can adapt the designs, using them as tools in their methodological toolboxes rather than as formulas to be followed. Beginning with an overview of experiments, single-case designs, and strategic issues, the book then moves onto a review of measurement approaches, different tactics for research designs, and ways to understand data and analysis. Boxed features throughout offer readers more explanation and background of key methodological concepts. Reflection questions at the end of each chapter help students reinforce their knowledge. This brief text concisely and thoroughly covers the landscape of single-case designs.
Single-Case Designs for Applied Research
by Craig H. KennedySingle-Case Designs for Applied Research by Craig Kennedy helps readers explore single-subject research designs, grounded in real-world examples drawn from classic and contemporary research in education and beyond. This text aims to give readers precise and highly applicable information and concepts in single-case, or single-subject, designs so readers can apply this knowledge to their own research and practice. By focusing on the experimental nature of this design, students learn about the purposes of single-case research so they can adapt the designs, using them as tools in their methodological toolboxes rather than as formulas to be followed. Beginning with an overview of experiments, single-case designs, and strategic issues, the book then moves onto a review of measurement approaches, different tactics for research designs, and ways to understand data and analysis. Boxed features throughout offer readers more explanation and background of key methodological concepts. Reflection questions at the end of each chapter help students reinforce their knowledge. This brief text concisely and thoroughly covers the landscape of single-case designs.
Single-Case Research Methods in Sport and Exercise Psychology
by Aidan Moran Marc Jones Paul McCarthy Jamie BarkerWhat is single-case research? How can single-case methods be used within sport and exercise? Single-case research is a powerful method for examining change in outcome variables such as behaviour, performance and psychological constructs, and for assessing the efficacy of interventions. It has innumerable uses within the context of sport and exercise science, such as in the development of more effective performance techniques for athletes and sportspeople and in helping us to better understand exercise behaviours in clinical populations. However, the fundamental principles and techniques of single-case research have not always been clearly understood by students and researchers working in these fields. Single-Case Research Methods in Sport and Exercise Psychology is the first book to fully explain single-case research in the context of sport and exercise. Starting with first principles, the book offers a comprehensive introduction to the single-case research process, from study design to data analysis and presentation. Including case studies and examples from across sport and exercise psychology, the book provides practical guidance for students and researchers and demonstrates the advantages and common pitfalls of single-case research for anybody working in applied or behavioural science in a sport or exercise setting.
Single-Cell Assays: Microfluidics, Genomics, and Drug Discovery (Methods in Molecular Biology #2689)
by Paul C. H. Li Angela Ruohao WuThis detailed volume explores the use of single-cell assays in research for drug discovery, microfluidics, and more. The book delves into methodologies involving a variety of cell types and diseases, small molecules and biologics, as well as studies of the genome and transciptome. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Single-Cell Assays: Microfluidics, Genomics, and Drug Discovery serves to enable researchers to obtain a rapid overview in state-of-the-art microfluidic single-cell assays and an impression of what possibilities these assays offer to drug discovery.
Single-Sided NMR
by Bernhard Blümich Federico Casanova Juan PerloThis book describes the design of the first functioning single-sided tomograph, the related measurement methods, and a number of applications in medicine, materials science, and chemical engineering. It will be the first comprehensive account of this new device and its applications. Among the key advances of this method is that images can be obtained in much shorter times than originally anticipated, and that even vector maps of flow fields can be measured although the magnetic fields are highly inhomogeneous. Furthermore, the equipment is small, mobile and affordable to small and medium enterprises and can be located in doctors' offices.
Single-Use Technology in Biopharmaceutical Manufacture
by Regine Eibl Dieter EiblThis book gives an overview of commonly-used disposables in the manufacture of biopharmaceuticals, their working principles, characteristics, engineering aspects, economics, and applications. With this information, readers will be able to come to an easier decision for or against disposable alternatives and to choose the appropriate system. The book is divided into two parts - the first is related to basic knowledge about disposable equipment; and the second discusses applications through case studies that illustrate manufacturing, quality assurance, and environmental influence.
