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Small Molecule Therapy for Genetic Disease
by Jess G. ThoeneThoene summarises the substantial work that has been accomplished in the treatment of inborn errors of metabolism with simple molecules. This handbook will enable interested clinician scientists to rapidly survey the field, thus ascertaining what has been done as well as future directions for therapeutic research. Its important introductory chapters discuss the infrastructure of the field. The book closely analyses the cofactors used to augment the function of defective enzymes and the compounds that are able to utilise an alternative pathway in order to avoid the consequences of the metabolic block present in the patient. Among other therapies, the authors discuss the use of zinc and tetrathiomolybdate to treat Wilson's disease and the use of cysteamine to treat nephropathic cystinosis.
Small Molecules for Cancer Treatment
by Asim K. Duttaroy Surajit Pathak Antara BanerjeeThe book explores role of small molecules and peptides in cancer therapy, with a focus on (Aptamer-drug conjugates, Androgen Receptor and Tyrosine Kinase inhibitors, and Glycosylation inhibitors. Small molecule inhibitors targeting oncogenic pathways such as EGFR and PI3K inhibitors, Peptides in oral cancer such as Antimicrobial peptides, Cell Penetrating Peptides, Tumour targeting peptides, Natural small molecules with anti-cancer effects such as phenolic compounds, alkaloids, terpenoids and steroids, Phthalides and lectins, Peptides targeting the tumor microenvironment such as GM-CSF's, LAG3, PD 1, CCL2, CCR-5, CXCR4 inhibitors). An introductory chapter covers the foundation for understanding their significance in cancer treatment. The book delves into the versatility and precision of small molecules, highlighting their advantages in drug delivery and formulation strategies. It emphasizes the expansion of therapeutic horizons through small molecule peptides, shedding light on their potential in targeting tumor microenvironments and advancing cancer therapeutics. Additionally, the book discusses combination therapies and synergistic effects, offering a deeper understanding of integrating different therapeutic approaches. Furthermore, it addresses emerging trends, challenges, safety considerations, and the relevance of small-molecule inhibitors. This book provides a crucial update on the latest advancements and serves as a valuable resource for researchers, clinicians, and students interested in the rapidly evolving landscape of cancer treatment, offering an overview of the potential and complexities associated with these compounds in the fight against cancer.
Small Molecules in Hematology (Recent Results in Cancer Research #212)
by Uwe M. MartensThis book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title.
Small Molecules in Neurodegeneration
by Nawab John Dar Shahnawaz Ali BhatNeurodegenerative diseases, like Alzheimer's, Parkinson's, and Huntington's, cast a long shadow over millions of lives, stealing memories, independence, and futures. The rising tide of these age-related disorders threatens to overwhelm healthcare systems worldwide, prompting an urgent search for effective treatments. While current options offer temporary relief, they fail to halt the relentless march of these devastating conditions. However, a beacon of hope shines at the intersection of cutting-edge neuroscience and the world of small molecules. These tiny chemical warriors, with their inherent advantages of cost-effectiveness, scalability, and diverse functionalities, are emerging as powerful weapons in the fight against neurodegeneration. This book stands as a testament to this increasing revolution. It investigates deep into the intricacies of small molecules, exploring their potential to unravel the mysteries of neurodegenerative diseases and pave the way for innovative therapeutic interventions.Key Features: Provides a comprehensive and accessible overview of the emerging field of small molecules in neurodegenerative diseases. Bridges the gap in current literature by addressing the specific impact of small molecules on these devastating conditions. Offers an in-depth exploration of the various mechanisms by which small molecules can combat neurodegeneration. Serves as a valuable resource for a wide audience, from students to professionals in the field. Lays the foundation for a deeper understanding of neurodegenerative diseases and unlocks new avenues for the development of effective therapies.
Small Molecules in Oncology
by Uwe M. MartensExtensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.