Single-Use Technology in Biopharmaceutical Manufacture
by Regine Eibl Dieter EiblAuthoritative guide to the principles, characteristics, engineering aspects, economics, and applications of disposables in the manufacture of biopharmaceuticals The revised and updated second edition of Single-Use Technology in Biopharmaceutical Manufacture offers a comprehensive examination of the most-commonly used disposables in the manufacture of biopharmaceuticals. The authors—noted experts on the topic—provide the essential information on the principles, characteristics, engineering aspects, economics, and applications. This authoritative guide contains the basic knowledge and information about disposable equipment. The author also discusses biopharmaceuticals’ applications through the lens of case studies that clearly illustrate the role of manufacturing, quality assurance, and environmental influences. This updated second edition revises existing information with recent developments that have taken place since the first edition was published. The book also presents the latest advances in the field of single-use technology and explores topics including applying single-use devices for microorganisms, human mesenchymal stem cells, and T-cells. This important book: • Contains an updated and end-to-end view of the development and manufacturing of single-use biologics • Helps in the identification of appropriate disposables and relevant vendors • Offers illustrative case studies that examine manufacturing, quality assurance, and environmental influences • Includes updated coverage on cross-functional/transversal dependencies, significant improvements made by suppliers, and the successful application of the single-use technologies Written for biopharmaceutical manufacturers, process developers, and biological and chemical engineers, Single-Use Technology in Biopharmaceutical Manufacture, 2nd Edition provides the information needed for professionals to come to an easier decision for or against disposable alternatives and to choose the appropriate system.
Single-case and Small-n Experimental Designs: A Practical Guide To Randomization Tests, Second Edition
by Pat Dugard Portia File Jonathan TodmanThis practical guide explains the use of randomization tests and provides example designs and macros for implementation in IBM SPSS and Excel. It reviews the theory and practice of single-case and small-n designs so readers can draw valid causal inferences from small-scale clinical studies. The macros and example data are provided on the book’s website so that users can run analyses of the text data as well as data from their own studies. The new edition features: More explanation as to why randomization tests are useful and how to apply them. More varied and expanded examples that demonstrate the use of these tests in education, clinical work and psychology. A website with the macros and datasets for all of the text examples in IBM SPSS and Excel. Exercises at the end of most chapters that help readers test their understanding of the material. A new glossary that defines the key words that appear in italics when they are first introduced. A new appendix that reviews the basic skills needed to do randomization tests. New appendices that provide annotated SPSS and Excel macros to help readers write their own or tinker with the ones provided in the book. The book opens with an overview of single case and small n designs -- why they are needed and how they differ from descriptive case studies. Chapter 2 focuses on the basic concepts of randoization tests. Next how to choose and implement a randomization design is reviewed including material on how to perform the randomizations, how to select the number of observations, and how to record the data. Chapter 5 focuses on how to analyze the data including how to use the macros and understand the results. Chapter 6 shows how randomization tests fit into the body of statistical inference. Chapter 7 discusses size and power. The book concludes with a demonstration of how to edit or modify the macros or use parts of them to write your own. Ideal as a text for courses on single-case, small n design, and/or randomization tests taught at the graduate level in psychology (especially clinical, counseling, educational, and school), education, human development, nursing, and other social and health sciences, this inexpensive book also serves as a supplement in statistics or research methods courses. Practitioners and researchers with an applied clinical focus also appreciate this book’s accessible approach. An introduction to basic statistics, SPSS, and Excel is assumed.
Single-cell Sequencing and Methylation: Methods and Clinical Applications (Advances in Experimental Medicine and Biology #1255)
by Li Li Xiangdong Wang Buwei Yu Jiaqiang Zhang Yiming ZengWith the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients.