Small Molecules in Oncology (Recent Results in Cancer Research #211)
by Uwe M. MartensThis book, written by respected experts, discusses in detail the latest developments in targeted oncology therapy using small molecules. It covers a wide range of small molecules, including tyrosine kinase inhibitors, mTOR, MEK, PARP, and multikinase inhibitors, as well as cell cycle and NTRK interacting agents. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book is the third edition of Small Molecules in Oncology, but has now been divided into two volumes, with the other volume focusing specifically on small molecules in hematology.
Small Pleasures: Longlisted for the Women's Prize for Fiction
by Clare ChambersLONGLISTED FOR THE WOMEN'S PRIZE FOR FICTIONA BBC 2 'BETWEEN THE COVERS' BOOK CLUB PICK'Wonderful' RICHARD OSMAN'Perfect' INDIA KNIGHT'Beautiful' JESSIE BURTON'Witty and sharp' DAVID NICHOLLS1957, the suburbs of south east London. Jean Swinney is a journalist on a local paper, trapped in a life of duty and disappointment from which there is no likelihood of escape. When a young woman, Gretchen Tilbury, contacts the paper to claim that her daughter is the result of a virgin birth, it is down to Jean to discover whether she is a miracle or a fraud. As the investigation turns her quiet life inside out, Jean is suddenly given an unexpected chance at friendship, love and - possibly - happiness.'Gorgeous . . . I could not recommend it more' PANDORA SYKES'Remarkable . . . Small Pleasures is no small pleasure' THE TIMES'Irresistible . . . wry, perceptive and quietly devastating' MAIL ON SUNDAY
Small Supernumerary Marker Chromosomes (sSMC)
by Thomas Liehr UniqueHuman beings normally have a total of 46 chromosomes, with each chromosome present twice, apart from the X and Y chromosomes in males. Some three million people worldwide, however, have 47 chromosomes: they have a small supernumerary marker chromosome (sSMC) in addition to the 46 normal ones. This sSMC can originate from any one of the 24 human chromosomes and can have different shapes. Approximately one third of sSMC carriers show clinical symptoms, while the remaining two thirds manifest no phenotypic effects. This guide represents the first book ever published on this topic. It presents the latest research results on sSMC and current knowledge about the genotype-phenotype correlation. The focus is on genetic diagnostics as well as on prenatal and fertility-related genetic counseling. A unique feature is that research meets practice: numerous patient reports complement the clinical aspects and depict the experiences of families living with a family member with an sSMC.
Small Talk: Bringing Listening and Spoken Language to Your Young Child with Hearing Loss
by Jenna Voss Ellie WhiteSmall Talk is a resource for families of young children with hearing loss and for professionals guiding families through the early stages of listening and spoken language development. The book contains key information needed to support optimal development presented in an engaging and encouraging way. It's up-to-date, evidence-based and family friendly. Graduate students preparing for careers with children with hearing loss will benefit from the well-organized content and developmentally appropriate focus.
Small Volume Biopsy in Pediatric Tumors
by Jerzy Klijanienko Živa Pohar Marinšek Henryk A DomanskiThis richly illustrated book will help presurgically diagnose pediatric/young adult tumors. The content is divided into two parts. The first part shows step-by-step how to perform a small volume specimen such as fine needle aspiration/core needle biopsy and how to correlate the morphology with the clinical, radiological, and/or molecular information. In turn, the second part presents a comprehensive overview of the various tumor entities. The content represents diagnostic modalities from the major diagnostic centers worldwide, and is supplemented by the authors` 25 years of experience in diagnosing pediatric tumors. This book will successfully guide practitioners, researchers and oncology pediatricians through the process of sample harvesting and diagnosing. Pediatric tumors represent a large variety of lesions including pseudotumors of inflammatory and non-inflammatory origin, various types of lympadenopathy, benign lesions, specific sarcomas, and blastemal malignancies. These age-specific and histotype-specific tumors of various origin, evolution and prognosis are often characteristic in morphological and molecular levels, making their diagnosis highly specialized.
Small's Practical Guide to Botulinum Toxin Procedures
by Rebecca SmallSmall’s Practical Guide to Botulinum Toxin Procedures, Second Edition, is the highly anticipated revision of the best-selling step-by-step guide to performing minimally invasive botulinum toxin procedures. With over four hundred 5-star reviews online, the First Edition established itself as the go-to resource for providers looking to enhance their practice by performing medical aesthetic procedures. In the Second Edition, insights from Dr. Small’s additional 10 years of clinical practice, research, and teaching create an even more valuable resource, whether you are new to aesthetic medicine or an experienced practitioner. Small’s Practical Guide provides you with the latest information and techniques, best practices for risk reduction, and expert guidance for optimal results.
Small-Gauge Vitrectomy for Diabetic Retinopathy
by Ulrich Spandau Zoran TomicThis book describes step by step how to operate on the patient with diabetic retinopathy. After thorough explanation of surgical planning, including the potential need to perform individual procedures at different time points, each stage of the vitrectomy is clearly documented with the aid of color photographs and drawings as well as online surgical videos. Variations in approach are described that are potentially of value, depending on whether one is dealing with a straightforward diabetic retinopathy or a difficult case of tractional retinal detachment. In the second part of the book, a series of case reports are presented that illustrate the surgical procedures applicable in different circumstances. In addition, pearls and pitfalls are highlighted. Small-Gauge Vitrectomy for Diabetic Retinopathy will be an ideal source of information and guidance for all who are embarking upon such surgery or wish to further hone their skills.
Small-Gauge Vitrectomy for Diabetic Retinopathy
by Ulrich Spandau Zoran TomicThis book describes step by step how to operate on the patient with diabetic retinopathy. After thorough explanation of surgical planning, including the potential need to perform individual procedures at different time points, each stage of the vitrectomy is clearly documented with the aid of color photographs and drawings as well as online surgical videos. Variations in approach are described that are potentially of value, depending on whether one is dealing with a straightforward diabetic retinopathy or a difficult case of tractional retinal detachment. In the second part of the book, a series of case reports are presented that illustrate the surgical procedures applicable in different circumstances. In addition, pearls and pitfalls are highlighted. Small-Gauge Vitrectomy for Diabetic Retinopathy, 2nd Edition has been updated in response to the rapid increase of diabetes worldwide and the technical advancements in ocular surgery. New chapters on anatomy, surgery and novel laser photocoagulation strategies for diabetic retinopathy also feature in this revised edition. This book is an ideal source of information and guidance for all who are embarking upon such surgery or wish to further hone their skills.
Small-Molecule Inhibitors of Protein-Protein Interactions
by David Fry Lyubomir VassilevIn this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. There are various focal points, including methodologies and the molecules themselves. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field
Small-N und Big-N-Data in der Sportwissenschaft: Einführung in Forschungsdesign und Methoden (essentials)
by Jochen Mayerl Michael Fröhlich Andrea Pieter Wolfgang KemmlerIm Rahmen dieses essentials legen die Autoren das Augenmerk auf die Besonderheiten des Umgangs mit kleinen und großen Datenmengen in der Sportwissenschaft. Kurz und überblickartig wird dargestellt, welche Designs im Rahmen von Single-Case-Studies zum Einsatz gelangen können und wie solche Studien ausgewertet werden. Weiterhin wird erläutert, wie man die beste wissenschaftliche Evidenz in die (medizinische) Praxis integriert und wie im Rahmen von Forschungsprojekten die erhobenen Daten gesichert und öffentlich zugänglich gemacht werden. Darüber hinaus wird dargestellt, was alles unter dem Begriff Big Data subsumiert wird und welche Möglichkeiten und Grenzen für die Wissenschaft mit Big Data verbunden sind.