Singular Differential Equations and Special Functions (Mathematics and Physics for Science and Technology)
by Luis Manuel Braga da Costa CamposSingular Differential Equations and Special Functions is the fifth book within Ordinary Differential Equations with Applications to Trajectories and Vibrations, Six-volume Set. As a set they are the fourth volume in the series Mathematics and Physics Applied to Science and Technology. This fifth book consists of one chapter (chapter 9 of the set). The chapter starts with general classes of differential equations and simultaneous systems for which the properties of the solutions can be established 'a priori', such as existence and unicity of solution, robustness and uniformity with regard to changes in boundary conditions and parameters, and stability and asymptotic behavior. The book proceeds to consider the most important class of linear differential equations with variable coefficients, that can be analytic functions or have regular or irregular singularities. The solution of singular differential equations by means of (i) power series; (ii) parametric integral transforms; and (iii) continued fractions lead to more than 20 special functions; among these is given greater attention to generalized circular, hyperbolic, Airy, Bessel and hypergeometric differential equations, and the special functions that specify their solutions. Includes existence, unicity, robustness, uniformity, and other theorems for non-linear differential equations Discusses properties of dynamical systems derived from the differential equations describing them, using methods such as Liapunov functions Includes linear differential equations with periodic coefficients, including Floquet theory, Hill infinite determinants and multiple parametric resonance Details theory of the generalized Bessel differential equation, and of the generalized, Gaussian, confluent and extended hypergeometric functions and relations with other 20 special functions Examines Linear Differential Equations with analytic coefficients or regular or irregular singularities, and solutions via power series, parametric integral transforms, and continued fractions
Singular Intimacies: Becoming a Doctor at Bellevue
by Danielle OfriIn a series of fifteen essays, Ofri traces her evolution as a physician, from frightened medical student to confident senior resident. Her training is conducted at Bellevue in Manhattan, where she treats a vast cross-section of society. Each essay focuses on her treatment of and interactions with a particular patient, and shows her emotional growth as well as her acquisition of medical knowledge. In the course of the book Ofri struggles to come to terms with her own helplessness before the inevitability of death.
Singular Spectrum Analysis of Biomedical Signals
by Saeid Sanei Hossein HassaniRecent advancements in signal processing and computerised methods are expected to underpin the future progress of biomedical research and technology, particularly in measuring and assessing signals and images from the human body. This book focuses on singular spectrum analysis (SSA), an effective approach for single channel signal analysis, and its
Singular Spectrum Analysis with R (Use R!)
by Anatoly Zhigljavsky Nina Golyandina Anton KorobeynikovThis comprehensive and richly illustrated volume provides up-to-date material on Singular Spectrum Analysis (SSA). SSA is a well-known methodology for the analysis and forecasting of time series. Since quite recently, SSA is also being used to analyze digital images and other objects that are not necessarily of planar or rectangular form and may contain gaps. SSA is multi-purpose and naturally combines both model-free and parametric techniques, which makes it a very special and attractive methodology for solving a wide range of problems arising in diverse areas, most notably those associated with time series and digital images. An effective, comfortable and accessible implementation of SSA is provided by the R-package Rssa, which is available from CRAN and reviewed in this book. Written by prominent statisticians who have extensive experience with SSA, the book (a) presents the up-to-date SSA methodology, including multidimensional extensions, in language accessible to a large circle of users, (b) combines different versions of SSA into a single tool, (c) shows the diverse tasks that SSA can be used for, (d) formally describes the main SSA methods and algorithms, and (e) provides tutorials on the Rssa package and the use of SSA. The book offers a valuable resource for a very wide readership, including professional statisticians, specialists in signal and image processing, as well as specialists in numerous applied disciplines interested in using statistical methods for time series analysis, forecasting, signal and image processing. The book is written on a level accessible to a broad audience and includes a wealth of examples; hence it can also be used as a textbook for undergraduate and postgraduate courses on time series analysis and signal processing.
Singularity Hypotheses
by James H Moor Amnon H. Eden Johnny H Soraker Eric SteinhartSingularity Hypotheses: A Scientific and Philosophical Assessment offers authoritative, jargon-free essays and critical commentaries on accelerating technological progress and the notion of technological singularity. It focuses on conjectures about the intelligence explosion, transhumanism, and whole brain emulation. Recent years have seen a plethora of forecasts about the profound, disruptive impact that is likely to result from further progress in these areas. Many commentators however doubt the scientific rigor of these forecasts, rejecting them as speculative and unfounded. We therefore invited prominent computer scientists, physicists, philosophers, biologists, economists and other thinkers to assess the singularity hypotheses. Their contributions go beyond speculation, providing deep insights into the main issues and a balanced picture of the debate.