Smallpox: The Death of a Disease
by D. A. HendersonFor more than 3000 years, hundreds of millions of people have died or been left permanently scarred or blind by the relentless, incurable disease called smallpox. In 1967, Dr. D.A. Henderson became director of a worldwide campaign to eliminate this disease from the face of the earth.This spellbinding book is Dr. Henderson's personal story of how he led the World Health Organization's campaign to eradicate smallpox--the only disease in history to have been deliberately eliminated. Some have called this feat "the greatest scientific and humanitarian achievement of the past century."In a lively, engrossing narrative, Dr. Henderson makes it clear that the gargantuan international effort involved more than straightforward mass vaccination. He and his staff had to cope with civil wars, floods, impassable roads, and refugees as well as formidable bureaucratic and cultural obstacles, shortages of local health personnel and meager budgets. Countries across the world joined in the effort; the United States and the Soviet Union worked together through the darkest cold war days; and professionals from more than 70 nations served as WHO field staff. On October 26, 1976, the last case of smallpox occurred. The disease that annually had killed two million people or more had been vanquished-and in just over ten years.The story did not end there. Dr. Henderson recounts in vivid detail the continuing struggle over whether to destroy the remaining virus in the two laboratories still that held it. Then came the startling discovery that the Soviet Union had been experimenting with smallpox virus as a biological weapon and producing it in large quantities. The threat of its possible use by a rogue nation or a terrorist has had to be taken seriously and Dr. Henderson has been a central figure in plans for coping with it.New methods for mass smallpox vaccination were so successful that he sought to expand the program of smallpox immunization to include polio, measles, whooping cough, diphtheria, and tetanus vaccines. That program now reaches more than four out of five children in the world and is eradicating poliomyelitis.This unique book is to be treasured--a personal and true story that proves that through cooperation and perseverance the most daunting of obstacles can be overcome.
Smart Biomaterial Devices: Polymers in Biomedical Sciences
by Atul Tiwari A.K. Bajpai Jaya Bajpai Rajesh Kumar Saini Priyanka AgrawalPolymers have emerged as one of the most innovative classes of materials in modern materials science, leading to new applications in medicine and pharmacy. This book offers a convincing and understandable approach to polymer biomaterial devices being used in various areas related to biomedical and pharmaceutical fields. The polymer materials finding application as biomaterials are discussed and described in detail pertaining to the areas of artificial implants, orthopedics, ocular devices, dental implants, drug delivery systems, burns and wounds.
Smart Biomaterials
by Ravin Narain Mitsuhiro Ebara Yohei Kotsuchibashi Naokazu Idota Young-Jin Kim John M. Hoffman Koichiro Uto Takao AoyagiThis book provides comprehensive coverage of smart biomaterials and their potential applications, a field that is developing at a very rapid pace. Because smart biomaterials are an emerging class of biomaterials that respond to small changes in external stimuli with large discontinuous changes in their physical properties, they have been designed to act as an "on-off" switch for, among others, bio separation, immunoanalysis, drug delivery technologies, gene therapy, diagnostics, bio sensors and artificial muscles. After an introduction to the topic and the history of smart biomaterials, the author gives the reader an in-depth look at the properties, mechanics, and characterization of smart biomaterials including hydrogels, particles, assemblies, surfaces, fibers and conjugates. Information on the wide range of applications for these materials follows, including drug delivery, tissue engineering, diagnostics, biosensors, bio separation and actuators. In addition, recent advances in shape memory biomaterials as active components of medical devices are also presented.
Smart Career: Wie Sie die seelischen Kosten der Karriere minimieren
by Werner GrossIn diesem Sachbuch soll es einmal nicht nur um die Schokoladenseiten der Karriere gehen, sondern auch um die Schattenseiten: Selbstdisziplin bis zur Selbstverleugnung, übertriebene Außenorientierung und exzessive Anpassungsleistungen nach unausgesprochenen Wohlverhaltensklauseln produzieren mitunter zunehmendes Fassadenverhalten: Stoßfest, bruchsicher, formschön und abwaschbar heißt für viele die Devise auf der Karriereleiter. Gar nicht so selten geht damit ein schleichender Verlust der Menschlichkeit einher. Geschrieben für Laien und Interessierte; Psychotherapeuten, Coaches, Berater können prozessbegleitend empfehlen. Aus dem Inhalt: Die beruflichen Anforderungen bis zum Jahr 2025 – Gefahren auf der Karriereleiter (körperliche, seelische, soziale) – Warum und wie man in berufliche Krisen gerät – Krise als Chance und als Möglichkeit, sein Leben neu auszurichten – 4 Bereiche einer gesunden Identität – „Funktionslust“ oder: der Spaß am Beruf – Von der Karriereleiter zum Karrierenetzwerk – Zwischen Effizienz und Menschlichkeit: Ressourcen aktivieren, psychosoziale Reibungsverluste minimieren, Arbeitsprozesse optimieren, angemessene Problemlösungen finden – Gibt es mehr im Leben, als Effizienz und Geschwindigkeit zu erhöhen? – Expatriates, Downshifting und Sabbatical – Hilfen von außen: Coaching, Supervision, Psychotherapie. Über den Autor: Werner Gross, Dipl.-Psychologe, Psychotherapeut, Supervisor und Coach, Organisations- und Unternehmensberater.
Smart Cities in Application: Healthcare, Policy, and Innovation
by Stan McClellanThis book explores categories of applications and driving factors surrounding the Smart City phenomenon. The contributing authors provide perspective on the Smart Cities, covering numerous applications and classes of applications. The book uses a top-down exploration of the driving factors in Smart Cities, by including focal areas including “Smart Healthcare,” “Public Safety & Policy Issues,” and “Science, Technology, & Innovation.” Contributors have direct and substantive experience with important aspects of Smart Cities and discuss issues with technologies & standards, roadblocks to implementation, innovations that create new opportunities, and other factors relevant to emerging Smart City infrastructures.Features an exploration of Smart City issues and solutions from a variety of stakeholders in the evolving fieldPresents conversational, nuanced, and forward thinking perspectives on Smart Cities, their implications, limitations, obstacles, and opportunitiesIncludes contributions from industry insiders who have direct, relevant experience with their respective subjects as well as positioning and corporate stature
Smart Computational Intelligence in Biomedical and Health Informatics (Computational Intelligence Techniques)
by Amit Kumar ManochaSmart Computational Intelligence in Biomedical and Health Informatics presents state-of-the-art innovations; research, design, and implementation of methodological and algorithmic solutions to data processing problems, including analysis of evolving trends in health informatics and computer-aided diagnosis. This book describes practical, applications-led research regarding the use of methods and devices in clinical diagnosis, disease prevention, and patient monitoring and management. It also covers simulation and modeling, measurement and control, analysis, information extraction and monitoring of physiological data in clinical medicine and the biological sciences. FEATURES Covers evolutionary approaches to solve optimization problems in biomedical engineering Discusses IoT, Cloud computing, and data analytics in healthcare informatics Provides computational intelligence-based solution for diagnosis of diseases Reviews modelling and simulations in designing of biomedical equipment Promotes machine learning-based approaches to improvements in biomedical engineering problems This book is for researchers, graduate students in healthcare, biomedical engineers, and those interested in health informatics, computational intelligence, and machine learning.
Smart Devices for Medical 4.0 Technologies (Advances in Smart Healthcare Technologies)
by Martin Margala Chinmay Chakraborty Manisha GuduriThe aim of this book is to identify some of the challenges that need to be addressed to accelerate the deployment and adoption of smart health technologies for ubiquitous healthcare access especially in wearable devices. These wearable devices may include pacemakers, defibrillators, RFID devices, assistive devices for the visually impaired, magnifiers, and talking assistants. It also explores how Internet of Things (IoT) and big data technologies can be combined with these wearable devices to provide better healthcare solutions. Features: Focuses on real-time implementation of deep and machine learning techniques as well as novel algorithms for smart healthcare. Explores innovative challenges and solutions to complex problems in assistive devices with Medical 4.0 technologies. Presents an overview of challenges in the design of medical wearable devices. Discusses different techniques on VLSI for medical devices. Includes a case study on an AI-tuned cardiac pacemaker. This book is aimed at graduate students and researchers in biomedical, electrical, computer engineering, and medical technologies.