Sino-African Cooperation for Schistosomiasis Control in Zanzibar: A Blueprint for Combating other Parasitic Diseases (Parasitology Research Monographs #15)
by Heinz Mehlhorn Kun YangOffering an example for transnational cooperation and successful reduction of a neglected tropical disease, this volume shows how Chinese scientists and local physicians controlled schistosomiasis in Zanzibar. Over a four-year study, local medical specialists and the population of Zanzibar were taught how to diagnose the parasitosis caused by flukes (trematode worms) of the genus Schistosoma. Furthermore, methods to eliminate the disease and prevent new infections were established. The developed control system will avoid repeated increase of human schistosomiasis, which is still prevalent in the tropics and subtropics. Rural populations and poor communities lacking access to clean drinking water and adequate sanitation are most affected. This book is a blueprint of activities urgently needed to combat schistosomiasis in countries with low medical impact. The strategies outlined are particularly relevant to parasitologists and professionals in public health, physicians, medical personnel and also governmental, healthcare and pharmaceutical institutions.
Sinonasal and Skull Base Malignancies
by Nabil F. Saba Derrick T. LinThis book reviews the standard surgical, radiotherapeutic, and systemic management of sinonasal and skull base tumors. It provides up-to-date information on epidemiology, diagnostic modalities, molecular biology, staging, treatment complications, principles of supportive care, and current controversies. Sinonasal and skull base tumors display histologic and anatomic heterogeneity, as well as wide variation in clinical behavior. Accordingly, they pose significant diagnostic and treatment challenges. A multidisciplinary approach offers the best chance of a successful outcome. In addition to documenting in detail the currently accepted management approaches, this book sheds light on various promising novel therapeutic strategies. Sinonasal and Skull Base Malignancies is an invaluable reference for all specialists involved in treating these tumors, including otolaryngologists, head and neck surgeons, reconstructive surgeons, medical and radiation oncologists, neuroradiologists, specialized head and neck pathologists, prosthodontists, and speech and swallow therapists.
Sinus Grafting Techniques
by Ronald Younes Nabih Nader Georges KhouryPlacement of endosseous implants in the posterior maxilla is often difficult because of a lack of supporting bone. Sinus augmentation procedures have therefore been extensively used for the treatment of the edentulous atrophic posterior maxilla prior to implant placement. This book describes in detail the most widely used sinus grafting techniques as well as some innovative variations, with full coverage of both lateral and crestal approaches. A key aim is to assist the practitioner in selecting the appropriate sinus grafting technique based on the evaluation of a number of parameters that are described in detail and codified in a simple and practical way. Up-to-date information is also provided on grafting materials and on potential complications of sinus augmentation procedures and their treatment.
Sinus Headache, Migraine, and the Otolaryngologist
by Mark E. MehleThis volume will serve as a comprehensive and useful guide for ENT physicians in the recognition, diagnosis, and treatment of patients who suffer from sinus headaches and migraines. The text reviews key issues such as identification and management of migraine, and appropriate surgical and nonsurgical treatment that is often not part of ENT resident training. With 20% of women and 6% of men having migraines (only 50% recognized) this text will serve to expand management options to physicians already operating on sinuses or seeing cosmetic patients with head and neck concerns. Other forms of intervention in migraineurs, such as surgery, Botulinum Toxin injections and adjunctive and integrative therapy, are covered. Sinus Headache, Migraine, and the Otolaryngologist will be an invaluable resource for ENT and allergy specialists, and any physician or medical professional with an interest in sinus headache or migraine.
Sinusitis: From Microbiology To Management
by Itzhak BrookFilling a gap in the literature, this reference provides concise and practical guidelines for the diagnosis and management of sinusitis and furnishes an authoritative outline of our current understanding of the pathophysiology of this condition. Addressing a wide spectrum of issues related to the identification, epidemiology, and etiology of sinusi
Sirens
by Joshua MohrAcclaimed novelist Joshua Mohr provides a captivating and complicated account of his years of substance abuse and culpability in his non-fiction debut. Employing the characterization and chimerical prose for which he has been lauded, Mohr traces his childhood swilling fuzzy navels as a latch-key kid, through his first failed marriage, parenthood, heart-surgery, and his everyday struggle against relapse.
Sisterhood
by V. B. Grey'A BEAUTIFULLY WRITTEN STORY OF SISTERS AND THEIR FAMILIES WHOSE LIVES ARE PROFOUNDLY CHANGED BY WAR. GREY IS NOT AFRAID TO SEARCH IN THE SHADOWS FOR THE TRUTH. A TERRIFIC AND THOUGHT PROVOKING READ' ELIZABETH BUCHANIdentical twin sisters Freya and Shona take very different paths, leading to long-buried family secrets that reverberate through the generations in this thrilling novel of psychological suspense by the author of Tell Me How It Ends. There are some choices you can't come back from.It is 1944 in war-battered London. Freya and Shona are identical twins, close despite their different characters. Freya is a newly qualified doctor treating the injured in an East End hospital, while Shona has been recruited by the SOE. The sisters are so physically alike that they can fool people into thinking that one is the other. It's a game they've played since childhood. But when Shona persuades her twin to swap roles to meet her Polish lover, he is angered at being tricked. Then Shona proposes a far more dangerous swapping of roles. At first Freya refuses but finally she agrees, with consequences that threaten not only the happiness but the lives of both sisters. Forty-five years later in November 1989 Freya, now aged 69, is watching television with her daughter Kirsty. Freya is gripped as she witnesses crowds of Berliners attempting to knock down their hated Wall. This sight stirs memories of her own and her sister's war, especially the tragedy of the Warsaw Uprising - memories that she has never shared with anyone. Even if she wanted to reveal them now, she can't. She's suffering from a brain tumour and is unable to speak although her reason is unimpaired. And this is what she's thinking: if they succeed in knocking down the Wall, what secrets will come tumbling through? If her own were revealed, it would be devastating for all those close to her, especially her daughter, Kirsty.(P)2021 Quercus Editions Ltd
Sisters In Arms: British Army Nurses Tell Their Story
by Nicola TyrerThe remarkable true story of the Queen Alexandra frontline nurses in the Second World War.The amazing experiences of the Queen Alexandra nurses in the Second World War form one of the greatest adventure stories of modern times, and - incredibly - remain largely untold. Thousands of middle-class girls, barely out of school, were plucked from sheltered backgrounds, subjected to training regimes unimaginably tough by today's standards, and sent forth to share the harsh conditions of the fighting services. They had to deal with the most appalling suffering, yet most found reserves of inner strength that carried them through episodes of unrelieved horror.Over 200 nurses died, torpedoed in hospital ships, bombed in field hospitals or murdered in Japanese prison camps. Dozens won medals for gallantry. From the beaches of Dunkirk, to Singapore and D-Day, they saw it all. Whether tending burned pilots from the Battle of Britain or improvising medical treatment in Japanese death camps, their dedication was second to none. This is their story.
Sisters In Arms: British Army Nurses Tell Their Story
by Nicola TyrerThe amazing experiences of the Queen Alexandra nurses in the Second World War form one of the greatest adventure stories of modern times, and - incredibly - remain largely untold. Thousands of middle-class girls, barely out of school, were plucked from sheltered backgrounds, subjected to training regimes unimaginably tough by today's standards, and sent forth to share the harsh conditions of the fighting services. They had to deal with the most appalling suffering, yet most found reserves of inner strength that carried them through episodes of unrelieved horror.Over 200 nurses died, torpedoed in hospital ships, bombed in field hospitals or murdered in Japanese prison camps. Dozens won medals for gallantry. From the beaches of Dunkirk, to Singapore and D-Day, they saw it all. Whether tending burned pilots from the Battle of Britain or improvising medical treatment in Japanese death camps, their dedication was second to none. This is their story.Read by Barbara Flynn and Sian Thomas(p) 2008 Orion Publishing Group