Smart Distributed Embedded Systems for Healthcare Applications (Explainable AI (XAI) for Engineering Applications)
by Jafar A. Alzubi Joel J. P. C. Rodrigues Bhawna Singla Preeti Nagrath A. K. VermaThis book discusses the applications and optimization of emerging smart technologies in the field of healthcare. It further explains different modeling scenarios of the latest technologies in the healthcare system and compares the results to better understand the nature and progress of diseases in the human body, which would ultimately lead to early diagnosis and better treatment and cure of diseases with the help of distributed technology. Covers the implementation models using technologies such as artificial intelligence, machine learning, and deep learning with distributed systems for better diagnosis and treatment of diseases. Gives in-depth review of technological advancements like advanced sensing technologies such as plasmonic sensors, usage of RFIDs, and electronic diagnostic tools in the field of healthcare engineering. Discusses possibilities of augmented reality and virtual reality interventions for providing unique solutions in medical science, clinical research, psychology, and neurological disorders. Highlights the future challenges and risks involved in the application of smart technologies such as cloud computing, fog computing, IOT, and distributed computing in healthcare. Confers to utilize the AI and ML and associated aids in healthcare sectors in the post-Covid 19 period to revitalize the medical setup. Contributions included in the book will motivate technological developers and researchers to develop new algorithms and protocols in the healthcare field. It will serve as a vast platform for gaining knowledge regarding healthcare delivery, health- care management, healthcare in governance, and health monitoring approaches using distributed environments. It will serve as an ideal reference text for graduate students and researchers in diverse engineering fields including electrical, electronics and communication, computer, and biomedical fields.
Smart Electromechanical Systems: The Central Nervous System
by Andrey E. Gorodetskiy Vugar G. KurbanovThis book describes approaches to solving the problems of developing the central nervous system of robots (CNSR) based on smart electromechanical systems (SEMS) modules, principles of construction of the various modules of the central nervous system and variants of mathematical software CNSR in control systems for intelligent robots. It presents the latest advances in theory and practice at the Russian Academy of Sciences. Developers of intelligent robots to solve modern problems in robotics are increasingly addressing the use of the bionic approach to create robots that mimic the complexity and adaptability of biological systems. These have smart electromechanical system (SEMS), which are used in various cyber-physical systems (CPhS), and allow the functions of calculation, control, communications, information storage, monitoring, measurement and control of parameters and environmental parameters to be integrated. The behavior of such systems is based on the information received from the central nervous system of the robot (CNSR) on the state of the environment and system state. Recent advances in computer science, measuring and computing techniques have stimulated the practical realization of the CNSR, providing a fundamentally new approach to the methods and algorithms of formation of appropriate robot behavior. Intelligent robots with CNSR occupy a special place among the highly efficient robotic systems with parallel structures and play an important role in modern automated industries, and this timely book is a valuable resource for specialists in the field of robotics and control, as well as for students majoring in "Robots", "System analysis and management", and "Automation and control".
Smart Health
by Yong Zhang Chunxiao Xing Ye LiangThis book constitutes the thoroughly refereed post-conference proceedings of the International Conference for Smart Health, ICSH 2016, held in Haikou, Hainan, China, in December 2016. The 23 full papers presented were carefully reviewed and selected from 52 submissions. They are organized around the following topics: big data and smart health; health data analysis and management; healthcare intelligent systems and clinical practice; medical monitoring and information extraction; clinical and medical data mining.